ALLANTOIN

Skin-Conditioning Agent - Miscellaneous; Skin Protectant; SKIN CONDITIONING; SKIN PROTECTING; SOOTHING  

Also listed as

(2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; GLYOXYLDIUREID; GLYOXYLDIUREIDE; GLYOXYLIC DIUREIDE; UREA, (2,5-DIOXO-4-IMIDAZOLIDINYL) -; 5-UREIDOHYDANTOIN; (2,5-DIOXO-4-IMIDAZOLIDINYL) - UREA; UREA, (2,5DIOXO4IMIDAZOLIDINYL) ; (2,5-DIOXO-4-IMIDAZOLIDINYL) UREA; 5-UREIDOHYDANTOIN; AI3-15281


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
noCancer
noDevelopmental/reproductive toxicity
noViolations, restrictions & warnings
noAllergies/immunotoxicity
noContamination concerns
noLesser or emerging concerns for this ingredient:
Data gaps
 
See products containing ALLANTOIN

About ALLANTOIN: Allantoin is a heterocyclic organic compound. In the United States, Allantoin may be used as an active ingredient in OTC drug products. When used as an active drug ingredient, the established name is Allantoin. See "Regulatory and Ingredient Use Information," regarding the labeling names for U.S. OT C Drug Ingredients in Volume 1, Introduction, Part A.

This ingredient may be derived from animals. From PETA's Caring Consumer: Uric acid from cows, most mammals. Also in many plants (especially comfrey). In cosmetics (especially creams and lotions) and used in treatment of wounds and ulcers. Derivatives: Alcloxa, Aldioxa. Alternatives: extract of comfrey root, synthetics.

ALLANTOIN has reported used in the following product types: facial moisturizer/treatment (617); moisturizer (406); anti-aging (358); facial cleanser (261); lipstick (167); around-eye cream (160); sunscreen: SPF 15-30 (140); after shave (129); acne treatment (117); mask (113)


Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
222 studies on toxicity in PubMed see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin     Environmental Canada Domestic Substance List

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful     Environmental Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative     Environmental Canada Domestic Substance List
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Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
Environmental Canada Domestic Substance ListUREA, (2,5-DIOXO-4-IMIDAZOLIDINYL)-•This chemical was NOT flagged by CEPA for further attention.
Environmental Canada Domestic Substance ListALLANTOIN•This chemical was NOT flagged by CEPA for further attention.
IFRA Fragrance Ingredient ListALLANTOIN•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.

references

government/industry list/academic study reference
Environmental Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.

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