Novartis || Skin Deep: Cosmetic Safety Reviews

Manufacturer: Novartis

Brands: Aosept, CIBA Vision, Eye, Gerber, Lamisil, Miraflow, Pure Eyes, Aquify, Desenex, Eye Scrub, GenTeal, Hypo Tears, Hypotears, Nupercainal, Boost, Cruex, Novartis, Novartis Consumer Health, Novartis Medical Health, Lamisilk

COMPANY SUMMARY

product score range	1	to	8
product count	64		(browse)
ingredient count	94
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this company -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this company:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this company: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 64 products by Novartis

Product type(s) by this company in Skin Deep: anti-fungal treatment (6), anti-itch/rash cream (2), athlete's foot treatment (3), baby bubble bath (1), baby shampoo (4), baby soap (3), body wash/cleanser (1), contact lens cleaners (1), eye drops/artificial tears (9), foot moisturizer (3), foot odor control (1)

ingredients

	score	data gap	products *	concerns
METHYLPARABEN	10	63%	2 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
ALUMINUM STARCH OCTENYLSUCCINATE	9	74%	2 products	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ARSENIC, LEAD, HEAVY METALS)
BORIC ACID	9	65%	4 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Occupational hazards
FRAGRANCE	8	100%	7 products	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-20	5	71%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-80 SORBITAN LAURATE	6	70%	4 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-400	5	69%	1 products	Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
SILICA	7	69%	1 products	Cancer, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
BENZALKONIUM CHLORIDE	7	62%	1 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ISOBUTANE	6	79%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Contamination concerns (BUTADIENE), Occupational hazards
PEG-150 DISTEARATE	4	73%	4 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
P-CHLORO-M-CRESOL	6	66%	1 products	Neurotoxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
QUATERNIUM-15	6	65%	4 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (FORMALDEHYDE)
BENZYL ALCOHOL	6	64%	2 products	Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
ETHANOL	5	74%	2 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
D&C VIOLET 2	5	71%	2 products	Cancer, Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
PROPYLPARABEN	5	71%	2 products	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
RETINYL PALMITATE	5	68%	4 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
COCAMIDOPROPYL BETAINE	5	63%	4 products	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
PROPRIETARY INGREDIENTS	4	100%	1 products	Miscellaneous
ALUMINUM CHLOROHYDREX	4	89%	1 products	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
CETETH-20	4	84%	2 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
POLOXAMER 407	2	82%	1 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
SD ALCOHOL 40B	4	81%	3 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption
TOCOPHERYL ACETATE	4	81%	4 products	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
PROPANE	4	77%	2 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards
D&C RED 33	4	75%	2 products	Violations, restrictions & warnings
MINERAL OIL	2	73%	2 products	Organ system toxicity (non-reproductive), Occupational hazards
ISOPROPYL ALCOHOL	4	72%	1 products	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
TOLNAFTATE	4	71%	1 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
SODIUM PERBORATE	3	69%	7 products	Violations, restrictions & warnings
UREA	4	67%	2 products	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs), Enhanced skin absorption
CHOLECALCIFEROL	4	61%	4 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Occupational hazards
PROPYLENE GLYCOL	4	60%	3 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
