BHT || Skin Deep: Cosmetic Safety Reviews

BHT

Antioxidant; Fragrance Ingredient; MASKING

SCORE

	7	high hazard
	61%	data gap
(why scores have changed)

Also listed as

DBPC; ADVASTAB 401; AGIDOL; AGIDOL 1; ALKOFEN BP; ANTIOXIDANT 29; ANTIOXIDANT 30; ANTIOXIDANT 4; ANTIOXIDANT 4K; ANTIOXIDANT KB; ANTRANCINE 8

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other strong concerns for this ingredient: Occupational hazards
	Other moderate concerns for this ingredient: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
	Lesser or emerging concerns for this ingredient: Data gaps
	See products containing BHT

About BHT: BHT is a substituted toluene.

BHT has reported used in the following product types: lipstick (716); facial moisturizer/treatment (410); lip gloss (357); moisturizer (356); eye shadow (292); foundation (271); anti-aging (260); fragrance for women (223); sunscreen: makeup (188); eye liner (152)

Allergies/immunotoxicity

type of concern	product conditions	reference
Known human immune system toxicant		National Library of Medicine HazMap
Human skin toxicant - strong evidence

Neurotoxicity

type of concern

product conditions

reference

One or more animal studies show brain and nervous system effects at low doses

RTECS^®- Journal of Medicinal Chemistry 1980

Endocrine disruption

type of concern

product conditions

reference

One or more studies show endocrine system disruption at low doses

RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994

Occupational hazards

type of concern	product conditions	reference
Allowed workplace exposures restricted to low doses		RTECS^®- TLV/BEI,2006
Allowed workplace exposures restricted to low doses		RTECS^®- TLV/BEI,2005
Allowed workplace exposures restricted to low doses		RTECS^®- TLV/BEI,2007

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Classified as expected to be toxic or harmful

Environmental Canada Domestic Substance List

One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	RTECS^®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002
One or more animal studies show blood effects at low doses		RTECS^®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002
One or more animal studies show broad systemic effects at low doses		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show liver effects at low doses		RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992
One or more animal studies show blood effects at low doses		RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	RTECS^®- Toxicology and Applied Pharmacology 1981
One or more animal studies show blood effects at low doses		RTECS^®- Toxicology and Applied Pharmacology 1981
One or more animal studies show blood effects at low doses		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show liver effects at low doses		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
Limited evidence of sense organ toxicity		Harvell, 1995; A Relational Database of Hazardous Chemicals and Occupational Diseases
Limited evidence of respiratory toxicity		Foth, 1995
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002
One or more animal studies show metabolic effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show blood effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999
One or more animal studies show gastrointestinal effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- New England Journal of Medicine 1986
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- Science Reports of the Research Institutes, Tohoku University, Series C: Medicine 1989
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Health 1955
One or more animal studies show respiratory effects at high doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- AMA Archives of Industrial Health 1955
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show blood effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show kidney or renal system effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Cancer Letters (Shannon, Ireland) 1999
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1998
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1984
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1984
One or more animal studies show cardiovascular effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992
One or more animal studies show cardiovascular effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1993
One or more animal studies show respiratory effects at high doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- Toxicology 2001
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Chemical Toxicology 1996
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Chemical Toxicology 1996
One or more animal studies show respiratory effects at high doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- Toxicology Letters 1986
One or more animal studies show kidney or renal system effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Chemical Toxicology 1992
One or more animal studies show respiratory effects at high doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- Food and Chemical Toxicology 1992
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Chemical Toxicology 1992
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Cosmetics Toxicology 1965
One or more animal studies show blood effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Acta Pharmacologica et Toxicologica 1981
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Acta Pharmacologica et Toxicologica 1981
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology 1977
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Australian Journal of Experimental Biology and Medical Science 1959
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Australian Journal of Experimental Biology and Medical Science 1959
One or more animal studies show kidney or renal system effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Cosmetics Toxicology 1965
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Australian Journal of Experimental Biology and Medical Science 1961
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Australian Journal of Experimental Biology and Medical Science 1961
One or more animal studies show blood effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Cosmetics Toxicology 1981
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology Letters 1982
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology Letters 1996

