Shiseido Co., Ltd. || Skin Deep: Cosmetic Safety Reviews

Manufacturer: Shiseido Co., Ltd.

Brands: Decléor, Shiseido, Cle De Peau Beaute, Qiora

COMPANY SUMMARY

product score range	5	to	8
product count	50		(browse)
ingredient count	100
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this company -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this company:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this company: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 50 products by Shiseido Co., Ltd.

Product type(s) by this company in Skin Deep: anti-aging (2), around-eye cream (1), concealer (1), facial cleanser (1), makeup remover (1), moisturizer (1), oil controller (1), sunscreen: SPF greater than 30 (2)

ingredients

	score	data gap	products *	concerns
NANO TITANIUM DIOXIDE	2	87%	2 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
METHYLPARABEN	10	63%	5 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
NANO ZINC OXIDE (20-60nm)	3	70%	2 products	Violations, restrictions & warnings, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
FRAGRANCE	8	100%	7 products	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
POLOXAMER 184	7	82%	1 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Contamination concerns (ACETIC ACID, FORMIC ACID, PROPYLENE OXIDE, ETHYLENE OXIDE, 1,4-DIOXANE, ALDEHYDES)
POLYETHYLENE	6	69%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-150	5	69%	1 products	Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
OCTINOXATE (OCTYL METHOXYCINNAMATE)	8	65%	2 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
SILICA	1	69%	2 products	Biochemical or cellular level changes
ALUMINUM DISTEARATE	5	83%	1 products	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Occupational hazards
BUTYLPARABEN	6	79%	1 products	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PEG-12 DIOLEATE	4	75%	1 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
BHT	6	61%	3 products	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
ZINC OXIDE (NON-NANO)	2	82%	1 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
ETHYLPARABEN	5	80%	3 products	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
ETHANOL	5	74%	4 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
ALUMINUM HYDROXIDE	4	86%	3 products	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
TITANIUM DIOXIDE (NON-NANO)	1	81%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
TOCOPHERYL ACETATE	4	81%	3 products	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
MINERAL OIL	2	73%	1 products	Organ system toxicity (non-reproductive), Occupational hazards
PHENOXYETHANOL	4	67%	3 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
BENZOIC ACID	4	65%	1 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
DIHYDROCHOLETH 30	3	100%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
TALC	3	86%	1 products	Organ system toxicity (non-reproductive), Contamination concerns (ASBESTIFORM FIBERS), Occupational hazards
ZINC MYRISTATE	2	82%	2 products	Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
CYCLOPENTASILOXANE	2	79%	2 products	Persistence and bioaccumulation
SODIUM GLUTAMATE	3	79%	4 products	Neurotoxicity, Endocrine disruption
DISODIUM EDTA	3	78%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
MICA	3	75%	1 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
DIMETHICONE	2	74%	4 products	Violations, restrictions & warnings
SODIUM HEXAMETAPHOSPHATE	3	72%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (LEAD)
POTASSIUM ASCORBYL TOCOPHERYL PHOSPHATE	2	99%	2 products	Contamination concerns (HYDROQUINONE)
POTASSIUM LAURATE	2	97%	1 products	Multiple, additive exposure sources
PETROLATUM	2	94%	2 products	Organ system toxicity (non-reproductive), Contamination concerns (PAHS)
ULTRAMARINES	2	90%	1 products	Multiple, additive exposure sources
POLYMETHYL METHACRYLATE	1	89%	3 products	Organ system toxicity (non-reproductive)
TOCOPHEROL	2	87%	3 products	Contamination concerns (HYDROQUINONE)
