Topix Pharmaceuticals || Skin Deep: Cosmetic Safety Reviews

Manufacturer: Topix Pharmaceuticals

Brands: Topix, Resurfix, Citrix, Replenix

COMPANY SUMMARY

product score range	1	to	8
product count	68		(browse)
ingredient count	140
(why scores have changed)

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients used by this company -- not the products -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients used by this company:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used by this company: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

See all 68 products by Topix Pharmaceuticals

Product type(s) by this company in Skin Deep: acne treatment (4), anti-aging (3), anti-itch/rash cream (1), body firming lotion (2), conditioner (1), facial cleanser (6), facial moisturizer/treatment (8), hair-loss treatment (1), mask (1), moisturizer (5), shampoo (2), sunscreen: moisturizer (1), sunscreen: SPF 15-30 (3), sunscreen: SPF greater than 30 (1), toners/astringents (1)

ingredients

	score	data gap	products *	concerns
NANO TITANIUM DIOXIDE	2	87%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
METHYLPARABEN	10	63%	17 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
NANO ZINC OXIDE (20-60nm)	3	70%	2 products	Violations, restrictions & warnings, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
OXYBENZONE (BENZOPHENONE-3)	9	55%	4 products	Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
FRAGRANCE	8	100%	7 products	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-20	5	71%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-80 SORBITAN LAURATE	6	70%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
OCTINOXATE (OCTYL METHOXYCINNAMATE)	8	65%	5 products	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
PEG-100 STEARATE	4	69%	3 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
BENZOYL PEROXIDE	7	55%	4 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
PEG-12 DIMETHICONE	4	75%	3 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
PEG-8 DISTEARATE	4	75%	1 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
PEG/ PPG-18/ 18 DIMETHICONE	4	75%	3 products	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
LECITHIN	3	70%	1 products	Multiple, additive exposure sources, Enhanced skin absorption, Contamination concerns (NITROSAMINES)
QUATERNIUM-15	6	65%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (FORMALDEHYDE)
BENZYL ALCOHOL	6	64%	6 products	Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
METHYLCHLOROISOTHIAZOLINONE	6	63%	3 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
METHYLISOTHIAZOLINONE	6	63%	3 products	Violations, restrictions & warnings, Allergies/immunotoxicity
COCAMIDE DEA	6	61%	2 products	Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES)
DIAZOLIDINYL UREA	6	59%	2 products	Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE)
TRIETHANOLAMINE	6	58%	10 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
ZINC OXIDE (NON-NANO)	2	82%	1 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
SD ALCOHOL	5	76%	1 products	Cancer, Developmental/reproductive toxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption
ALCOHOL DENATURED	5	71%	1 products	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
PROPYLPARABEN	5	71%	11 products	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
IMIDAZOLIDINYL UREA	5	70%	10 products	Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE)
VITAMIN A	5	70%	3 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
RETINYL PALMITATE	5	68%	3 products	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PAPAIN	5	68%	1 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
COCAMIDOPROPYL BETAINE	5	63%	2 products	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
