BENZOPHENONE-1
Ultraviolet Light Absorber; UV ABSORBER
Also listed as
BENZORESORCINOL; 4-BENZOYL RESORCINOL; 2,4-DIHYDROXYBENZOPHENONE; (2,4-DIHYDROXYPHENYL) PHENYLMETHANONE; METHANONE, (2,4-DIHYDROXYPHENYL) PHENYL-; (2,4-DIHYDROXYPHENYL) PHENYL- METHANONE; METHANONE, (2,4DIHYDROXYPHENYL) PHENYL; 2,4-DIHYDROXYBENZOFENON (CZECH) ; 2,4-DIHYDROXYBENZOPHENONE; EASTMAN INHIBITOR DHPB; QUINSORB 010
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive) |
 | Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Data gaps |
|
See products containing BENZOPHENONE-1 | |
About BENZOPHENONE-1: Benzophenone-1 is a benzophenone derivative.
ingredient UV blocking strength
| possible* sunscreen concentrations |
UV blocking strength |
|
1.0% |
| |
5.0% |
| |
10.0% |
|
* Skin Deep does not have any concentration information for this ingredient in products. The concentrations shown are only for illustrative purposes.
BENZOPHENONE-1 has reported used in the following product types: nail polish (558); nail treatment (47); fragrance for women (17); polish remover (17); body spray (9); conditioner (8); moisturizer (7); fragrance for men (7); body wash/cleanser (7); after shave (6)
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Human skin toxicant - strong evidence | Cosmetic Ingredient Review Assessments | |
| Human skin toxicant - strong evidence |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at low doses | RTECS®- National Technical Information Service | |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine disruption at moderate doses | RTECS®- Journal of Agricultural and Food Chemistry 1970 | |
| show more | ||
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at high doses | RTECS®- Roczniki Panstwowego Zakladu Higieny 1968 |
Data gaps
| type of concern | product conditions | reference |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments | |
| 34 studies on toxicity in PubMed see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Cosmetic Ingredient Review Assessments | BENZOPHENONE-1 | •Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin |
| Kunz PY, Fent K, 2006 | BENZOPHENONE-1 | Benzophenone-1 is weakly estrogenic in in vitro tests with rainbow trout estrogen receptor |
| Schlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, Henseler M, et al, 2004 | BENZOPHENONE (BP)-1 | In vitro and in vivo estrogenic activity; increased uterine weight in immature rats |
| European Commission on Endocrine Disruption | 2,4-DIHYDROXYBENZOPHENON = RESBENZOPHENONE | HH-CAT1;WF-CAT1 |
| Environmental Canada Domestic Substance List | METHANONE, (2,4-DIHYDROXYPHENYL)PHENYL- | •This chemical was NOT flagged by CEPA for further attention. |
| RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 | BENZOPHENONE-1 | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | BENZOPHENONE-1 | • metabolic - Weight loss or decreased weight gain (rat TDLo) • kidney or renal system - Changes in tubules (including acute renal failure, acute tubular (mouse LD50) • gastrointestinal - Other changes (mouse LD50) |
| RTECS®- British Journal of Pharmacology and Chemotherapy 1964 | BENZOPHENONE-1 | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Journal of Agricultural and Food Chemistry 1970 | BENZOPHENONE-1 | • endocrine system - Estrogenic (rat TDLo) |
| RTECS®- National Technical Information Service | BENZOPHENONE-1 | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Roczniki Panstwowego Zakladu Higieny 1968 | BENZOPHENONE-1 | • blood - Changes in erythrocyte (RBC) count (rat TDLo) • liver - Changes in liver weight (rat TDLo) • brain and nervous system - Food intake (animal) (rat LD50) • gastrointestinal - Hypermotility, diarrhea (rat LD50) • blood - Pigmented or nucleated red blood cells (rat TDLo) • brain and nervous system - Somnolence (general depressed activity) (rat LD50) |
| RTECS®- Toxicology and Applied Pharmacology 2005 | BENZOPHENONE-1 | • endocrine system - Changes in uterine weight (rat TDLo) • endocrine system - Estrogenic (rat TDLo) |
references
| government/industry list/academic study | reference |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| Open scientific literature | Kunz PY, Fent K. 2006. Estrogenic activity of UV filter mixtures. Toxicol Appl Pharmacol 217(1): 86-99. |
| Open scientific literature | Schlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, Henseler M, et al. 2004. Endocrine activity and developmental toxicity of cosmetic UV filters--an update. Toxicology 205(1-2): 113-122. |
| European Commission on Endocrine Disruption | EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 | RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,652,1986 |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,470,1994 |
| RTECS®- British Journal of Pharmacology and Chemotherapy 1964 | RTECS®- British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. 22,221,1964 |
| RTECS®- Journal of Agricultural and Food Chemistry 1970 | RTECS®- Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- 18,1108,1970 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD277-689 |
| RTECS®- Roczniki Panstwowego Zakladu Higieny 1968 | RTECS®- Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- -1950 19,179,1968 |
| RTECS®- Toxicology and Applied Pharmacology 2005 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 203,9,2005 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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