LAURYL BETAINE	2	86%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive)
IRON OXIDES	2	85%	3 products	Persistence and bioaccumulation, Enhanced skin absorption
CYCLOMETHICONE	2	83%	3 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
PARAFFIN	2	80%	1 products	Organ system toxicity (non-reproductive), Occupational hazards
POLYSORBATE-80	2	80%	1 products	Developmental/reproductive toxicity
KAOLIN	1	79%	1 products	Occupational hazards
SODIUM DEHYDROACETATE	2	78%	1 products	Organ system toxicity (non-reproductive), Occupational hazards
GLYCERIN	2	74%	6 products	Organ system toxicity (non-reproductive), Occupational hazards
HYDROGENATED LECITHIN	2	74%	1 products	Enhanced skin absorption, Contamination concerns (NITROSAMINES)
LAURIC ACID	2	74%	1 products	Neurotoxicity
MYRISTIC ACID	2	74%	1 products	Neurotoxicity, Irritation (skin, eyes, or lungs)
STEARIC ACID	2	74%	2 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
SODIUM PCA	2	71%	2 products	Contamination concerns (NITROSAMINES)
SODIUM BENZOATE	2	69%	1 products	Organ system toxicity (non-reproductive)
POTASSIUM MYRISTATE	1	100%	1 products	Multiple, additive exposure sources
GLYCOL DISTEARATE	1	93%	1 products	Multiple, additive exposure sources
ISOSTEARIC ACID	0	93%	2 products	none identified
MICROCRYSTALLINE WAX (CERA MICROCRISTALLINA)	1	93%	2 products	Organ system toxicity (non-reproductive)
SQUALANE	1	93%	2 products	Irritation (skin, eyes, or lungs)
HYDROXYPROLINE	1	92%	2 products	none identified
PANAX GINSENG (GINSENG) ROOT EXTRACT	1	91%	2 products	none identified
GLYCERYL OLEATE	1	90%	1 products	Irritation (skin, eyes, or lungs)
MALTITOL	1	90%	1 products	none identified
ERYTHRITOL	1	89%	1 products	none identified
HYDROXYPROPYL METHYLCELLULOSE	1	88%	1 products	none identified
XYLITOL	1	88%	2 products	none identified
TRISODIUM EDTA	1	86%	6 products	Enhanced skin absorption
CALCIUM STEARATE	1	85%	1 products	Occupational hazards
QUATERNIUM-18	1	85%	1 products	Organ system toxicity (non-reproductive)
DIPROPYLENE GLYCOL	1	84%	3 products	Irritation (skin, eyes, or lungs)
ARGININE HYDROCHLORIDE	1	83%	2 products	none identified
GLUTATHIONE	1	83%	2 products	none identified
CELLULOSE GUM	1	80%	1 products	none identified
BUTYLENE GLYCOL	1	79%	6 products	Irritation (skin, eyes, or lungs)
POLYVINYL ALCOHOL	1	79%	1 products	none identified
PALMITIC ACID	1	76%	1 products	Neurotoxicity
DIPOTASSIUM GLYCYRRHIZATE	1	75%	2 products	none identified
ACRYLATES/ DIMETHICONE COPOLYMER	0	100%	2 products	none identified
CETYL OCTANOATE	0	100%	1 products	none identified
CHLORELLA VULGARIS (DERMOCHLORELLA ALGAE) EXTRACT	0	100%	2 products	none identified
DEXTRIN PALMITATE	0	100%	2 products	none identified
DISTEARDIMONIUM HECTORITE	0	100%	3 products	none identified
ECTOIN	0	100%	2 products	none identified
ONONIS SPINOSA (SPINY REST HARROW) ROOT EXTRACT	0	100%	2 products	none identified
PHYTOSTEARYL/ OCTYLDODECYL LAUROYL GLUTAMATE	0	100%	1 products	none identified
PHYTOSTERYL/ OCTYLDODECYL LAUROYL GLUTAMATE	0	100%	1 products	none identified
ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT	0	100%	2 products	none identified
SODIUM METHYL COCOYL TAURATE	0	100%	1 products	none identified
TRIMETHYLSILOXYSILICATE	0	100%	3 products	none identified
GLUCOSYL HESPERIDIN	0	100%	1 products	none identified
HYDROGENATED C6-14 OLEFIN POLYMERS	0	100%	4 products	none identified
PAEONIA ALBIFLORA ROOT EXTRACT	0	100%	1 products	none identified
POLYBUTYLENE GLYCOL/PPG-9/1 COPOLYMER	0	100%	2 products	none identified
SODIUM ACETYLATED HYALURONATE	0	100%	2 products	none identified
SODIUM LAURYL GLYCOL CARBOXYLATE	0	100%	1 products	none identified
THIOTAURINE	0	100%	2 products	none identified
SCUTELLARIA BAICALENSIS EXTRACT	0	100%	2 products	none identified
MAGNESIUM ASCORBYL PHOSPHATE	0	99%	1 products	none identified
METHICONE	0	99%	1 products	none identified
METHYL GLUCETH-10	0	94%	2 products	none identified
POLYGLYCERYL-2 DIISOSTEARATE	0	94%	2 products	none identified
BEESWAX	0	93%	1 products	none identified
WATER	0	0%	7 products	innocuous

