Vagisil || Skin Deep: Cosmetic Safety Reviews

BRAND: Vagisil

Manufacturer: Combe Inc.

BRAND SUMMARY

product score range	7	to	8
product count	11 (browse)
ingredient count	40
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this brand -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this brand:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this brand: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 11 products by Vagisil

Product type(s) by this brand in Skin Deep: anti-itch/rash cream (1), feminine moisturizer (1), lubricant/spermicide (2), personal cleansing (1)

ingredients

	score	data gap	products *	concerns
METHYLPARABEN	10	63%	3 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
RESORCINOL	10	52%	1 products	Cancer, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
DMDM HYDANTOIN	7	71%	2 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
FRAGRANCE	8	100%	2 products	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
PEG-100 STEARATE	4	69%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
BENZOCAINE	7	61%	1 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
POLYOXYMETHYLENE UREA	6	73%	1 products	Violations, restrictions & warnings, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
DIAZOLIDINYL UREA	6	59%	2 products	Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE)
TRIETHANOLAMINE	6	58%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
PROPYLPARABEN	5	71%	2 products	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
RETINYL PALMITATE	5	68%	2 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
TOCOPHERYL ACETATE	4	81%	4 products	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
MINERAL OIL	4	73%	2 products	Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
BENZETHONIUM CHLORIDE	4	70%	1 products	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive)
CHOLECALCIFEROL	4	61%	2 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Occupational hazards
PROPYLENE GLYCOL	4	60%	3 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
POLYQUATERNIUM-5	3	94%	2 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources
LANOLIN ALCOHOL	2	87%	1 products	Allergies/immunotoxicity
SODIUM SULFITE	3	87%	1 products	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
ANTHEMIS NOBILIS (CHAMOMILE)	3	80%	2 products	Multiple, additive exposure sources, Enhanced skin absorption
DISODIUM EDTA	3	78%	2 products	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
CITRIC ACID	2	72%	2 products	Violations, restrictions & warnings
SODIUM BICARBONATE	2	80%	1 products	none identified
ZEA MAYS (CORN) OIL	2	79%	2 products	Neurotoxicity
GLYCERIN	2	74%	2 products	Organ system toxicity (non-reproductive), Occupational hazards
ISOPROPYL STEARATE	1	89%	1 products	Irritation (skin, eyes, or lungs)
GLYCERYL MONOSTEARATE	1	88%	1 products	none identified
CETYL ALCOHOL	1	87%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ISOPROPYL PALMITATE	1	87%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ISOPROPYL MYRISTATE	1	86%	1 products	Irritation (skin, eyes, or lungs)
POLYSORBATE-20	1	84%	2 products	none identified
MAGNESIUM STEARATE	1	83%	1 products	Occupational hazards
ZEA MAYS (CORN) STARCH	1	83%	1 products	Occupational hazards
HYDROXYETHYLCELLULOSE	1	82%	2 products	none identified
ALOE BARBADENSIS (ALOE VERA)	1	72%	2 products	none identified
ALOE BARBADENSIS (ALOE VERA) GEL	1	72%	2 products	none identified
TRICALCIUM PHOSPHATE	0	94%	1 products	none identified
CARBOMER	0	93%	1 products	none identified
TRISODIUM HEDTA	0	90%	1 products	Enhanced skin absorption
WATER	0	0%	3 products	innocuous