Cancer

type of concern

product conditions

reference

One or more in vitro tests on mammalian cells show positive mutation results

RTECS^®- Food and Chemical Toxicology 1987

One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Toxicology and Applied Pharmacology 1989
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Carcinogenesis (London) 1984
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Doklady Akademii Nauk SSSR 1986
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Environmental Mutagenesis 1986
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Environmental and Molecular Mutagenesis 1988
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Mutation Research 2002
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Chemico-Biological Interactions 1977
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Mutation Research 1995
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- National Technical Information Service
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Chemical Mutagens 1978
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Mutation Research 2006
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Biochemical and Biophysical Research Communications 1978
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Carcinogenesis (London) 1992
One or more animal studies show tumor formation at high doses		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show tumor formation at high doses		RTECS^®- Cancer Letters (Shannon, Ireland) 1999
One or more animal studies show tumor formation at high doses		RTECS^®- Food and Chemical Toxicology 1986
One or more animal studies show tumor formation at high doses		RTECS^®- Toxicology 1986
One or more animal studies show tumor formation at high doses		RTECS^®- Food and Cosmetics Toxicology 1974
One or more animal studies show tumor formation at high doses		RTECS^®- Carcinogenesis (London) 1983
Cancer - not classifiable/not likely to be human carcinogen		Int'l Agency for Research on Cancer (IARC) - Carcinogens

Biochemical or cellular level changes

type of concern

product conditions

reference

One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood

RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992

One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1998
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1993
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Toxicology 2001
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1987
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Food and Chemical Toxicology 1996
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Food and Cosmetics Toxicology 1972
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Food and Cosmetics Toxicology 1965
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Acta Pharmacologica et Toxicologica 1981
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- Toxicology 1977

Developmental/reproductive toxicity

type of concern

product conditions

reference

One or more animal studies show reproductive effects at high doses

RTECS^®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho 1977

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

One or more animal studies show skin irritation at low doses

RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1952

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food
Designated as safe for general or specific, limited use in food		FDA Food Additive Status

Data gaps

type of concern	product conditions	reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		Cosmetic Ingredient Review Assessments
1,603 studies on toxicity in PubMed see search results ->		PubMed