* Product counts only include current formulations sold by this company. The company may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this company that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO), NANO TITANIUM DIOXIDE
Cancer - not classifiable/not likely to be human carcinogen	products that may be aerosolized (airborne)	SILICA
Cancer - not classifiable/not likely to be human carcinogen		BHT, POLYETHYLENE, POLYMETHYL METHACRYLATE, POLYVINYL ALCOHOL
Not likely to be carcinogenic in humans		BENZOIC ACID, LAURIC ACID, MYRISTIC ACID, PALMITIC ACID, STEARIC ACID
Cancer - limited evidence	products that may be aerosolized (airborne)	MINERAL OIL
Cancer - limited evidence		ETHANOL
One or more in vitro tests on mammalian cells show positive mutation results		BUTYLPARABEN, DISODIUM EDTA, ETHYLPARABEN, GLUTATHIONE, GLYCERIN, HYDROXYPROLINE, METHYLPARABEN, POLYSORBATE-80, SODIUM BENZOATE, SODIUM DEHYDROACETATE, TOCOPHEROL, TOCOPHERYL ACETATE, ZINC OXIDE (NON-NANO), PEG-150,
One or more in vitro tests on mammalian cells show positive mutation results		NANO ZINC OXIDE (20-60nm)
One or more animal studies show tumor formation at moderate doses		PARAFFIN,
One or more animal studies show tumor formation at moderate doses		CYCLOPENTASILOXANE
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL
One or more animal studies show tumor formation at high doses		CELLULOSE GUM

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of reproductive toxicity		ETHANOL
Human nervous system toxicant - moderate evidence		ALUMINUM DISTEARATE, ALUMINUM HYDROXIDE
One or more animal studies show any effects at very low doses		BUTYLPARABEN
One or more animal studies show reproductive effects at very low doses		POLYSORBATE-80, PEG-150
One or more animal studies show reproductive effects at moderate doses		ARGININE HYDROCHLORIDE, CELLULOSE GUM, GLYCERIN, MALTITOL,
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show developmental effects at high doses		NANO ZINC OXIDE (20-60nm), ZINC OXIDE (NON-NANO)
One or more animal studies show reproductive effects at high doses		BHT, BUTYLENE GLYCOL, DISODIUM EDTA, ETHYLPARABEN, GLUTATHIONE, KAOLIN, POLYVINYL ALCOHOL, SODIUM BENZOATE, SODIUM DEHYDROACETATE, SODIUM GLUTAMATE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	POLYETHYLENE, PEG-12 DIOLEATE, PEG-150
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any		NANO ZINC OXIDE (20-60nm), BENZOIC ACID, PHENOXYETHANOL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE
Determined safe for use in cosmetics, subject to concentration or use limitations - Restrictions on impurities recommended by industry safety panel		DIPOTASSIUM GLYCYRRHIZATE, BENZOIC ACID, HYDROGENATED LECITHIN, POLYETHYLENE, SODIUM BENZOATE, SODIUM HEXAMETAPHOSPHATE, SODIUM PCA, PEG-12 DIOLEATE, PEG-150

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Strong evidence of human neurotoxicity		ALUMINUM DISTEARATE, ALUMINUM HYDROXIDE
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		SODIUM GLUTAMATE, STEARIC ACID
One or more animal studies show brain and nervous system effects at low doses		BHT, DISODIUM EDTA, LAURIC ACID, LAURYL BETAINE, MYRISTIC ACID, PALMITIC ACID
One or more animal studies show any effects at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show brain and nervous system effects at moderate doses		BENZOIC ACID, KAOLIN, METHYLPARABEN, PHENOXYETHANOL, POLYVINYL ALCOHOL, QUATERNIUM-18, SODIUM BENZOATE
One or more animal studies show brain and nervous system effects at high doses		ARGININE HYDROCHLORIDE, BUTYLENE GLYCOL, DIPROPYLENE GLYCOL, GLYCERIN, NANO ZINC OXIDE (20-60nm), POLYETHYLENE, POLYSORBATE-80, SODIUM DEHYDROACETATE, SODIUM HEXAMETAPHOSPHATE, ULTRAMARINES, XYLITOL, ZINC OXIDE (NON-NANO), POLOXAMER 184
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		ETHANOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		BUTYLPARABEN, ETHYLPARABEN, METHYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more studies show endocrine system disruption at very low doses		SODIUM GLUTAMATE
One or more animal studies show endocrine disruption at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show endocrine system disruption at high doses		BHT, BUTYLENE GLYCOL, DISODIUM EDTA, GLYCERIN, SODIUM PCA

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		BHT, FRAGRANCE
Possible human immune system toxicant	products that may be aerosolized (airborne)	MINERAL OIL
Human immune and respiratory toxicant - strong evidence		NANO ZINC OXIDE (20-60nm), ZINC OXIDE (NON-NANO)
Human immune system toxicant - strong evidence	products that may be aerosolized (airborne)	SILICA, POLOXAMER 184
Human skin toxicant - strong evidence		BUTYLPARABEN, ETHYLPARABEN, METHYLPARABEN, TOCOPHERYL ACETATE
Limited evidence of immune system toxicity		ZINC MYRISTATE
Human immune system toxicant - moderate evidence		POLYETHYLENE
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO), NANO TITANIUM DIOXIDE
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
One or more animal studies show gastrointestinal effects at moderate doses		MICA

