METHYLCHLOROISOTHIAZOLINONE
Preservative
Also listed as
5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE; 4-ISOTHIAZOLIN-3-ONE, 5-CHLORO-2-METHYL-; 5-CHLORO-2-METHYL- 4-ISOTHIAZOLIN-3-ONE; METHYLCHLOROTHIAZOLINONE; 3 (2H) ISOTHIAZOLONE, 5CHLORO2METHYL; 5-CHLORO-2-METHYL-2H-ISOTHIAZOL-3-ONE; 3 (2H) -ISOTHIAZOLONE, 5-CHLORO-2-METHYL-; 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE; KATHON CG 5243
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive) |
|
See products containing METHYLCHLOROISOTHIAZOLINONE | |
About METHYLCHLOROISOTHIAZOLINONE: Methylchloroisothiazolinone is the heterocyclic organic compound that conforms to theformula:
METHYLCHLOROISOTHIAZOLINONE has reported used in the following product types: shampoo (769); conditioner (615); hair color and bleaching (587); body wash/cleanser (366); facial cleanser (115); styling gel/lotion (100); bubble bath (76); moisturizer (71); exfoliant/scrub (68); dandruff/scalp treatment (61)
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Known human immune system toxicant | National Library of Medicine HazMap | |
| Human skin toxicant - strong evidence | Cosmetic Ingredient Review Assessments | |
| Limited evidence of immune system toxicity | Nordic Council of Ministers (Nordic Allergy Project), 1991 | |
| Human immune system toxicant - moderate evidence | National Library of Medicine HazMap | |
| show more | ||
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics when combined with certain other ingredients | Japan's Standards for Cosmetics | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s) | Japan's Standards for Cosmetics | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Possible human immune system toxicant | National Library of Medicine HazMap | |
| show more | ||
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests non-mammalian cells show positive mutation results | RTECS®- Mutation Research 1983 |
Data gaps
| type of concern | product conditions | reference |
| 118 studies on toxicity in PubMed see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Canada - Prohibited and Restricted Cosmetics Ingredients | METHYLCHLOROISOTHIAZOLINONE | •Use is restricted in Canadian cosmetics |
| Cosmetic Ingredient Review Assessments | METHYLCHLOROISOTHIAZOLINONE | •Safe for use in cosmetics with some qualifications •Distinction between safe conc in leave-on and rinse-off products |
| Cosmetic Ingredient Review Assessments | METHYLCHLOROISOTHIAZOLINONE | •Safe for use in cosmetics with some qualifications •Distinction between safe conc in leave-on and rinse-off products • • • •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin |
| National Library of Medicine HazMap | METHYLCHLORO-ISOTHIAZOLINONE | •Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents: Yes; •Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes; |
| Japan's Standards for Cosmetics | METHYLCHLORO ISOTHIAZOLINONE | •Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s) |
| Japan's Standards for Cosmetics | METHYLCHLORO ISOTHIAZOLINONE | •Japan - prohibited for use in some types of cosmetics when combined with certain other ingredients |
| Japan's Standards for Cosmetics | METHYLCHLORO ISOTHIAZOLINONE | •Japan - prohibited for use in some types of cosmetics when combined with certain other ingredients |
| Nordic Council of Ministers (Nordic Allergy Project), 1991 | 5-KLOR-2-METYL-4-ISOTIAZOLIN-3-ON OCH 2-METYL-4-ISOTIAZOLIN-3-ON (I FĂ–RHĂ…LLANDE 3:1) >15PPM | •Immunotoxicity hazards: suspected |
| Environmental Canada Domestic Substance List | 3(2H)-ISOTHIAZOLONE, 5-CHLORO-2-METHYL- | •This chemical was NOT flagged by CEPA for further attention. |
| IFRA Fragrance Ingredient List | 3(2H)-ISOTHIAZOLONE, 5-CHLORO-2-METHYL- | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| RTECS®- Mutation Research 1983 | METHYLCHLOROISOTHIAZOLINONE | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
| RTECS®- Mutation Research 1983 | METHYLCHLOROISOTHIAZOLINONE | • mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) |
references
| government/industry list/academic study | reference |
| Canada - Prohibited and Restricted Cosmetics Ingredients | Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| Japan's Standards for Cosmetics | Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau. |
| Scorecard.org Toxicity Information | Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.; Swedish National Chemicals Inspectorate. Labelling of chemical products, Swedish regulations and general advice with regard to the classification and labelling of chemical products hazardous to health, flammables and explosives. List of Allergenic Substances. National Chemicals Inspectorate, Solna, Sweden. 1987, 1990-1992. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| RTECS®- Mutation Research 1983 | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 118,129,1983 |
| RTECS®- Mutation Research 1983 | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 118,129,1983 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
All rights reserved.
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