Combe Inc. || Skin Deep: Cosmetic Safety Reviews

Manufacturer: Combe Inc.

Brands: Aqua Velva, Brylcreem, Cepacol, Grecian Formula, Johnson's Foot Soap, Just For Men, Lanacane, Maxim, Odor-Eaters, Scalpicin, Vagisil, Williams, Grecian, Gynecort, Just 5, Lanacort, Combe

COMPANY SUMMARY

product score range	3	to	10
product count	149		(browse)
ingredient count	162
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this company -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this company:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this company: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 149 products by Combe Inc.

Product type(s) by this company in Skin Deep: after shave (3), after sun product (1), anti-itch/rash cream (7), conditioner (2), dandruff/scalp treatment (2), feminine moisturizer (1), foot odor control (2), fragrance for men (2), hair color and bleaching (25), hair growth inhibitor (1), lubricant/spermicide (2), pain relief (1), personal cleansing (1), shampoo (3), shaving cream (1), shaving cream (men's) (2), styling gel/lotion (3)

ingredients

	score	data gap	products *	concerns
METHYLPARABEN	10	63%	11 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
P-PHENYLENEDIAMINE	10	52%	23 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
RESORCINOL	10	52%	22 products	Cancer, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
LEAD ACETATE	10	46%	5 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
DMDM HYDANTOIN	7	71%	2 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
OCTOXYNOL-40	9	68%	1 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, C9 PHENOLS, ETHYLENE OXIDE, 1,4-DIOXANE, C9 PHENOLS)
P-AMINOPHENOL	8	57%	18 products	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
FRAGRANCE	8	100%	45 products	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-20	5	71%	2 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-60	5	69%	1 products	Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
OCTOXYNOL-9	8	68%	4 products	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Contamination concerns (C9 PHENOLS, ETHYLENE OXIDE, 1,4-DIOXANE, C9 PHENOLS)
OCTINOXATE (OCTYL METHOXYCINNAMATE)	6	65%	1 products	Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
M-PHENYLENEDIAMINE	7	63%	6 products	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
1-NAPHTHOL	8	60%	10 products	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
PEG-100 STEARATE	7	69%	9 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
ETHANOLAMINE	7	66%	12 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
SALICYLIC ACID	7	66%	1 products	Violations, restrictions & warnings, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption
SULFURIC ACID	5	65%	2 products	Cancer, Organ system toxicity (non-reproductive), Occupational hazards
BENZOCAINE	7	61%	5 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
SODIUM BORATE	6	51%	2 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Occupational hazards
EXT D&C VIOLET 2	6	73%	2 products	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity
POLYOXYMETHYLENE UREA	6	73%	1 products	Violations, restrictions & warnings, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
PEG-60 HYDROGENATED CASTOR OIL	4	73%	1 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
4-CHLORORESORCINOL	5	68%	11 products	Cancer, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity
HYDROGEN PEROXIDE	3	65%	19 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
M-AMINOPHENOL	6	65%	21 products	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
BHT	6	61%	1 products	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
DIAZOLIDINYL UREA	6	59%	5 products	Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE)
TRIETHANOLAMINE	6	58%	5 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
ZINC OXIDE (NON-NANO)	2	82%	2 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
BENZOPHENONE-1	5	79%	3 products	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
SD ALCOHOL 40	5	77%	4 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption, Contamination concerns (BRUCINE, T-BUTYL ALCOHOL, BRUCINE SULFATE, QUASSIN)
D&C ORANGE 4	5	72%	2 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
D&C VIOLET 2	5	71%	3 products	Cancer, Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
PROPYLPARABEN	5	71%	10 products	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
VITAMIN A	5	70%	2 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PHENYL METHYL PYRAZOLONE	5	68%	10 products	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity
RETINYL PALMITATE	5	68%	5 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
VITAMIN D2	5	68%	2 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
BENZOPHENONE-2	5	67%	1 products	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
ZINC PYRITHIONE	5	66%	5 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
SD ALCOHOL 40B	4	81%	6 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption
TITANIUM DIOXIDE (NON-NANO)	1	81%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
TOCOPHERYL ACETATE	4	81%	31 products	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
HYDROCORTISONE ACETATE	4	79%	1 products	Developmental/reproductive toxicity, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PROPANE	4	77%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards
COCAMIDE MEA	2	75%	6 products	Contamination concerns (NITROSAMINES)
ACETIC ACID	2	74%	5 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
FD&C RED 4	4	73%	2 products	Violations, restrictions & warnings
MINERAL OIL	4	73%	7 products	Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
ISOPROPYL ALCOHOL	4	72%	5 products	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
VEGETABLE FATTY ACID	4	72%	10 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
BENZETHONIUM CHLORIDE	4	70%	7 products	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive)
FD&C YELLOW 6	1	70%	1 products	none identified
SULISOBENZONE (BENZOPHENONE-4)	3	66%	2 products	Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Enhanced skin absorption
CHOLECALCIFEROL	4	61%	5 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Occupational hazards
PROPYLENE GLYCOL	4	60%	18 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
ISOLAURETH-6	3	100%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
OLETH-3	3	99%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
LAURETH-4	3	96%	6 products	Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
POLYQUATERNIUM-5	3	94%	2 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources
LANOLIN ALCOHOL	2	87%	1 products	Allergies/immunotoxicity
SODIUM SULFITE	3	87%	24 products	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
