SODIUM DEHYDROACETATE
Preservative
Also listed as
3-ACETYL-6-METHYL-2H-PYRAN-2,4 (3H) -DIONE, ION (1-) , SODIUM SALT; 2H-PYRAN-2,4 (3H) -DIONE, 3-ACETYL-6-METHYL-, ION (1-) , SODIUM; SODIUM SALT 3-ACETYL-6-METHYL-2H-PYRAN-2,4 (3H) -DIONE, ION (1-) ; SODIUM 2H-PYRAN-2,4 (3H) -DIONE, 3-ACETYL-6-METHYL-, ION (1-) ; ION (1-) SODIUM SALT 3-ACETYL-6-METHYL-2H-PYRAN-2,4 (3H) -DIONE; ION (1-) SODIUM 2H-PYRAN-2,4 (3H) -DIONE, 3-ACETYL-6-METHYL-; 2HPYRAN2,4 (3H) DIONE, 3ACETYL6METHYL, ION (1) , SODIUM; 3-ACETYL-6-METHYL-2H-PYRAN-2,4 (3H) -DIONE, ION (1-) , SODIUM; SODIUM 1- (3,4-DIHYDRO-6-METHYL-2,4-DIOXO-2H-PYRAN-3-YLIDENE) ETHANOLATE; 3- (1-HYDROXYETHYLIDENE) -6-METHYL-2H-PYRAN-2,4 (3H) -DIONE, SODIUM SALT; 4-HEXENOIC ACID, 2-ACETYL-5-HYDROXY-3-OXO, DELTA-LACTONE, SODIUM DERIV.
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
 | Other strong concerns for this ingredient: Occupational hazards |
 | Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive) |
| Lesser or emerging concerns for this ingredient: Neurotoxicity, Data gaps |
|
See products containing SODIUM DEHYDROACETATE | |
About SODIUM DEHYDROACETATE: Sodium Dehydroacetate is the heterocyclic compound that conforms generally to the formula:
SODIUM DEHYDROACETATE has reported used in the following product types: foundation (210); eye shadow (167); facial powder (125); blush (68); mascara (56); sunscreen: makeup (43); facial moisturizer/treatment (42); anti-aging (37); bronzer/highlighter (30); concealer (21)
Occupational hazards
| type of concern | product conditions | reference |
| Allowed workplace exposures restricted to low doses | European Union - Classification & Labelling |
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- Food and Chemical Toxicology 1988 | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Classified as toxic or harmful | products for use around the mouth; products for use on the lips | European Union - Classification & Labelling |
| show more | ||
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at high doses | RTECS®- Eisei Shikenjo Hokoku 1988 | |
| show more | ||
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain, nervous system, or behavioral effects at high doses | RTECS®- Journal of Pharmacology and Experimental Therapeutics 1950 |
Data gaps
| type of concern | product conditions | reference |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments | |
| 57 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Multiple, additive exposure sources
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environment Canada Domestic Substance List | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| European Union - Classification & Labelling | SODIUM 1-(3,4-DIHYDRO-6-METHYL-2,4-DIOXO-2H-PYRAN-3-YLIDENE)ETHONOLATE | •Harmful •Harmful if swallowed |
| Cosmetic Ingredient Review Assessments | SODIUM DEHYDROACETATE | •Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product |
| FDA Everything Added to Food | SODIUM DEHYDROACETATE | • Fully up-to-date toxicology information has been sought. |
| Environment Canada Domestic Substance List | 2H-PYRAN-2,4(3H)-DIONE, 3-ACETYL-6-METHYL-, ION(1-), SODIUM | •This chemical was NOT flagged by CEPA for further attention. |
| IFRA Fragrance Ingredient List | 2H-PYRAN-2,4(3H)-DIONE, 3-ACETYL-6-METHYL-, ION(1-), SODIUM | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| RTECS®- Eisei Shikenjo Hokoku 1988 | SODIUM DEHYDROACETATE | • reproductive - Fetotoxicity (rat TDLo) |
| RTECS®- Food and Chemical Toxicology 1984 | SODIUM DEHYDROACETATE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr) |
| RTECS®- Food and Chemical Toxicology 1988 | SODIUM DEHYDROACETATE | • mutagenic - Positive mutation assay: Micronucleus test (mouse ipr) |
| RTECS®- Food and Chemical Toxicology 1984 | SODIUM DEHYDROACETATE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr) |
| RTECS®- Food and Chemical Toxicology 1988 | SODIUM DEHYDROACETATE | • mutagenic - Positive mutation assay: Micronucleus test (mouse ipr) |
| RTECS®- Gann Monograph on Cancer Research 1981 | SODIUM DEHYDROACETATE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster lng) |
| RTECS®- Gann Monograph on Cancer Research 1981 | SODIUM DEHYDROACETATE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster lng) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1950 | SODIUM DEHYDROACETATE | • metabolic - Weight loss or decreased weight gain (monkey TDLo) • brain, nervous system, or behavioral effect - Convulsions or effect on seizure threshold (monkey TDLo) |
| RTECS®- Journal of the American College of Toxicology 1985 | SODIUM DEHYDROACETATE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Journal of the American College of Toxicology 1985 | SODIUM DEHYDROACETATE | • broad systemic - Broad systemic toxicity (rat LD50) • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Nippon Koshu Eisei Zasshi 1980 | SODIUM DEHYDROACETATE | • reproductive - Fetotoxicity (mouse TDLo) • reproductive - Litter size (mouse TDLo) |
| RTECS®- Personal Communication from LONZA Ltd 1980 | SODIUM DEHYDROACETATE | • broad systemic - Broad systemic toxicity (rabbit LD50) |
references
| government/industry list/academic study | reference |
| European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| RTECS®- Eisei Shikenjo Hokoku 1988 | RTECS®- Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- (106),54,1988 |
| RTECS®- Food and Chemical Toxicology 1984 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 22,623,1984 |
| RTECS®- Food and Chemical Toxicology 1988 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 26,487,1988 |
| RTECS®- Food and Chemical Toxicology 1984 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 22,623,1984 |
| RTECS®- Food and Chemical Toxicology 1988 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 26,487,1988 |
| RTECS®- Gann Monograph on Cancer Research 1981 | RTECS®- Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- 27,95,1981 |
| RTECS®- Gann Monograph on Cancer Research 1981 | RTECS®- Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 27,95,1981 |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1950 | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 99,57,1950 |
| RTECS®- Journal of the American College of Toxicology 1985 | RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 4(3),123,1985 |
| RTECS®- Journal of the American College of Toxicology 1985 | RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 4(3),123,1985 |
| RTECS®- Nippon Koshu Eisei Zasshi 1980 | RTECS®- Nippon Koshu Eisei Zasshi. Japanese Journal of Public Health. (Nippon Koshu Eisei Gakkai, 1-29-8 Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1954- 27,91,1980 |
| RTECS®- Personal Communication from LONZA Ltd 1980 | RTECS®- Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland 02JUN1980 |
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