BISABOLOL
Fragrance Ingredient; Skin-Conditioning Agent - Miscellaneous; MASKING; SKIN CONDITIONING; SOOTHING
Also listed as
.ALPHA.-BISABOLOL; ALPHA BISABOLOL; (+-) -ALPHA-BISABOLOL; (-) -ALPHA-BISABOLOL; ALPHA-BISABOLOL; DL-ALPHA-BISABOLOL; DRAGOSANTOL
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
 | Other strong concerns for this ingredient: Enhanced skin absorption |
 | Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Data gaps |
|
See products containing BISABOLOL | |
About BISABOLOL: Bisabolol is the terpene.
BISABOLOL has reported used in the following product types: facial moisturizer/treatment (296); anti-aging (172); moisturizer (129); facial cleanser (95); sunscreen: SPF 15-30 (83); around-eye cream (78); foundation (77); after shave (76); lipstick (71); sunscreen: makeup (57)
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at moderate doses | RTECS®- International Journal of Toxicology |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient) | products that may be aerosolized (airborne) | RTECS®- International Journal of Toxicology |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- International Journal of Toxicology |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| One or more animal studies show skin irritation at moderate doses | RTECS®- International Journal of Toxicology |
Enhanced skin absorption
| type of concern | product conditions | reference |
| Penetration enhancer | Cosmetic Ingredient Review Assessments |
Data gaps
| type of concern | product conditions | reference |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments | |
| 41 studies on toxicity in PubMed see search results -> | PubMed |
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Cosmetic Ingredient Review Assessments | BISABOLOL | •Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Penetration enhancer - alters skin structure, allows other chemicals to penetrate deeper into the skin |
| Environmental Canada Domestic Substance List | 3-CYCLOHEXENE-1-METHANOL, _,4-DIMETHYL-_-(4-METHYL-3-PENTENYL)-, (R,R)- | •This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected bioaccumulation. |
| IFRA Fragrance Ingredient List | .ALPHA.-BISABOLOL | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| RTECS®- International Journal of Toxicology | BISABOLOL | • metabolic - Weight loss or decreased weight gain (rat TDLo) • liver - Changes in liver weight (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) • respiratory - Dyspnea (mouse LD50) • skin - Hair (mouse LD50) • brain and nervous system - Tremor (mouse LD50) |
references
| government/industry list/academic study | reference |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| RTECS®- International Journal of Toxicology | RTECS®- International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997- 18(Suppl |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
All rights reserved.
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