MENTHOL	3	85%	3 products	Organ system toxicity (non-reproductive), Multiple, additive exposure sources
FD&C YELLOW 5	2	82%	2 products	Neurotoxicity, Organ system toxicity (non-reproductive)
ANTHEMIS NOBILIS (CHAMOMILE)	3	80%	2 products	Multiple, additive exposure sources, Enhanced skin absorption
DISODIUM EDTA	3	78%	6 products	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
AMMONIUM CHLORIDE	3	77%	3 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
DIMETHICONE	2	74%	5 products	Violations, restrictions & warnings
2-METHYL-5-HYDROXYETHYLAMINOPHENOL	3	73%	2 products	Cancer, Allergies/immunotoxicity
D&C YELLOW 10	3	73%	2 products	Violations, restrictions & warnings
1,2,4-TRIHYDROXYBENZENE	3	73%	2 products	Cancer, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CITRIC ACID	2	72%	3 products	Violations, restrictions & warnings
N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE	3	69%	15 products	Cancer, Allergies/immunotoxicity
PANTHENOL	2	88%	28 products	Multiple, additive exposure sources
ACETYLATED LANOLIN ALCOHOL	2	87%	4 products	Allergies/immunotoxicity
TOCOPHEROL	2	87%	2 products	Contamination concerns (HYDROQUINONE)
2-METHYLRESORCINOL	2	84%	5 products	Allergies/immunotoxicity
CALCIUM HYDROXIDE	1	83%	1 products	Occupational hazards
FD&C BLUE 1	1	83%	1 products	none identified
ETHOXYDIGLYCOL	2	82%	17 products	Organ system toxicity (non-reproductive)
MAGNESIUM SULFATE	2	82%	1 products	Organ system toxicity (non-reproductive)
DIOCTYL SODIUM SULFOSUCCINATE	2	81%	2 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
POLYSORBATE-80	2	80%	1 products	Developmental/reproductive toxicity
SODIUM BICARBONATE	2	80%	3 products	none identified
ZEA MAYS (CORN) OIL	2	79%	5 products	Neurotoxicity
CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT	2	76%	2 products	Violations, restrictions & warnings
GLYCERIN	2	74%	12 products	Organ system toxicity (non-reproductive), Occupational hazards
STEARIC ACID	2	74%	3 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ACETAMIDE MEA	1	73%	1 products	Contamination concerns (ACETAMIDE MEA)
AMINOMETHYL PROPANOL	2	71%	11 products	Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES, OXAZOLIDINE)
CITRUS GRANDIS (GRAPEFRUIT) FRUIT EXTRACT	1	100%	1 products	Multiple, additive exposure sources
SODIUM TALLOWATE	0	94%	1 products	none identified
CETEARYL ALCOHOL	0	93%	1 products	none identified
CETYL ACETATE	1	93%	4 products	none identified
LINOLEIC ACID	1	93%	5 products	Irritation (skin, eyes, or lungs)
MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL	1	93%	2 products	Endocrine disruption, Allergies/immunotoxicity
CARAMEL	1	92%	6 products	none identified
SORBITAN STEARATE	1	92%	3 products	none identified
D&C GREEN 5	1	91%	2 products	none identified
DENATONIUM BENZOATE	1	90%	3 products	none identified
TRITICUM VULGARE (WHEAT) GERM OIL	1	90%	5 products	none identified
ISOPROPYL STEARATE	1	89%	1 products	Irritation (skin, eyes, or lungs)
TETRASODIUM ETIDRONATE	1	89%	1 products	none identified
VP/ VA COPOLYMER	1	89%	2 products	none identified
GLYCERYL MONOSTEARATE	1	88%	10 products	none identified
HYDROXYPROPYL METHYLCELLULOSE	1	88%	1 products	none identified
C11-15 PARETH-3	1	88%	9 products	Organ system toxicity (non-reproductive)
DIMETHYL OXAZOLIDINE	1	88%	1 products	none identified
CETYL ALCOHOL	1	87%	15 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ERYTHORBIC ACID	1	87%	23 products	none identified
ISOPROPYL PALMITATE	1	87%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
OLEYL ALCOHOL	1	87%	15 products	Irritation (skin, eyes, or lungs)
ISOPROPYL MYRISTATE	1	86%	5 products	Irritation (skin, eyes, or lungs)
SULFUR	1	86%	5 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
TRISODIUM EDTA	1	86%	23 products	Enhanced skin absorption
POTASSIUM STEARATE	1	85%	1 products	Occupational hazards
STEARALKONIUM CHLORIDE	1	85%	1 products	Organ system toxicity (non-reproductive)
1-DODECANOL	1	84%	5 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL	1	84%	2 products	none identified
POLYSORBATE-20	1	84%	2 products	none identified
STEARYL ALCOHOL	1	84%	1 products	Irritation (skin, eyes, or lungs)
MAGNESIUM STEARATE	1	83%	1 products	Occupational hazards
ZEA MAYS (CORN) STARCH	1	83%	3 products	Occupational hazards
HYDROXYETHYLCELLULOSE	1	82%	2 products	none identified
PVP	1	81%	2 products	Organ system toxicity (non-reproductive)
ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT	1	80%	9 products	Enhanced skin absorption
ANTHEMIS NOBILIS (CHAMOMILE) EXTRACT	1	80%	12 products	Enhanced skin absorption
ISOPROPYL ACETATE	1	79%	2 products	Irritation (skin, eyes, or lungs), Occupational hazards
2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE	1	76%	4 products	Cancer
2,4-DIAMINOPHENOXYETHANOL SULFATE	1	76%	5 products	Cancer
ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT	1	75%	23 products	none identified
PENTASODIUM PENTETATE	0	74%	1 products	none identified
4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL	1	73%	2 products	none identified
ALOE BARBADENSIS (ALOE VERA)	1	72%	4 products	none identified
ALOE BARBADENSIS (ALOE VERA) GEL	1	72%	6 products	none identified
CENTAUREA (MILLER)	0	100%	1 products	none identified
CINNAMIDOPROPYLTRIMONIUM CHLORIDE	0	100%	8 products	none identified
CITRUS PARADISI (GRAPEFRUIT) EXRACT	0	100%	2 products	none identified
COCO-GLUCOSIDE	0	100%	8 products	none identified
HYDROCORTISONE ALCOHOL	0	100%	1 products	none identified
LAURDIMONIUM HYDROXYPROPYL HYDROLYZED WHEAT PROTEIN	0	100%	6 products	none identified
MYRISTATE	0	100%	1 products	none identified
PANTHENYL HYDROXYPROPYL STEARDIMONIUM CHLORIDE	0	100%	1 products	none identified
POLYQUATERNIUM-22	0	100%	10 products	none identified
STARCH/ ACRYLATES/ ACRYLAMIDE COPOLYMER	0	100%	2 products	none identified
STEARAMIDOPROPYL PG-DIMONIUM CHLORIDE PHOSPHATE	0	100%	3 products	none identified
TRIMETHYLSILYLAMODIMETHICONE	0	100%	1 products	none identified
HYDROXYPROPYL METHYCELLULOSE	0	100%	1 products	none identified
DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE	0	100%	1 products	none identified
HYDROLYZED ELASTIN	0	94%	2 products	none identified
VP/ EICOSENE COPOLYMER	0	94%	1 products	none identified
SODIUM COCOATE	0	94%	1 products	none identified
SULFATED CASTOR OIL	0	94%	2 products	none identified
TRICALCIUM PHOSPHATE	0	94%	3 products	none identified
BEESWAX	0	93%	1 products	none identified
CARBOMER	0	93%	11 products	none identified
GLYCERYL STEARATE SE	0	93%	2 products	none identified
HYDROGENATED CASTOR OIL	0	93%	1 products	none identified
POLYQUATERNIUM-11	0	93%	2 products	none identified
TRISODIUM HEDTA	0	90%	3 products	Enhanced skin absorption
WATER	0	0%	47 products	innocuous