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife and humans	products that may be aerosolized (airborne)	SILICA
Persistent, bioaccumulative in wildlife and humans		MICA, IRON OXIDES
Persistent, bioaccumulative in wildlife		CYCLOMETHICONE, CYCLOPENTASILOXANE, NANO ZINC OXIDE (20-60nm), ZINC MYRISTATE, ZINC OXIDE (NON-NANO)
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Not suspected to be persistent		ARGININE HYDROCHLORIDE, BENZOIC ACID, BUTYLENE GLYCOL, BUTYLPARABEN, CALCIUM STEARATE, DIMETHICONE, DIPROPYLENE GLYCOL, DISODIUM EDTA, ETHYLPARABEN, GLUTATHIONE, GLYCERIN, GLYCERYL OLEATE, GLYCOL DISTEARATE, HYDROXYPROLINE, ISOSTEARIC ACID, LAURIC ACID, LAURYL BETAINE, METHYLPARABEN, MYRISTIC ACID, PALMITIC ACID, PHENOXYETHANOL, POLYVINYL ALCOHOL, SODIUM BENZOATE, SODIUM DEHYDROACETATE, SODIUM GLUTAMATE, SODIUM PCA, SQUALANE, STEARIC ACID, TRISODIUM EDTA, ERYTHRITOL, PEG-12 DIOLEATE
Not suspected to be persistent		QUATERNIUM-18
Not suspected to be bioaccumulative		ALUMINUM DISTEARATE, KAOLIN, METHYL GLUCETH-10, POLYETHYLENE, POLYGLYCERYL-2 DIISOSTEARATE, SODIUM HEXAMETAPHOSPHATE, TOCOPHEROL, TOCOPHERYL ACETATE, WATER
Not suspected to be bioaccumulative		ALUMINUM HYDROXIDE, ETHANOL, MICROCRYSTALLINE WAX (CERA MICROCRISTALLINA), PETROLATUM, POLYMETHYL METHACRYLATE, TALC, TITANIUM DIOXIDE (NON-NANO), PEG-150, POLOXAMER 184, NANO TITANIUM DIOXIDE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human any toxicant		METHYLPARABEN
Known human respiratory toxicant	products that may be aerosolized (airborne)	SILICA
Possible human immune system toxicant		POLYETHYLENE, MICA
One or more animal studies show broad systemic effects at very low doses		PEG-150, GLYCERIN,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	STEARIC ACID, TITANIUM DIOXIDE (NON-NANO), NANO TITANIUM DIOXIDE
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	BENZOIC ACID, ETHANOL, PHENOXYETHANOL
One or more animal studies show broad systemic effects at low doses		ALUMINUM HYDROXIDE, DISODIUM EDTA, LAURYL BETAINE, SODIUM BENZOATE, SODIUM HEXAMETAPHOSPHATE, POLOXAMER 184,
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	BHT
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	MINERAL OIL
Classified as toxic or harmful	products for use around the mouth; products for use on the lips	SODIUM DEHYDROACETATE
Limited evidence of any toxicity	products that may be aerosolized (airborne)	ALUMINUM DISTEARATE, NANO ZINC OXIDE (20-60nm), ZINC MYRISTATE, ZINC OXIDE (NON-NANO), KAOLIN, TALC
Limited evidence of sense organ toxicity		BUTYLPARABEN, ETHYLPARABEN, PEG-12 DIOLEATE
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		TOCOPHERYL ACETATE, TRISODIUM EDTA, QUATERNIUM-18,
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	SODIUM GLUTAMATE
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	BUTYLENE GLYCOL, CYCLOMETHICONE, CYCLOPENTASILOXANE, DIPROPYLENE GLYCOL, GLYCERYL OLEATE, LAURIC ACID, MYRISTIC ACID, PARAFFIN, POLYSORBATE-80
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		CELLULOSE GUM, GLUTATHIONE, HYDROXYPROPYL METHYLCELLULOSE, POLYVINYL ALCOHOL, SODIUM PCA, XYLITOL, ERYTHRITOL, ARGININE HYDROCHLORIDE, ULTRAMARINES, PANAX GINSENG (GINSENG) ROOT EXTRACT,
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Classified as expected to be toxic or harmful		DIMETHICONE
Classified as expected to be toxic or harmful		MICROCRYSTALLINE WAX (CERA MICROCRISTALLINA), PETROLATUM, POLYMETHYL METHACRYLATE
Classified as not expected to be potentially toxic or harmful		BEESWAX, CALCIUM STEARATE, GLYCOL DISTEARATE, HYDROXYPROLINE, ISOSTEARIC ACID, METHYL GLUCETH-10, PALMITIC ACID, POLYGLYCERYL-2 DIISOSTEARATE, SQUALANE, IRON OXIDES, TOCOPHEROL, WATER