SODIUM LAURETH-13 CARBOXYLATE	3	100%	4 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
TALC	3	86%	3 products	Organ system toxicity (non-reproductive), Contamination concerns (ASBESTIFORM FIBERS), Occupational hazards
MENTHOL	2	85%	1 products	Multiple, additive exposure sources
DAIDAI205	2	83%	1 products	Developmental/reproductive toxicity
DISODIUM EDTA	3	78%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
SODIUM HYDROXIDE	3	77%	5 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CITRIC ACID	3	72%	5 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
WHITE PETROLATUM	2	94%	2 products	Organ system toxicity (non-reproductive), Contamination concerns (PAHS)
PANTHENOL	2	88%	4 products	Multiple, additive exposure sources
CALCIUM CHLORIDE	2	83%	3 products	Organ system toxicity (non-reproductive)
POTASSIUM CHLORIDE	2	82%	4 products	Neurotoxicity, Organ system toxicity (non-reproductive)
TETRASODIUM EDTA	2	81%	4 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
PHOSPHORIC ACID	2	79%	5 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
MICONAZOLE NITRATE	2	78%	2 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
GLYCERIN	2	74%	4 products	Organ system toxicity (non-reproductive), Occupational hazards
TRIDECYL TRIMELLITATE	0	94%	2 products	none identified
STEARALKONIUM HECTORITE	1	93%	2 products	Contamination concerns (NITROSAMINES, FREE AMINES)
CETYL PALMITATE	1	92%	2 products	Irritation (skin, eyes, or lungs)
SORBITAN STEARATE	1	92%	2 products	none identified
GLYCERYL OLEATE	1	90%	1 products	Irritation (skin, eyes, or lungs)
KI203	1	89%	1 products	none identified
HYDROXYPROPYL METHYLCELLULOSE	1	88%	7 products	none identified
SOAP	1	88%	1 products	none identified
SORBITOL	1	88%	5 products	none identified
CETYL ALCOHOL	1	87%	3 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
DIISOPROPYL ADIPATE	1	87%	1 products	none identified
TARTARIC ACID	1	87%	1 products	none identified
ISOPROPYL MYRISTATE	1	86%	6 products	Irritation (skin, eyes, or lungs)
SORBITAN OLEATE	1	86%	2 products	none identified
PROPYLENE CARBONATE	1	85%	2 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
STEARYL ALCOHOL	1	84%	3 products	Irritation (skin, eyes, or lungs)
POLYSORBATE-60	1	81%	2 products	none identified
CELLULOSE GUM	1	80%	1 products	none identified
PHOSPHONIC ACID	1	80%	2 products	Organ system toxicity (non-reproductive), Occupational hazards
POLYVINYL ALCOHOL	1	79%	1 products	none identified
ALOE BARBADENSIS (ALOE VERA) GEL	1	72%	4 products	none identified
AMPHOTERIC-10	0	100%	1 products	none identified
AVENA SATIVA (OAT) KERNEL EXTRACT	0	100%	1 products	none identified
CARBOPOL 980	0	100%	3 products	none identified
CHAMOMILLA RECUTITA (MATRICARIA) FLOWER EXTRACT	0	100%	4 products	none identified
COCO-GLUCOSIDE	0	100%	1 products	none identified
CORN STARCH/ ACRYLAMIDE/ SODIUM ACRYLATE COPOLYMER	0	100%	1 products	none identified
DIMETHYL ISOSORBIDE	0	100%	2 products	none identified
DISODIUM LAUROAMPHODIACETATE	0	100%	4 products	none identified
EMULSIFYING WAX	0	100%	2 products	none identified
HYDROLYZED OATS	0	100%	1 products	none identified
HYDROLYZED SILK PROTEIN	0	100%	4 products	none identified
IPOMOEA PURPUREA (MORNING GLORY) EXTRACT	0	100%	1 products	none identified
LAVANDULA ANGUSTIFOLIA (LAVENDER) EXTRACT	0	100%	2 products	none identified
SODIUM LAUROYL OAT AMINO ACIDS	0	100%	1 products	none identified
SODIUM TRIDECETH-3 SULFATE	0	100%	2 products	none identified
WHEAT AMINO ACIDS	0	100%	1 products	none identified
MAGNESIUM CHLORIDE HEXAHYDRATE	0	100%	1 products	none identified
TERBINAFINE HYDROCHLORIDE	0	100%	4 products	none identified
NEOPENTYL GLYCOL DICAPRYLATE/ DICAPRATE	0	94%	2 products	none identified
SODIUM TRIDECETH SULFATE	0	94%	2 products	none identified
TRIDECYL STEARATE	0	94%	2 products	none identified
POLYQUATERNIUM-10	0	93%	1 products	none identified
SODIUM CHLORIDE	0	0%	7 products	innocuous
WATER	0	0%	21 products	innocuous