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
FDA Food Additive Status	BHT	• Food additive: antioxidant • GRAS (generally recognized as safe) - use in food presumed safe based either on a history of use before 1958 or on published scientific evidence; need not be approved by the FDA prior to use in food; most have not limit for use but must conform to good manufacturing practices; some GRAS substances have quantitative limit for use in foods; by definition under Sec 201(s) of FD&C Act, not food additives • 0.02% -Of fat or oil content • including essential oil • of food • including oleomargarine refers to part number under Title 21 Code of Federal Regulations 166 - Margarine • Food additive: permitted as optional ingredient in a standardized food • 33 parts per million in rice - In enriched parboiled rice - refers to part number under Title 21 Code of Federal Regulations 137.350 • Food additive: permitted as optional ingredient in a standardized food • <0.02% in oleomargarine - In any animal fat ingredient permitted in oleo-mar
Cosmetic Ingredient Review Assessments	BHT	•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product
FDA Everything Added to Food	BUTYLATED HYDROXYTOLUENE	• Fully up-to-date toxicology information has been sought.
Environmental Canada Domestic Substance List	PHENOL, 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYL-	•This chemical was deemed a moderate human health priority and was flagged by CEPA for further attention.
IFRA Fragrance Ingredient List	BUTYLATED HYDROXYTOLUENE	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
National Library of Medicine HazMap	BUTYLATED HYDROXYTOLUENE	•Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes; •TLV (ACGIH) - Threshold limit value (ACGIH): 2 mg/m3, inhalable fraction (vapor and aerosol);
Int'l Agency for Research on Cancer (IARC) - Carcinogens	BUTYLATED HYDROXYTOLUENE (BHT)	•IARC Group 3 (no cancer link)
Foth, 1995	2,6-DI-TERT-BUTYL-P-CRESOL	•Respiratory toxicity hazards: suspected
Harvell, 1995; A Relational Database of Hazardous Chemicals and Occupational Diseases	2,6-DI-TERT-BUTYL-P-CRESOL	•Skin or sense organ toxicity hazards: suspected
RTECS^®- TLV/BEI,2005	BHT	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- TLV/BEI,2006	BHT	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- TLV/BEI,2007	BHT	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	BHT	• sense organ - Primary eye irritant (rabbit )
RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994	BHT	• endocrine system - Death in the "U" data type field (rat TDLo) • blood - Hemorrhage (rat TDLo) • metabolic - Weight loss or decreased weight gain (mouse TDLo) • broad systemic - Broad systemic toxicity (mouse LD50) • blood - Change in clotting factors (rat TDLo) • brain and nervous system - Changes in circulation (Hemorrhage, thrombosis, etc.) (rat TDLo) • respiratory - Changes in lung weight (mouse TDLo) • respiratory - Fibrosis (interstitial) (mouse TDLo) • liver - Multiple effects (rat TDLo) • biochemical - Multiple enzyme effects (rat TDLo) • liver - Other changes (rat TDLo) • brain and nervous system - Tremor (hamster TDLo)
RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994	BHT	• metabolic - Weight loss or decreased weight gain (rat TDLo) • brain and nervous system - Changes in brain weight (rat TDLo) • liver - Changes in liver weight (rat TDLo) • mutagenic - kidney or renal system (mouse TDLo) • cancer - liver (mouse TDLo) • gastrointestinal - Tumors (mouse TDLo)
RTECS^®- Acta Pharmacologica et Toxicologica 1981	BHT	• blood - Changes in erythrocyte (RBC) count (rat TDLo) • liver - Changes in liver weight (rat TDLo) • biochemical - Transaminases (rat TDLo)
RTECS^®- AMA Archives of Industrial Health 1955	BHT	• gastrointestinal - Hypermotility, diarrhea (rabbit LDLo) • respiratory - Respiratory depression (rabbit LDLo) • brain and nervous system - Tremor (rabbit LDLo)
RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1952	BHT	• skin - Primary skin irritant (rabbit )
RTECS^®- Australian Journal of Experimental Biology and Medical Science 1959	BHT	• metabolic - Weight loss or decreased weight gain (rat TDLo) • liver - Changes in liver weight (rat TDLo) • skin - Hair (rat TDLo)
RTECS^®- Australian Journal of Experimental Biology and Medical Science 1961	BHT	• metabolic - Weight loss or decreased weight gain (rat TDLo) • endocrine system - Changes in adrenal weight (rat TDLo) • liver - Changes in liver weight (rat TDLo)
RTECS^®- Biochemical and Biophysical Research Communications 1978	BHT	• mutagenic - Positive mutation assay: DNA Inhibition ( human lym)
