ARGININE
Fragrance Ingredient; Hair Conditioning Agent; Skin-Conditioning Agent - Miscellaneous; ANTISTATIC; MASKING; SKIN CONDITIONING
Also listed as
L-A-AMINO-D -GUANIDINOVALERIC ACID; L-ARGININE; L-ORNITHINE, N5- (AMINOIMINOMETHYL) -; N5- (AMINOIMINOMETHYL) - L-ORNITHINE; (L) -ARGININE; L- (+) -ARGININE; L-ARGININE; L-ORNITHINE, N5- (AMINOIMINOMETHYL) -
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
 | Other moderate concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive) |
| Lesser or emerging concerns for this ingredient: Endocrine disruption, Data gaps, Biochemical or cellular level changes |
|
See products containing ARGININE | |
About ARGININE: Arginine is the amino acid.
ARGININE has reported used in the following product types: facial moisturizer/treatment (152); anti-aging (103); conditioner (85); shampoo (68); moisturizer (55); facial cleanser (34); sunscreen: SPF 15-30 (31); acne treatment (30); around-eye cream (27); sunscreen: makeup (25)
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at very low doses | RTECS®- Brazilian Journal of Medical and Biological Research 2003 | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show cardiovascular effects at very low doses | RTECS®- British Journal of Pharmacology 2003 | |
| show more | ||
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- Mutation Research 1996 | |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine disruption at moderate doses | RTECS®- Toxicology and Applied Pharmacology 2004 |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at moderate doses | RTECS®- Toxicology and Applied Pharmacology 2004 | |
| show more | ||
Biochemical or cellular level changes
| type of concern | product conditions | reference |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | RTECS®- Journal of Korean Medical Science 2002 | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 17,296 studies on toxicity in PubMed see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Multiple, additive exposure sources
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status | |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| FDA Food Additive Status | ARGININE (L FORM ONLY) | • NUTR/DS • Food additive: food additive for which a petition has been filed and a regulation issued - CFR172.320 |
| FDA Everything Added to Food | L-ARGININE | • Fully up-to-date toxicology information has been sought. |
| Environmental Canada Domestic Substance List | L-ARGININE | •This chemical was NOT flagged by CEPA for further attention. |
| RTECS®- Brazilian Journal of Medical and Biological Research 2003 | ARGININE | • brain and nervous system - Analgesia (rat TDLo) |
| RTECS®- Brazilian Journal of Medical and Biological Research 2003 | ARGININE | • cardiovascular - BP lowering not characterized in autonomic section (rat TDLo) • kidney or renal system - Other changes in urine composition (rat TDLo) • kidney or renal system - Urine volume increased (rat TDLo) |
| RTECS®- British Journal of Pharmacology 2003 | ARGININE | • cardiovascular - BP lowering not characterized in autonomic section (rat TDLo) • cardiovascular - Change in rate (rat TDLo) |
| RTECS®- Clinical and Experimental Pharmacology and Physiology 2000 | ARGININE | • cardiovascular - BP lowering not characterized in autonomic section (rat TDLo) • kidney or renal system - Other changes in urine composition (rat TDLo) • kidney or renal system - Urine volume increased (rat TDLo) |
| RTECS®- Clinical and Experimental Pharmacology and Physiology 2001 | ARGININE | • metabolic - Na (rat TDLo) • cardiovascular - BP lowering not characterized in autonomic section (rat TDLo) • kidney or renal system - Urine volume increased (rat TDLo) |
| RTECS®- Clinical and Experimental Pharmacology and Physiology 2002 | ARGININE | • kidney or renal system - Changes in blood vessels or in circulation of kidney (rat TDLo) • cardiovascular - BP lowering not characterized in autonomic section (rat TDLo) • kidney or renal system - Urine volume increased (rat TDLo) |
| RTECS®- European Journal of Pharmacology 2004 | ARGININE | • biochemical - Other (rabbit TDLo) • cardiovascular - Other changes (rabbit TDLo) |
| RTECS®- Indian Journal of Experimental Biology 1986 | ARGININE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (grasshopper par) |
| RTECS®- Indian Journal of Experimental Biology 1986 | ARGININE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (grasshopper par) |
| RTECS®- Journal of Applied Toxicology (John Wiley & Sons, Ltd 2004 | ARGININE | • biochemical - Catalases (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • biochemical - Isomerases (rat TDLo) • liver - Other changes (rat TDLo) |
| RTECS®- Journal of Korean Medical Science 2002 | ARGININE | • biochemical - Catalases (rat TDLo) • biochemical - Lipids, including transport (rat TDLo) • liver - Other changes (rat TDLo) |