* Product counts only include current formulations sold by this company. The company may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this company that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human carcinogen		SULFURIC ACID
Possible human carcinogen		LEAD ACETATE
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
Cancer - not classifiable/not likely to be human carcinogen		BHT, FD&C BLUE 1, FD&C RED 4, FD&C YELLOW 6, HYDROGEN PEROXIDE, ISOPROPYL ALCOHOL, P-PHENYLENEDIAMINE, PVP, RESORCINOL, TRIETHANOLAMINE
Mutagen - limited evidence		M-PHENYLENEDIAMINE, P-AMINOPHENOL
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - limited evidence	products that may be aerosolized (airborne)	MINERAL OIL
Cancer - limited evidence		1-NAPHTHOL, 2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE, 2-METHYL-5-HYDROXYETHYLAMINOPHENOL, 4-CHLORORESORCINOL, D&C VIOLET 2, EXT D&C VIOLET 2, M-AMINOPHENOL, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, PHENYL METHYL PYRAZOLONE, RETINYL PALMITATE, SD ALCOHOL 40, SD ALCOHOL 40B, VITAMIN A, 1,2,4-TRIHYDROXYBENZENE, 2,4-DIAMINOPHENOXYETHANOL SULFATE
Cancer - not classifiable/not likely to be human carcinogen		SALICYLIC ACID
One or more in vitro tests on mammalian cells show positive mutation results		ACETIC ACID, AMMONIUM CHLORIDE, BENZETHONIUM CHLORIDE, BENZOPHENONE-2, CALCIUM HYDROXIDE, CARAMEL, D&C ORANGE 4, DIAZOLIDINYL UREA, DISODIUM EDTA, ERYTHORBIC ACID, ETHANOLAMINE, FD&C YELLOW 5, GLYCERIN, HYDROCORTISONE ACETATE, MENTHOL, METHYLPARABEN, OCTOXYNOL-9, POLYSORBATE-80, PROPYLENE GLYCOL, PROPYLPARABEN, SODIUM BICARBONATE, SODIUM SULFITE, TOCOPHEROL, TOCOPHERYL ACETATE, ZINC OXIDE (NON-NANO), DIMETHYL OXAZOLIDINE, OCTOXYNOL-40, PEG-60
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE
One or more in vitro tests non-mammalian cells show positive mutation results		ALOE BARBADENSIS (ALOE VERA), ETHOXYDIGLYCOL, MAGNESIUM SULFATE, POLYOXYMETHYLENE UREA, SODIUM BORATE, TRITICUM VULGARE (WHEAT) GERM OIL
Not likely to be mutagenic in humans		SULISOBENZONE (BENZOPHENONE-4)
One or more animal studies show tumor formation at high doses		1-DODECANOL, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL, STEARYL ALCOHOL, ZEA MAYS (CORN) OIL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human reproductive toxicant		LEAD ACETATE
Limited evidence of reproductive toxicity		SD ALCOHOL 40, SD ALCOHOL 40B, SODIUM BORATE
Human nervous system toxicant - moderate evidence		P-PHENYLENEDIAMINE
One or more animal studies show reproductive effects at very low doses		HYDROCORTISONE ACETATE, POLYSORBATE-80, VITAMIN D2, PEG-60
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at low doses		D&C ORANGE 4, RETINYL PALMITATE, VITAMIN A
Limited evidence of developmental toxicity		ISOPROPYL ALCOHOL
One or more animal studies show any effects at moderate doses		ALOE BARBADENSIS (ALOE VERA) GEL
One or more animal studies show reproductive effects at moderate doses		1-NAPHTHOL, CHOLECALCIFEROL, GLYCERIN, P-AMINOPHENOL, PROPYLENE GLYCOL, SALICYLIC ACID, SODIUM BICARBONATE, ZINC PYRITHIONE,
One or more animal studies show reproductive effects at moderate doses		ALOE BARBADENSIS (ALOE VERA), OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show developmental effects at high doses		ZINC OXIDE (NON-NANO)
One or more animal studies show reproductive effects at high doses		4-CHLORORESORCINOL, ACETIC ACID, BHT, DIOCTYL SODIUM SULFOSUCCINATE, DISODIUM EDTA, ETHANOLAMINE, ETHOXYDIGLYCOL, FD&C YELLOW 5, HYDROXYETHYLCELLULOSE, M-AMINOPHENOL, M-PHENYLENEDIAMINE, MAGNESIUM SULFATE, OCTOXYNOL-9, PHENYL METHYL PYRAZOLONE, POLYSORBATE-20, ZEA MAYS (CORN) OIL, OCTOXYNOL-40, PEG-100 STEARATE, FD&C YELLOW 6