RTECS^®- Biochemical and Biophysical Research Communications 1978	BHT	• mutagenic - Positive mutation assay: DNA Inhibition ( human lym)
RTECS^®- Cancer Letters (Shannon, Ireland) 1999	BHT	• cancer - Active as anti-cancer agent (rat TDLo) • cancer - Protects against induction of experimental tumors (rat TDLo) • liver - Tumors (rat TDLo)
RTECS^®- Cancer Letters (Shannon, Ireland) 1999	BHT	• cancer - respiratory neoplasms (mouse TDLo) • cancer - Tumor types after systemic administration not seen spontaneously (mouse TDLo)
RTECS^®- Carcinogenesis (London) 1992	BHT	• mutagenic - Positive mutation assay: DNA Inhibition ( human hla)
RTECS^®- Carcinogenesis (London) 1983	BHT	• cancer - Cells (cultured) transformed (rat TDLo) • cancer - kidney or renal system tumors (rat TDLo)
RTECS^®- Carcinogenesis (London) 1984	BHT	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat lvr)
RTECS^®- Carcinogenesis (London) 1992	BHT	• mutagenic - Positive mutation assay: DNA Inhibition ( human hla)
RTECS^®- Carcinogenesis (London) 1984	BHT	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat lvr)
RTECS^®- Chemical Mutagens 1978	BHT	• mutagenic - Positive mutation assay: sperm (mouse ipr)
RTECS^®- Chemical Mutagens 1978	BHT	• mutagenic - Positive mutation assay: sperm (mouse ipr)
RTECS^®- Chemico-Biological Interactions 1977	BHT	• mutagenic - Positive mutation assay: DNA Inhibition (mouse ipr)
RTECS^®- Chemico-Biological Interactions 1977	BHT	• mutagenic - Positive mutation assay: DNA Inhibition (mouse ipr)
RTECS^®- Doklady Akademii Nauk SSSR 1986	BHT	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat ipr)
RTECS^®- Doklady Akademii Nauk SSSR 1986	BHT	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat ipr)
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1993	BHT	• biochemical - Lipids, including transport (rat TDLo) • cardiovascular - Other changes (rat TDLo)
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1998	BHT	• biochemical - Lipids, including transport (rat TDLo) • gastrointestinal - Other changes (rat TDLo)
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999	BHT	• blood - Change in clotting factors (rat TDLo)
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999	BHT	• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • biochemical - Effect on inflammation or mediation of inflammation (mouse TDLo) • biochemical - Other enzymes (rat TDLo) • biochemical - Transaminases (rat TDLo)
RTECS^®- Environmental and Molecular Mutagenesis 1988	BHT	• mutagenic - Positive mutation assay: Mutation in Micro-organism (mouse lym) • mutagenic - Positive mutation assay: Mutation in Mammalian Somatic Cells (mouse lym)
RTECS^®- Environmental and Molecular Mutagenesis 1988	BHT	• mutagenic - Positive mutation assay: Mutation in Micro-organism (mouse lym) • mutagenic - Positive mutation assay: Mutation in Mammalian Somatic Cells (mouse lym)
RTECS^®- Environmental Mutagenesis 1986	BHT	• reproductive - Pre-implantation mortality (rat TDLo) • mutagenic - Positive mutation assay: Dominant Lethal Strain (rat orl)
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1984	BHT	• gastrointestinal - Other changes (rat TDLo)
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1987	BHT	• biochemical - Other transferases (rat TDLo)
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992	BHT	• biochemical - Lipids, including transport (rabbit TDLo) • cardiovascular - Other changes (rabbit TDLo)
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992	BHT	• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • biochemical - Lipids, including transport (rat TDLo) • liver - Other changes (rat TDLo)
RTECS^®- Federation Proceedings, Federation of American Societies for Experimental Biology 1972	BHT	• reproductive - Behavioral (mouse TDLo)
RTECS^®- Food and Chemical Toxicology 1987	BHT	• mutagenic - Positive mutation assay: DNA Damage (rat orl)
RTECS^®- Food and Chemical Toxicology 1986	BHT	• reproductive - Growth statistics (rat TDLo) • mutagenic - liver tumors (rat TD) • cancer - reproductive neoplasms (rat TD) • cancer - reproductive tumors (rat TD)
RTECS^®- Food and Chemical Toxicology 1986	BHT	• cancer - gastrointestinal tumors (rat TD)
RTECS^®- Food and Chemical Toxicology 1986	BHT	• cancer - liver tumors (rat TD)
RTECS^®- Food and Chemical Toxicology 1987	BHT	• mutagenic - Positive mutation assay: DNA Damage (rat orl)
RTECS^®- Food and Chemical Toxicology 1992	BHT	• liver - Changes in liver weight (mouse TDLo) • respiratory - Changes in lung weight (mouse TDLo) • kidney or renal system - Changes in tubules (including acute renal failure, acute tubular (mouse TDLo)
