Pacific Bioscience Laboratories, Inc. || Skin Deep: Cosmetic Safety Reviews

Manufacturer: Pacific Bioscience Laboratories, Inc.

Brands: Clarisonic, Pacific Bioscience Laboratories

COMPANY SUMMARY

product score range	4	to	7
product count	4		(browse)
ingredient count	63
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this company -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this company:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this company: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 4 products by Pacific Bioscience Laboratories, Inc.

Product type(s) by this company in Skin Deep: body wash/cleanser (1), facial cleanser (2)

ingredients

	score	data gap	products *	concerns
METHYLPARABEN	10	63%	1 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
DMDM HYDANTOIN	7	71%	1 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
FRAGRANCE	8	100%	2 products	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
POLYETHYLENE GLYCOL	5	69%	1 products	Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-12 GLYCERYL DISTEARATE	4	76%	1 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
COCAMIDE DEA	6	61%	1 products	Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES)
TRIETHANOLAMINE	6	58%	2 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
PROPYLPARABEN	5	71%	1 products	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
IMIDAZOLIDINYL UREA	5	70%	1 products	Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE)
HEXYLENE GLYCOL	5	67%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
COCAMIDOPROPYL BETAINE	5	63%	1 products	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
NONOXYNOL-9	4	90%	1 products	Persistence and bioaccumulation, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
SODIUM LAURETH SULFATE	4	86%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TITANIUM DIOXIDE (NON-NANO)	1	81%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
TOCOPHERYL ACETATE	4	81%	1 products	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
CYMBOPOGON SCHOENANTHUS OIL	4	72%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
PHENOXYETHANOL	4	67%	2 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
UREA	4	67%	1 products	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs), Enhanced skin absorption
DISODIUM EDTA	3	78%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
SODIUM HYDROXIDE	3	77%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
DIMETHICONE	2	74%	1 products	Violations, restrictions & warnings
GLYCERYL COCOATE	3	73%	1 products	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (GLYCERYL DIESTERS)
PANTHENOL	2	88%	2 products	Multiple, additive exposure sources
CYANOCOBALAMIN	2	83%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive)
TETRASODIUM EDTA	2	81%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT	2	76%	1 products	Violations, restrictions & warnings
GLYCERIN	2	74%	2 products	Organ system toxicity (non-reproductive), Occupational hazards
STEARIC ACID	2	74%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
SODIUM PCA	2	71%	1 products	Contamination concerns (NITROSAMINES)
VITIS VINIFERA (GRAPE) SEED EXTRACT	1	100%	1 products	Multiple, additive exposure sources
CAPRYLIC/ CAPRIC TRIGLYCERIDE	0	94%	2 products	none identified
SALIX ALBA (WHITE WILLOW) BARK EXTRACT	1	93%	1 products	Organ system toxicity (non-reproductive)
ETHYLHEXYLGLYCERIN	1	90%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
OLEA EUROPAEA (OLIVE) OIL	1	88%	1 products	Irritation (skin, eyes, or lungs)
SORBITAN SESQUIOLEATE	1	88%	1 products	none identified
CETYL ALCOHOL	1	87%	2 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
OCTYLDODECANOL	1	87%	1 products	Irritation (skin, eyes, or lungs)
GLUCOSAMINE HCL	1	86%	1 products	none identified
POTASSIUM SORBATE	1	85%	1 products	none identified
UBIQUINONE	1	84%	1 products	none identified
SODIUM HYALURONATE	1	83%	1 products	none identified
POLYSORBATE-60	1	81%	1 products	none identified
ALOE BARBADENSIS (ALOE VERA) LEAF GEL	1	73%	1 products	none identified
ALOE BARBADENSIS (ALOE VERA) GEL	1	72%	1 products	none identified
ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER	0	100%	1 products	none identified
ARCTOSTAPHYLOS UVA-URSI (BEARBERRY) LEAF EXTRACT	0	100%	1 products	none identified
CAMELLIA OLEIFERA (TEA-OIL CAMELLIA) LEAF EXTRACT	0	100%	2 products	none identified
CHAMOMILLA RECUTITA (MATRICARIA) FLOWER EXTRACT	0	100%	1 products	none identified
CUCUMIS SATIVUS (CUCUMBER) FRUIT EXTRACT	0	100%	1 products	none identified
LAMINARIA DIGITATA (HORSETAIL KELP) EXTRACT	0	100%	1 products	none identified
POTASSIUM CETYL PHOSPHATE	0	100%	1 products	none identified
SODIUM COCOYL GLUTAMATE	0	100%	1 products	none identified
SUCROSE COCOATE	0	100%	1 products	none identified
WHITE TEA	0	100%	1 products	none identified
ALGAE EXTRACT	0	94%	1 products	none identified
BUTYROSPERMUM PARKII (SHEA BUTTER)	0	94%	1 products	none identified
CAPRYLYL GLYCOL	0	94%	2 products	none identified
HYDROGENATED VEGETABLE OIL	0	94%	1 products	none identified
OENOTHERA BIENNIS (EVENING PRIMROSE) OIL	0	94%	1 products	none identified
CARBOMER	0	93%	2 products	none identified
GLYCERYL STEARATE SE	0	93%	2 products	none identified
SACCHAROMYCES/ CEREVISIAE EXTRACT	0	93%	1 products	none identified
WATER	0	0%	3 products	innocuous

