Rohto Pharmaceutical Co. Ltd. || Skin Deep: Cosmetic Safety Reviews

Manufacturer: Rohto Pharmaceutical Co. Ltd.

Brands: Mentholatum, Natural Ice, Rohto, Rohto Pharmaceutical Co.

COMPANY SUMMARY

product score range	3	to	6
product count	22		(browse)
ingredient count	44
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this company -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this company:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this company: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 22 products by Rohto Pharmaceutical Co. Ltd.

Product type(s) by this company in Skin Deep: eye drops/artificial tears (6), lip balm (9), muscle/joint soreness (1), pain relief (1), sunscreen: lip balm (8), vapor rubs (2)

ingredients

	score	data gap	products *	concerns
BORIC ACID	9	65%	6 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Occupational hazards
FRAGRANCE	8	100%	7 products	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
OCTINOXATE (OCTYL METHOXYCINNAMATE)	8	65%	8 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
BENZALKONIUM CHLORIDE	7	62%	5 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
SODIUM BORATE	6	51%	6 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Occupational hazards
QUATERNIUM-15	6	65%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (FORMALDEHYDE)
ETHANOL	5	74%	4 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
ZINC SULFATE	5	73%	1 products	Cancer, Developmental/reproductive toxicity, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
TETRAHYDROZOLINE HYDROCHLORIDE	5	72%	2 products	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive)
RETINYL PALMITATE	5	68%	2 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
FLAVOR	4	100%	5 products	Miscellaneous
POLOXAMER 407	2	82%	3 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
TITANIUM DIOXIDE (NON-NANO)	1	81%	2 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
NAPHAZOLINE HYDROCHLORIDE	3	75%	2 products	Violations, restrictions & warnings
MINERAL OIL	2	73%	8 products	Organ system toxicity (non-reproductive), Occupational hazards
LANOLIN	4	71%	6 products	Allergies/immunotoxicity
METHYL SALICYLATE	4	71%	1 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CAMPHOR	4	69%	7 products	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
OCTISALATE	3	68%	8 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Enhanced skin absorption
CHOLECALCIFEROL	4	61%	2 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Occupational hazards
ISOCETETH-20	3	93%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
MENTHOL	3	85%	15 products	Organ system toxicity (non-reproductive), Multiple, additive exposure sources
PYRIDOXINE HCL	3	79%	1 products	Developmental/reproductive toxicity, Neurotoxicity
DISODIUM EDTA	3	78%	4 products	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
DIMETHICONE	2	74%	8 products	Violations, restrictions & warnings
SODIUM LAURYL SULFATE	3	68%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
PETROLATUM	2	94%	10 products	Organ system toxicity (non-reproductive), Contamination concerns (PAHS)
TOCOPHEROL	2	87%	2 products	Contamination concerns (HYDROQUINONE)
POTASSIUM CHLORIDE	2	82%	2 products	Neurotoxicity, Organ system toxicity (non-reproductive)
POLYSORBATE-80	2	80%	6 products	Developmental/reproductive toxicity
ZEA MAYS (CORN) OIL	2	79%	2 products	Neurotoxicity
AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)	2	73%	2 products	Violations, restrictions & warnings, Contamination concerns (BENZOIC ACID, 4-T-BUTYLBENZOIC ACID, BENZALDEHYDE, P-ANISIC ACID, ACETOPHENONE, DIBENZOYLMETHANE)
CHLOROBUTANOL	2	73%	3 products	Violations, restrictions & warnings
POTASSIUM ASPARTATE	1	93%	1 products	none identified
SORBITAN STEARATE	1	92%	1 products	none identified
OZOKERITE	1	91%	8 products	none identified
COCOS NUCIFERA (COCONUT) OIL	1	89%	2 products	none identified
GLYCERYL MONOSTEARATE	1	88%	1 products	none identified
HYDROXYPROPYL METHYLCELLULOSE	1	88%	2 products	none identified
PVP	1	81%	2 products	Organ system toxicity (non-reproductive)
ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT	1	75%	2 products	none identified
TRICAPRIN	0	90%	2 products	Enhanced skin absorption
SODIUM CHLORIDE	0	0%	2 products	innocuous
WATER	0	0%	7 products	innocuous