SODIUM LAURETH SULFATE	4	86%	3 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TOCOPHERYL ACETATE	4	81%	2 products	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
CAFFEINE	4	75%	3 products	Developmental/reproductive toxicity, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
MINERAL OIL	2	73%	1 products	Organ system toxicity (non-reproductive), Occupational hazards
SODIUM LAUROYL SARCOSINATE	4	73%	2 products	Violations, restrictions & warnings, Enhanced skin absorption, Contamination concerns (NITROSAMINES)
OCTISALATE	3	68%	5 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Enhanced skin absorption
PHENOXYETHANOL	4	67%	6 products	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL	4	60%	5 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
LAURETH-7	3	100%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
SODIUM LAURETH-13 CARBOXYLATE	3	100%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
OLETH-5	3	99%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
CETETH-5	3	99%	1 products	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
CHROMIUM OXIDE GREENS	3	86%	1 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Enhanced skin absorption, Occupational hazards
FD&C YELLOW 5	2	82%	3 products	Neurotoxicity, Organ system toxicity (non-reproductive)
SORBIC ACID	3	80%	2 products	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
SILICONE FLUID	3	79%	3 products	Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
DISODIUM EDTA	3	78%	4 products	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
DIMETHICONE	2	74%	12 products	Violations, restrictions & warnings
BENTONITE	3	72%	1 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
CITRIC ACID	3	72%	5 products	Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
POLYACRYLAMIDE	3	71%	1 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Contamination concerns (ACRYLAMIDE)
LAURAMIDE DEA	3	70%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES)
SODIUM HYDROXYMETHYLGLYCINATE	2	100%	2 products	Contamination concerns (FORMALDEHYDE)
PANTHENOL	2	88%	1 products	Multiple, additive exposure sources
TOCOPHEROL	2	87%	2 products	Contamination concerns (HYDROQUINONE)
CYCLOMETHICONE	2	83%	10 products	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
FD&C BLUE 1	1	83%	2 products	none identified
TETRASODIUM EDTA	2	81%	4 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
HYDROCORTISONE	2	80%	1 products	Developmental/reproductive toxicity, Biochemical or cellular level changes
KAOLIN	1	79%	1 products	Occupational hazards
CAMELLIA SINENSIS (GREEN TEA) EXTRACT	2	76%	3 products	Violations, restrictions & warnings
CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT	2	76%	1 products	Violations, restrictions & warnings
SODIUM C14-16 OLEFIN SULFONATE	2	75%	2 products	Organ system toxicity (non-reproductive), Contamination concerns (GAMMA SULTONE)
GLYCERIN	2	74%	8 products	Organ system toxicity (non-reproductive), Occupational hazards
STEARAMIDE MEA	2	74%	1 products	Contamination concerns (NITROSAMINES)
STEARIC ACID	2	74%	1 products	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)	2	73%	3 products	Violations, restrictions & warnings, Contamination concerns (BENZOIC ACID, 4-T-BUTYLBENZOIC ACID, BENZALDEHYDE, P-ANISIC ACID, ACETOPHENONE, DIBENZOYLMETHANE)
SODIUM PCA	2	71%	1 products	Contamination concerns (NITROSAMINES)
SUPEROXIDE DISMUTASE	1	95%	2 products	none identified
C12-15 ALKYL BENZOATE	0	94%	4 products	none identified
CAPRYLIC/ CAPRIC TRIGLYCERIDE	0	94%	2 products	none identified
CETYL PHOSPHATE	0	94%	2 products	none identified
STEARAMIDOPROPYL DIMETHYLAMINE	0	94%	1 products	none identified
C13-14 ISOPARAFFIN	1	93%	1 products	none identified
CETEARYL ALCOHOL	0	93%	5 products	none identified
CIMICIFUGA RACEMOSA (BLACK COHOSH) ROOT EXTRACT	1	93%	1 products	Organ system toxicity (non-reproductive)