* Product counts only include current formulations sold by this company. The company may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this company that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Cancer - not classifiable/not likely to be human carcinogen	products that may be aerosolized (airborne)	SILICA
Cancer - not classifiable/not likely to be human carcinogen		ISOPROPYL ALCOHOL, POLYVINYL ALCOHOL
Cancer - limited evidence	products that may be aerosolized (airborne)	MINERAL OIL
Cancer - limited evidence		D&C VIOLET 2, ETHANOL, RETINYL PALMITATE, SD ALCOHOL 40B
One or more in vitro tests on mammalian cells show positive mutation results		BENZALKONIUM CHLORIDE, BENZYL ALCOHOL, CALCIUM CHLORIDE, DISODIUM EDTA, GLYCERIN, MENTHOL, METHYLPARABEN, PEG-400, POTASSIUM CHLORIDE, PROPYLENE GLYCOL, PROPYLPARABEN, SODIUM CHLORIDE, SODIUM HYDROXIDE, SORBITAN OLEATE, SORBITOL, TOCOPHERYL ACETATE, UREA, DAIDAI205
One or more in vitro tests non-mammalian cells show positive mutation results		BORIC ACID, D&C RED 33, QUATERNIUM-15, P-CHLORO-M-CRESOL
One or more animal studies show tumor formation at high doses		CELLULOSE GUM, POLYSORBATE-60, STEARYL ALCOHOL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of reproductive toxicity		BORIC ACID, ETHANOL, SD ALCOHOL 40B
Human nervous system toxicant - moderate evidence		ALUMINUM STARCH OCTENYLSUCCINATE, ALUMINUM CHLOROHYDREX
One or more animal studies show reproductive effects at very low doses		PEG-400
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at low doses		RETINYL PALMITATE, DAIDAI205
Limited evidence of developmental toxicity		ISOPROPYL ALCOHOL
One or more animal studies show any effects at moderate doses		ALOE BARBADENSIS (ALOE VERA) GEL
One or more animal studies show reproductive effects at moderate doses		CELLULOSE GUM, CHOLECALCIFEROL, GLYCERIN, PROPYLENE GLYCOL, TOLNAFTATE
One or more animal studies show reproductive effects at high doses		BENZYL ALCOHOL, DISODIUM EDTA, MICONAZOLE NITRATE, PEG-80 SORBITAN LAURATE, POLYSORBATE-60, POLYVINYL ALCOHOL, QUATERNIUM-15, SOAP, UREA

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN, BORIC ACID
Violation of government restrictions - Banned or found unsafe for use in cosmetics	product not intended as hair dye/bleach	SODIUM PERBORATE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		TOLNAFTATE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use only	products for use around the mouth, lips, eyes, or on damaged skin	D&C VIOLET 2
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes	products for use around the eyes	D&C RED 33
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on infant skin	products for use on infant skin	BORIC ACID
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	CETEARETH-20, PEG-150 DISTEARATE, PEG-400, PEG-80 SORBITAN LAURATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		BENZALKONIUM CHLORIDE, BORIC ACID, CHOLECALCIFEROL, CITRIC ACID, RETINYL PALMITATE, UREA
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics	products for use on the lips	SODIUM PERBORATE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		BENZYL ALCOHOL
Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmetics		D&C RED 33, ALOE BARBADENSIS (ALOE VERA) GEL, ALUMINUM STARCH OCTENYLSUCCINATE, BENZALKONIUM CHLORIDE, BENZYL ALCOHOL, BORIC ACID, CETEARETH-20, COCAMIDOPROPYL BETAINE, PEG-150 DISTEARATE, PEG-400, PEG-80 SORBITAN LAURATE, PROPYLENE GLYCOL, P-CHLORO-M-CRESOL

