Crest || Skin Deep: Cosmetic Safety Reviews

BRAND: Crest

Manufacturer: Procter & Gamble

BRAND SUMMARY

product score range	2	to	7
product count	153 (browse)
ingredient count	70
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this brand -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this brand:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this brand: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 153 products by Crest

Product type(s) by this brand in Skin Deep: breath fresheners (1), mouthwash (5), oral pain relief (1), tooth whitening (41), toothpaste (70)

ingredients

	score	data gap	products *	concerns
METHYLPARABEN	10	63%	3 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
SODIUM FLUORIDE	9	63%	66 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
POLYETHYLENE	5	69%	11 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-6	4	74%	29 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
SILICA	1	69%	5 products	Biochemical or cellular level changes
PEG-12	4	76%	7 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
STANNOUS FLUORIDE	6	69%	3 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
HYDROGEN PEROXIDE	6	65%	10 products	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
ETHANOL	5	74%	10 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
ALCOHOL DENATURED	5	71%	1 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
PROPYLPARABEN	5	71%	3 products	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
COCAMIDOPROPYL BETAINE	5	63%	4 products	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
FLAVOR	4	100%	75 products	Miscellaneous
BLUE 1 ALUMINUM LAKE	3	91%	3 products	Developmental/reproductive toxicity, Neurotoxicity
YELLOW 10 ALUMINUM LAKE	3	91%	9 products	Developmental/reproductive toxicity, Neurotoxicity
POLOXAMER 407	2	82%	27 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
TITANIUM DIOXIDE (NON-NANO)	1	81%	61 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
FD&C GREEN 3	1	73%	1 products	none identified
CI 42053	4	73%	1 products	Violations, restrictions & warnings
FD&C YELLOW 6	1	70%	6 products	none identified
BENZOIC ACID	4	65%	9 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
PROPYLENE GLYCOL	4	60%	14 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
MENTHOL	3	85%	1 products	Organ system toxicity (non-reproductive), Multiple, additive exposure sources
FD&C YELLOW 5	2	82%	11 products	Neurotoxicity, Organ system toxicity (non-reproductive)
SODIUM HYDROXIDE	3	77%	19 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CARRAGEENAN	2	75%	3 products	Organ system toxicity (non-reproductive), Contamination concerns (DEGRADED CARRAGEENAN), Biochemical or cellular level changes
MICA	3	75%	11 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
MENTHA PIPERITA (PEPPERMINT) OIL	3	73%	1 products	Enhanced skin absorption, Contamination concerns (LIMONENE, MENTHOL, MENTHONE)
CITRIC ACID	3	72%	2 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
SODIUM HEXAMETAPHOSPHATE	3	72%	9 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (LEAD)
SODIUM LAURYL SULFATE	3	68%	70 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
IRON OXIDES	2	85%	2 products	Persistence and bioaccumulation, Enhanced skin absorption
FD&C BLUE 1	1	83%	43 products	none identified
ZINC LACTATE	2	83%	3 products	Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
SODIUM CARBONATE	2	82%	8 products	Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
TETRASODIUM PYROPHOSPHATE	2	82%	38 products	Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
POLYSORBATE-80	2	80%	9 products	Developmental/reproductive toxicity
SODIUM BICARBONATE	2	80%	11 products	none identified
SODIUM SACCHARIN	2	80%	82 products	Neurotoxicity
HYDRATED SILICA	2	79%	65 products	Persistence and bioaccumulation
CALCIUM PEROXIDE	0	75%	3 products	none identified
GLYCERIN	2	74%	64 products	Organ system toxicity (non-reproductive), Occupational hazards
CETYLPYRIDINIUM CHLORIDE	2	73%	13 products	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs)
SODIUM BENZOATE	2	69%	9 products	Organ system toxicity (non-reproductive)
SUCRALOSE	1	95%	12 products	none identified
DISODIUM PYROPHOSPHATE	1	89%	28 products	Organ system toxicity (non-reproductive)
SODIUM GLUCONATE	1	89%	3 products	none identified
SODIUM PHOSPHATE	1	89%	15 products	none identified
DOMIPHEN BROMIDE	1	88%	2 products	Organ system toxicity (non-reproductive)
ILLICIUM VERUM (ANISE) OIL	1	88%	1 products	none identified
SODIUM STANNATE	1	88%	1 products	Occupational hazards
SORBITOL	1	88%	66 products	none identified
TRISODIUM PHOSPHATE	1	88%	20 products	none identified
TETRAPOTASSIUM PYROPHOSPHATE	1	87%	13 products	none identified
FD&C RED 40	1	84%	4 products	none identified
PENTASODIUM TRIPHOSPHATE	1	83%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
POTASSIUM NITRATE	1	81%	2 products	Organ system toxicity (non-reproductive)
CELLULOSE GUM	1	80%	36 products	none identified
CARBOMER 956	0	100%	48 products	none identified
CARBOPOL 956	0	100%	2 products	none identified
CITRUS MEDICA LIMONUM (LEMON) EXTRACT	0	100%	1 products	none identified
POLYETHELENE OXIDE	0	100%	4 products	none identified
PYRO PHOSPHATE	0	100%	1 products	none identified
SODIUM CITRATE	0	94%	2 products	none identified
XANTHAN GUM	0	94%	51 products	none identified
CI 18965	0	94%	1 products	none identified
CARBOMER	0	93%	3 products	none identified
COPERNICIA CERIFERA (CARNAUBA) WAX	0	93%	17 products	none identified
CELLULOSE	0	0%	5 products	innocuous
WATER	0	0%	83 products	innocuous