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE
Occupational hazards related to handling		ETHANOL

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		ALUMINUM DISTEARATE, ETHANOL, GLYCOL DISTEARATE, POTASSIUM LAURATE, POTASSIUM MYRISTATE, ULTRAMARINES
Designated as safe for general or specific, limited use in food	products that may be aerosolized (airborne)	SILICA
Designated as safe for general or specific, limited use in food		ALUMINUM DISTEARATE, ALUMINUM HYDROXIDE, BEESWAX, BENZOIC ACID, BHT, BUTYLENE GLYCOL, BUTYLPARABEN, CALCIUM STEARATE, CELLULOSE GUM, DIMETHICONE, DISODIUM EDTA, ETHANOL, GLYCERIN, GLYCERYL OLEATE, HYDROXYPROPYL METHYLCELLULOSE, LAURIC ACID, METHICONE, METHYLPARABEN, MINERAL OIL, MYRISTIC ACID, NANO ZINC OXIDE (20-60nm), PALMITIC ACID, PARAFFIN, PETROLATUM, POLYETHYLENE, POLYSORBATE-80, POLYVINYL ALCOHOL, POTASSIUM LAURATE, POTASSIUM MYRISTATE, ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT, SODIUM BENZOATE, SODIUM DEHYDROACETATE, SODIUM GLUTAMATE, SODIUM HEXAMETAPHOSPHATE, STEARIC ACID, IRON OXIDES, TALC, TITANIUM DIOXIDE (NON-NANO), TOCOPHEROL, TOCOPHERYL ACETATE, XYLITOL, ZINC OXIDE (NON-NANO), PEG-12 DIOLEATE, PEG-150, POLOXAMER 184, NANO TITANIUM DIOXIDE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		PHENOXYETHANOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	BUTYLENE GLYCOL, DIPROPYLENE GLYCOL, GLYCERYL OLEATE, POLYETHYLENE, SODIUM HEXAMETAPHOSPHATE
One or more animal studies show significant but moderate pulmonary irritation at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show significant but moderate pulmonary irritation at low doses		NANO TITANIUM DIOXIDE
One or more animal studies show skin irritation at low doses		BENZOIC ACID, BHT, ETHANOL, METHYLPARABEN, MYRISTIC ACID, SQUALANE, STEARIC ACID
One or more animal studies show skin irritation at moderate doses		BUTYLPARABEN, CYCLOMETHICONE, CYCLOPENTASILOXANE, GLYCERIN, LAURIC ACID, LAURYL BETAINE, MINERAL OIL, NANO ZINC OXIDE (20-60nm), PALMITIC ACID, PARAFFIN, QUATERNIUM-18, TALC, ZINC OXIDE (NON-NANO), PEG-150
One or more animal studies show skin irritation at high doses		POTASSIUM LAURATE, SODIUM BENZOATE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), NANO TITANIUM DIOXIDE, PHENOXYETHANOL, SODIUM DEHYDROACETATE
Allowed workplace exposures restricted to low doses		ALUMINUM DISTEARATE, BHT, KAOLIN, MICA, NANO ZINC OXIDE (20-60nm), PARAFFIN, TALC, ZINC OXIDE (NON-NANO)
Allowed workplace exposures restricted to moderate doses		CALCIUM STEARATE, GLYCERIN, MINERAL OIL
Allowed workplace exposures restricted to high doses		ETHANOL
No workplace limits set	products that may be aerosolized (airborne)	POLYMETHYL METHACRYLATE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		SILICA, NANO TITANIUM DIOXIDE,
One or more animal studies show respiratory changes at very low doses where the human health implications are not yet well understood	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		BHT
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		SODIUM GLUTAMATE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CELLULOSE GUM, CYCLOMETHICONE, CYCLOPENTASILOXANE, ETHANOL, GLUTATHIONE, GLYCERIN, PANAX GINSENG (GINSENG) ROOT EXTRACT, POLYETHYLENE, POLYVINYL ALCOHOL, SODIUM BENZOATE, XYLITOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		BUTYLPARABEN, METHYLPARABEN