Colgate || Skin Deep: Cosmetic Safety Reviews

BRAND: Colgate

Manufacturer: Colgate-Palmolive Company

BRAND SUMMARY

product score range	2	to	6
product count	162 (browse)
ingredient count	63
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this brand -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this brand:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this brand: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 162 products by Colgate

Product type(s) by this brand in Skin Deep: breath fresheners (1), mouthwash (12), no match (1), tooth whitening (33), toothpaste (65)

ingredients

	score	data gap	products *	concerns
SODIUM FLUORIDE	9	63%	65 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
PEG-40 SORBITAN DIISOSTEARATE	6	73%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
POLYETHYLENE	6	69%	2 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
FLUORIDE ION	7	71%	1 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Occupational hazards
SILICA	1	69%	1 products	Biochemical or cellular level changes
TRICLOSAN	7	67%	37 products	Violations, restrictions & warnings, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (CHLOROFORM, DIOXIN)
ALUMINA	6	85%	1 products	Developmental/reproductive toxicity, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Enhanced skin absorption, Occupational hazards
PEG-12	4	76%	19 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-600	4	76%	1 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
TARTRAZINE	5	70%	1 products	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive)
SODIUM MONOFLUOROPHOSPHATE	6	69%	4 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
HYDROGEN PEROXIDE	6	65%	3 products	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
BHT	6	61%	1 products	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
MANGANESE GLUCONATE	5	84%	1 products	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
ETHANOL	5	74%	3 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
COCAMIDOPROPYL BETAINE	5	63%	16 products	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
PROPRIETARY INGREDIENTS	4	100%	1 products	Miscellaneous
FLAVOR	4	100%	73 products	Miscellaneous
UNSPECIFIED POLYMER	4	100%	1 products	Miscellaneous
POLOXAMER 338	2	82%	2 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
POLOXAMER 407	2	82%	3 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
TITANIUM DIOXIDE (NON-NANO)	1	81%	54 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
D&C RED 33	1	75%	6 products	none identified
FD&C GREEN 3	1	73%	1 products	none identified
FD&C RED 4	4	73%	1 products	Violations, restrictions & warnings
METHYL SALICYLATE	4	71%	2 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
FD&C YELLOW 6	1	70%	1 products	none identified
PROPYLENE GLYCOL	4	60%	37 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
MENTHOL	3	85%	2 products	Organ system toxicity (non-reproductive), Multiple, additive exposure sources
FD&C YELLOW 5	2	82%	3 products	Neurotoxicity, Organ system toxicity (non-reproductive)
ZINC CITRATE TRIHYDRATE	2	80%	1 products	Allergies/immunotoxicity, Persistence and bioaccumulation
SODIUM HYDROXIDE	3	77%	49 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CARRAGEENAN	2	75%	45 products	Organ system toxicity (non-reproductive), Contamination concerns (DEGRADED CARRAGEENAN), Biochemical or cellular level changes
MICA	3	75%	29 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
D&C YELLOW 10	1	73%	9 products	none identified
SODIUM LAURYL SULFATE	3	68%	66 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
FD&C BLUE 1	1	83%	39 products	none identified
TETRASODIUM PYROPHOSPHATE	2	82%	25 products	Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
SODIUM BICARBONATE	2	80%	2 products	none identified
SODIUM SACCHARIN	2	80%	69 products	Neurotoxicity
PHOSPHORIC ACID	2	79%	7 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
HYDRATED SILICA	2	79%	63 products	Persistence and bioaccumulation
CALCIUM PEROXIDE	0	75%	2 products	none identified
GLYCERIN	2	74%	50 products	Organ system toxicity (non-reproductive), Occupational hazards
CETYLPYRIDINIUM CHLORIDE	2	73%	1 products	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs)
SODIUM BENZOATE	2	69%	1 products	Organ system toxicity (non-reproductive)
PVM/ MA COPOLYMER	1	93%	43 products	Irritation (skin, eyes, or lungs)
SODIUM PHOSPHATE	1	89%	6 products	none identified
KI203	1	89%	2 products	none identified
METHYLCELLULOSE	1	88%	6 products	none identified
SORBITOL	1	88%	74 products	none identified
POTASSIUM SORBATE	1	85%	6 products	none identified
FD&C RED 40	1	84%	5 products	none identified
POLYSORBATE-20	1	84%	8 products	none identified
PENTASODIUM TRIPHOSPHATE	1	83%	8 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
POTASSIUM NITRATE	1	81%	3 products	Organ system toxicity (non-reproductive)
CELLULOSE GUM	1	80%	63 products	none identified
DICALCIUM PHOSPHATE DIHYDRATE	0	100%	1 products	none identified
FD&C RED 33	0	100%	1 products	none identified
SODIUM MAGNESIUM SILICATE	0	99%	1 products	none identified
XANTHAN GUM	0	94%	7 products	none identified
CARBOMER	0	93%	1 products	none identified
WATER	0	0%	74 products	innocuous

