SODIUM PCA
Hair Conditioning Agent; Humectant; Skin-Conditioning Agent - Humectant; ANTISTATIC; SKIN CONDITIONING
Also listed as
5-OXO-DL-PROLINE, MONOSODIUM SALT; PCA SODA; DL-PROLINE, 5-OXO-, MONOSODIUM SALT; SODIUM PYROGLUTAMATE; SODIUM DL-2-PYRROLIDONE-5-CARBOXYLATE; SODIUM DL-PYRROLIDONECARBOXYLATE SOLUTION; MONOSODIUM SALT 5-OXO-DL-PROLINE; MONOSODIUM SALT DL-PROLINE, 5-OXO-; 5-OXO- MONOSODIUM SALT DL-PROLINE; SODIUM 5-OXO-L-PROLINATE; 5-OXO-L-PROLINE MONOSODIUM SALT
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
| Allergies/immunotoxicity |
 | Contamination concerns - NITROSAMINES |
| Lesser or emerging concerns for this ingredient: Endocrine disruption, Organ system toxicity (non-reproductive) |
|
See products containing SODIUM PCA | |
About SODIUM PCA: Sodium PCA is the sodium salt of PCA (q.v.).
SODIUM PCA has reported used in the following product types: facial moisturizer/treatment (417); moisturizer (269); anti-aging (216); facial cleanser (177); conditioner (97); around-eye cream (94); toners/astringents (88); foundation (86); body wash/cleanser (82); sunscreen: SPF 15-30 (74)
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- Iyakuhin Kenkyu 1992 |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) | RTECS®- International Journal of Toxicology | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Cosmetic Ingredient Review Assessments | SODIUM PCA | •Safe for use in cosmetics with some qualifications •Amine: forms carcinogenic nitrosamine compounds if mixed with nitrosating agents |
| Environmental Canada Domestic Substance List | DL-PROLINE, 5-OXO-, MONOSODIUM SALT | •This chemical was NOT flagged by CEPA for further attention. |
| RTECS®- International Journal of Toxicology | SODIUM PCA | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Iyakuhin Kenkyu 1992 | SODIUM PCA | • kidney or renal system - Changes in bladder weight (rat TDLo) • cardiovascular - Changes in heart weight (rat TDLo) • liver - Changes in liver weight (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) |
references
| government/industry list/academic study | reference |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| RTECS®- International Journal of Toxicology | RTECS®- International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997- 18(Suppl |
| RTECS®- Iyakuhin Kenkyu 1992 | RTECS®- Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- 23,717,1992 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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