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN
Violation of government restrictions - Banned or found unsafe for use in cosmetics	product not intended as hair dye/bleach	HYDROGEN PEROXIDE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		BENZOCAINE, LEAD ACETATE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use only	products for use around the mouth, lips, eyes, or on damaged skin	D&C ORANGE 4, D&C VIOLET 2, EXT D&C VIOLET 2, FD&C RED 4
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes	products for use around the eyes	D&C YELLOW 10, FD&C YELLOW 6, LEAD ACETATE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR)	products that may be aerosolized (airborne)	COCAMIDE MEA, DMDM HYDANTOIN, POLYOXYMETHYLENE UREA
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on infant skin	products for use on infant skin	SODIUM BORATE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	CETEARETH-20, PEG-100 STEARATE, PEG-60, PEG-60 HYDROGENATED CASTOR OIL
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Unsafe in products left on skin and not rinsed off	products that are intended to be left on the skin	ETHANOLAMINE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		RESORCINOL, DMDM HYDANTOIN, ZINC PYRITHIONE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		BENZETHONIUM CHLORIDE, CHOLECALCIFEROL, CITRIC ACID, P-PHENYLENEDIAMINE, RETINYL PALMITATE, SALICYLIC ACID, SODIUM BORATE, VEGETABLE FATTY ACID, VITAMIN A, VITAMIN D2
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics	products for use on the lips	HYDROGEN PEROXIDE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, 1-NAPHTHOL, 4-CHLORORESORCINOL, DIMETHICONE, EXT D&C VIOLET 2, M-AMINOPHENOL, M-PHENYLENEDIAMINE, P-AMINOPHENOL, P-PHENYLENEDIAMINE, PHENYL METHYL PYRAZOLONE, OCTOXYNOL-40
Determined safe for use in cosmetics, subject to concentration or use limitations - any		1-NAPHTHOL, 2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE, 2-METHYL-5-HYDROXYETHYLAMINOPHENOL, 4-CHLORORESORCINOL, M-AMINOPHENOL, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, P-AMINOPHENOL, P-PHENYLENEDIAMINE, PHENYL METHYL PYRAZOLONE, RESORCINOL, 1,2,4-TRIHYDROXYBENZENE, 2,4-DIAMINOPHENOXYETHANOL SULFATE
Determined safe for use in cosmetics, subject to concentration or use limitations - Determined safe for use when formulated to avoid irritation, in assessment by industry safety panel (Cosmetic Ingredient Review, CIR)	products for use on damaged skin or infants	PENTASODIUM PENTETATE
Determined safe for use in cosmetics, subject to concentration or use limitations - Restrictions on impurities recommended by industry safety panel		OCTOXYNOL-9, 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL, ACETAMIDE MEA, ALOE BARBADENSIS (ALOE VERA), ALOE BARBADENSIS (ALOE VERA) GEL, ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT, AMINOMETHYL PROPANOL, BENZETHONIUM CHLORIDE, CETEARETH-20, COCAMIDE MEA, DIAZOLIDINYL UREA, ETHANOLAMINE, EXT D&C VIOLET 2, M-PHENYLENEDIAMINE, POLYOXYMETHYLENE UREA, PROPYLENE GLYCOL, SALICYLIC ACID, SODIUM BORATE, TRIETHANOLAMINE, OCTOXYNOL-40, PEG-100 STEARATE, PEG-60, PEG-60 HYDROGENATED CASTOR OIL