SQUALANE	1	93%	5 products	Irritation (skin, eyes, or lungs)
CARAMEL	1	92%	1 products	none identified
MENTHYL ANTHRANILATE	1	92%	1 products	Organ system toxicity (non-reproductive)
ASCORBIC ACID (VITAMIN C)	1	91%	4 products	none identified
COCOS NUCIFERA (COCONUT) OIL	1	89%	1 products	none identified
STEARETH-5	1	89%	1 products	none identified
ASCORBYL PALMITATE (VITAMIN C PALMITATE)	1	88%	3 products	none identified
ETHYLENE BRASSYLATE	1	88%	2 products	Irritation (skin, eyes, or lungs)
GLYCERYL MONOSTEARATE	1	88%	4 products	none identified
HYDROLYZED COLLAGEN	0	88%	1 products	none identified
HYDROXYPROPYL METHYLCELLULOSE	1	88%	1 products	none identified
HYDROXYPROPYLCELLULOSE	1	88%	1 products	none identified
SORBITOL	1	88%	1 products	none identified
CETYL ALCOHOL	1	87%	3 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ISOPROPYL MYRISTATE	1	86%	1 products	Irritation (skin, eyes, or lungs)
SORBITAN OLEATE	1	86%	1 products	none identified
SULFUR	1	86%	1 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
STEARALKONIUM CHLORIDE	1	85%	1 products	Organ system toxicity (non-reproductive)
POLYSORBATE-20	1	84%	6 products	none identified
STEARYL ALCOHOL	1	84%	4 products	Irritation (skin, eyes, or lungs)
UBIQUINONE	1	84%	3 products	none identified
SODIUM HYALURONATE	1	83%	4 products	none identified
HYDROXYETHYLCELLULOSE	1	82%	1 products	none identified
POLYSORBATE-60	1	81%	2 products	none identified
ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT	1	80%	1 products	Enhanced skin absorption
BISABOLOL	1	80%	5 products	Enhanced skin absorption
AMMONIUM LAURYL SULFATE	1	73%	2 products	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ALOE BARBADENSIS (ALOE VERA) GEL	1	72%	3 products	none identified
ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER	0	100%	1 products	none identified
ACRYLATES/ OCTYLACRYLAMIDE COPOLYMER	0	100%	2 products	none identified
ASCORBYL GLUCOSAMINE	0	100%	2 products	none identified
CAMELLIA OLEIFERA (TEA-OIL CAMELLIA) SEED EXTRACT	0	100%	1 products	none identified
CETEARYL GLUCOSIDE	0	100%	1 products	none identified
CHAMOMILLA RECUTITA (MATRICARIA) FLOWER EXTRACT	0	100%	1 products	none identified
CUCUMIS SATIVUS (CUCUMBER) FRUIT EXTRACT	0	100%	4 products	none identified
DIMETHICONE COPOYOL	0	100%	1 products	none identified
DIOCTYL MALATE	0	100%	1 products	none identified
DISODIUM LAUROAMPHODIACETATE	0	100%	1 products	none identified
ECTOIN	0	100%	2 products	none identified
EMULSIFYING WAX	0	100%	3 products	none identified
GLYCINE SOJA (SOYBEAN) PHOSPHOLIPIDS	0	100%	1 products	none identified
GLYCOSAMINOGLYCANS	0	100%	1 products	none identified
PHOSPHOLIPIDS	0	100%	3 products	none identified
POLYPHENOLS	0	100%	8 products	none identified
POLYSILICONE-11	0	100%	3 products	none identified
PPG-2 MYRISTYL ETHER PROPIONATE	0	100%	3 products	none identified
SILYBUM MARIANUM (LADY'S THISTLE) FRUIT EXTRACT	0	100%	2 products	none identified
WHITE TEA	0	100%	1 products	none identified
DISODIUM LAURIMINODIPROPIONATE TOCOPHERYL PHOSPHATES	0	100%	2 products	none identified
TGF-BETA-1 (TRANSFORMING GROWTH FACTOR)	0	100%	1 products	none identified
CAPRYLYL GLYCOL	0	94%	2 products	none identified
COCAMIDOPROPYL HYDROXYSULTAINE	0	94%	1 products	none identified
DEA LAURYL SULFATE	0	94%	3 products	none identified
DEA-CETYL PHOSPHATE	0	94%	1 products	none identified
HYALURONIC ACID	0	94%	4 products	none identified
SODIUM TRIDECETH SULFATE	0	94%	1 products	none identified
XANTHAN GUM	0	94%	3 products	none identified
BEESWAX	0	93%	3 products	none identified
CARBOMER	0	93%	11 products	none identified
CETYL ESTERS	0	93%	1 products	none identified
POLYQUATERNIUM-10	0	93%	1 products	none identified
LANETH-5	0	93%	1 products	none identified
SODIUM CHLORIDE	0	0%	1 products	innocuous
WATER	0	0%	24 products	innocuous