* Product counts only include current formulations sold by this brand. The brand may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this brand that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
Cancer - not classifiable/not likely to be human carcinogen	products that may be aerosolized (airborne)	SILICA
Cancer - not classifiable/not likely to be human carcinogen		BHT, FD&C BLUE 1, FD&C GREEN 3, FD&C RED 4, FD&C YELLOW 6, HYDROGEN PEROXIDE, POLYETHYLENE, HYDRATED SILICA
Not likely to be carcinogenic in humans		CARRAGEENAN
Cancer - limited evidence		ETHANOL, FLUORIDE ION
One or more animal studies show tumor formation at low doses		SODIUM FLUORIDE
One or more in vitro tests on mammalian cells show positive mutation results		FD&C RED 40, FD&C YELLOW 5, GLYCERIN, MENTHOL, POTASSIUM SORBATE, PROPYLENE GLYCOL, SODIUM BENZOATE, SODIUM BICARBONATE, SODIUM HYDROXIDE, SODIUM LAURYL SULFATE, SODIUM MONOFLUOROPHOSPHATE, SODIUM SACCHARIN, SORBITOL, TARTRAZINE
One or more animal studies show tumor formation at moderate doses		ALUMINA
One or more in vitro tests non-mammalian cells show positive mutation results		D&C RED 33, METHYL SALICYLATE, POTASSIUM NITRATE, TRICLOSAN
One or more animal studies show tumor formation at high doses		CELLULOSE GUM

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of reproductive toxicity		ETHANOL
Human nervous system toxicant - moderate evidence		ALUMINA, FLUORIDE ION, MANGANESE GLUCONATE, SODIUM FLUORIDE, SODIUM MONOFLUOROPHOSPHATE
Limited evidence of reproductive toxicity		METHYL SALICYLATE
One or more animal studies show reproductive effects at moderate doses		CELLULOSE GUM, GLYCERIN, PROPYLENE GLYCOL, SODIUM BICARBONATE, ZINC CITRATE TRIHYDRATE
One or more animal studies show reproductive effects at high doses		BHT, FD&C RED 40, FD&C YELLOW 5, POLYSORBATE-20, POTASSIUM NITRATE, SODIUM BENZOATE, SODIUM LAURYL SULFATE, SODIUM SACCHARIN, TARTRAZINE, TRICLOSAN, FD&C YELLOW 6

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		TARTRAZINE
Violation of government restrictions - Banned or found unsafe for use in cosmetics	product not intended as hair dye/bleach	HYDROGEN PEROXIDE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use only	products for use around the mouth, lips, eyes, or on damaged skin	FD&C RED 4
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes	products for use around the eyes	D&C RED 33, D&C YELLOW 10, FD&C GREEN 3, FD&C YELLOW 6
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-12, PEG-40 SORBITAN DIISOSTEARATE, PEG-600, POLYETHYLENE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		CETYLPYRIDINIUM CHLORIDE, FLUORIDE ION, METHYL SALICYLATE, SODIUM FLUORIDE, SODIUM MONOFLUOROPHOSPHATE, TRICLOSAN
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics	products for use on the lips	CALCIUM PEROXIDE, HYDROGEN PEROXIDE
Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmetics		D&C RED 33, COCAMIDOPROPYL BETAINE, METHYL SALICYLATE, PEG-12, PEG-40 SORBITAN DIISOSTEARATE, PEG-600, POLYETHYLENE, PROPYLENE GLYCOL, SODIUM BENZOATE, SODIUM LAURYL SULFATE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Strong evidence of human neurotoxicity		ALUMINA, FLUORIDE ION, MANGANESE GLUCONATE, SODIUM FLUORIDE, SODIUM MONOFLUOROPHOSPHATE
One or more animal studies show brain and nervous system effects at very low doses		FD&C YELLOW 5, HYDROGEN PEROXIDE, SODIUM HYDROXIDE, SODIUM SACCHARIN, TARTRAZINE
One or more animal studies show brain and nervous system effects at low doses		BHT, TETRASODIUM PYROPHOSPHATE
One or more animal studies show brain and nervous system effects at moderate doses		CARRAGEENAN, MENTHOL, METHYL SALICYLATE, PENTASODIUM TRIPHOSPHATE, PHOSPHORIC ACID, SODIUM BENZOATE, SODIUM LAURYL SULFATE
One or more animal studies show brain and nervous system effects at high doses		FD&C BLUE 1, FD&C YELLOW 6, GLYCERIN, POLYETHYLENE, POTASSIUM SORBATE, PROPYLENE GLYCOL, SODIUM BICARBONATE, POLOXAMER 338, POLOXAMER 407
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		ETHANOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more studies show endocrine disruption at very low doses		TRICLOSAN
One or more studies show endocrine system disruption at low doses		SODIUM FLUORIDE
Limited evidence of endocrine disruption		FLUORIDE ION
One or more animal studies show endocrine system disruption at high doses		BHT, GLYCERIN, HYDROGEN PEROXIDE, PENTASODIUM TRIPHOSPHATE, POTASSIUM NITRATE, SODIUM LAURYL SULFATE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		BHT, COCAMIDOPROPYL BETAINE
Human immune system toxicant - strong evidence	products that may be aerosolized (airborne)	SILICA, POLOXAMER 338, POLOXAMER 407
Human skin toxicant - strong evidence		PEG-40 SORBITAN DIISOSTEARATE
Limited evidence of immune system toxicity		ZINC CITRATE TRIHYDRATE, PROPYLENE GLYCOL
Human immune system toxicant - moderate evidence		POLYETHYLENE
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show gastrointestinal effects at moderate doses		MICA