RTECS^®- Food and Chemical Toxicology 1996	BHT	• metabolic - Weight loss or decreased weight gain (hamster TDLo) • liver - Changes in liver weight (hamster TDLo) • biochemical - Other transferases (hamster TDLo)
RTECS^®- Food and Cosmetics Toxicology 1972	BHT	• biochemical - Phosphatases (monkey TDLo)
RTECS^®- Food and Cosmetics Toxicology 1974	BHT	• mutagenic - gastrointestinal tumors (mouse TDLo) • cancer - respiratory tumors (mouse TDLo)
RTECS^®- Food and Cosmetics Toxicology 1981	BHT	• blood - Changes in erythrocyte (RBC) count (rat TDLo) • blood - Changes in leucocyte (WBC) count (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo)
RTECS^®- Food and Cosmetics Toxicology 1981	BHT	• reproductive - Growth statistics (rat TDLo) • reproductive - Weaning or lactation index (rat TDLo)
RTECS^®- Food and Cosmetics Toxicology 1965	BHT	• developmental - Growth statistics (mouse TDLo) • reproductive - Parturition (mouse TDLo)
RTECS^®- Food and Cosmetics Toxicology 1965	BHT	• liver - Changes in liver weight (mouse TDLo) • biochemical - Other enzymes (mouse TDLo)
RTECS^®- Food and Cosmetics Toxicology 1965	BHT	• liver - Changes in liver weight (rat TDLo) • kidney or renal system - Other changes in urine composition (rat TDLo)
RTECS^®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002	BHT	• blood - Hemorrhage (mouse LD50) • respiratory - Acute pulmonary edema (mouse LD50) • brain and nervous system - Ataxia (mouse LD50) • broad systemic - Broad systemic toxicity (rat LD50) • respiratory - Other changes (mouse LD50) • brain and nervous system - Tremor (mouse LD50)
RTECS^®- Journal of Medicinal Chemistry 1980	BHT	• brain and nervous system - Sleep (mouse LD50)
RTECS^®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho 1977	BHT	• reproductive - Musculoskeletal system (mouse TDLo)
RTECS^®- Mutation Research 1995	BHT	• mutagenic - Positive mutation assay: other mutation test systems (mouse orl)
RTECS^®- Mutation Research 1995	BHT	• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster ovr)
RTECS^®- Mutation Research 2002	BHT	• mutagenic - Positive mutation assay: DNA Damage (mouse orl)
RTECS^®- Mutation Research 2006	BHT	• mutagenic - Positive mutation assay: (mouse oth)
RTECS^®- Mutation Research 1995	BHT	• mutagenic - Positive mutation assay: other mutation test systems (mouse orl)
RTECS^®- Mutation Research 1995	BHT	• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster ovr)
RTECS^®- Mutation Research 2002	BHT	• mutagenic - Positive mutation assay: DNA Damage (mouse orl)
RTECS^®- Mutation Research 2006	BHT	• mutagenic - Positive mutation assay: (mouse oth)
RTECS^®- National Technical Information Service	BHT	• mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse orl)
RTECS^®- National Technical Information Service	BHT	• mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse orl)
RTECS^®- New England Journal of Medicine 1986	BHT	• brain and nervous system - Coma (woman TDLo) • gastrointestinal - Gastritis (woman TDLo) • gastrointestinal - Nausea or vomiting (woman TDLo)
RTECS^®- Science Reports of the Research Institutes, Tohoku University, Series C: Medicine 1989	BHT	• respiratory - Chronic pulmonary edema (mouse LD50) • brain and nervous system - Tremor (mouse LD50)
RTECS^®- Toxicology and Applied Pharmacology 1981	BHT	• blood - Hemorrhage (mouse LD50) • respiratory - Chronic pulmonary edema (mouse LD50) • respiratory - Other changes (mouse LD50)
RTECS^®- Toxicology and Applied Pharmacology 1989	BHT	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat orl)
RTECS^®- Toxicology and Applied Pharmacology 1989	BHT	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat orl)
RTECS^®- Toxicology Letters 1982	BHT	• liver - Changes in liver weight (rat TDLo) • endocrine system - Changes in thyroid weight (rat TDLo) • endocrine system - Evidence of thyroid hyperfunction (rat TDLo)
RTECS^®- Toxicology Letters 1986	BHT	• endocrine system - Death in the "U" data type field (mouse TDLo) • respiratory - Changes in lung weight (mouse TDLo)
RTECS^®- Toxicology Letters 1996	BHT	• liver - Changes in liver weight (rat TDLo) • liver - Other changes (rat TDLo)
RTECS^®- Toxicology 2001	BHT	• biochemical - Effect on inflammation or mediation of inflammation (mouse TDLo) • respiratory - Other changes (mouse TDLo) • biochemical - Other enzymes (mouse TDLo)
RTECS^®- Toxicology 1986	BHT	• cancer - liver neoplasms (mouse TD)
RTECS^®- Toxicology 1977	BHT	• liver - Changes in liver weight (rat TDLo) • biochemical - Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) (rat TDLo) • biochemical - Other proteins (rat TDLo)