* Product counts only include current formulations sold by this company. The company may have other discontinued formulations that use this ingredient. Clicking on the link "X products" will identify all product formulations by this company that have used the ingredient.

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	NANO TITANIUM DIOXIDE
Cancer - not classifiable/not likely to be human carcinogen		BENZOYL PEROXIDE, CAFFEINE, CHROMIUM OXIDE GREENS, FD&C BLUE 1, TRIETHANOLAMINE
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - limited evidence	products that may be aerosolized (airborne)	MINERAL OIL
Cancer - limited evidence		ALCOHOL DENATURED, COCAMIDE DEA, RETINYL PALMITATE, SD ALCOHOL, VITAMIN A
One or more in vitro tests on mammalian cells show positive mutation results		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), MENTHYL ANTHRANILATE
One or more in vitro tests on mammalian cells show positive mutation results		ASCORBIC ACID (VITAMIN C), BENZYL ALCOHOL, CARAMEL, DIAZOLIDINYL UREA, DISODIUM EDTA, FD&C YELLOW 5, GLYCERIN, HYDROCORTISONE, METHYLPARABEN, PROPYLENE GLYCOL, PROPYLPARABEN, SODIUM CHLORIDE, SORBIC ACID, SORBITAN OLEATE, SORBITOL, SUPEROXIDE DISMUTASE, TOCOPHEROL, TOCOPHERYL ACETATE, ZINC OXIDE (NON-NANO),
One or more in vitro tests on mammalian cells show positive mutation results		NANO ZINC OXIDE (20-60nm)
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE
One or more in vitro tests non-mammalian cells show positive mutation results		METHYLCHLOROISOTHIAZOLINONE, OXYBENZONE (BENZOPHENONE-3), PHENOXYETHANOL, QUATERNIUM-15
One or more animal studies show tumor formation at high doses		BENTONITE, LAURAMIDE DEA, POLYSORBATE-60, SILICONE FLUID, STEARYL ALCOHOL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of reproductive toxicity		SD ALCOHOL
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at low doses		CAFFEINE, HYDROCORTISONE, RETINYL PALMITATE, VITAMIN A
Limited evidence of developmental toxicity		OXYBENZONE (BENZOPHENONE-3), ALCOHOL DENATURED
One or more animal studies show any effects at moderate doses		ALOE BARBADENSIS (ALOE VERA) GEL
One or more animal studies show reproductive effects at moderate doses		GLYCERIN, PROPYLENE GLYCOL, SODIUM HYALURONATE, UBIQUINONE,
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show developmental effects at high doses		NANO ZINC OXIDE (20-60nm), ZINC OXIDE (NON-NANO)
One or more animal studies show reproductive effects at high doses		BENZYL ALCOHOL, DISODIUM EDTA, FD&C YELLOW 5, HYDROXYETHYLCELLULOSE, KAOLIN, PEG-80 SORBITAN LAURATE, POLYSORBATE-20, POLYSORBATE-60, QUATERNIUM-15, SILICONE FLUID, PAPAIN, PEG-100 STEARATE,