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Strong evidence of human neurotoxicity		ISOPROPYL ALCOHOL, LEAD ACETATE, P-PHENYLENEDIAMINE
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		BENZETHONIUM CHLORIDE, FD&C YELLOW 5, HYDROCORTISONE ACETATE, HYDROGEN PEROXIDE, STEARIC ACID, 1,2,4-TRIHYDROXYBENZENE
One or more animal studies show brain and nervous system effects at low doses		4-CHLORORESORCINOL, BHT, DISODIUM EDTA, SALICYLIC ACID, SODIUM SULFITE, VITAMIN D2, ZEA MAYS (CORN) OIL
One or more animal studies show brain and nervous system effects at moderate doses		AMINOMETHYL PROPANOL, AMMONIUM CHLORIDE, ANTHEMIS NOBILIS (CHAMOMILE), ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, CETEARETH-20, CHOLECALCIFEROL, DENATONIUM BENZOATE, DIOCTYL SODIUM SULFOSUCCINATE, ETHANOLAMINE, M-AMINOPHENOL, M-PHENYLENEDIAMINE, MAGNESIUM SULFATE, MENTHOL, METHYLPARABEN, P-AMINOPHENOL, RESORCINOL, STEARALKONIUM CHLORIDE, ZINC PYRITHIONE, ANTHEMIS NOBILIS (CHAMOMILE) EXTRACT
One or more animal studies show brain and nervous system effects at high doses		1-NAPHTHOL, 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL, ACETIC ACID, BENZOCAINE, BENZOPHENONE-1, DIAZOLIDINYL UREA, ETHOXYDIGLYCOL, FD&C BLUE 1, FD&C YELLOW 6, GLYCERIN, HYDROXYETHYLCELLULOSE, PHENYL METHYL PYRAZOLONE, POLYSORBATE-80, PROPYLENE GLYCOL, RETINYL PALMITATE, SODIUM BICARBONATE, SODIUM BORATE, VITAMIN A, ZINC OXIDE (NON-NANO)
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		ISOPROPYL ACETATE, PROPANE, SD ALCOHOL 40, SD ALCOHOL 40B

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		BENZOPHENONE-1, BENZOPHENONE-2, METHYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE), PROPYLPARABEN, RESORCINOL
One or more studies show endocrine system disruption at low doses		HYDROCORTISONE ACETATE
Limited evidence of any disruption		MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL, OCTOXYNOL-9, OCTOXYNOL-40
One or more animal studies show endocrine disruption at moderate doses		1-NAPHTHOL, BENZETHONIUM CHLORIDE
One or more animal studies show endocrine system disruption at high doses		AMMONIUM CHLORIDE, ANTHEMIS NOBILIS (CHAMOMILE), ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BHT, DIAZOLIDINYL UREA, DISODIUM EDTA, GLYCERIN, HYDROGEN PEROXIDE, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, P-PHENYLENEDIAMINE, PVP, SODIUM BORATE, TRIETHANOLAMINE, ANTHEMIS NOBILIS (CHAMOMILE) EXTRACT
Associated with endocrine disruption		SULISOBENZONE (BENZOPHENONE-4)