* Product counts only include current formulations sold by this brand. The brand may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this brand that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
Cancer - not classifiable/not likely to be human carcinogen	products that may be aerosolized (airborne)	SILICA
Cancer - not classifiable/not likely to be human carcinogen		FD&C BLUE 1, FD&C GREEN 3, FD&C YELLOW 6, HYDROGEN PEROXIDE, POLYETHYLENE, CI 42053, HYDRATED SILICA
Not likely to be carcinogenic in humans		BENZOIC ACID, CARRAGEENAN
Cancer - limited evidence		ALCOHOL DENATURED, ETHANOL
One or more animal studies show tumor formation at low doses		SODIUM FLUORIDE
One or more in vitro tests on mammalian cells show positive mutation results		FD&C RED 40, FD&C YELLOW 5, GLYCERIN, ILLICIUM VERUM (ANISE) OIL, MENTHOL, METHYLPARABEN, POLYSORBATE-80, PROPYLENE GLYCOL, PROPYLPARABEN, SODIUM BENZOATE, SODIUM BICARBONATE, SODIUM HYDROXIDE, SODIUM LAURYL SULFATE, SODIUM SACCHARIN, SORBITOL, SUCRALOSE
One or more in vitro tests non-mammalian cells show positive mutation results		DOMIPHEN BROMIDE, MENTHA PIPERITA (PEPPERMINT) OIL, POTASSIUM NITRATE, TRISODIUM PHOSPHATE, STANNOUS FLUORIDE
One or more animal studies show tumor formation at high doses		CELLULOSE GUM

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of reproductive toxicity		ETHANOL
Human nervous system toxicant - moderate evidence		BLUE 1 ALUMINUM LAKE, SODIUM FLUORIDE, YELLOW 10 ALUMINUM LAKE, STANNOUS FLUORIDE
One or more animal studies show reproductive effects at very low doses		POLYSORBATE-80, SODIUM CARBONATE
One or more animal studies show any effects at low doses		PROPYLPARABEN
Limited evidence of reproductive toxicity		ALCOHOL DENATURED
One or more animal studies show reproductive effects at moderate doses		CELLULOSE GUM, GLYCERIN, PROPYLENE GLYCOL, SODIUM BICARBONATE
One or more animal studies show reproductive effects at high doses		FD&C RED 40, FD&C YELLOW 5, POTASSIUM NITRATE, SODIUM BENZOATE, SODIUM LAURYL SULFATE, SODIUM SACCHARIN, FD&C YELLOW 6

