ETHOXYDIGLYCOL
Fragrance Ingredient; Solvent; Viscosity Decreasing Agent; HUMECTANT; PERFUMING
Also listed as
DIETHYLENE GLYCOL MONOETHYL ETHER; ETHANOL, 2- (2-ETHOXYETHOXY) -; 2- (2-ETHOXYETHOXY) ETHANOL; 2- (2-ETHOXYETHOXY) - ETHANOL; ETHANOL, 2 (2ETHOXYETHOXY) ; 2- (2-ETHOXYETHOXY) ETHANOL; 3,6-DIOXA-1-OCTANOL; 3,6-DIOXA-1-OKTANOL (CZECH) ; AETHYLDIAETHYLENGLYCOL (GERMAN) ; CARBITOL; DIETHYLENE GLYCOL ETHYL ETHER
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
| Other moderate concerns for this ingredient: Persistence and bioaccumulation, Organ system toxicity (non-reproductive) |
| Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Ecotoxicology, Irritation (skin, eyes, or lungs), Data gaps |
|
See products containing ETHOXYDIGLYCOL | |
About ETHOXYDIGLYCOL: Ethoxydiglycol is the ether alcohol.
ETHOXYDIGLYCOL has reported used in the following product types: hair color and bleaching (599); facial moisturizer/treatment (105); anti-aging (81); sunless tanning (65); facial cleanser (35); conditioner (31); shampoo (28); moisturizer (28); around-eye cream (25); foundation (22)
Cancer
| type of concern | product conditions | reference |
| Possible carcinogen | Environmental Canada Domestic Substance List | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Classified as a high human health priority | Environmental Canada Domestic Substance List | |
| Classified as expected to be toxic or harmful | Environmental Canada Domestic Substance List | |
| show more | ||
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Persistent or bioaccumulative and moderate to high toxicity concern in humans | Environmental Canada Domestic Substance List |
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- National Technical Information Service 6797 |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at high doses | RTECS®- EHP, Environmental Health Perspectives 1984 | |
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Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at high doses | RTECS®- National Technical Information Service 0960 |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| One or more animal studies show skin irritation at moderate doses | RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944 |
Ecotoxicology
| type of concern | product conditions | reference |
| Suspected to be an environmental toxin and be persistent or bioaccumulative | Environmental Canada Domestic Substance List | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments | |
| 122 studies on toxicity in PubMed see search results -> | PubMed |
Multiple, additive exposure sources
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| FDA Food Additive Status | DIETHYLENE GLYCOL MONOETHYL ETHER | • Used in food processing: sanitizing agent • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Adequate drainage - CFR178.1010 |
| Cosmetic Ingredient Review Assessments | ETHOXYDIGLYCOL | •Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product |
| Environmental Canada Domestic Substance List | ETHANOL, 2-(2-ETHOXYETHOXY)- | •This chemical was deemed a moderate human health priority and was flagged by CEPA for further attention. |
| IFRA Fragrance Ingredient List | DIETHYLENE GLYCOL MONOETHYL ETHER | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| EPA Categorized List of Inert Pesticide Ingredients | DIETHYLENE GLYCOL MONOETHYL ETHER | •Pesticide inerts: potentially toxic, testing priority, according to EPA (Environmental Protection Agency) |
| Klaassen, C, 1996 | DIETHYLENE GLYCOL MONOETHYL ETHER | •Cardiovascular or blood toxicity hazards: suspected |
| RTECS®- Archives of Dermatology and Syphilology 1942 | ETHOXYDIGLYCOL | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Bollettino Chimico Farmaceutico 1986 | ETHOXYDIGLYCOL | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
| RTECS®- Bollettino Chimico Farmaceutico 1986 | ETHOXYDIGLYCOL | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
| RTECS®- EHP, Environmental Health Perspectives 1984 | ETHOXYDIGLYCOL | • reproductive - Growth statistics (mouse TDLo) • reproductive - Other neonatal measures or effects (mouse TDLo) |
| RTECS®- Food and Cosmetics Toxicology 1968 | ETHOXYDIGLYCOL | • metabolic - Weight loss or decreased weight gain (rat TDLo) • kidney or renal system - Changes in bladder weight (rat TDLo) • kidney or renal system - Changes in tubules (including acute renal failure, acute tubular (rat TDLo) |
| RTECS®- Fundamental and Applied Toxicology 1990 | ETHOXYDIGLYCOL | • reproductive - Urogenital system (mouse TDLo) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944 | ETHOXYDIGLYCOL | • skin - Primary skin irritant (rabbit ) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944 | ETHOXYDIGLYCOL | • skin - Primary skin irritant (rabbit ) |
| RTECS®- National Technical Information Service 7123 | ETHOXYDIGLYCOL | • reproductive - Central nervous system (mouse TDLo) • reproductive - Growth statistics (mouse TDLo) • developmental - Urogenital system (mouse TDLo) |
| RTECS®- National Technical Information Service 6797 | ETHOXYDIGLYCOL | • endocrine system - Death in the "U" data type field (rat TDLo) • blood - Changes in spleen (rat TDLo) • kidney or renal system - Changes in tubules (including acute renal failure, acute tubular (rat TDLo) |
| RTECS®- National Technical Information Service 0960 | ETHOXYDIGLYCOL | • blood - Changes in erythrocyte (RBC) count (rat TDLo) • kidney or renal system - Hematuria (rat TDLo) • brain and nervous system - Somnolence (general depressed activity) (rat TDLo) |
| RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis 1987 | ETHOXYDIGLYCOL | • developmental - Growth statistics (mouse TDLo) • reproductive - Litter size (mouse TDLo) |
| RTECS®- Union Carbide Data Sheet 1968 | ETHOXYDIGLYCOL | • sense organ - Primary eye irritant (rabbit ) |
references
| government/industry list/academic study | reference |
| FDA Food Additive Status | FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| EPA Categorized List of Inert Pesticide Ingredients | EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients. |
| Scorecard.org Toxicity Information | Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996. |
| RTECS®- Archives of Dermatology and Syphilology 1942 | RTECS®- Archives of Dermatology and Syphilology. (Chicago, IL) V.1-62, 1920-50. For publisher information, see ARDEAC. 45,553,1942 |
| RTECS®- Bollettino Chimico Farmaceutico 1986 | RTECS®- Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- 125,401,1986 |
| RTECS®- Bollettino Chimico Farmaceutico 1986 | RTECS®- Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 125,401,1986 |
| RTECS®- EHP, Environmental Health Perspectives 1984 | RTECS®- EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- 57,141,1984 |
| RTECS®- Food and Cosmetics Toxicology 1968 | RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 6,689,1968 |
| RTECS®- Fundamental and Applied Toxicology 1990 | RTECS®- Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 14,622,1990 |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944 | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 82,377,1944 |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1944 | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 82,377,1944 |
| RTECS®- National Technical Information Service 7123 | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. #PB85137123 |
| RTECS®- National Technical Information Service 6797 | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0516797 |
| RTECS®- National Technical Information Service 0960 | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0570960 |
| RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis 1987 | RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- 7,29,1987 |
| RTECS®- Union Carbide Data Sheet 1968 | RTECS®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 11/22/1968 |
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