MEXORYL SX

Ultraviolet Light Absorber; UV ABSORBER; UV FILTER  

SCORE

3

moderate hazard

 

75%

data gap

(why scores have changed)

Also listed as

TEREPHTHALYLIDENE DICAMPHOR SULFONIC ACID, BIS [7,7-DIMETHYL-2-OXO-; TDSA; ECAMSULE


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
yes, weakCancer
noDevelopmental/reproductive toxicity
yes, moderateViolations, restrictions & warnings
yes, weakAllergies/immunotoxicity
noContamination concerns
noLesser or emerging concerns for this ingredient:
Data gaps
 
See products containing MEXORYL SX

About MEXORYL SX: FDA approved use of this UVA-absorbing agent in 2006. 2 hours of sunlight can degrade as much as 40% of this active ingredient. Low skin penetration.

ingredient UV blocking strength

Sunscreens: What
common sunscreen
concentrations		 UV blocking strength

2.0%


3.0%


4.0%


10.0%


MEXORYL SX has reported used in the following product types: sunscreen: SPF 15-30 (6); moisturizer (3); facial moisturizer/treatment (2); sunscreen: moisturizer (2); after sun product (1); sunscreen: SPF greater than 30 (1); anti-aging (1); sunscreen: makeup (1)


Violations, restrictions & warnings

type of concern product conditions reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)   Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics   Japan's Standards for Cosmetics

Cancer

type of concern product conditions reference
One or more in vitro tests on mammalian cells show positive mutation results    Cantrell, 1999

Allergies/immunotoxicity

type of concern product conditions reference
One or more human case studies show equivocal skin allergy effects    FDA, 2006

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
28 studies on toxicity in PubMed see search results ->   PubMed



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
Japan's Standards for CosmeticsTEREPHTHALYLIDENE DICAMPHOR SULFONIC ACID•Japan - restricted for use in some types of cosmetics (concentration limit)
Japan's Standards for CosmeticsTEREPHTHALYLIDENE DICAMPHOR SULFONIC ACID•Japan - prohibited for use in some types of cosmetics
Japan's Standards for CosmeticsTEREPHTHALYLIDENE DICAMPHOR SULFONIC ACID•Japan - restricted for use in some types of cosmetics (concentration limit)
Cantrell, 1999TEREPHTHALYLIDENE DICAMPHOR SULFONIC ACIDProduces damaging reactive oxygen species upon exposure to sunlight
FDA, 2006ECAMSULEIndustry documents reveal allergic skin reactions occur rarely, with adverse skin effects more often reported in children than in adults.

references

government/industry list/academic study reference
Japan's Standards for CosmeticsJapan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
Open scientific literature{Cantrell, 1999}
Open scientific literatureFDA. 2006. Center for Drug Evaluation and Research Application Number 21-502: Medical Review. Center for Drug Evaluation and Research, Food and Drug Administration. July 11, 2006.

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