* Product counts only include current formulations sold by this company. The company may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this company that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
Cancer - not classifiable/not likely to be human carcinogen		TRIETHANOLAMINE
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - limited evidence		COCAMIDE DEA
One or more in vitro tests on mammalian cells show positive mutation results		DISODIUM EDTA, GLYCERIN, METHYLPARABEN, POLYETHYLENE GLYCOL, POTASSIUM SORBATE, PROPYLPARABEN, SODIUM HYDROXIDE, TOCOPHERYL ACETATE, UREA
One or more in vitro tests non-mammalian cells show positive mutation results		OLEA EUROPAEA (OLIVE) OIL, PHENOXYETHANOL
One or more animal studies show tumor formation at high doses		POLYSORBATE-60
One or more in vitro tests on microorganisms show positive mutation results		GLUCOSAMINE HCL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at very low doses		POLYETHYLENE GLYCOL
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show any effects at moderate doses		ALOE BARBADENSIS (ALOE VERA) GEL, ALOE BARBADENSIS (ALOE VERA) LEAF GEL
One or more animal studies show reproductive effects at moderate doses		CYANOCOBALAMIN, GLYCERIN, SODIUM HYALURONATE, UBIQUINONE
One or more animal studies show reproductive effects at high doses		DISODIUM EDTA, POLYSORBATE-60, UREA

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR)	products that may be aerosolized (airborne)	DMDM HYDANTOIN
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-12 GLYCERYL DISTEARATE, POLYETHYLENE GLYCOL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		PHENOXYETHANOL, DMDM HYDANTOIN, UREA
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, DIMETHICONE, GLYCERYL COCOATE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		ALOE BARBADENSIS (ALOE VERA) GEL, ALOE BARBADENSIS (ALOE VERA) LEAF GEL, COCAMIDE DEA, COCAMIDOPROPYL BETAINE, PEG-12 GLYCERYL DISTEARATE, POLYETHYLENE GLYCOL, SODIUM PCA, TRIETHANOLAMINE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		CYANOCOBALAMIN, SODIUM HYDROXIDE, STEARIC ACID
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA
One or more animal studies show brain and nervous system effects at moderate doses		METHYLPARABEN, PHENOXYETHANOL, SODIUM HYALURONATE, UREA
One or more animal studies show brain and nervous system effects at high doses		GLUCOSAMINE HCL, GLYCERIN, POTASSIUM SORBATE, UBIQUINONE
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		HEXYLENE GLYCOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		METHYLPARABEN, PROPYLPARABEN
One or more animal studies show endocrine system disruption at high doses		DISODIUM EDTA, GLYCERIN, HEXYLENE GLYCOL, SODIUM PCA, TRIETHANOLAMINE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		COCAMIDE DEA, COCAMIDOPROPYL BETAINE, DMDM HYDANTOIN, FRAGRANCE, HEXYLENE GLYCOL, IMIDAZOLIDINYL UREA, TRIETHANOLAMINE, CYMBOPOGON SCHOENANTHUS OIL
Human skin toxicant - strong evidence		METHYLPARABEN, PROPYLPARABEN, TOCOPHERYL ACETATE
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife		NONOXYNOL-9
Not suspected to be persistent		CAPRYLIC/ CAPRIC TRIGLYCERIDE, CAPRYLYL GLYCOL, COCAMIDOPROPYL BETAINE, DIMETHICONE, DISODIUM EDTA, DMDM HYDANTOIN, GLUCOSAMINE HCL, GLYCERIN, GLYCERYL COCOATE, GLYCERYL STEARATE SE, HEXYLENE GLYCOL, IMIDAZOLIDINYL UREA, METHYLPARABEN, OCTYLDODECANOL, PANTHENOL, PHENOXYETHANOL, POTASSIUM SORBATE, PROPYLPARABEN, SODIUM PCA, STEARIC ACID, UREA
Not suspected to be persistent		CETYL ALCOHOL
Not suspected to be bioaccumulative		CARBOMER, CYANOCOBALAMIN, OLEA EUROPAEA (OLIVE) OIL, TOCOPHERYL ACETATE, WATER
Not suspected to be bioaccumulative		POLYETHYLENE GLYCOL, SODIUM HYDROXIDE, TITANIUM DIOXIDE (NON-NANO), TRIETHANOLAMINE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human any toxicant		METHYLPARABEN
Limited evidence of any toxicity		SALIX ALBA (WHITE WILLOW) BARK EXTRACT
Limited evidence of eye toxicity	products for use around the eyes	ETHYLHEXYLGLYCERIN, TETRASODIUM EDTA
Possible human immune system toxicant		TRIETHANOLAMINE
One or more animal studies show broad systemic effects at very low doses		POLYETHYLENE GLYCOL, GLYCERIN, SODIUM HYDROXIDE,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	CYANOCOBALAMIN, STEARIC ACID, TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	COCAMIDE DEA, HEXYLENE GLYCOL, PHENOXYETHANOL, SODIUM LAURETH SULFATE
One or more animal studies show broad systemic effects at low doses		DISODIUM EDTA
Limited evidence of sense organ toxicity		PEG-12 GLYCERYL DISTEARATE, PROPYLPARABEN
One or more animal studies show blood effects at moderate doses (low dose studies may be unavailable for this ingredient)		UBIQUINONE, ALOE BARBADENSIS (ALOE VERA) GEL, DMDM HYDANTOIN, GLUCOSAMINE HCL, OLEA EUROPAEA (OLIVE) OIL, POLYSORBATE-60, POTASSIUM SORBATE, TOCOPHERYL ACETATE,
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	UREA
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	CETYL ALCOHOL, OCTYLDODECANOL, SODIUM HYALURONATE, SORBITAN SESQUIOLEATE
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		PANTHENOL, SODIUM PCA, IMIDAZOLIDINYL UREA
Classified as expected to be toxic or harmful		DIMETHICONE
Classified as expected to be toxic or harmful		CYMBOPOGON SCHOENANTHUS OIL
Classified as not expected to be potentially toxic or harmful		ALGAE EXTRACT, BUTYROSPERMUM PARKII (SHEA BUTTER), CAPRYLIC/ CAPRIC TRIGLYCERIDE, CAPRYLYL GLYCOL, CARBOMER, COCAMIDOPROPYL BETAINE, GLYCERYL COCOATE, GLYCERYL STEARATE SE, HYDROGENATED VEGETABLE OIL, OENOTHERA BIENNIS (EVENING PRIMROSE) OIL, WATER