* Product counts only include current formulations sold by this brand. The brand may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this brand that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Cancer - not classifiable/not likely to be human carcinogen		RESORCINOL, TRIETHANOLAMINE
Cancer - limited evidence	products that may be aerosolized (airborne)	MINERAL OIL
Cancer - limited evidence		RETINYL PALMITATE
One or more in vitro tests on mammalian cells show positive mutation results		BENZETHONIUM CHLORIDE, DIAZOLIDINYL UREA, DISODIUM EDTA, GLYCERIN, METHYLPARABEN, PROPYLENE GLYCOL, PROPYLPARABEN, SODIUM BICARBONATE, SODIUM SULFITE, TOCOPHERYL ACETATE
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE
One or more in vitro tests non-mammalian cells show positive mutation results		ALOE BARBADENSIS (ALOE VERA), POLYOXYMETHYLENE UREA
One or more animal studies show tumor formation at high doses		ZEA MAYS (CORN) OIL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at low doses		RETINYL PALMITATE
One or more animal studies show any effects at moderate doses		ALOE BARBADENSIS (ALOE VERA) GEL
One or more animal studies show reproductive effects at moderate doses		CHOLECALCIFEROL, GLYCERIN, PROPYLENE GLYCOL, SODIUM BICARBONATE,
One or more animal studies show reproductive effects at moderate doses		ALOE BARBADENSIS (ALOE VERA)
One or more animal studies show reproductive effects at high doses		DISODIUM EDTA, HYDROXYETHYLCELLULOSE, POLYSORBATE-20, ZEA MAYS (CORN) OIL, PEG-100 STEARATE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN, BENZOCAINE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR)	products that may be aerosolized (airborne)	DMDM HYDANTOIN, POLYOXYMETHYLENE UREA
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-100 STEARATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		RESORCINOL, DMDM HYDANTOIN, BENZETHONIUM CHLORIDE, CHOLECALCIFEROL, CITRIC ACID, RETINYL PALMITATE
Determined safe for use in cosmetics, subject to concentration or use limitations - any		RESORCINOL, ALOE BARBADENSIS (ALOE VERA), ALOE BARBADENSIS (ALOE VERA) GEL, BENZETHONIUM CHLORIDE, DIAZOLIDINYL UREA, POLYOXYMETHYLENE UREA, PROPYLENE GLYCOL, TRIETHANOLAMINE, PEG-100 STEARATE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		BENZETHONIUM CHLORIDE
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA, SODIUM SULFITE, ZEA MAYS (CORN) OIL
One or more animal studies show brain and nervous system effects at moderate doses		ANTHEMIS NOBILIS (CHAMOMILE), CHOLECALCIFEROL, METHYLPARABEN, RESORCINOL
One or more animal studies show brain and nervous system effects at high doses		BENZOCAINE, DIAZOLIDINYL UREA, GLYCERIN, HYDROXYETHYLCELLULOSE, PROPYLENE GLYCOL, RETINYL PALMITATE, SODIUM BICARBONATE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		METHYLPARABEN, PROPYLPARABEN, RESORCINOL
One or more animal studies show endocrine disruption at moderate doses		BENZETHONIUM CHLORIDE
One or more animal studies show endocrine system disruption at high doses		ANTHEMIS NOBILIS (CHAMOMILE), DIAZOLIDINYL UREA, DISODIUM EDTA, GLYCERIN, TRIETHANOLAMINE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		BENZOCAINE, DIAZOLIDINYL UREA, DMDM HYDANTOIN, FRAGRANCE, RESORCINOL, TRIETHANOLAMINE
Possible human immune system toxicant	products that may be aerosolized (airborne)	MINERAL OIL
Human skin toxicant - strong evidence		LANOLIN ALCOHOL, METHYLPARABEN, PROPYLPARABEN, TOCOPHERYL ACETATE
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human immune system toxicant - moderate evidence		SODIUM SULFITE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be persistent		ANTHEMIS NOBILIS (CHAMOMILE), BENZOCAINE, CHOLECALCIFEROL, CITRIC ACID, DIAZOLIDINYL UREA, DISODIUM EDTA, DMDM HYDANTOIN, GLYCERIN, GLYCERYL MONOSTEARATE, ISOPROPYL MYRISTATE, ISOPROPYL PALMITATE, MAGNESIUM STEARATE, METHYLPARABEN, PROPYLPARABEN, RETINYL PALMITATE, PEG-100 STEARATE, TRISODIUM HEDTA
Not suspected to be persistent		CETYL ALCOHOL
Not suspected to be bioaccumulative		BENZETHONIUM CHLORIDE, CARBOMER, SODIUM BICARBONATE, SODIUM SULFITE, TOCOPHERYL ACETATE, TRICALCIUM PHOSPHATE, WATER, ZEA MAYS (CORN) OIL
Not suspected to be bioaccumulative		POLYOXYMETHYLENE UREA, POLYQUATERNIUM-5, TRIETHANOLAMINE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human any toxicant		METHYLPARABEN
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	PROPYLENE GLYCOL
Possible human immune system toxicant		SODIUM SULFITE, TRIETHANOLAMINE
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	BENZETHONIUM CHLORIDE
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	CITRIC ACID, POLYOXYMETHYLENE UREA, RESORCINOL
One or more animal studies show blood effects at low doses		BENZOCAINE, CHOLECALCIFEROL, DISODIUM EDTA, ISOPROPYL PALMITATE,
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	MINERAL OIL
Limited evidence of sense organ toxicity		PROPYLPARABEN, PEG-100 STEARATE, RETINYL PALMITATE
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		ALOE BARBADENSIS (ALOE VERA) GEL, DMDM HYDANTOIN, GLYCERYL MONOSTEARATE, TOCOPHERYL ACETATE, SODIUM BICARBONATE, ZEA MAYS (CORN) OIL,
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	ANTHEMIS NOBILIS (CHAMOMILE)
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	CETYL ALCOHOL
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		DIAZOLIDINYL UREA, ISOPROPYL MYRISTATE, ISOPROPYL STEARATE, ZEA MAYS (CORN) STARCH, HYDROXYETHYLCELLULOSE, POLYSORBATE-20, MAGNESIUM STEARATE
Classified as expected to be toxic or harmful		POLYQUATERNIUM-5
Classified as not expected to be potentially toxic or harmful		ALOE BARBADENSIS (ALOE VERA), CARBOMER, LANOLIN ALCOHOL, TRICALCIUM PHOSPHATE, WATER, TRISODIUM HEDTA