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife and humans	products that may be aerosolized (airborne)	SILICA
Persistent, bioaccumulative in wildlife and humans		MICA, HYDRATED SILICA
Persistent, bioaccumulative in wildlife		TRICLOSAN, ZINC CITRATE TRIHYDRATE
Not suspected to be persistent		CETYLPYRIDINIUM CHLORIDE, COCAMIDOPROPYL BETAINE, D&C YELLOW 10, FD&C RED 4, FD&C RED 40, FD&C YELLOW 6, GLYCERIN, MENTHOL, METHYL SALICYLATE, POTASSIUM SORBATE, SODIUM BENZOATE, SODIUM SACCHARIN, SORBITOL, KI203
Not suspected to be persistent		SODIUM LAURYL SULFATE
Not suspected to be bioaccumulative		CALCIUM PEROXIDE, CARBOMER, D&C RED 33, FD&C BLUE 1, FD&C GREEN 3, FD&C YELLOW 5, MANGANESE GLUCONATE, PENTASODIUM TRIPHOSPHATE, POLYETHYLENE, PVM/ MA COPOLYMER, SODIUM BICARBONATE, SODIUM FLUORIDE, SODIUM MONOFLUOROPHOSPHATE, SODIUM PHOSPHATE, TARTRAZINE, TETRASODIUM PYROPHOSPHATE, WATER
Not suspected to be bioaccumulative		ALUMINA, ETHANOL, PHOSPHORIC ACID, POTASSIUM NITRATE, SODIUM HYDROXIDE, TITANIUM DIOXIDE (NON-NANO), POLOXAMER 338, POLOXAMER 407

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human respiratory toxicant		MANGANESE GLUCONATE
Known human respiratory toxicant	products that may be aerosolized (airborne)	SILICA
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	PROPYLENE GLYCOL
Possible human immune system toxicant		POLYETHYLENE, FLUORIDE ION, MICA
One or more animal studies show blood effects at very low doses		CARRAGEENAN, SODIUM MONOFLUOROPHOSPHATE, SODIUM FLUORIDE, GLYCERIN, SODIUM HYDROXIDE, FD&C YELLOW 5, TARTRAZINE,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	ETHANOL, HYDROGEN PEROXIDE, MENTHOL, METHYL SALICYLATE, PHOSPHORIC ACID
One or more animal studies show blood effects at low doses		POTASSIUM NITRATE, PENTASODIUM TRIPHOSPHATE, SODIUM BENZOATE, SODIUM LAURYL SULFATE, TRICLOSAN, POLOXAMER 338, POLOXAMER 407, TETRASODIUM PYROPHOSPHATE,
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	BHT
Limited evidence of any toxicity	products that may be aerosolized (airborne)	ALUMINA, ZINC CITRATE TRIHYDRATE
Limited evidence of sense organ toxicity		PEG-12, PEG-40 SORBITAN DIISOSTEARATE, PEG-600
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		CETYLPYRIDINIUM CHLORIDE, METHYLCELLULOSE, POTASSIUM SORBATE, SODIUM PHOSPHATE, SODIUM BICARBONATE,
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		FD&C BLUE 1
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		CELLULOSE GUM, D&C YELLOW 10, SODIUM SACCHARIN, KI203, FD&C YELLOW 6, POLYSORBATE-20, SORBITOL, FD&C RED 40
Classified as not expected to be potentially toxic or harmful		CALCIUM PEROXIDE, CARBOMER, COCAMIDOPROPYL BETAINE, D&C RED 33, FD&C GREEN 3, FD&C RED 4, PVM/ MA COPOLYMER, WATER, XANTHAN GUM, HYDRATED SILICA