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE
Occupational hazards related to handling		SODIUM HYDROXIDE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		PANTHENOL, VITIS VINIFERA (GRAPE) SEED EXTRACT
Designated as safe for general or specific, limited use in food		ALOE BARBADENSIS (ALOE VERA) GEL, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, CETYL ALCOHOL, COCAMIDE DEA, CYANOCOBALAMIN, DIMETHICONE, DISODIUM EDTA, GLYCERIN, GLYCERYL STEARATE SE, METHYLPARABEN, PEG-12 GLYCERYL DISTEARATE, POLYETHYLENE GLYCOL, POLYSORBATE-60, POTASSIUM SORBATE, PROPYLPARABEN, SODIUM HYDROXIDE, STEARIC ACID, TETRASODIUM EDTA, TITANIUM DIOXIDE (NON-NANO), TOCOPHERYL ACETATE, TRIETHANOLAMINE, UREA, CYMBOPOGON SCHOENANTHUS OIL

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		ETHYLHEXYLGLYCERIN, HEXYLENE GLYCOL, PHENOXYETHANOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	DMDM HYDANTOIN, GLYCERYL COCOATE, OCTYLDODECANOL, SODIUM LAURETH SULFATE
One or more animal studies show skin irritation at very low doses		CETYL ALCOHOL, SODIUM HYDROXIDE, TRIETHANOLAMINE
One or more animal studies show significant but moderate pulmonary irritation at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show skin irritation at low doses		COCAMIDE DEA, METHYLPARABEN, OLEA EUROPAEA (OLIVE) OIL, STEARIC ACID, TETRASODIUM EDTA, UREA, CYMBOPOGON SCHOENANTHUS OIL
One or more animal studies show skin irritation at moderate doses		GLYCERIN, POLYETHYLENE GLYCOL, SODIUM HYALURONATE, SORBITAN SESQUIOLEATE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), PHENOXYETHANOL, TETRASODIUM EDTA
Allowed workplace exposures restricted to moderate doses		GLYCERIN, TRIETHANOLAMINE
No workplace limits set		SODIUM HYDROXIDE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show respiratory changes at very low doses where the human health implications are not yet well understood	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		UBIQUINONE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		GLYCERIN
Interferes with gene expresion		METHYLPARABEN