PLACENTAL EXTRACT

 

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
noCancer
noDevelopmental/reproductive toxicity
yes, moderateViolations, restrictions & warnings
noAllergies/immunotoxicity
yesContamination concerns - PROGESTERONE, ESTROGEN, ESTRONE
noOther moderate concerns for this ingredient:
Organ system toxicity (non-reproductive)
noLesser or emerging concerns for this ingredient:
Endocrine disruption, Data gaps
 
See products containing PLACENTAL EXTRACT

About PLACENTAL EXTRACT: This ingredient is derived from the placenta, an organ that develops in female mammals during pregnancy, lining the uterine wall and attached by the umbilical cord to provide nourishment and oxygen to the fetus. The placenta produces progesterone, estrogen, and other hormones, which raise potential health concerns in personal care products. In one study four girls between one and eight years of age developed breasts or pubic hair two to 24 months after starting the use of estrogen- or pla ... read more

This ingredient may be derived from animals. From PETA's Caring Consumer: Contains waste matter eliminated by the fetus. Derived from the uterus of slaughtered animals. Animal placenta is widely used in skin creams, shampoos, masks, etc. Alternatives: kelp, olive oil, wheat germ oil, coconut oil, flaxseed oil, almond oil, safflower oil, etc.

PLACENTAL EXTRACT has reported used in the following product types: conditioner (8); facial moisturizer/treatment (4); anti-aging (1); mask (1); toners/astringents (1)


Violations, restrictions & warnings

type of concern product conditions reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics   Canada - Prohibited and Restricted Cosmetics Ingredients

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Potential risk of infectious disease - Must be free of detectable pathogenic viruses or infectious agents    Cosmetic Ingredient Review Assessments
Potential risk of infectious disease -    FDA Ingredients with Bovine Spongiform Encephalopathy Concern

Endocrine disruption

type of concern product conditions reference
One or more studies show weak endocrine disruption    Tiwary, C, 1998
show more

Data gaps

type of concern product conditions reference
Insufficient data to determine safety   Cosmetic Ingredient Review Assessments
37 studies on toxicity in PubMed see search results ->   PubMed



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
FDA Ingredients with Bovine Spongiform Encephalopathy ConcernBOVINE PLACENTA•High risk: bovine spongiform encephalopathy (BSE), a fatal transmissible disease; FDA advises companies to ensure safety of ingredients imported from countries where BSE is prevalent
Canada - Prohibited and Restricted Cosmetics IngredientsHUMAN PLACENTAL EXTRACTS•Use is restricted in Canadian cosmetics
Cosmetic Ingredient Review AssessmentsPLACENTAL PROTEIN•Insufficient data to support safe use in cosmetics
•Should not deliver any metabolic or endocrine activity
•Must be free of detectable pathogenic viruses or infectious agents: warning from industry safety panel (Cosmetic Ingredient Review, CIR)
•May contain harmful impurities
FDA, 2006ESTROGEN, ESTRONE, ESTRADIOL, PROGESTERONE, PLACENTAL EXTRACT OR VITAMINSFDA may consider this a misbranded cosmetic if the extract has been prepared from placentas from which the hormones and other biologically active substances have not been removed and the extracted substance consists principally of protein.
FDA, 2006PLACENTAL EXTRACTImpurity: estradiol, estrone, progesterone
Tiwary, C, 1998PLACENTA-CONTAINING HAIR PRODUCTSGirls developed breasts or pubic hair 2 to 24 months after starting the use of estrogen or placenta-containing hair products

references

government/industry list/academic study reference
FDA Ingredients with Bovine Spongiform Encephalopathy ConcernFDA (U.S. Food and Drug Administration). 2000. FDA Center for Food Safety and Applied Nutrition. Cosmetics Compliance Program. Domestic Cosmetics Program. Coverage of Bovine-Derived Ingredients for Bovine Spongiform Encephalopathy (BSE). Issued July 31, 2000.
Canada - Prohibited and Restricted Cosmetics IngredientsHealth Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Open scientific literatureFDA, 2006. "GUIDE TO INSPECTIONS OF COSMETIC PRODUCT MANUFACTURERS," U.S. Food and Drug Administration, Accessed on May 14th, 2007 at: http://www.fda.gov/ora/inspect_ref/igs/cosmet.html.
Open scientific literatureFDA, 2006. "GUIDE TO INSPECTIONS OF COSMETIC PRODUCT MANUFACTURERS," U.S. Food and Drug Administration, Accessed on May 14th, 2007 at: http://www.fda.gov/ora/inspect_ref/igs/cosmet.html.
Open scientific literatureTiwary, C. M. (1998). "Premature sexual development in children following the use of estrogen- or placenta-containing hair products." Clin Pediatr (Phila) 37(12): 733-9.

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.

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