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN, CI 42053
Violation of government restrictions - Banned or found unsafe for use in cosmetics	product not intended as hair dye/bleach	HYDROGEN PEROXIDE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes	products for use around the eyes	FD&C GREEN 3, FD&C YELLOW 6
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-12, PEG-6, POLYETHYLENE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		BENZOIC ACID, CETYLPYRIDINIUM CHLORIDE, CITRIC ACID, SODIUM FLUORIDE, STANNOUS FLUORIDE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics	products for use on the lips	CALCIUM PEROXIDE, HYDROGEN PEROXIDE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		BENZOIC ACID, COCAMIDOPROPYL BETAINE, MENTHA PIPERITA (PEPPERMINT) OIL, PEG-12, PEG-6, POLYETHYLENE, PROPYLENE GLYCOL, SODIUM BENZOATE, SODIUM HEXAMETAPHOSPHATE, SODIUM LAURYL SULFATE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Strong evidence of human neurotoxicity		BLUE 1 ALUMINUM LAKE, SODIUM FLUORIDE, YELLOW 10 ALUMINUM LAKE, STANNOUS FLUORIDE
One or more animal studies show brain and nervous system effects at very low doses		FD&C YELLOW 5, HYDROGEN PEROXIDE, SODIUM HYDROXIDE, SODIUM SACCHARIN
One or more animal studies show brain and nervous system effects at low doses		TETRASODIUM PYROPHOSPHATE
One or more animal studies show brain and nervous system effects at moderate doses		BENZOIC ACID, CARRAGEENAN, MENTHA PIPERITA (PEPPERMINT) OIL, MENTHOL, METHYLPARABEN, PENTASODIUM TRIPHOSPHATE, SODIUM BENZOATE, SODIUM LAURYL SULFATE
One or more animal studies show brain and nervous system effects at high doses		FD&C BLUE 1, FD&C YELLOW 6, GLYCERIN, PEG-6, POLYETHYLENE, POLYSORBATE-80, PROPYLENE GLYCOL, SODIUM BICARBONATE, SODIUM HEXAMETAPHOSPHATE, TETRAPOTASSIUM PYROPHOSPHATE, POLOXAMER 407
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		ETHANOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		METHYLPARABEN, PROPYLPARABEN
One or more studies show endocrine system disruption at low doses		SODIUM FLUORIDE
One or more animal studies show endocrine system disruption at high doses		ALCOHOL DENATURED, GLYCERIN, HYDROGEN PEROXIDE, PENTASODIUM TRIPHOSPHATE, POTASSIUM NITRATE, SODIUM LAURYL SULFATE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		COCAMIDOPROPYL BETAINE
Human immune system toxicant - strong evidence	products that may be aerosolized (airborne)	SILICA, POLOXAMER 407
Human skin toxicant - strong evidence		METHYLPARABEN, PROPYLPARABEN
Limited evidence of immune system toxicity		ZINC LACTATE, PROPYLENE GLYCOL
Human immune system toxicant - moderate evidence		POLYETHYLENE
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show gastrointestinal effects at moderate doses		MICA

