EUGENOL

Denaturant; Fragrance Ingredient; MASKING; TONIC  

Also listed as

ALLYLGUAIACOL; 1-ALLYL-4-HYDROXY-3-METHOXYBENZENE; CARYOPHYLLIC ACID; EUGENIC ACID; 2-HYDROXY-5-ALLYLANISOLE; 1-HYDROXY-2-METHOXY-4-ALLYLBENZENE; 2-METHOXY-4- (2-PROPENYL) PHENOL; PHENOL, 2-METHOXY-4- (2-PROPENYL) -; 2-METHOXY-4- (2-PROPENYL) - PHENOL; PHENOL, 2METHOXY4 (2PROPENYL) ; 1,3,4-EUGENOL


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
yes, weakCancer
noDevelopmental/reproductive toxicity
yes, moderateViolations, restrictions & warnings
yes, strongAllergies/immunotoxicity
noContamination concerns
noOther moderate concerns for this ingredient:
Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
noLesser or emerging concerns for this ingredient:
Endocrine disruption, Data gaps
 
See products containing EUGENOL

About EUGENOL: Eugenol is the substituted phenol.

EUGENOL has reported used in the following product types: fragrance for women (147); hair color and bleaching (105); moisturizer (81); fragrance for men (56); body spray (41); facial moisturizer/treatment (40); lip gloss (36); styling gel/lotion (23); body wash/cleanser (23); anti-aging (19)


Allergies/immunotoxicity

type of concern product conditions reference
Known human immune system toxicant    EU Banned and Restricted Fragrances
Known human immune system toxicant    National Library of Medicine HazMap

Violations, restrictions & warnings

type of concern product conditions reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)   International Fragrance Association Codes & Standards

Neurotoxicity

type of concern product conditions reference
One or more animal studies show brain and nervous system effects at low doses    RTECS®- Archives Internationales de Pharmacodynamie et de Therapie 1966
show more

Organ system toxicity (non-reproductive)

type of concern product conditions reference
One or more animal studies show respiratory effects at very low doses products that may be aerosolized (airborne)  RTECS®- Archives of Toxicology 1986
Classified as expected to be toxic or harmful    Environmental Canada Domestic Substance List
show more

Cancer

type of concern product conditions reference
One or more in vitro tests on mammalian cells show positive mutation results    RTECS®- Shigaku 1987
show more

Endocrine disruption

type of concern product conditions reference
One or more animal studies show endocrine system disruption at high doses    RTECS®- Toxicology and Applied Pharmacology 1965
show more

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
One or more animal studies show skin irritation at very low doses    RTECS®- Cosmetics and Toiletries 1979
show more

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
1,209 studies on toxicity in PubMed see search results ->   PubMed