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		BENZOCAINE, BHT, DIAZOLIDINYL UREA, DMDM HYDANTOIN, FRAGRANCE, P-AMINOPHENOL, P-PHENYLENEDIAMINE, RESORCINOL, TRIETHANOLAMINE
Possible human immune system toxicant	products that may be aerosolized (airborne)	MINERAL OIL
Human any toxicant - strong evidence		PROPANE
Human immune and respiratory toxicant - strong evidence		ACETIC ACID, ETHANOLAMINE, ZINC OXIDE (NON-NANO), SULFURIC ACID
Human skin toxicant - strong evidence		1-NAPHTHOL, 2-METHYL-5-HYDROXYETHYLAMINOPHENOL, 2-METHYLRESORCINOL, 4-CHLORORESORCINOL, ACETYLATED LANOLIN ALCOHOL, BENZOPHENONE-1, BENZOPHENONE-2, EXT D&C VIOLET 2, LANOLIN ALCOHOL, M-AMINOPHENOL, M-PHENYLENEDIAMINE, METHYLPARABEN, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, OCTOXYNOL-9, PHENYL METHYL PYRAZOLONE, PROPYLPARABEN, SULISOBENZONE (BENZOPHENONE-4), TOCOPHERYL ACETATE, OCTOXYNOL-40
Limited evidence of immune system toxicity		LEAD ACETATE, ZINC PYRITHIONE, PROPYLENE GLYCOL
Human immune system toxicant - moderate evidence		SODIUM SULFITE, VEGETABLE FATTY ACID
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Limited evidence of any toxicity		MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife and humans		LEAD ACETATE
Persistent, bioaccumulative in wildlife		SALICYLIC ACID, ZINC OXIDE (NON-NANO), ZINC PYRITHIONE
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Not suspected to be persistent		1-NAPHTHOL, 2-METHYLRESORCINOL, 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL, 4-CHLORORESORCINOL, ACETAMIDE MEA, ACETYLATED LANOLIN ALCOHOL, AMINOMETHYL PROPANOL, ANTHEMIS NOBILIS (CHAMOMILE), ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BENZOCAINE, BENZOPHENONE-1, BENZOPHENONE-2, CETEARETH-20, CETEARYL ALCOHOL, CETYL ACETATE, CHOLECALCIFEROL, CITRIC ACID, COCAMIDE MEA, D&C YELLOW 10, DENATONIUM BENZOATE, DIAZOLIDINYL UREA, DIMETHICONE, DISODIUM EDTA, DMDM HYDANTOIN, ERYTHORBIC ACID, FD&C RED 4, FD&C YELLOW 6, GLYCERIN, GLYCERYL MONOSTEARATE, GLYCERYL STEARATE SE, HYDROCORTISONE ACETATE, HYDROGENATED CASTOR OIL, ISOPROPYL MYRISTATE, ISOPROPYL PALMITATE, LINOLEIC ACID, M-PHENYLENEDIAMINE, MAGNESIUM STEARATE, MENTHOL, METHYLPARABEN, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, OLEYL ALCOHOL, P-AMINOPHENOL, P-PHENYLENEDIAMINE, PANTHENOL, PHENYL METHYL PYRAZOLONE, POTASSIUM STEARATE, PROPYLPARABEN, RETINYL PALMITATE, SODIUM COCOATE, SODIUM TALLOWATE, SORBITAN STEARATE, STEARALKONIUM CHLORIDE, STEARIC ACID, STEARYL ALCOHOL, SULFATED CASTOR OIL, SULISOBENZONE (BENZOPHENONE-4), TETRASODIUM ETIDRONATE, TRISODIUM EDTA, VITAMIN D2, C11-15 PARETH-3, DIMETHYL OXAZOLIDINE, PEG-100 STEARATE, TRISODIUM HEDTA, ANTHEMIS NOBILIS (CHAMOMILE) EXTRACT
Not suspected to be persistent		1-DODECANOL, CETYL ALCOHOL, OCTOXYNOL-9, OCTOXYNOL-40
Not suspected to be bioaccumulative		BENZETHONIUM CHLORIDE, CALCIUM HYDROXIDE, CARBOMER, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL, D&C GREEN 5, D&C ORANGE 4, EXT D&C VIOLET 2, FD&C BLUE 1, FD&C YELLOW 5, ISOPROPYL ACETATE, M-AMINOPHENOL, MAGNESIUM SULFATE, PENTASODIUM PENTETATE, POLYQUATERNIUM-11, VP/ EICOSENE COPOLYMER, SODIUM BICARBONATE, SODIUM SULFITE, SULFUR, TOCOPHEROL, TOCOPHERYL ACETATE, TRICALCIUM PHOSPHATE, VEGETABLE FATTY ACID, VP/ VA COPOLYMER, WATER, ZEA MAYS (CORN) OIL
Not suspected to be bioaccumulative		AMMONIUM CHLORIDE, D&C VIOLET 2, ISOPROPYL ALCOHOL, POLYOXYMETHYLENE UREA, POLYQUATERNIUM-5, PROPANE, PVP, SODIUM BORATE, TITANIUM DIOXIDE (NON-NANO), TRIETHANOLAMINE, PEG-60, SULFURIC ACID

