N,N-DIETHYL-M-TOLUAMIDE
Not Reported; SKIN PROTECTING
Also listed as
DIETHYL TOLUAMIDE, BENZAMIDE, N,N-DIETHYL-3-METHYL-; DEET; M-DELPHENE; N,N-DIETHYL-3-METHYLBENZAMIDE; N,N-DIETHYL-3-METHYL- BENZAMIDE; BENZAMIDE, N,NDIETHYL3METHYL; 3-METHYL-N,N-DIETHYLBENZAMIDE; AI 3-22542; AMINCENE C-EM; AUTAN; BENZAMIDE, N,N-DIETHYL-3-METHYL-
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Other strong concerns for this ingredient: Irritation (skin, eyes, or lungs), Occupational hazards |
 | Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive) |
| Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Ecotoxicology, Data gaps |
|
See products containing N,N-DIETHYL-M-TOLUAMIDE | |
About N,N-DIETHYL-M-TOLUAMIDE: Diethyl Toluamide is the aromatic amide.
N,N-DIETHYL-M-TOLUAMIDE has reported used in the following product types: insect/pest repellant (15); body spray (1)
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show cardiovascular effects at very low doses | RTECS®- Journal of Analytical Toxicology 1995 | |
| show more | ||
Occupational hazards
| type of concern | product conditions | reference |
| Allowed workplace exposures restricted to low doses | European Union - Classification & Labelling | |
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Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- U |
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at moderate doses | RTECS®- JAMA, Journal of the American Medical Association 1987 | |
| show more | ||
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| Classified as irritant | European Union - Classification & Labelling | |
| show more | ||
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at high doses | RTECS®- Handbook of pesticide toxicology 2001 | |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- Toxicology and Applied Pharmacology 1959 |
Ecotoxicology
| type of concern | product conditions | reference |
| Wildlife and environmental toxicity | European Union - Classification & Labelling | |
| show more | ||
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be bioaccumulative | Environmental Canada Domestic Substance List |
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 21,935 studies on toxicity in PubMed see search results -> | PubMed |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| European Union - Classification & Labelling | N,N-DIETHYL-M-TOLUAMIDE | •Harmful •Harmful if swallowed •Irritant (eyes, skin, or lungs) •Irritating to eyes and skin •Harmful to aquatic organisms |
| Canada - Prohibited and Restricted Cosmetics Ingredients | DIETHYL TOLUAMIDE | •Prohibited from use in Canadian cosmetics |
| Frazier , L, 1998 | DEET | •Reproductive toxicity hazards: suspected |
| Harvell, J, 1994 | DEET | •Skin or sense organ toxicity hazards: suspected |
| Environmental Canada Domestic Substance List | BENZAMIDE, N,N-DIETHYL-3-METHYL- | •This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected persistence. |
| Association of Occupational and Environmental Clinics | N,N-DIETHYL-M-TOLUAMIDE | • P |
| RTECS®- Farmakologiya i Toksikologiya (Moscow) 1975 | N,N-DIETHYL-M-TOLUAMIDE | • reproductive - Viability index (rat TDLo) |
| RTECS®- Fundamental and Applied Toxicology 1994 | N,N-DIETHYL-M-TOLUAMIDE | • reproductive - Other effects (rabbit TDLo) |
| RTECS®- Handbook of pesticide toxicology 2001 | N,N-DIETHYL-M-TOLUAMIDE | • reproductive - Fetotoxicity (rat TDLo) • reproductive - Growth statistics (rat TDLo) |
| RTECS®- JAMA, Journal of the American Medical Association 1987 | N,N-DIETHYL-M-TOLUAMIDE | • brain and nervous system - Coma (woman LDLo) • brain and nervous system - Convulsions or effect on seizure threshold (child TDLo) • sense organ - Mydriasis (pupillary dilation) (woman TDLo) • gastrointestinal - Nausea or vomiting (woman LDLo) • respiratory - Other changes (woman LDLo) • brain and nervous system - Stiffness (child TDLo) |
| RTECS®- Journal of Analytical Toxicology 1995 | N,N-DIETHYL-M-TOLUAMIDE | • cardiovascular - BP lowering not characterized in autonomic section (woman TDLo) • cardiovascular - EKG changes not diagnostic of above (woman TDLo) • cardiovascular - Pulse rate increase without fall in BP (woman TDLo) |
| RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1984 | N,N-DIETHYL-M-TOLUAMIDE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1984 | N,N-DIETHYL-M-TOLUAMIDE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- National Technical Information Service | N,N-DIETHYL-M-TOLUAMIDE | • skin - Primary skin irritant (rabbit ) |
| RTECS®- National Technical Information Service | N,N-DIETHYL-M-TOLUAMIDE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- National Technical Information Service | N,N-DIETHYL-M-TOLUAMIDE | • skin - Primary skin irritant (rabbit ) |
| RTECS®- National Technical Information Service | N,N-DIETHYL-M-TOLUAMIDE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 1999 | N,N-DIETHYL-M-TOLUAMIDE | • metabolic - Weight loss or decreased weight gain (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • brain and nervous system - Food intake (animal) (rat TDLo) |
| RTECS®- Toxicology and Applied Pharmacology 1959 | N,N-DIETHYL-M-TOLUAMIDE | • kidney or renal system - Changes in bladder weight (rat TDLo) • liver - Changes in liver weight (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) • skin - Dermatitis, other ( human TDLo) |
| RTECS®- U | N,N-DIETHYL-M-TOLUAMIDE | • mutagenic - Positive mutation assay: sperm (rat ihl) |
references
| government/industry list/academic study | reference |
| European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex I of Directive 67/548/EEC through the 31st ATP. |
| Canada - Prohibited and Restricted Cosmetics Ingredients | Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| Scorecard.org Toxicity Information | Frazier , L. and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf. |
| Scorecard.org Toxicity Information | Harvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria)., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| Association of Occupational and Environmental Clinics | AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation. |
| RTECS®- Farmakologiya i Toksikologiya (Moscow) 1975 | RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 38,202,1975 |
| RTECS®- Fundamental and Applied Toxicology 1994 | RTECS®- Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 23,63,1994 |
| RTECS®- Handbook of pesticide toxicology 2001 | RTECS®- Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 2,1444,2001 |
| RTECS®- JAMA, Journal of the American Medical Association 1987 | RTECS®- JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- 258,1509,1987 |
| RTECS®- Journal of Analytical Toxicology 1995 | RTECS®- Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- -1977 19,197,1995 |
| RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1984 | RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- 3,17,1984 |
| RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1984 | RTECS®- Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 3,17,1984 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-A106-944 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-A107-736 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-A106-944 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-A107-736 |
| RTECS®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 1999 | RTECS®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998- 47,99,1999 |
| RTECS®- Toxicology and Applied Pharmacology 1959 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 1,97,1959 |
| RTECS®- U | RTECS®- U.S. Army, Environmental Hygiene Agency Reports. (Edgewood Arsenal, MD 21010) 75-51-0034-80 |
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