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife and humans	products that may be aerosolized (airborne)	SILICA
Persistent, bioaccumulative in wildlife and humans		MICA, IRON OXIDES, HYDRATED SILICA
Persistent, bioaccumulative in wildlife		ZINC LACTATE
Not suspected to be persistent		BENZOIC ACID, CETYLPYRIDINIUM CHLORIDE, CITRIC ACID, COCAMIDOPROPYL BETAINE, DOMIPHEN BROMIDE, FD&C RED 40, FD&C YELLOW 6, GLYCERIN, MENTHA PIPERITA (PEPPERMINT) OIL, MENTHOL, METHYLPARABEN, PROPYLPARABEN, SODIUM BENZOATE, SODIUM CITRATE, SODIUM GLUCONATE, SODIUM SACCHARIN, SORBITOL
Not suspected to be persistent		SODIUM LAURYL SULFATE
Not suspected to be bioaccumulative		CALCIUM PEROXIDE, CARBOMER, DISODIUM PYROPHOSPHATE, FD&C BLUE 1, FD&C GREEN 3, FD&C YELLOW 5, PENTASODIUM TRIPHOSPHATE, POLYETHYLENE, SODIUM BICARBONATE, SODIUM CARBONATE, SODIUM FLUORIDE, SODIUM HEXAMETAPHOSPHATE, SODIUM PHOSPHATE, TETRAPOTASSIUM PYROPHOSPHATE, TETRASODIUM PYROPHOSPHATE, TRISODIUM PHOSPHATE, WATER, CI 18965, CI 42053, STANNOUS FLUORIDE
Not suspected to be bioaccumulative		ALCOHOL DENATURED, ETHANOL, POTASSIUM NITRATE, SODIUM HYDROXIDE, TITANIUM DIOXIDE (NON-NANO), POLOXAMER 407

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human any toxicant		METHYLPARABEN
Known human respiratory toxicant	products that may be aerosolized (airborne)	SILICA
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	PROPYLENE GLYCOL
Possible human immune system toxicant		POLYETHYLENE, MICA
One or more animal studies show blood effects at very low doses		CARRAGEENAN, DOMIPHEN BROMIDE, STANNOUS FLUORIDE, SODIUM FLUORIDE, GLYCERIN, SODIUM HYDROXIDE, FD&C YELLOW 5,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	ALCOHOL DENATURED, BENZOIC ACID, CITRIC ACID, ETHANOL, HYDROGEN PEROXIDE, MENTHOL, SODIUM CARBONATE
One or more animal studies show blood effects at low doses		POTASSIUM NITRATE, DISODIUM PYROPHOSPHATE, PENTASODIUM TRIPHOSPHATE, SODIUM BENZOATE, SODIUM HEXAMETAPHOSPHATE, SODIUM LAURYL SULFATE, POLOXAMER 407, TETRASODIUM PYROPHOSPHATE
Limited evidence of any toxicity	products that may be aerosolized (airborne)	BLUE 1 ALUMINUM LAKE, YELLOW 10 ALUMINUM LAKE, ZINC LACTATE
Limited evidence of sense organ toxicity		PEG-12, PEG-6, PROPYLPARABEN
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		CETYLPYRIDINIUM CHLORIDE, SODIUM PHOSPHATE, TRISODIUM PHOSPHATE, SODIUM BICARBONATE,
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		FD&C BLUE 1
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	MENTHA PIPERITA (PEPPERMINT) OIL
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	POLYSORBATE-80
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		CELLULOSE GUM, ILLICIUM VERUM (ANISE) OIL, SODIUM GLUCONATE, SODIUM SACCHARIN, FD&C YELLOW 6, SORBITOL, TETRAPOTASSIUM PYROPHOSPHATE, FD&C RED 40
Classified as not expected to be potentially toxic or harmful		CALCIUM PEROXIDE, CARBOMER, COPERNICIA CERIFERA (CARNAUBA) WAX, CELLULOSE, COCAMIDOPROPYL BETAINE, FD&C GREEN 3, SODIUM CITRATE, IRON OXIDES, WATER, XANTHAN GUM, CI 18965, CI 42053, HYDRATED SILICA

