2-BROMO-2-NITROPROPANE-1,3-DIOL
Preservative
Also listed as
BRONOPOL; 1,3-PROPANEDIOL, 2-BROMO-2-NITRO-; 2-BROMO-2-NITRO- 1,3-PROPANEDIOL; 1,3PROPANEDIOL, 2BROMO2NITRO; 2-BROMO-2-NITRO-1,3-PROPANEDIOL; 2-BROMO-2-NITROPROPAN-1,3-DIOL; 2-BRONOPOL; BETA-BROMO-BETA-NITROTRIMETHYLENEGLYCOL; BRONIDIOL; BRONOCOT; BRONOPOL
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
 | Contamination concerns - FORMALDEHYDE, NITROSAMINES |
| Other strong concerns for this ingredient: Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| Other moderate concerns for this ingredient: Neurotoxicity |
| Lesser or emerging concerns for this ingredient: Endocrine disruption, Ecotoxicology |
|
See products containing 2-BROMO-2-NITROPROPANE-1,3-DIOL | |
About 2-BROMO-2-NITROPROPANE-1,3-DIOL: 2-Bromo-2-Nitropropane-1,3-Diol is a substituted aliphatic diol.
2-BROMO-2-NITROPROPANE-1,3-DIOL has reported used in the following product types: conditioner (21); baby wipes (18); moisturizer (14); facial moisturizer/treatment (13); body wash/cleanser (8); facial cleanser (8); exfoliant/scrub (5); personal cleansing (4); makeup remover (4); anti-aging (3)
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Known human immune system toxicant | National Library of Medicine HazMap | |
| Human skin toxicant - strong evidence |
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Known human lung and skin toxicant | products that may be aerosolized (airborne); products for use on skin | European Union - Classification & Labelling |
| One or more animal studies show gastrointestinal effects at very low doses | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | |
| One or more animal studies show broad systemic effects at very low doses | RTECS®- Khimiko-Farmatsevticheskii Zhurnal 1977 | |
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Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at low doses | RTECS®- Kiso to Rinsho 1974 |
Occupational hazards
| type of concern | product conditions | reference |
| Allowed workplace exposures restricted to low doses | European Union - Classification & Labelling |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| Classified as lung and skin irritant | products that may be aerosolized (airborne); products for use on skin | European Union - Classification & Labelling |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- Federal Register 2002 |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at high doses | RTECS®- Federal Register 2002 |
Ecotoxicology
| type of concern | product conditions | reference |
| Wildlife and environmental toxicity | European Union - Classification & Labelling | |
| show more | ||
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| 68 studies on toxicity in PubMed see search results -> | PubMed |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| European Union - Classification & Labelling | BRONOPOL (INN); 2-BROMO-2-NITROPROPANE-1,3-DIOL | •Harmful •Irritating to respiratory system and skin •Very toxic to aquatic organisms |
| Canada - Prohibited and Restricted Cosmetics Ingredients | 2-BROMO-2-NITROPROPANE-1,3-DIOL | •Use is restricted in Canadian cosmetics |
| Cosmetic Ingredient Review Assessments | 2-BROMO-2-NITROPROPANE-1,3-DIOL | •Safe for use in cosmetics with some qualifications •Determined safe for use in cosmetics up to a specified concentration limit •Nitrosating agent: forms carcinogenic nitrosamine compounds if mixed with amines |
| National Library of Medicine HazMap | BRONOPOL | •Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes; |
| EPA Toxic Release Inventory PBTs | 2BROMO2NITRO1,3PROPANEDIOL | •Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs |
| US EPA, 1788 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | •Gastrointestinal or liver toxicity hazards: suspected |
| A Relational Database of Hazardous Chemicals and Occupational Diseases | 2-BROMO-2-NITROPROPANE-1,3-DIOL | •Skin or sense organ toxicity hazards: suspected |
| Environmental Canada Domestic Substance List | 1,3-PROPANEDIOL, 2-BROMO-2-NITRO- | •This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected aquatic toxicity. |
| RTECS®- "Pesticide Index," Frear, E 1976 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • gastrointestinal - Gastritis (rabbit LD50) • respiratory - Other changes (rabbit LD50) • gastrointestinal - Peritonitis (rat LD50) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • respiratory - Dyspnea (rat TDLo) • gastrointestinal - Other changes (rat TDLo) • skin - Primary skin irritant (rat ) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • skin - Primary skin irritant (rat ) |
| RTECS®- Federal Register 2002 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • gastrointestinal - Changes in structure or function of salivary glands (rat TDLo) • endocrine system - Death in the "U" data type field (rat TDLo) • reproductive - Other effects (rabbit TDLo) • metabolic - Weight loss or decreased weight gain (rat TDLo) • kidney or renal system - Changes primarily in glomeruli (rat TDLo) • kidney or renal system - Hematuria (rat TDLo) • gastrointestinal - Other changes (rat TDLo) • respiratory - Respiratory depression (rat TDLo) • gastrointestinal - Ulceration or bleeding from stomach (rat TDLo) |
| RTECS®- Iyakuhin Kenkyu 1977 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- Journal of Environmental Pathology and Toxicology 1980 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • skin - Primary skin irritant (rabbit ) |
| RTECS®- Journal of the Society of Cosmetic Chemists 1978 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • broad systemic - Broad systemic toxicity (rat LD50) • sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant ( human ) |
| RTECS®- Journal of the Society of Cosmetic Chemists 1978 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant ( human ) |
| RTECS®- Khimiko-Farmatsevticheskii Zhurnal 1977 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Kiso to Rinsho 1974 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • skin - Hair (rat LD50) • brain and nervous system - Somnolence (general depressed activity) (rat LD50) |
| RTECS®- Pesticide Manual 1991 | 2-BROMO-2-NITROPROPANE-1,3-DIOL | • broad systemic - Broad systemic toxicity (mouse LD50) |
references
| government/industry list/academic study | reference |
| European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex I of Directive 67/548/EEC through the 31st ATP. |
| Canada - Prohibited and Restricted Cosmetics Ingredients | Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| EPA Toxic Release Inventory PBTs | EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
| Scorecard.org Toxicity Information | US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm |
| Scorecard.org Toxicity Information | A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html - testing a change |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| RTECS®- "Pesticide Index," Frear, E 1976 | RTECS®- "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 5,30,1976 |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,193,1994 |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,194,1994 |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. -,194,1994 |
| RTECS®- Federal Register 2002 | RTECS®- Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- 67,78459,2002 |
| RTECS®- Iyakuhin Kenkyu 1977 | RTECS®- Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- 8,680,1977 |
| RTECS®- Journal of Environmental Pathology and Toxicology 1980 | RTECS®- Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. 4(4),47,1980 |
| RTECS®- Journal of the Society of Cosmetic Chemists 1978 | RTECS®- Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- 29,3,1978 |
| RTECS®- Journal of the Society of Cosmetic Chemists 1978 | RTECS®- Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 29,3,1978 |
| RTECS®- Khimiko-Farmatsevticheskii Zhurnal 1977 | RTECS®- Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- 11(1),73,1977 |
| RTECS®- Kiso to Rinsho 1974 | RTECS®- Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- 8,1029,1974 |
| RTECS®- Pesticide Manual 1991 | RTECS®- Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- 9,103,1991 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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