BENZOPHENONE-6
Fragrance Ingredient; Ultraviolet Light Absorber; MASKING; UV ABSORBER
Also listed as
BIS (2-HYDROXY-4-METHOXYPHENYL) METHANONE; DIHYDROXY DIMETHOXY BENZOPHENONE; 2,2'-DIHYDROXY-4,4'-DIMETHOXYBENZOPHENONE; METHANONE, BIS (2-HYDROXY-4-METHOXYPHENYL) -; BIS (2-HYDROXY-4-METHOXYPHENYL) - METHANONE; METHANONE, BIS (2HYDROXY4METHOXYPHENYL) ; 2,2'-DIHYDROXY-4,4'-DIMETHOXYBENZOPHENONE; BIS (2-HYDROXY-4-METHOXYPHENYL) METHANONE; CYASORB UV 12; METHANONE, BIS (2-HYDROXY-4-METHOXYPHENYL) - (9CI) ; UVINUL D 49
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
| Lesser or emerging concerns for this ingredient: Endocrine disruption, Ecotoxicology, Data gaps |
|
See products containing BENZOPHENONE-6 | |
About BENZOPHENONE-6: Benzophenone-6 is a benzophenone derivative.
ingredient UV blocking strength
| possible* sunscreen concentrations |
UV blocking strength |
|
1.0% |
| |
5.0% |
| |
10.0% |
|
* Skin Deep does not have any concentration information for this ingredient in products. The concentrations shown are only for illustrative purposes.
BENZOPHENONE-6 has reported used in the following product types: hair spray (1)
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Human skin toxicant - strong evidence | Cosmetic Ingredient Review Assessments |
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | products for use around the eyes; products for use on the lips | Japan's Standards for Cosmetics |
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine disruption at moderate doses | RTECS®- Journal of Agricultural and Food Chemistry 1970 |
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests non-mammalian cells show positive mutation results | RTECS®- Journal of the American College of Toxicology 1983 |
Ecotoxicology
| type of concern | product conditions | reference |
| Suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Data gaps
| type of concern | product conditions | reference |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments | |
| 1 studies on toxicity in PubMed see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Classified as not expected to be potentially toxic or harmful | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Cosmetic Ingredient Review Assessments | BENZOPHENONE-6 | •Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin |
| Environmental Canada Domestic Substance List | METHANONE, BIS(2-HYDROXY-4-METHOXYPHENYL)- | •This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected aquatic toxicity. |
| European Commission on Endocrine Disruption | 2,2'-DIHYDROXY-4,4'-DIMETHOXYBENZOPHENON | HH-CAT2;WF-CAT3b |
| Japan's Standards for Cosmetics | DIHYDROXYDIMETHOXYBENZOPHENONE | •Japan - restricted for use in some types of cosmetics (concentration limit) |
| RTECS®- Journal of Agricultural and Food Chemistry 1970 | BENZOPHENONE-6 | • endocrine system - Estrogenic (rat TDLo) |
| RTECS®- Journal of the American College of Toxicology 1983 | BENZOPHENONE-6 | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
| RTECS®- Journal of the American College of Toxicology 1983 | BENZOPHENONE-6 | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
references
| government/industry list/academic study | reference |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| European Commission on Endocrine Disruption | EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998. |
| Japan's Standards for Cosmetics | Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau. |
| RTECS®- Journal of Agricultural and Food Chemistry 1970 | RTECS®- Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- 18,1108,1970 |
| RTECS®- Journal of the American College of Toxicology 1983 | RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 2(5),35,1983 |
| RTECS®- Journal of the American College of Toxicology 1983 | RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 2(5),35,1983 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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