references

government/industry list/academic study	reference
FDA Food Additive Status	FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Int'l Agency for Research on Cancer (IARC) - Carcinogens	IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
Scorecard.org Toxicity Information	Foth, 1995
Scorecard.org Toxicity Information	Harvell, 1995; A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html; Klaassen, 1996
RTECS^®- TLV/BEI,2005	RTECS^®- TLV/BEI,2005
RTECS^®- TLV/BEI,2006	RTECS^®- TLV/BEI,2006
RTECS^®- TLV/BEI,2007	RTECS^®- TLV/BEI,2007
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,229,1986
RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994	RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,212,1994
RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994	RTECS^®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,213,1994
RTECS^®- Acta Pharmacologica et Toxicologica 1981	RTECS^®- Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH 49,14,1981
RTECS^®- AMA Archives of Industrial Health 1955	RTECS^®- AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. 11,93,1955
RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1952	RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. 5,311,1952
RTECS^®- Australian Journal of Experimental Biology and Medical Science 1959	RTECS^®- Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. 37,533,1959
RTECS^®- Australian Journal of Experimental Biology and Medical Science 1961	RTECS^®- Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. 39,353,1961
RTECS^®- Biochemical and Biophysical Research Communications 1978	RTECS^®- Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 80,963,1978
RTECS^®- Biochemical and Biophysical Research Communications 1978	RTECS^®- Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 80,963,1978
RTECS^®- Cancer Letters (Shannon, Ireland) 1999	RTECS^®- Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- 143,173,1999
RTECS^®- Cancer Letters (Shannon, Ireland) 1999	RTECS^®- Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- 145,101,1999
RTECS^®- Carcinogenesis (London) 1992	RTECS^®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- 13,2389,1992
RTECS^®- Carcinogenesis (London) 1983	RTECS^®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- 4,895,1983
RTECS^®- Carcinogenesis (London) 1984	RTECS^®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- 5,1547,1984
RTECS^®- Carcinogenesis (London) 1992	RTECS^®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 13,2389,1992
RTECS^®- Carcinogenesis (London) 1984	RTECS^®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 5,1547,1984
RTECS^®- Chemical Mutagens 1978	RTECS^®- Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971- 5,257,1978
RTECS^®- Chemical Mutagens 1978	RTECS^®- Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 5,257,1978
RTECS^®- Chemico-Biological Interactions 1977	RTECS^®- Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- 19,279,1977
RTECS^®- Chemico-Biological Interactions 1977	RTECS^®- Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 19,279,1977
RTECS^®- Doklady Akademii Nauk SSSR 1986	RTECS^®- Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- 287,371,1986
RTECS^®- Doklady Akademii Nauk SSSR 1986	RTECS^®- Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- -1933 287,371,1986
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1993	RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 56,47,1993
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1998	RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 61,21,1998
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999	RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 62,38,1999
RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999	RTECS^®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 62,56,1999
RTECS^®- Environmental and Molecular Mutagenesis 1988	RTECS^®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 11,91,1988
RTECS^®- Environmental and Molecular Mutagenesis 1988	RTECS^®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 11,91,1988
RTECS^®- Environmental Mutagenesis 1986	RTECS^®- Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. 8,357,1986
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1984	RTECS^®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 47,87,1984
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1987	RTECS^®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 50,81,1987
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992	RTECS^®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 55,19,1992
RTECS^®- Farmakologiya i Toksikologiya (Moscow) 1992	RTECS^®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 55,34,1992
RTECS^®- Federation Proceedings, Federation of American Societies for Experimental Biology 1972	RTECS^®- Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. 31,596,1972