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE
Occupational hazards related to handling	products for use around the mouth; products for use on the lips; products for use on skin	CHOLECALCIFEROL

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		ANTHEMIS NOBILIS (CHAMOMILE), POLYQUATERNIUM-5
Designated as safe for general or specific, limited use in food		ALOE BARBADENSIS (ALOE VERA), ALOE BARBADENSIS (ALOE VERA) GEL, ANTHEMIS NOBILIS (CHAMOMILE), CETYL ALCOHOL, CHOLECALCIFEROL, CITRIC ACID, DISODIUM EDTA, GLYCERIN, GLYCERYL MONOSTEARATE, ISOPROPYL MYRISTATE, ISOPROPYL PALMITATE, MAGNESIUM STEARATE, METHYLPARABEN, MINERAL OIL, POLYSORBATE-20, PROPYLENE GLYCOL, PROPYLPARABEN, RESORCINOL, RETINYL PALMITATE, SODIUM BICARBONATE, SODIUM SULFITE, TOCOPHERYL ACETATE, TRICALCIUM PHOSPHATE, TRIETHANOLAMINE, ZEA MAYS (CORN) STARCH, PEG-100 STEARATE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		RESORCINOL, PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	DMDM HYDANTOIN, ISOPROPYL MYRISTATE, ISOPROPYL STEARATE
One or more animal studies show skin irritation at very low doses		CETYL ALCOHOL, POLYOXYMETHYLENE UREA, TRIETHANOLAMINE, PEG-100 STEARATE
One or more animal studies show skin irritation at low doses		ISOPROPYL PALMITATE, METHYLPARABEN
One or more animal studies show skin irritation at moderate doses		ANTHEMIS NOBILIS (CHAMOMILE), BENZETHONIUM CHLORIDE, BENZOCAINE, CITRIC ACID, GLYCERIN, MINERAL OIL, POLYSORBATE-20, SODIUM BICARBONATE, ZEA MAYS (CORN) OIL, ZEA MAYS (CORN) STARCH
One or more animal studies show skin irritation at high doses		SODIUM SULFITE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		CHOLECALCIFEROL
Allowed workplace exposures restricted to low doses		RESORCINOL
Allowed workplace exposures restricted to moderate doses		GLYCERIN, MAGNESIUM STEARATE, MINERAL OIL, TRIETHANOLAMINE, ZEA MAYS (CORN) STARCH

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CITRIC ACID, GLYCERIN, SODIUM BICARBONATE, ZEA MAYS (CORN) OIL, PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL PALMITATE
Interferes with gene expresion		METHYLPARABEN