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Strong evidence of human neurotoxicity		BENZYL ALCOHOL, ISOPROPYL ALCOHOL, ALUMINUM STARCH OCTENYLSUCCINATE, ALUMINUM CHLOROHYDREX
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		SODIUM HYDROXIDE
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA, POTASSIUM CHLORIDE, P-CHLORO-M-CRESOL
One or more animal studies show brain and nervous system effects at moderate doses		BORIC ACID, CALCIUM CHLORIDE, CETEARETH-20, CHOLECALCIFEROL, MENTHOL, METHYLPARABEN, MICONAZOLE NITRATE, PHOSPHORIC ACID, POLYVINYL ALCOHOL, TARTARIC ACID, UREA
One or more animal studies show brain and nervous system effects at high doses		CETETH-20, GLYCERIN, PROPYLENE GLYCOL, QUATERNIUM-15, RETINYL PALMITATE, POLOXAMER 407
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		ETHANOL, PROPANE, SD ALCOHOL 40B

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		BORIC ACID, METHYLPARABEN, PROPYLPARABEN
Human any disruptor - moderate evidence		P-CHLORO-M-CRESOL
One or more animal studies show endocrine system disruption at high doses		DISODIUM EDTA, GLYCERIN, MICONAZOLE NITRATE, POTASSIUM CHLORIDE, QUATERNIUM-15

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		BENZALKONIUM CHLORIDE, COCAMIDOPROPYL BETAINE, FRAGRANCE, QUATERNIUM-15
Possible human immune system toxicant	products that may be aerosolized (airborne)	MINERAL OIL
Human any toxicant - strong evidence		ISOBUTANE, PROPANE
Human immune system toxicant - strong evidence	products that may be aerosolized (airborne)	SILICA, POLOXAMER 407
Human skin toxicant - strong evidence		METHYLPARABEN, PEG-80 SORBITAN LAURATE, PROPYLPARABEN, TOCOPHERYL ACETATE, P-CHLORO-M-CRESOL
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
One or more human case studies show possible allergenic effects		BENZYL ALCOHOL

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife and humans	products that may be aerosolized (airborne)	SILICA
Persistent, bioaccumulative in wildlife		MICONAZOLE NITRATE
Not suspected to be persistent		BENZALKONIUM CHLORIDE, CETEARETH-20, CETETH-20, CETYL PALMITATE, CHOLECALCIFEROL, CITRIC ACID, COCAMIDOPROPYL BETAINE, DIISOPROPYL ADIPATE, DISODIUM EDTA, GLYCERIN, GLYCERYL OLEATE, ISOPROPYL MYRISTATE, MENTHOL, METHYLPARABEN, NEOPENTYL GLYCOL DICAPRYLATE/ DICAPRATE, PANTHENOL, PEG-150 DISTEARATE, POLYVINYL ALCOHOL, PROPYLENE CARBONATE, PROPYLPARABEN, RETINYL PALMITATE, SOAP, SODIUM TRIDECETH SULFATE, SORBITAN OLEATE, SORBITAN STEARATE, SORBITOL, STEARYL ALCOHOL, TARTARIC ACID, TOLNAFTATE, TRIDECYL STEARATE, UREA, KI203
Not suspected to be persistent		CETYL ALCOHOL
Not suspected to be bioaccumulative		BORIC ACID, CALCIUM CHLORIDE, D&C RED 33, PHOSPHONIC ACID, POTASSIUM CHLORIDE, SODIUM CHLORIDE, SODIUM PERBORATE, TOCOPHERYL ACETATE, TRIDECYL TRIMELLITATE, WATER, DAIDAI205, P-CHLORO-M-CRESOL
Not suspected to be bioaccumulative		D&C VIOLET 2, ETHANOL, ISOBUTANE, ISOPROPYL ALCOHOL, PEG-400, PHOSPHORIC ACID, PROPANE, QUATERNIUM-15, SODIUM HYDROXIDE, TALC, WHITE PETROLATUM, POLOXAMER 407