RTECS^®- Food and Chemical Toxicology 1987	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 25,603,1987
RTECS^®- Food and Chemical Toxicology 1986	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 24,1,1986
RTECS^®- Food and Chemical Toxicology 1986	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 24,1071,1986
RTECS^®- Food and Chemical Toxicology 1986	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 24,1121,1986
RTECS^®- Food and Chemical Toxicology 1987	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 25,603,1987
RTECS^®- Food and Chemical Toxicology 1992	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 30,89,1992
RTECS^®- Food and Chemical Toxicology 1996	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 34,595,1996
RTECS^®- Food and Cosmetics Toxicology 1972	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 10,769,1972
RTECS^®- Food and Cosmetics Toxicology 1974	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 12,367,1974
RTECS^®- Food and Cosmetics Toxicology 1981	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 19,147,1981
RTECS^®- Food and Cosmetics Toxicology 1981	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 19,153,1981
RTECS^®- Food and Cosmetics Toxicology 1965	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 3,371,1965
RTECS^®- Food and Cosmetics Toxicology 1965	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 3,417,1965
RTECS^®- Food and Cosmetics Toxicology 1965	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 3,433,1965
RTECS^®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002	RTECS^®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997- 21,19,2002
RTECS^®- Journal of Medicinal Chemistry 1980	RTECS^®- Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- 23,1350,1980
RTECS^®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho 1977	RTECS^®- Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- 28(2),45,1977
RTECS^®- Mutation Research 1995	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 343,157,1995
RTECS^®- Mutation Research 1995	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 345,73,1995
RTECS^®- Mutation Research 2002	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 519,103,2002
RTECS^®- Mutation Research 2006	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 608,29,2006
RTECS^®- Mutation Research 1995	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 343,157,1995
RTECS^®- Mutation Research 1995	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 345,73,1995
RTECS^®- Mutation Research 2002	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 519,103,2002
RTECS^®- Mutation Research 2006	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 608,29,2006
RTECS^®- National Technical Information Service	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB278-026
RTECS^®- National Technical Information Service	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB278-026
RTECS^®- New England Journal of Medicine 1986	RTECS^®- New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- 314,648,1986
RTECS^®- Science Reports of the Research Institutes, Tohoku University, Series C: Medicine 1989	RTECS^®- Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- 36(1-4),10,1989
RTECS^®- Toxicology and Applied Pharmacology 1981	RTECS^®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 61,475,1981
RTECS^®- Toxicology and Applied Pharmacology 1989	RTECS^®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 99,37,1989
RTECS^®- Toxicology and Applied Pharmacology 1989	RTECS^®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 99,37,1989
RTECS^®- Toxicology Letters 1982	RTECS^®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 10,239,1982
RTECS^®- Toxicology Letters 1986	RTECS^®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 34,99,1986
RTECS^®- Toxicology Letters 1996	RTECS^®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 87,103,1996
RTECS^®- Toxicology 2001	RTECS^®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 169,1,2001
RTECS^®- Toxicology 1986	RTECS^®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 38,151,1986
RTECS^®- Toxicology 1977	RTECS^®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 7,289,1977

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.

BHT

Antioxidant; Fragrance Ingredient; MASKING

SCORE

Also listed as

Allergies/immunotoxicity

Neurotoxicity

Endocrine disruption

Occupational hazards

Organ system toxicity (non-reproductive)

Cancer

Biochemical or cellular level changes

Developmental/reproductive toxicity

Irritation (skin, eyes, or lungs)

Multiple, additive exposure sources

Data gaps

Government, industry, academic studies and classifications

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