* Product counts only include current formulations sold by this company. The company may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this company that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
Cancer - not classifiable/not likely to be human carcinogen		PVP
Cancer - limited evidence	products that may be aerosolized (airborne)	MINERAL OIL
Cancer - limited evidence		ETHANOL, RETINYL PALMITATE
One or more animal studies show tumor formation at low doses		ZINC SULFATE
One or more in vitro tests on mammalian cells show positive mutation results		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)
One or more in vitro tests on mammalian cells show positive mutation results		BENZALKONIUM CHLORIDE, CAMPHOR, DISODIUM EDTA, MENTHOL, POLYSORBATE-80, POTASSIUM CHLORIDE, PYRIDOXINE HCL, SODIUM CHLORIDE, SODIUM LAURYL SULFATE, TOCOPHEROL
One or more in vitro tests non-mammalian cells show positive mutation results		BORIC ACID, CHLOROBUTANOL, METHYL SALICYLATE, QUATERNIUM-15, SODIUM BORATE
One or more animal studies show tumor formation at high doses		ZEA MAYS (CORN) OIL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of reproductive toxicity		BORIC ACID, ETHANOL, SODIUM BORATE
One or more animal studies show reproductive effects at very low doses		POLYSORBATE-80, PYRIDOXINE HCL, ZINC SULFATE
One or more animal studies show reproductive effects at low doses		RETINYL PALMITATE
Limited evidence of reproductive toxicity		METHYL SALICYLATE
One or more animal studies show reproductive effects at moderate doses		CHOLECALCIFEROL,
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show reproductive effects at high doses		DISODIUM EDTA, QUATERNIUM-15, SODIUM LAURYL SULFATE, ZEA MAYS (CORN) OIL

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		BORIC ACID, NAPHAZOLINE HYDROCHLORIDE, TETRAHYDROZOLINE HYDROCHLORIDE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on infant skin	products for use on infant skin	BORIC ACID, SODIUM BORATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), CHLOROBUTANOL, OCTISALATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		BENZALKONIUM CHLORIDE, BORIC ACID, CAMPHOR, CHOLECALCIFEROL, METHYL SALICYLATE, RETINYL PALMITATE, SODIUM BORATE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT, BENZALKONIUM CHLORIDE, BORIC ACID, METHYL SALICYLATE, SODIUM BORATE, SODIUM LAURYL SULFATE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at low doses		CAMPHOR, DISODIUM EDTA, POTASSIUM CHLORIDE, PYRIDOXINE HCL, TETRAHYDROZOLINE HYDROCHLORIDE, ZEA MAYS (CORN) OIL
One or more animal studies show brain and nervous system effects at moderate doses		BORIC ACID, CHOLECALCIFEROL, MENTHOL, METHYL SALICYLATE, SODIUM LAURYL SULFATE
One or more animal studies show brain and nervous system effects at high doses		POLYSORBATE-80, QUATERNIUM-15, RETINYL PALMITATE, SODIUM BORATE, POLOXAMER 407
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		ETHANOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		BORIC ACID, OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show endocrine disruption at moderate doses		TETRAHYDROZOLINE HYDROCHLORIDE, ZINC SULFATE
One or more animal studies show endocrine system disruption at high doses		DISODIUM EDTA, POTASSIUM CHLORIDE, PVP, PYRIDOXINE HCL, QUATERNIUM-15, SODIUM BORATE, SODIUM LAURYL SULFATE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		BENZALKONIUM CHLORIDE, FRAGRANCE, LANOLIN, QUATERNIUM-15
Possible human immune system toxicant	products that may be aerosolized (airborne)	MINERAL OIL
Human immune system toxicant - strong evidence	products that may be aerosolized (airborne)	POLOXAMER 407
Limited evidence of immune system toxicity		ZINC SULFATE
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more human case studies show possible immune effects		OCTISALATE, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Associated with immunotoxicity		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife		ZINC SULFATE
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Not suspected to be persistent		BENZALKONIUM CHLORIDE, CAMPHOR, CHOLECALCIFEROL, DIMETHICONE, DISODIUM EDTA, GLYCERYL MONOSTEARATE, ISOCETETH-20, LANOLIN, MENTHOL, METHYL SALICYLATE, NAPHAZOLINE HYDROCHLORIDE, OCTISALATE, PYRIDOXINE HCL, RETINYL PALMITATE, SORBITAN STEARATE, TRICAPRIN
Not suspected to be persistent		SODIUM LAURYL SULFATE
Not suspected to be bioaccumulative		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), BORIC ACID, CHLOROBUTANOL, COCOS NUCIFERA (COCONUT) OIL, POTASSIUM CHLORIDE, SODIUM CHLORIDE, TOCOPHEROL, WATER, ZEA MAYS (CORN) OIL
Not suspected to be bioaccumulative		ETHANOL, PETROLATUM, PVP, QUATERNIUM-15, SODIUM BORATE, TITANIUM DIOXIDE (NON-NANO), POLOXAMER 407