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human any toxicant		METHYLPARABEN
Known human lung and skin toxicant	products that may be aerosolized (airborne); products for use on skin	1-NAPHTHOL
Known human respiratory toxicant		LEAD ACETATE, P-PHENYLENEDIAMINE
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	PROPYLENE GLYCOL
Possible human immune system toxicant		ETHANOLAMINE, P-AMINOPHENOL, SODIUM SULFITE, TRIETHANOLAMINE, VEGETABLE FATTY ACID
One or more animal studies show broad systemic effects at very low doses		AMMONIUM CHLORIDE, MAGNESIUM SULFATE, SULFUR, VITAMIN D2, PEG-60, ACETIC ACID, GLYCERIN, FD&C YELLOW 5,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	BENZETHONIUM CHLORIDE, STEARIC ACID, TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	ACETAMIDE MEA, CALCIUM HYDROXIDE, CITRIC ACID, DIOCTYL SODIUM SULFOSUCCINATE, HYDROGEN PEROXIDE, ISOPROPYL ALCOHOL, M-PHENYLENEDIAMINE, MENTHOL, POLYOXYMETHYLENE UREA, RESORCINOL, SALICYLIC ACID, STEARALKONIUM CHLORIDE, C11-15 PARETH-3, SULFURIC ACID
One or more animal studies show blood effects at low doses		BENZOCAINE, BENZOPHENONE-1, CHOLECALCIFEROL, DISODIUM EDTA, HYDROCORTISONE ACETATE, ISOPROPYL PALMITATE, SODIUM BORATE, ZINC PYRITHIONE, 1,2,4-TRIHYDROXYBENZENE, OCTOXYNOL-40,
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	BHT
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	BENZOPHENONE-2, CETEARETH-20, ETHOXYDIGLYCOL, M-AMINOPHENOL, MINERAL OIL, OCTOXYNOL-9, SULISOBENZONE (BENZOPHENONE-4)
Limited evidence of any toxicity	products that may be aerosolized (airborne)	ZINC OXIDE (NON-NANO)
Limited evidence of gastrointestinal or liver toxicity		SD ALCOHOL 40, SD ALCOHOL 40B, PROPYLPARABEN, PEG-100 STEARATE, PEG-60 HYDROGENATED CASTOR OIL, RETINYL PALMITATE, VITAMIN A
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		1-DODECANOL, 2-METHYL-5-HYDROXYETHYLAMINOPHENOL, 2-METHYLRESORCINOL, ALOE BARBADENSIS (ALOE VERA) GEL, DMDM HYDANTOIN, GLYCERYL MONOSTEARATE, LINOLEIC ACID, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, PVP, TOCOPHERYL ACETATE, DIMETHYL OXAZOLIDINE, SODIUM BICARBONATE,
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		FD&C BLUE 1, PROPANE
One or more animal studies show kidney or renal system effects at moderate doses (low dose studies may be unavailable for this ingredient)		TETRASODIUM ETIDRONATE, TRISODIUM EDTA, ZEA MAYS (CORN) OIL,
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	AMINOMETHYL PROPANOL, ANTHEMIS NOBILIS (CHAMOMILE), ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, ANTHEMIS NOBILIS (CHAMOMILE) EXTRACT
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	4-CHLORORESORCINOL, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL, CETYL ALCOHOL, D&C GREEN 5, OLEYL ALCOHOL, PHENYL METHYL PYRAZOLONE, POLYSORBATE-80, STEARYL ALCOHOL, TRITICUM VULGARE (WHEAT) GERM OIL
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		D&C YELLOW 10, DIAZOLIDINYL UREA, ERYTHORBIC ACID, HYDROXYPROPYL METHYLCELLULOSE, ISOPROPYL MYRISTATE, ISOPROPYL STEARATE, PANTHENOL, ZEA MAYS (CORN) STARCH, HYDROXYETHYLCELLULOSE, FD&C YELLOW 6, POLYSORBATE-20, D&C ORANGE 4, MAGNESIUM STEARATE,
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		VP/ VA COPOLYMER,
One or more animal studies show sense organ effects at high doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	D&C VIOLET 2, ISOPROPYL ACETATE
Classified as expected to be toxic or harmful		DIMETHICONE
Classified as expected to be toxic or harmful		POLYQUATERNIUM-5
Classified as not expected to be potentially toxic or harmful		4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL, ACETYLATED LANOLIN ALCOHOL, ALOE BARBADENSIS (ALOE VERA), BEESWAX, CARAMEL, CARBOMER, CETEARYL ALCOHOL, CETYL ACETATE, COCAMIDE MEA, DENATONIUM BENZOATE, EXT D&C VIOLET 2, FD&C RED 4, GLYCERYL STEARATE SE, HYDROGENATED CASTOR OIL, HYDROLYZED ELASTIN, LANOLIN ALCOHOL, MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL, PENTASODIUM PENTETATE, POLYQUATERNIUM-11, POTASSIUM STEARATE, VP/ EICOSENE COPOLYMER, SODIUM COCOATE, SODIUM TALLOWATE, SORBITAN STEARATE, SULFATED CASTOR OIL, TOCOPHEROL, TRICALCIUM PHOSPHATE, WATER, TRISODIUM HEDTA

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE
Prohibited for use in food		SODIUM BORATE
Occupational hazards related to handling		ACETIC ACID, ETHANOLAMINE, HYDROGEN PEROXIDE, ISOPROPYL ACETATE, ISOPROPYL ALCOHOL, PROPANE, SD ALCOHOL 40, SD ALCOHOL 40B, SULFURIC ACID
Occupational hazards related to handling	products for use around the mouth; products for use on the lips; products for use on skin	CHOLECALCIFEROL

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		ANTHEMIS NOBILIS (CHAMOMILE), MENTHOL, OCTOXYNOL-9, PANTHENOL, POLYQUATERNIUM-5, PROPANE, SALICYLIC ACID, SD ALCOHOL 40, SD ALCOHOL 40B, SODIUM BORATE, CITRUS GRANDIS (GRAPEFRUIT) FRUIT EXTRACT, OCTOXYNOL-40
Designated as safe for general or specific, limited use in food		1-DODECANOL, ACETIC ACID, ALOE BARBADENSIS (ALOE VERA), ALOE BARBADENSIS (ALOE VERA) GEL, AMMONIUM CHLORIDE, ANTHEMIS NOBILIS (CHAMOMILE), ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BEESWAX, BHT, CALCIUM HYDROXIDE, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, CARAMEL, CETYL ALCOHOL, CHOLECALCIFEROL, CITRIC ACID, DIMETHICONE, DIOCTYL SODIUM SULFOSUCCINATE, DISODIUM EDTA, ERYTHORBIC ACID, ETHANOLAMINE, ETHOXYDIGLYCOL, FD&C BLUE 1, FD&C YELLOW 5, FD&C YELLOW 6, GLYCERIN, GLYCERYL MONOSTEARATE, GLYCERYL STEARATE SE, HYDROGEN PEROXIDE, HYDROXYPROPYL METHYLCELLULOSE, ISOPROPYL ACETATE, ISOPROPYL ALCOHOL, ISOPROPYL MYRISTATE, ISOPROPYL PALMITATE, LINOLEIC ACID, MAGNESIUM STEARATE, MAGNESIUM SULFATE, MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL, MENTHOL, METHYLPARABEN, MINERAL OIL, POLYSORBATE-20, POLYSORBATE-80, POTASSIUM STEARATE, PROPANE, PROPYLENE GLYCOL, PROPYLPARABEN, PVP, RESORCINOL, RETINYL PALMITATE, SALICYLIC ACID, SODIUM BICARBONATE, SODIUM SULFITE, SORBITAN STEARATE, STEARIC ACID, STEARYL ALCOHOL, TITANIUM DIOXIDE (NON-NANO), TOCOPHEROL, TOCOPHERYL ACETATE, TRICALCIUM PHOSPHATE, TRIETHANOLAMINE, VITAMIN A, VITAMIN D2, ZEA MAYS (CORN) STARCH, ZINC OXIDE (NON-NANO), PEG-100 STEARATE, PEG-60, PEG-60 HYDROGENATED CASTOR OIL, SULFURIC ACID