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FLAVOR
Occupational hazards related to handling		ALCOHOL DENATURED, ETHANOL, HYDROGEN PEROXIDE, SODIUM FLUORIDE, SODIUM HYDROXIDE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		ALCOHOL DENATURED, ETHANOL, MENTHOL, SODIUM FLUORIDE
Designated as safe for general or specific, limited use in food	products that may be aerosolized (airborne)	SILICA
Designated as safe for general or specific, limited use in food		ALCOHOL DENATURED, BENZOIC ACID, CALCIUM PEROXIDE, COPERNICIA CERIFERA (CARNAUBA) WAX, CARRAGEENAN, CELLULOSE GUM, CETYLPYRIDINIUM CHLORIDE, CITRIC ACID, CITRUS MEDICA LIMONUM (LEMON) EXTRACT, DISODIUM PYROPHOSPHATE, ETHANOL, FD&C BLUE 1, FD&C GREEN 3, FD&C RED 40, FD&C YELLOW 5, FD&C YELLOW 6, GLYCERIN, HYDROGEN PEROXIDE, ILLICIUM VERUM (ANISE) OIL, MENTHA PIPERITA (PEPPERMINT) OIL, MENTHOL, METHYLPARABEN, PEG-12, PEG-6, PENTASODIUM TRIPHOSPHATE, POLYETHYLENE, POLYSORBATE-80, POTASSIUM NITRATE, PROPYLENE GLYCOL, PROPYLPARABEN, SODIUM BENZOATE, SODIUM BICARBONATE, SODIUM CARBONATE, SODIUM CITRATE, SODIUM FLUORIDE, SODIUM GLUCONATE, SODIUM HEXAMETAPHOSPHATE, SODIUM HYDROXIDE, SODIUM LAURYL SULFATE, SODIUM PHOSPHATE, SODIUM SACCHARIN, SORBITOL, SUCRALOSE, IRON OXIDES, TETRAPOTASSIUM PYROPHOSPHATE, TETRASODIUM PYROPHOSPHATE, TITANIUM DIOXIDE (NON-NANO), TRISODIUM PHOSPHATE, XANTHAN GUM, CI 42053, POLOXAMER 407

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		SODIUM CARBONATE, PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	POLYETHYLENE, SODIUM HEXAMETAPHOSPHATE, SODIUM LAURYL SULFATE
Human skin irritant - moderate evidence		HYDROGEN PEROXIDE
One or more animal studies show skin irritation at very low doses		SODIUM HYDROXIDE
One or more animal studies show significant but moderate pulmonary irritation at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show skin irritation at low doses		ALCOHOL DENATURED, BENZOIC ACID, CETYLPYRIDINIUM CHLORIDE, ETHANOL, METHYLPARABEN, PENTASODIUM TRIPHOSPHATE
One or more animal studies show skin irritation at moderate doses		CITRIC ACID, GLYCERIN, MENTHOL, SODIUM BICARBONATE
One or more animal studies show skin irritation at high doses		SODIUM BENZOATE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		SODIUM FLUORIDE
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), HYDROGEN PEROXIDE
Allowed workplace exposures restricted to low doses		MICA, SODIUM STANNATE, STANNOUS FLUORIDE
Allowed workplace exposures restricted to moderate doses		CELLULOSE, GLYCERIN, TETRASODIUM PYROPHOSPHATE
Allowed workplace exposures restricted to high doses		ETHANOL,
Allowed workplace exposures restricted to high doses		ALCOHOL DENATURED
No workplace limits set		SODIUM HYDROXIDE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		CARRAGEENAN, SILICA, SODIUM FLUORIDE,
One or more animal studies show respiratory changes at very low doses where the human health implications are not yet well understood	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		SODIUM LAURYL SULFATE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		ALCOHOL DENATURED, CELLULOSE GUM, CITRIC ACID, ETHANOL, GLYCERIN, HYDROGEN PEROXIDE, POLYETHYLENE, SODIUM BENZOATE, SODIUM BICARBONATE, STANNOUS FLUORIDE, PROPYLENE GLYCOL
Interferes with gene expresion		METHYLPARABEN