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of eye toxicity	products for use around the eyes	ZINC SULFATE
Possible human immune system toxicant		BENZALKONIUM CHLORIDE
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	ETHANOL, MENTHOL, METHYL SALICYLATE
One or more animal studies show broad systemic effects at low doses		BORIC ACID, CHOLECALCIFEROL, DISODIUM EDTA, QUATERNIUM-15, SODIUM BORATE, SODIUM LAURYL SULFATE, POLOXAMER 407,
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	POTASSIUM CHLORIDE, TETRAHYDROZOLINE HYDROCHLORIDE
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	CAMPHOR, MINERAL OIL, SODIUM CHLORIDE
Limited evidence of skin toxicity		RETINYL PALMITATE
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		GLYCERYL MONOSTEARATE, OCTISALATE, POTASSIUM ASPARTATE, PVP, ZEA MAYS (CORN) OIL,
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	PYRIDOXINE HCL
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	CHLOROBUTANOL, OZOKERITE, POLYSORBATE-80
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		HYDROXYPROPYL METHYLCELLULOSE, COCOS NUCIFERA (COCONUT) OIL,
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Classified as expected to be toxic or harmful		DIMETHICONE
Classified as expected to be toxic or harmful		PETROLATUM
Classified as not expected to be potentially toxic or harmful		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), ISOCETETH-20, LANOLIN, NAPHAZOLINE HYDROCHLORIDE, SORBITAN STEARATE, TOCOPHEROL, TRICAPRIN, WATER

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE, FLAVOR
Prohibited for use in food		SODIUM BORATE
Occupational hazards related to handling		ETHANOL
Occupational hazards related to handling	products for use around the mouth; products for use on the lips; products for use on skin	CHOLECALCIFEROL

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		BORIC ACID, ETHANOL, MENTHOL, SODIUM BORATE
Designated as safe for general or specific, limited use in food		CAMPHOR, CHLOROBUTANOL, CHOLECALCIFEROL, COCOS NUCIFERA (COCONUT) OIL, DIMETHICONE, DISODIUM EDTA, ETHANOL, GLYCERYL MONOSTEARATE, HYDROXYPROPYL METHYLCELLULOSE, LANOLIN, MENTHOL, METHYL SALICYLATE, MINERAL OIL, PETROLATUM, POLYSORBATE-80, POTASSIUM CHLORIDE, PVP, PYRIDOXINE HCL, RETINYL PALMITATE, SODIUM CHLORIDE, SODIUM LAURYL SULFATE, SORBITAN STEARATE, TITANIUM DIOXIDE (NON-NANO), TOCOPHEROL, ZINC SULFATE, POLOXAMER 407

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	SODIUM LAURYL SULFATE
One or more animal studies show skin irritation at very low doses		METHYL SALICYLATE
One or more animal studies show significant but moderate pulmonary irritation at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show skin irritation at low doses		BENZALKONIUM CHLORIDE, ETHANOL, OCTISALATE
One or more animal studies show skin irritation at moderate doses		BORIC ACID, CHLOROBUTANOL, MENTHOL, MINERAL OIL, OZOKERITE, QUATERNIUM-15, SODIUM CHLORIDE, SORBITAN STEARATE, ZEA MAYS (CORN) OIL

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		CHOLECALCIFEROL
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), ZINC SULFATE
Allowed workplace exposures restricted to low doses		BORIC ACID, SODIUM BORATE
Allowed workplace exposures restricted to moderate doses		CAMPHOR, MINERAL OIL
Allowed workplace exposures restricted to high doses		ETHANOL

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		ZINC SULFATE,
One or more animal studies show respiratory changes at very low doses where the human health implications are not yet well understood	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		METHYL SALICYLATE, PYRIDOXINE HCL, SODIUM LAURYL SULFATE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		ETHANOL, ZEA MAYS (CORN) OIL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL PALMITATE, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Does not produces excess reactive oxygen species or other harmful biochemical changes.		OCTISALATE