| RTECS®- Journal of Korean Medical Science 2003 | ARGININE | • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • gastrointestinal - Changes in structure or function of endocrine pancreas (rat TDLo) • biochemical - Other hydrolases (rat TDLo) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 2001 | ARGININE | • biochemical - Effect on inflammation or mediation of inflammation (rat TDLo) • biochemical - Other proteins (rat TDLo) • cardiovascular - Structural changes in vessels (rat TDLo) |
| RTECS®- Mutation Research 1996 | ARGININE | • mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human lym) |
| RTECS®- Mutation Research 1996 | ARGININE | • mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human lym) |
| RTECS®- Psychopharmacology (Berlin) 2003 | ARGININE | • brain and nervous system - Alteration of operant conditioning (mouse TDLo) |
| RTECS®- Psychopharmacology (Berlin) 2004 | ARGININE | • brain and nervous system - Changes in motor activity (specific assay) (rat TDLo) |
| RTECS®- Psychopharmacology (Berlin) 2005 | ARGININE | • brain and nervous system - Changes in motor activity (specific assay) (mouse TDLo) |
| RTECS®- Toxicology and Applied Pharmacology 2004 | ARGININE | • reproductive - Fetotoxicity (rat TDLo) |
| RTECS®- Toxicology and Applied Pharmacology 2004 | ARGININE | • reproductive - Post-implantation mortality (rat TDLo) • reproductive - Prostate, seminal vesicle, Cowper's gland, accessory glands (rat TDLo) • reproductive - Testes, epididymis, sperm duct (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) |
| RTECS®- Toxicology 2005 | ARGININE | • cardiovascular - BP lowering not characterized in autonomic section (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • kidney or renal system - Other changes (rat TDLo) |
references
| government/industry list/academic study | reference |
| FDA Food Additive Status | FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| RTECS®- Brazilian Journal of Medical and Biological Research 2003 | RTECS®- Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- 36,1701,2003 |
| RTECS®- Brazilian Journal of Medical and Biological Research 2003 | RTECS®- Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- 36,943,2003 |
| RTECS®- British Journal of Pharmacology 2003 | RTECS®- British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- 138,584,2003 |
| RTECS®- Clinical and Experimental Pharmacology and Physiology 2000 | RTECS®- Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- 27,18,2000 |
| RTECS®- Clinical and Experimental Pharmacology and Physiology 2001 | RTECS®- Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- 28,528,2001 |
| RTECS®- Clinical and Experimental Pharmacology and Physiology 2002 | RTECS®- Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- 29,772,2002 |
| RTECS®- European Journal of Pharmacology 2004 | RTECS®- European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- 492,211,2004 |
| RTECS®- Indian Journal of Experimental Biology 1986 | RTECS®- Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 24,460,1986 |
| RTECS®- Indian Journal of Experimental Biology 1986 | RTECS®- Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 24,460,1986 |
| RTECS®- Journal of Applied Toxicology (John Wiley & Sons, Ltd 2004 | RTECS®- Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- 24,93,2004 |
| RTECS®- Journal of Korean Medical Science 2002 | RTECS®- Journal of Korean Medical Science. (Korean Academy of Medical Science, C.P.O. Box 2062, Seoul, S. Korea) V.1- 1986- 17,502,2002 |
| RTECS®- Journal of Korean Medical Science 2003 | RTECS®- Journal of Korean Medical Science. (Korean Academy of Medical Science, C.P.O. Box 2062, Seoul, S. Korea) V.1- 1986- 18,520,2003 |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 2001 | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 299,832,2001 |
| RTECS®- Mutation Research 1996 | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 372,75,1996 |
| RTECS®- Mutation Research 1996 | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 372,75,1996 |
| RTECS®- Psychopharmacology (Berlin) 2003 | RTECS®- Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- 167,291,2003 |
| RTECS®- Psychopharmacology (Berlin) 2004 | RTECS®- Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- 176,435,2004 |
| RTECS®- Psychopharmacology (Berlin) 2005 | RTECS®- Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- 178,500,2005 |
| RTECS®- Toxicology and Applied Pharmacology 2004 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 197,197,2004 |
| RTECS®- Toxicology and Applied Pharmacology 2004 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 197,351,2004 |
| RTECS®- Toxicology 2005 | RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 207,463,2005 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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