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		PROPRIETARY INGREDIENTS, FLAVOR, UNSPECIFIED POLYMER
Occupational hazards related to handling		ETHANOL, HYDROGEN PEROXIDE, PHOSPHORIC ACID, SODIUM FLUORIDE, SODIUM HYDROXIDE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		ETHANOL, MENTHOL, SODIUM FLUORIDE
Designated as safe for general or specific, limited use in food	products that may be aerosolized (airborne)	SILICA
Designated as safe for general or specific, limited use in food		BHT, CALCIUM PEROXIDE, CARRAGEENAN, CELLULOSE GUM, CETYLPYRIDINIUM CHLORIDE, DICALCIUM PHOSPHATE DIHYDRATE, ETHANOL, FD&C BLUE 1, FD&C GREEN 3, FD&C RED 40, FD&C YELLOW 5, FD&C YELLOW 6, GLYCERIN, HYDROGEN PEROXIDE, MANGANESE GLUCONATE, MENTHOL, METHYL SALICYLATE, METHYLCELLULOSE, PEG-12, PEG-40 SORBITAN DIISOSTEARATE, PEG-600, PENTASODIUM TRIPHOSPHATE, PHOSPHORIC ACID, POLYETHYLENE, POLYSORBATE-20, POTASSIUM NITRATE, POTASSIUM SORBATE, PROPYLENE GLYCOL, SODIUM BENZOATE, SODIUM BICARBONATE, SODIUM FLUORIDE, SODIUM HYDROXIDE, SODIUM LAURYL SULFATE, SODIUM PHOSPHATE, SODIUM SACCHARIN, SORBITOL, TARTRAZINE, TETRASODIUM PYROPHOSPHATE, TITANIUM DIOXIDE (NON-NANO), XANTHAN GUM, POLOXAMER 338, POLOXAMER 407

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		TRICLOSAN, PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	POLYETHYLENE, SODIUM LAURYL SULFATE
Human skin irritant - moderate evidence		HYDROGEN PEROXIDE, PHOSPHORIC ACID
One or more animal studies show skin irritation at very low doses		METHYL SALICYLATE, SODIUM HYDROXIDE
One or more animal studies show significant but moderate pulmonary irritation at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show skin irritation at low doses		BHT, CETYLPYRIDINIUM CHLORIDE, ETHANOL, PENTASODIUM TRIPHOSPHATE, PVM/ MA COPOLYMER
One or more animal studies show skin irritation at moderate doses		GLYCERIN, MENTHOL, POLYSORBATE-20, SODIUM BICARBONATE
One or more animal studies show skin irritation at high doses		SODIUM BENZOATE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		SODIUM FLUORIDE
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), HYDROGEN PEROXIDE
Allowed workplace exposures restricted to low doses		BHT, FLUORIDE ION, MICA, PHOSPHORIC ACID, SODIUM MONOFLUOROPHOSPHATE
Allowed workplace exposures restricted to moderate doses		ALUMINA, GLYCERIN, TETRASODIUM PYROPHOSPHATE
Allowed workplace exposures restricted to high doses		ETHANOL
No workplace limits set		SODIUM HYDROXIDE
Single case study detailing occupational hazards		MANGANESE GLUCONATE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		CARRAGEENAN, SILICA, SODIUM FLUORIDE,
One or more animal studies show respiratory changes at very low doses where the human health implications are not yet well understood	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		BHT
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		METHYL SALICYLATE, SODIUM LAURYL SULFATE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CELLULOSE GUM, ETHANOL, GLYCERIN, HYDROGEN PEROXIDE, POLYETHYLENE, SODIUM BENZOATE, SODIUM BICARBONATE, PROPYLENE GLYCOL