One or more animal studies show reproductive effects at high doses		BENZOYL PEROXIDE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	CETEARETH-20, PEG-12 DIMETHICONE, PEG-8 DISTEARATE, PEG-80 SORBITAN LAURATE, PEG/ PPG-18/ 18 DIMETHICONE, PEG-100 STEARATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any		NANO ZINC OXIDE (20-60nm), AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), PHENOXYETHANOL, OCTISALATE, OXYBENZONE (BENZOPHENONE-3), SODIUM LAUROYL SARCOSINATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		BENZOYL PEROXIDE, CITRIC ACID, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, RETINYL PALMITATE, VITAMIN A
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		CAMELLIA SINENSIS (GREEN TEA) EXTRACT, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, BENTONITE, BENZYL ALCOHOL, DIMETHICONE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		ALOE BARBADENSIS (ALOE VERA) GEL, AMMONIUM LAURYL SULFATE, BENZYL ALCOHOL, CETEARETH-20, COCAMIDE DEA, COCAMIDOPROPYL BETAINE, DIAZOLIDINYL UREA, LAURAMIDE DEA, LECITHIN, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, PEG-12 DIMETHICONE, PEG-8 DISTEARATE, PEG-80 SORBITAN LAURATE, PEG/ PPG-18/ 18 DIMETHICONE, POLYACRYLAMIDE, PROPYLENE GLYCOL, SODIUM C14-16 OLEFIN SULFONATE, SODIUM LAUROYL SARCOSINATE, SODIUM PCA, STEARAMIDE MEA, TRIETHANOLAMINE, PEG-100 STEARATE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Strong evidence of human neurotoxicity		BENZYL ALCOHOL
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		CAFFEINE, FD&C YELLOW 5, STEARIC ACID
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA
One or more animal studies show brain and nervous system effects at moderate doses		ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BISABOLOL, CETEARETH-20, KAOLIN, LECITHIN, METHYLPARABEN, PHENOXYETHANOL, SODIUM HYALURONATE, STEARALKONIUM CHLORIDE
One or more animal studies show brain and nervous system effects at high doses		DIAZOLIDINYL UREA, FD&C BLUE 1, GLYCERIN, HYDROXYETHYLCELLULOSE, NANO ZINC OXIDE (20-60nm), OXYBENZONE (BENZOPHENONE-3), POLYACRYLAMIDE, PROPYLENE GLYCOL, QUATERNIUM-15, RETINYL PALMITATE, UBIQUINONE, VITAMIN A, ZINC OXIDE (NON-NANO)
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		SD ALCOHOL
One or more in vitro tests on mammalian cells demonstrate neurotoxicity		METHYLISOTHIAZOLINONE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		METHYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE), PROPYLPARABEN
Human any disruptor - moderate evidence		OXYBENZONE (BENZOPHENONE-3)
One or more studies show endocrine system disruption at low doses		SILICONE FLUID
One or more animal studies show endocrine disruption at moderate doses		HYDROCORTISONE
One or more animal studies show endocrine system disruption at high doses		ALCOHOL DENATURED, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BISABOLOL, CAFFEINE, DIAZOLIDINYL UREA, DISODIUM EDTA, GLYCERIN, QUATERNIUM-15, SODIUM PCA, TRIETHANOLAMINE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		COCAMIDE DEA, COCAMIDOPROPYL BETAINE, DIAZOLIDINYL UREA, FRAGRANCE, IMIDAZOLIDINYL UREA, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, QUATERNIUM-15, TRIETHANOLAMINE, PAPAIN