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human any toxicant		METHYLPARABEN
Known human respiratory toxicant	products that may be aerosolized (airborne)	SILICA
Limited evidence of eye toxicity	products for use around the eyes	TETRASODIUM EDTA, P-CHLORO-M-CRESOL
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	PROPYLENE GLYCOL
Possible human immune system toxicant		BENZALKONIUM CHLORIDE
One or more animal studies show broad systemic effects at very low doses		MICONAZOLE NITRATE, PEG-400, CALCIUM CHLORIDE, GLYCERIN, SODIUM HYDROXIDE,
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	CITRIC ACID, ETHANOL, ISOPROPYL ALCOHOL, MENTHOL, PHOSPHORIC ACID
One or more animal studies show broad systemic effects at low doses		BORIC ACID, CHOLECALCIFEROL, DISODIUM EDTA, QUATERNIUM-15, TOLNAFTATE, POLOXAMER 407,
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	POTASSIUM CHLORIDE
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	CETEARETH-20, MINERAL OIL, PROPYLENE CARBONATE, SODIUM CHLORIDE
Classified as toxic or harmful	products for use around the mouth; products for use on the lips	PHOSPHONIC ACID
Classified as toxic or harmful	products for use around the mouth; products for use on the lips; products that may be aerosolized (airborne)	BENZYL ALCOHOL
Limited evidence of any toxicity	products that may be aerosolized (airborne)	ALUMINUM CHLOROHYDREX
Limited evidence of any toxicity		ALUMINUM STARCH OCTENYLSUCCINATE, SD ALCOHOL 40B
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	TALC
Limited evidence of sense organ toxicity		PEG-150 DISTEARATE, PEG-80 SORBITAN LAURATE, PROPYLPARABEN, RETINYL PALMITATE
One or more animal studies show blood effects at moderate doses (low dose studies may be unavailable for this ingredient)		TARTARIC ACID, ALOE BARBADENSIS (ALOE VERA) GEL, DIISOPROPYL ADIPATE, POLYSORBATE-60, TOCOPHERYL ACETATE,
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		PROPANE
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	UREA
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	CETYL ALCOHOL, GLYCERYL OLEATE, STEARYL ALCOHOL
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		CELLULOSE GUM, CETETH-20, HYDROXYPROPYL METHYLCELLULOSE, ISOPROPYL MYRISTATE, PANTHENOL, POLYVINYL ALCOHOL, KI203, SORBITOL, SORBITAN OLEATE, DAIDAI205,
One or more animal studies show sense organ effects at high doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	D&C VIOLET 2
Classified as expected to be toxic or harmful		TRIDECYL TRIMELLITATE
Classified as expected to be toxic or harmful		ISOBUTANE, WHITE PETROLATUM
Classified as not expected to be potentially toxic or harmful		CETYL PALMITATE, COCAMIDOPROPYL BETAINE, D&C RED 33, NEOPENTYL GLYCOL DICAPRYLATE/ DICAPRATE, POLYQUATERNIUM-10, SOAP, SODIUM PERBORATE, SODIUM TRIDECETH SULFATE, SORBITAN STEARATE, STEARALKONIUM HECTORITE, TRIDECYL STEARATE, WATER

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE, PROPRIETARY INGREDIENTS
Occupational hazards related to handling		ETHANOL, ISOBUTANE, ISOPROPYL ALCOHOL, PHOSPHONIC ACID, PHOSPHORIC ACID, PROPANE, SD ALCOHOL 40B, SODIUM HYDROXIDE, SODIUM PERBORATE
Occupational hazards related to handling	products for use around the mouth; products for use on the lips; products for use on skin	CHOLECALCIFEROL