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusEUGENOL• Food additive: synthetic flavor
• GRAS (generally recognized as safe) - use in food presumed safe based either on a history of use before 1958 or on published scientific evidence; need not be approved by the FDA prior to use in food; most have not limit for use but must conform to good manufacturing practices; some GRAS substances have quantitative limit for use in foods; by definition under Sec 201(s) of FD&C Act, not food additives - CFR184.1257
Association of Occupational and Environmental ClinicsEUGENOL• o
FDA Everything Added to FoodEUGENOL• Fully up-to-date toxicology information has been sought.
Environmental Canada Domestic Substance ListPHENOL, 2-METHOXY-4-(2-PROPENYL)-•This chemical was deemed a moderate human health priority and was flagged by CEPA for further attention.
EU Banned and Restricted FragrancesEUGENOLFragrance chemical, which, according to existing knowledge, is frequently reported as a well-recognised consumer allergen
IFRA Fragrance Ingredient ListEUGENOL•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
National Library of Medicine HazMapEUGENOL•Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes;
Int'l Agency for Research on Cancer (IARC) - CarcinogensEUGENOL•IARC Group 3 (no cancer link)
International Fragrance Association Codes & StandardsEUGENOL•Fragrance subject to restrictions: safe only within recommended use or concentration limits
International Fragrance Association Codes & StandardsEUGENOL•Fragrance subject to restrictions: safe only within recommended use or concentration limits
International Fragrance Association Codes & StandardsEUGENOL•Fragrance subject to restrictions: safe only within recommended use or concentration limits
International Fragrance Association Codes & Standards#29 EUGENOL•Fragrance subject to restrictions: safe only within recommended use or concentration limits
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994EUGENOL• brain and nervous system - Flaccid paralysis without anesthesia (usually neuromuscular blockage) (rat LD50)
• kidney or renal system - Hematuria (rat LD50)
RTECS®- Archives Internationales de Pharmacodynamie et de Therapie 1966EUGENOL• brain and nervous system - Convulsions or effect on seizure threshold (mouse LD50)
• respiratory - Dyspnea (mouse LD50)
• respiratory - Respiratory stimulation (mouse LD50)
RTECS®- Archives of Toxicology 1986EUGENOL• respiratory - Acute pulmonary edema (rat LD50)
• respiratory - Chronic pulmonary edema (rat LD50)
• respiratory - Structural or functional change in trachea or bronchi (rat LD50)
RTECS®- Cancer Letters (Shannon, Ireland) 1981EUGENOL• mutagenic - Positive mutation assay: other mutation test systems (hamster ovr)
RTECS®- Cancer Letters (Shannon, Ireland) 1981EUGENOL• mutagenic - Positive mutation assay: other mutation test systems (hamster ovr)
RTECS®- Comptes Rendus Hebdomadaires des Seances, Academie des Sciences 1960EUGENOL• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Cosmetics and Toiletries 1979EUGENOL• skin - Primary skin irritant (rabbit )
RTECS®- Cosmetics and Toiletries 1979EUGENOL• skin - Primary skin irritant (rabbit )
RTECS®- Environmental and Molecular Mutagenesis 1987EUGENOL• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster ovr)
• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr)
RTECS®- Environmental and Molecular Mutagenesis 1987EUGENOL• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster ovr)
• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr)
RTECS®- Food and Chemical Toxicology 1984EUGENOL• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr)
RTECS®- Food and Chemical Toxicology 1984EUGENOL• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr)
RTECS®- Food and Cosmetics Toxicology 1975EUGENOL• skin - Primary skin irritant ( human )
RTECS®- Food and Cosmetics Toxicology 1964EUGENOL• brain and nervous system - Somnolence (general depressed activity) (guinea pig LD50)
RTECS®- Journal of Ethnopharmacology 1995EUGENOL• cardiovascular - BP lowering not characterized in autonomic section (rat TDLo)
• cardiovascular - Change in rate (rat TDLo)
RTECS®- Journal of Oral Pathology 1986EUGENOL• mutagenic - Positive mutation assay: Micronucleus test (mouse ipr)
RTECS®- Journal of Oral Pathology 1986EUGENOL• mutagenic - Positive mutation assay: Micronucleus test (mouse ipr)
RTECS®- Journal of Toxicological Sciences 2001EUGENOL• metabolic - Weight loss or decreased weight gain (mouse TDLo)
• brain and nervous system - Food intake (animal) (mouse TDLo)
RTECS®- Mutation Research 1989EUGENOL• mutagenic - Positive mutation assay: Gene Conversion and Mitotic Recombination (Saccharomyces cerevisiae )
RTECS®- Mutation Research 1996EUGENOL• mutagenic - Positive mutation assay: DNA Damage (rat lvr)
RTECS®- Mutation Research 2003EUGENOL• mutagenic - Positive mutation assay: Cytogenetic Analysis ( human lym)
RTECS®- Mutation Research 2005EUGENOL• mutagenic - Positive mutation assay: (Drosophila melanogaster orl)
RTECS®- Mutation Research 2008EUGENOL• mutagenic - Positive mutation assay: Cytogenetic Analysis ( human oth)
RTECS®- Mutation Research 1989EUGENOL• mutagenic - Positive mutation assay: Gene Conversion and Mitotic Recombination (Saccharomyces cerevisiae )
RTECS®- Mutation Research 1996EUGENOL• mutagenic - Positive mutation assay: DNA Damage (rat lvr)
RTECS®- Mutation Research 2003EUGENOL• mutagenic - Positive mutation assay: Cytogenetic Analysis ( human lym)
RTECS®- Mutation Research 2005EUGENOL• mutagenic - Positive mutation assay: (Drosophila melanogaster orl)
RTECS®- National Technical Information Service EUGENOL• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- National Technical Information Service EUGENOL• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- National Technical Information Service 6402EUGENOL• cancer - liver neoplasms (mouse TDLo)
• cancer - liver tumors (mouse TDLo)
RTECS®- National Toxicology Program Technical Report Series 1983EUGENOL• endocrine system - Death in the "U" data type field (rat TDLo)
• cancer - liver tumor formations - equivocal (mouse TDLo)
RTECS®- Proceedings of the Society for Experimental Biology and Medicine 1950EUGENOL• brain and nervous system - Altered sleep time (including change in righting reflex) (rat LD50)
• brain and nervous system - Coma (rat LD50)
• respiratory - Dyspnea (rat LD50)
RTECS®- Revue Medicale de la Suisse Romande 1896EUGENOL• brain and nervous system - Convulsions or effect on seizure threshold (rat LDLo)
• brain and nervous system - Muscle weakness (rat LDLo)
• kidney or renal system - Other changes (rat LDLo)
RTECS®- Science 1987EUGENOL• mutagenic - Positive mutation assay: Mutation in Mammalian Somatic Cells (mouse lym)
RTECS®- Science 1987EUGENOL• mutagenic - Positive mutation assay: Mutation in Mammalian Somatic Cells (mouse lym)
RTECS®- Shigaku 1987EUGENOL• mutagenic - Positive mutation assay: Morphological Transform (hamster emb)
• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster emb)
• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (hamster emb)
RTECS®- Shigaku 1987EUGENOL• mutagenic - Positive mutation assay: Morphological Transform (hamster emb)
• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster emb)
• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (hamster emb)
RTECS®- Toxicology and Applied Pharmacology 1964EUGENOL• metabolic - Weight loss or decreased weight gain (rat TDLo)
• liver - Hepatitis (hepatocellular necrosis), zonal (rat TDLo)
RTECS®- Toxicology and Applied Pharmacology 1965EUGENOL• endocrine system - Death in the "U" data type field (rat TDLo)
• liver - Other changes (rat TDLo)
RTECS®- Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed 2000EUGENOL• musculoskeletal - Joints (rat TDLo)
• musculoskeletal - Other changes (rat TDLo)