Possible human immune system toxicant	products that may be aerosolized (airborne)	MINERAL OIL
Possible human photoallergenic toxicant		OXYBENZONE (BENZOPHENONE-3)
Human immune and respiratory toxicant - strong evidence		NANO ZINC OXIDE (20-60nm), ZINC OXIDE (NON-NANO)
Human immune and respiratory toxicant - strong evidence	AND products that may be aerosolized (airborne)	LECITHIN
Human skin toxicant - strong evidence		METHYLPARABEN, PEG-80 SORBITAN LAURATE, PROPYLPARABEN, SORBIC ACID, TOCOPHERYL ACETATE
Limited evidence of immune system toxicity		BENZOYL PEROXIDE, PROPYLENE GLYCOL
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	NANO TITANIUM DIOXIDE
One or more human case studies show possible allergenic effects		BENZYL ALCOHOL, OCTISALATE, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
Associated with immunotoxicity		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife		CAFFEINE, CYCLOMETHICONE, NANO ZINC OXIDE (20-60nm), SD ALCOHOL, ZINC OXIDE (NON-NANO)
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE), OXYBENZONE (BENZOPHENONE-3)
Not suspected to be persistent		ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, ASCORBIC ACID (VITAMIN C), ASCORBYL PALMITATE (VITAMIN C PALMITATE), BENZOYL PEROXIDE, BISABOLOL, C12-15 ALKYL BENZOATE, CAPRYLIC/ CAPRIC TRIGLYCERIDE, CAPRYLYL GLYCOL, CETEARETH-20, CETEARYL ALCOHOL, CETYL PHOSPHATE, CITRIC ACID, COCAMIDOPROPYL BETAINE, COCAMIDOPROPYL HYDROXYSULTAINE, DEA LAURYL SULFATE, DEA-CETYL PHOSPHATE, DIAZOLIDINYL UREA, DIMETHICONE, DISODIUM EDTA, ETHYLENE BRASSYLATE, GLYCERIN, GLYCERYL MONOSTEARATE, HYDROCORTISONE, IMIDAZOLIDINYL UREA, ISOPROPYL MYRISTATE, LECITHIN, MENTHYL ANTHRANILATE, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, METHYLPARABEN, OCTISALATE, PANTHENOL, PHENOXYETHANOL, PROPYLPARABEN, RETINYL PALMITATE, SODIUM LAUROYL SARCOSINATE, SODIUM PCA, SODIUM TRIDECETH SULFATE, SORBIC ACID, SORBITAN OLEATE, SORBITOL, SQUALANE, STEARALKONIUM CHLORIDE, STEARAMIDE MEA, STEARAMIDOPROPYL DIMETHYLAMINE, STEARIC ACID, STEARYL ALCOHOL, PEG-100 STEARATE, STEARETH-5
Not suspected to be persistent		CETYL ALCOHOL
Not suspected to be bioaccumulative		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), BENTONITE, CARBOMER, COCOS NUCIFERA (COCONUT) OIL, FD&C BLUE 1, FD&C YELLOW 5, KAOLIN, SODIUM CHLORIDE, SULFUR, TOCOPHEROL, TOCOPHERYL ACETATE, WATER
Not suspected to be bioaccumulative		ALCOHOL DENATURED, CHROMIUM OXIDE GREENS, POLYACRYLAMIDE, QUATERNIUM-15, TRIETHANOLAMINE, NANO TITANIUM DIOXIDE
Persistent or bioaccumulative and moderate to high toxicity concern in humans		SILICONE FLUID