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		BORIC ACID, ETHANOL, ISOBUTANE, MENTHOL, PANTHENOL, PROPANE, SD ALCOHOL 40B
Designated as safe for general or specific, limited use in food	products that may be aerosolized (airborne)	SILICA
Designated as safe for general or specific, limited use in food		ALOE BARBADENSIS (ALOE VERA) GEL, ALUMINUM STARCH OCTENYLSUCCINATE, BENZYL ALCOHOL, CALCIUM CHLORIDE, CELLULOSE GUM, CETYL ALCOHOL, CHOLECALCIFEROL, CITRIC ACID, DISODIUM EDTA, ETHANOL, GLYCERIN, GLYCERYL OLEATE, HYDROXYPROPYL METHYLCELLULOSE, ISOBUTANE, ISOPROPYL ALCOHOL, ISOPROPYL MYRISTATE, MENTHOL, METHYLPARABEN, MINERAL OIL, PEG-150 DISTEARATE, PEG-400, PEG-80 SORBITAN LAURATE, PHOSPHORIC ACID, POLYSORBATE-60, POLYVINYL ALCOHOL, POTASSIUM CHLORIDE, PROPANE, PROPYLENE GLYCOL, PROPYLPARABEN, RETINYL PALMITATE, SODIUM CHLORIDE, SODIUM HYDROXIDE, SORBITAN OLEATE, SORBITAN STEARATE, SORBITOL, STEARYL ALCOHOL, TALC, TARTARIC ACID, TETRASODIUM EDTA, TOCOPHERYL ACETATE, UREA, WHITE PETROLATUM, POLOXAMER 407

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		ISOPROPYL ALCOHOL, PROPYLENE CARBONATE, P-CHLORO-M-CRESOL
Classified as lung irritant	products that may be aerosolized (airborne)	SODIUM PERBORATE
Classified as skin irritant		PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	CETYL PALMITATE, GLYCERYL OLEATE, ISOBUTANE, ISOPROPYL MYRISTATE, PROPANE, STEARYL ALCOHOL
Human skin irritant - moderate evidence		PHOSPHORIC ACID
One or more animal studies show skin irritation at very low doses		CETYL ALCOHOL, SODIUM HYDROXIDE
One or more animal studies show skin irritation at low doses		BENZALKONIUM CHLORIDE, BENZYL ALCOHOL, CETEARETH-20, ETHANOL, METHYLPARABEN, TETRASODIUM EDTA, UREA
One or more animal studies show skin irritation at moderate doses		BORIC ACID, CALCIUM CHLORIDE, CITRIC ACID, DIISOPROPYL ADIPATE, GLYCERIN, MENTHOL, MINERAL OIL, PEG-400, PEG-80 SORBITAN LAURATE, QUATERNIUM-15, SODIUM CHLORIDE, SORBITAN OLEATE, SORBITAN STEARATE, TALC
One or more animal studies show skin irritation at high doses		CETETH-20

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		CHOLECALCIFEROL
Allowed workplace exposures restricted to low doses		BENZYL ALCOHOL, PHOSPHONIC ACID, TETRASODIUM EDTA, P-CHLORO-M-CRESOL
Allowed workplace exposures restricted to low doses		BORIC ACID, PHOSPHORIC ACID, TALC
Allowed workplace exposures restricted to moderate doses		GLYCERIN, MINERAL OIL,
Allowed workplace exposures restricted to moderate doses	products that may be aerosolized (airborne)	ISOPROPYL ALCOHOL
Allowed workplace exposures restricted to high doses		ETHANOL, ISOBUTANE, PROPANE
No workplace limits set		SODIUM HYDROXIDE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		SILICA
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CELLULOSE GUM, CETETH-20, CITRIC ACID, ETHANOL, GLYCERIN, MICONAZOLE NITRATE, PHOSPHONIC ACID, POLYVINYL ALCOHOL, DAIDAI205, PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL PALMITATE
Interferes with gene expresion		METHYLPARABEN