references

government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environmental Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU Banned and Restricted FragrancesSCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Int'l Agency for Research on Cancer (IARC) - CarcinogensIARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
International Fragrance Association Codes & StandardsIFRA (International Fragrance Association). 2006. Codes and Standards.
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,301,1994
RTECS®- Archives Internationales de Pharmacodynamie et de Therapie 1966RTECS®- Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- 164,30,1966
RTECS®- Archives of Toxicology 1986RTECS®- Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- 59,78,1986
RTECS®- Cancer Letters (Shannon, Ireland) 1981RTECS®- Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 14,251,1981
RTECS®- Cancer Letters (Shannon, Ireland) 1981RTECS®- Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- 14,251,1981
RTECS®- Comptes Rendus Hebdomadaires des Seances, Academie des Sciences 1960RTECS®- Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. 250,1148,1960
RTECS®- Cosmetics and Toiletries 1979RTECS®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- 94(8),41,1979
RTECS®- Cosmetics and Toiletries 1979RTECS®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 94(8),41,1979
RTECS®- Environmental and Molecular Mutagenesis 1987RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 10(Suppl 10),1,1987
RTECS®- Environmental and Molecular Mutagenesis 1987RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 10(Suppl 10),1,1987
RTECS®- Food and Chemical Toxicology 1984RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 22,623,1984
RTECS®- Food and Chemical Toxicology 1984RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 22,623,1984
RTECS®- Food and Cosmetics Toxicology 1975RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 13,545,1975
RTECS®- Food and Cosmetics Toxicology 1964RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 2,327,1964
RTECS®- Journal of Ethnopharmacology 1995RTECS®- Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- 45,183,1995
RTECS®- Journal of Oral Pathology 1986RTECS®- Journal of Oral Pathology. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1972- 15,450,1986
RTECS®- Journal of Oral Pathology 1986RTECS®- Journal of Oral Pathology. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 15,450,1986
RTECS®- Journal of Toxicological Sciences 2001RTECS®- Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- 26,129,2001
RTECS®- Mutation Research 1989RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 224,427,1989
RTECS®- Mutation Research 1996RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 368,59,1996
RTECS®- Mutation Research 2003RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 537,117,2003
RTECS®- Mutation Research 2005RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 582,87,2005
RTECS®- Mutation Research 2008RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 650,39,2008
RTECS®- Mutation Research 1989RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 224,427,1989
RTECS®- Mutation Research 1996RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 368,59,1996
RTECS®- Mutation Research 2003RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 537,117,2003
RTECS®- Mutation Research 2005RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 582,87,2005
RTECS®- National Technical Information Service RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-A116-715
RTECS®- National Technical Information Service RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-A116-715
RTECS®- National Technical Information Service 6402RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB84-186402
RTECS®- National Toxicology Program Technical Report Series 1983RTECS®- National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- NTP-TR-223,1983
RTECS®- Proceedings of the Society for Experimental Biology and Medicine 1950RTECS®- Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- 73,148,1950
RTECS®- Revue Medicale de la Suisse Romande 1896RTECS®- Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- 16,449,1896
RTECS®- Science 1987RTECS®- Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- 236,933,1987
RTECS®- Science 1987RTECS®- Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 236,933,1987
RTECS®- Shigaku 1987RTECS®- Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 74,1365,1987
RTECS®- Shigaku 1987RTECS®- Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949- 74,1365,1987
RTECS®- Toxicology and Applied Pharmacology 1964RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 6,378,1964
RTECS®- Toxicology and Applied Pharmacology 1965RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 7,18,1965
RTECS®- Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed 2000RTECS®- Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed., Humana press, 2000 -,126,2000

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.

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