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		1-NAPHTHOL, AMINOMETHYL PROPANOL, AMMONIUM CHLORIDE, ISOPROPYL ACETATE, ISOPROPYL ALCOHOL, M-PHENYLENEDIAMINE, P-PHENYLENEDIAMINE, RESORCINOL, SULFUR, PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	DMDM HYDANTOIN, ISOPROPYL MYRISTATE, ISOPROPYL STEARATE, LAURETH-4, OCTOXYNOL-9, OLEYL ALCOHOL, PROPANE, STEARYL ALCOHOL, SULISOBENZONE (BENZOPHENONE-4), OCTOXYNOL-40
Human skin irritant - moderate evidence		ETHANOLAMINE, HYDROGEN PEROXIDE
One or more animal studies show skin irritation at very low doses		1-DODECANOL, ACETIC ACID, CETYL ALCOHOL, POLYOXYMETHYLENE UREA, TRIETHANOLAMINE, 1,2,4-TRIHYDROXYBENZENE, PEG-100 STEARATE
One or more animal studies show significant but moderate pulmonary irritation at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show skin irritation at low doses		BHT, CETEARETH-20, DIOCTYL SODIUM SULFOSUCCINATE, ISOPROPYL PALMITATE, LINOLEIC ACID, METHYLPARABEN, STEARIC ACID
One or more animal studies show skin irritation at moderate doses		4-CHLORORESORCINOL, ACETAMIDE MEA, ANTHEMIS NOBILIS (CHAMOMILE), ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BENZETHONIUM CHLORIDE, BENZOCAINE, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL, CETYL ACETATE, CITRIC ACID, D&C GREEN 5, ETHOXYDIGLYCOL, GLYCERIN, M-AMINOPHENOL, MENTHOL, MINERAL OIL, P-AMINOPHENOL, POLYSORBATE-20, SALICYLIC ACID, SODIUM BICARBONATE, SORBITAN STEARATE, STEARALKONIUM CHLORIDE, TRITICUM VULGARE (WHEAT) GERM OIL, VITAMIN A, ZEA MAYS (CORN) OIL, ZEA MAYS (CORN) STARCH, ZINC OXIDE (NON-NANO), C11-15 PARETH-3, PEG-60, ANTHEMIS NOBILIS (CHAMOMILE) EXTRACT
One or more animal studies show skin irritation at high doses		SODIUM SULFITE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		CHOLECALCIFEROL, VITAMIN D2
Allowed workplace exposures restricted to very low doses		LEAD ACETATE, M-PHENYLENEDIAMINE, P-PHENYLENEDIAMINE, SULFURIC ACID
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), 1-NAPHTHOL, AMMONIUM CHLORIDE, ETHANOLAMINE, HYDROGEN PEROXIDE, M-AMINOPHENOL, P-AMINOPHENOL, RESORCINOL
Allowed workplace exposures restricted to low doses		BHT, SODIUM BORATE, ZINC OXIDE (NON-NANO)
Allowed workplace exposures restricted to moderate doses		ACETIC ACID, CALCIUM HYDROXIDE, GLYCERIN, MAGNESIUM STEARATE, MINERAL OIL, POTASSIUM STEARATE, TRIETHANOLAMINE, VEGETABLE FATTY ACID, ZEA MAYS (CORN) STARCH,
Allowed workplace exposures restricted to moderate doses	products that may be aerosolized (airborne)	ISOPROPYL ACETATE, ISOPROPYL ALCOHOL
Allowed workplace exposures restricted to high doses		PROPANE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		HYDROCORTISONE ACETATE,
One or more animal studies show respiratory changes at very low doses where the human health implications are not yet well understood	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		BHT
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		P-AMINOPHENOL
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		BENZOPHENONE-2, CITRIC ACID, D&C GREEN 5, D&C ORANGE 4, DIOCTYL SODIUM SULFOSUCCINATE, GLYCERIN, HYDROGEN PEROXIDE, MAGNESIUM SULFATE, SODIUM BICARBONATE, ZEA MAYS (CORN) OIL, PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL PALMITATE, VITAMIN A, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		METHYLPARABEN