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human any toxicant		METHYLPARABEN
Limited evidence of eye toxicity	products for use around the eyes	TETRASODIUM EDTA
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	PROPYLENE GLYCOL
Possible human immune system toxicant		METHYLCHLOROISOTHIAZOLINONE, TRIETHANOLAMINE, PAPAIN, BENTONITE
One or more animal studies show broad systemic effects at very low doses		SULFUR, CAFFEINE, GLYCERIN, FD&C YELLOW 5,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	STEARIC ACID, NANO TITANIUM DIOXIDE
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	ALCOHOL DENATURED, CITRIC ACID, COCAMIDE DEA, PHENOXYETHANOL, SODIUM LAURETH SULFATE, STEARALKONIUM CHLORIDE
One or more animal studies show broad systemic effects at low doses		BENZOYL PEROXIDE, DISODIUM EDTA, QUATERNIUM-15, CIMICIFUGA RACEMOSA (BLACK COHOSH) ROOT EXTRACT, SILICONE FLUID,
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	AMMONIUM LAURYL SULFATE, CETEARETH-20, LAURAMIDE DEA, MINERAL OIL, SODIUM CHLORIDE
Classified as toxic or harmful	products for use around the mouth; products for use on the lips; products that may be aerosolized (airborne)	BENZYL ALCOHOL
Limited evidence of any toxicity	products that may be aerosolized (airborne)	NANO ZINC OXIDE (20-60nm), ZINC OXIDE (NON-NANO)
Limited evidence of gastrointestinal or liver toxicity		SD ALCOHOL
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	KAOLIN
Limited evidence of sense organ toxicity		PEG-12 DIMETHICONE, PEG-8 DISTEARATE, PEG-80 SORBITAN LAURATE, PEG/ PPG-18/ 18 DIMETHICONE, PROPYLPARABEN, SORBIC ACID, PEG-100 STEARATE, RETINYL PALMITATE, VITAMIN A
One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient)		C13-14 ISOPARAFFIN
One or more animal studies show blood effects at moderate doses (low dose studies may be unavailable for this ingredient)		UBIQUINONE, ALOE BARBADENSIS (ALOE VERA) GEL, CHROMIUM OXIDE GREENS, ETHYLENE BRASSYLATE, GLYCERYL MONOSTEARATE, HYDROXYPROPYLCELLULOSE, OCTISALATE, POLYSORBATE-60, TOCOPHERYL ACETATE, STEARETH-5,
One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient)		OXYBENZONE (BENZOPHENONE-3), FD&C BLUE 1
One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient)		POLYACRYLAMIDE, HYDROCORTISONE,
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BISABOLOL
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	CETYL ALCOHOL, CYCLOMETHICONE, HYDROLYZED COLLAGEN, SODIUM HYALURONATE, STEARYL ALCOHOL
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		ASCORBYL PALMITATE (VITAMIN C PALMITATE), DIAZOLIDINYL UREA, HYDROXYPROPYL METHYLCELLULOSE, ISOPROPYL MYRISTATE, PANTHENOL, SODIUM PCA, HYDROXYETHYLCELLULOSE, IMIDAZOLIDINYL UREA, POLYSORBATE-20, SORBITOL, COCOS NUCIFERA (COCONUT) OIL, SORBITAN OLEATE,
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Classified as expected to be toxic or harmful		DIMETHICONE, MENTHYL ANTHRANILATE
Classified as expected to be toxic or harmful		SODIUM C14-16 OLEFIN SULFONATE
Classified as not expected to be potentially toxic or harmful		ASCORBIC ACID (VITAMIN C), AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), BEESWAX, C12-15 ALKYL BENZOATE, CAPRYLIC/ CAPRIC TRIGLYCERIDE, CAPRYLYL GLYCOL, CARAMEL, CARBOMER, CETEARYL ALCOHOL, CETYL ESTERS, CETYL PHOSPHATE, COCAMIDOPROPYL BETAINE, COCAMIDOPROPYL HYDROXYSULTAINE, DEA LAURYL SULFATE, DEA-CETYL PHOSPHATE, HYALURONIC ACID, LECITHIN, METHYLISOTHIAZOLINONE, POLYQUATERNIUM-10, SODIUM LAUROYL SARCOSINATE, SODIUM TRIDECETH SULFATE, SQUALANE, STEARAMIDE MEA, STEARAMIDOPROPYL DIMETHYLAMINE, TOCOPHEROL, WATER, XANTHAN GUM, LANETH-5

