IODOPROPYNYL BUTYLCARBAMATE
PRESERVATIVE
Also listed as
BUTYL-3-IODO-2-PROPYNYLCARBAMATE; CARBAMIC ACID, BUTYL-3-IODO-2-PROPYNYL ESTER; IPBC; BUTYL-3-IODO-2-PROPYNYL ESTER CARBAMIC ACID; IDOPROPYNL BUTYLCARBAMATE; IODOPROPYL BUTYLCARBAMATE; 3-IODO-2-PROPYNYL BUTYLCARBAMATE; BUTYLCARBAMIC ACID, 3-IODO-2-PROPYNYL ESTER; CARBAMIC ACID, BUTYL, 3IODO2PROPYNYL ESTER; IODOPROPYNL BUTYLCARBAMATE
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive) |
 | Lesser or emerging concerns for this ingredient: Ecotoxicology, Irritation (skin, eyes, or lungs), Data gaps |
|
See products containing IODOPROPYNYL BUTYLCARBAMATE | |
IODOPROPYNYL BUTYLCARBAMATE has reported used in the following product types: facial moisturizer/treatment (242); moisturizer (178); styling gel/lotion (139); anti-aging (123); facial cleanser (113); shampoo (112); body wash/cleanser (106); sunscreen: SPF 15-30 (97); conditioner (59); sunscreen: moisturizer (55)
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR) | products that may be aerosolized (airborne) | Cosmetic Ingredient Review Assessments |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | Japan's Standards for Cosmetics | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics | Japan's Standards for Cosmetics | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Human toxicant - strong evidence | Cosmetic Ingredient Review Assessments | |
| One or more human case studies show significant immune effects | Pazzaglia M, Tosti A, 1999 |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Limited evidence of gastrointestinal or liver toxicity | US EPA, 1788 | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| One or more animal studies show skin irritation at high doses | RTECS®- British Journal of Dermatology 2004 |
Data gaps
| type of concern | product conditions | reference |
| Safety assessment was based on related chemical | Cosmetic Ingredient Review Assessments | |
| 27 studies on toxicity in PubMed see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Cosmetic Ingredient Review Assessments | IODOPROPYNYL BUTYLCARBAMATE | •Safe for use in cosmetics with some qualifications •Determined safe for use in cosmetics based on concentrations of surrogate, related chemical in cosmetics, by industry safety panel (Cosmetic Ingredient Review, CIR) •Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR) •Lung sensitizer |
| Environmental Canada Domestic Substance List | CARBAMIC ACID, BUTYL-, 3-IODO-2-PROPYNYL ESTER | •This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected aquatic toxicity. |
| Japan's Standards for Cosmetics | IODOPROPYNYL BUTYLCARBAMATE | •Japan - restricted for use in some types of cosmetics (concentration limit) |
| Japan's Standards for Cosmetics | IODOPROPYNYL BUTYLCARBAMATE | •Japan - restricted for use in some types of cosmetics (concentration limit) |
| Japan's Standards for Cosmetics | IODOPROPYNYL BUTYLCARBAMATE | •Japan - restricted for use in some types of cosmetics (concentration limit) |
| Japan's Standards for Cosmetics | IODOPROPYNYL BUTYLCARBAMATE | •Japan - prohibited for use in some types of cosmetics |
| EPA Toxic Release Inventory PBTs | 3IODO2PROPYNYL ESTERCARBAMIC ACID, BUTYL | •Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs |
| Pazzaglia M, Tosti A, 1999 | IODOPROPYNL BUTYLCARBAMATE | Study demonstrates allergic contact dermatitis of chemical in cosmetic cream |
| US EPA, 1788 | 3-IODO-2-PROPYNYL BUTYLCARBAMATE | •Gastrointestinal or liver toxicity hazards: suspected |
| RTECS®- British Journal of Dermatology 2004 | IODOPROPYNYL BUTYLCARBAMATE | • skin - Primary skin irritant ( human ) |
references
| government/industry list/academic study | reference |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| Japan's Standards for Cosmetics | Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau. |
| EPA Toxic Release Inventory PBTs | EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
| Open scientific literature | Pazzaglia M, Tosti A. 1999. Allergic contact dermatitis from 3-iodo-2-propynyl-butylcarbamate in a cosmetic cream. Contact Dermatitis. 1999 Nov;41(5):290. |
| Scorecard.org Toxicity Information | US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm |
| RTECS®- British Journal of Dermatology 2004 | RTECS®- British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951- 151,608,2004 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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