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE
Occupational hazards related to handling		ALCOHOL DENATURED, BENZOYL PEROXIDE, SD ALCOHOL

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		ALCOHOL DENATURED, LECITHIN, PANTHENOL, SD ALCOHOL
Designated as safe for general or specific, limited use in food		ALCOHOL DENATURED, ALOE BARBADENSIS (ALOE VERA) GEL, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, ASCORBIC ACID (VITAMIN C), ASCORBYL PALMITATE (VITAMIN C PALMITATE), BEESWAX, BENTONITE, BENZOYL PEROXIDE, BENZYL ALCOHOL, CAFFEINE, CAMELLIA SINENSIS (GREEN TEA) EXTRACT, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, CARAMEL, CETYL ALCOHOL, CITRIC ACID, COCAMIDE DEA, COCOS NUCIFERA (COCONUT) OIL, DIMETHICONE, DISODIUM EDTA, ETHYLENE BRASSYLATE, FD&C BLUE 1, FD&C YELLOW 5, GLYCERIN, GLYCERYL MONOSTEARATE, HYDROCORTISONE, HYDROXYPROPYL METHYLCELLULOSE, HYDROXYPROPYLCELLULOSE, ISOPROPYL MYRISTATE, LAURAMIDE DEA, LECITHIN, METHYLPARABEN, MINERAL OIL, NANO ZINC OXIDE (20-60nm), PEG-12 DIMETHICONE, PEG-8 DISTEARATE, PEG-80 SORBITAN LAURATE, PEG/ PPG-18/ 18 DIMETHICONE, POLYACRYLAMIDE, POLYSORBATE-20, POLYSORBATE-60, PROPYLENE GLYCOL, PROPYLPARABEN, RETINYL PALMITATE, SODIUM CHLORIDE, SORBIC ACID, SORBITAN OLEATE, SORBITOL, STEARIC ACID, STEARYL ALCOHOL, TETRASODIUM EDTA, TOCOPHEROL, TOCOPHERYL ACETATE, TRIETHANOLAMINE, VITAMIN A, XANTHAN GUM, ZINC OXIDE (NON-NANO), PAPAIN, PEG-100 STEARATE, NANO TITANIUM DIOXIDE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		PHENOXYETHANOL, SULFUR, PAPAIN, PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	ISOPROPYL MYRISTATE, SODIUM LAURETH SULFATE, STEARYL ALCOHOL
One or more animal studies show skin irritation at very low doses		AMMONIUM LAURYL SULFATE, BENZOYL PEROXIDE, CETYL ALCOHOL, LAURAMIDE DEA, SORBIC ACID, TRIETHANOLAMINE, PEG-100 STEARATE
One or more animal studies show significant but moderate pulmonary irritation at low doses		NANO TITANIUM DIOXIDE
One or more animal studies show skin irritation at low doses		ALCOHOL DENATURED, BENZYL ALCOHOL, CETEARETH-20, COCAMIDE DEA, ETHYLENE BRASSYLATE, METHYLPARABEN, OCTISALATE, SQUALANE, STEARIC ACID, TETRASODIUM EDTA
One or more animal studies show skin irritation at moderate doses		ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, BISABOLOL, CAFFEINE, CITRIC ACID, CYCLOMETHICONE, GLYCERIN, MINERAL OIL, NANO ZINC OXIDE (20-60nm), PEG-80 SORBITAN LAURATE, POLYSORBATE-20, QUATERNIUM-15, SILICONE FLUID, SODIUM CHLORIDE, SODIUM HYALURONATE, SORBITAN OLEATE, STEARALKONIUM CHLORIDE, VITAMIN A, ZINC OXIDE (NON-NANO)
Not likely to be a skin irritant in humans		OXYBENZONE (BENZOPHENONE-3)

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		BENZOYL PEROXIDE
Allowed workplace exposures restricted to low doses		NANO TITANIUM DIOXIDE, BENZYL ALCOHOL, PHENOXYETHANOL, TETRASODIUM EDTA
Allowed workplace exposures restricted to low doses		CHROMIUM OXIDE GREENS, KAOLIN, NANO ZINC OXIDE (20-60nm), ZINC OXIDE (NON-NANO)
Allowed workplace exposures restricted to moderate doses		GLYCERIN, MINERAL OIL, TRIETHANOLAMINE
Allowed workplace exposures restricted to high doses		ALCOHOL DENATURED

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		CAFFEINE, NANO TITANIUM DIOXIDE
One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		HYDROCORTISONE
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		LAURAMIDE DEA, UBIQUINONE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		ALCOHOL DENATURED, BENTONITE, CITRIC ACID, CYCLOMETHICONE, GLYCERIN, POLYACRYLAMIDE, PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		OXYBENZONE (BENZOPHENONE-3), RETINYL PALMITATE, VITAMIN A, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		METHYLPARABEN
Does not produces excess reactive oxygen species or other harmful biochemical changes.		OCTISALATE