TRICLOSAN
Cosmetic Biocide; Deodorant Agent; Preservative
TRICLOSAN may be an impurity the following product types:
facial moisturizer/treatment (129)
moisturizer (126)
facial cleanser (64)
shampoo (55)
conditioner (53)
anti-aging (46)
body wash/cleanser (41)
hand cream (40)
toners/astringents (36)
exfoliant/scrub (32)
bar soap (30)
bath oil/salts/soak (27)
body spray (22)
around-eye cream (22)
mask (21)
Also listed as
5-CHLORO-2- (2,4-DICHLOROPHENOXY) PHENOL; PHENOL, 5-CHLORO-2- (2,4-DICHLOROPHENOXY) -; 2,4,4'-TRICHLORO-2'-HYDROXY DIPHENYL ETHER; 5-CHLORO-2- (2,4-DICHLOROPHENOXY) - PHENOL; PHENOL, 5CHLORO2 (2,4DICHLOROPHENOXY) ; 2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER; 5-CHLORO-2- (2,4-DICHLOROPHENOXY) PHENOL; CH 3565; IRGASAN; IRGASAN DP300; PHENOL, 5-CHLORO-2- (2,4-DICHLOROPHENOXY) -
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Restrictions & warnings |
 | Allergies/immunotoxicity |
 | Contamination concerns - CHLOROFORM, DIOXIN |
 | Other strong concerns for this ingredient: Irritation (skin, eyes, or lungs) |
| Other moderate concerns for this ingredient: Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive) |
| Lesser or emerging concerns for this ingredient: Ecotoxicology, Data gaps |
|
See products containing TRICLOSAN See ingredients that may have TRICLOSAN as an impurity See products that may have TRICLOSAN as an impurity | |
About TRICLOSAN: Triclosan is the substituted organic ether.
TRICLOSAN has reported used in the following product types: antiperspirant/deodorant (men's) (74); liquid hand soap (65); facial cleanser (42); toothpaste (34); acne treatment (28); lipstick (28); eye shadow (26); body wash/cleanser (22); antiperspirant/deodorant (21); tooth whitening (20)
Restrictions & warnings
| type of concern | product conditions | reference |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit) | Japan's Standards for Cosmetics |
Endocrine disruption
| type of concern | product conditions | reference |
| One or more studies show endocrine disruption at very low doses | Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006 |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List | |
| show more | ||
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Persistent, bioaccumulative in wildlife | Emerging PBTs from peer-reviewed literature |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| Classified as irritant | European Union - Classification & Labelling | |
| show more | ||
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests non-mammalian cells show positive mutation results | RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981 |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at high doses | RTECS®- Eisei Shikenjo Hokoku 1987 |
Ecotoxicology
| type of concern | product conditions | reference |
| Wildlife and environmental toxicity | European Union - Classification & Labelling | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 626 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| European Union - Classification & Labelling | TRICLOSAN | •Irritant (eyes, skin, or lungs) •Irritating to eyes and skin •Dangerous for the environment •Very toxic to aquatic organisms |
| Association of Occupational and Environmental Clinics | TRICLOSAN | • o |
| Canada - Prohibited and Restricted Cosmetics Ingredients | TRICLOSAN | •Use is restricted in Canadian cosmetics |
| Environment Canada Domestic Substance List | TRICLOSAN | •This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulation. |
| IFRA Fragrance Ingredient List | TRICLOSAN | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| National Library of Medicine HazMap | TRICLOSAN | |
| Japan's Standards for Cosmetics | TRICHLOROHYDROXYDIPHENYLETHER (TRICLOSAN) | •Japan - restricted for use in cosmetics (concentration limit) |
| Emerging PBTs from peer-reviewed literature | PHENOL, 5CHLORO2(2,4DICHLOROPHENOXY) | •Persistent, bioaccumulative toxicant - Limited or emerging evidence in open scientific literature |
| Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006 | TRICLOSAN | Affects thyroid hormone-associated gene expression and disrupts postembryonic development. Findings on the control of amphibian metamorphosis enhance our understanding of the regulation of postembryonic development by thyroid hormone in mammals and other |
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 | TRICLOSAN | • skin - Primary skin irritant ( human ) |
| RTECS®- "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J 1970 | TRICLOSAN | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- Eisei Shikenjo Hokoku 1987 | TRICLOSAN | • reproductive - Fetal death (rat TDLo) |
| RTECS®- Industrial Medicine and Surgery 1969 | TRICLOSAN | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981 | TRICLOSAN | • mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis ) |
| RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981 | TRICLOSAN | • mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis ) |
| RTECS®- Yakkyoku 1977 | TRICLOSAN | • broad systemic - Broad systemic toxicity (mouse LD50) • skin - Primary skin irritant (rabbit ) |
| RTECS®- Yakkyoku 1977 | TRICLOSAN | • skin - Primary skin irritant (rabbit ) |
references
| government/industry list/academic study | reference |
| European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
| Association of Occupational and Environmental Clinics | AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation. |
| Canada - Prohibited and Restricted Cosmetics Ingredients | Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| Japan's Standards for Cosmetics | Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau. |
| Emerging PBTs from peer-reviewed literature | Emerging PBTs from peer-reviewed literature |
| Open scientific literature | Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006. "The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development," Aquat Toxicol. 2006 Dec 1;80(3):217-27. Tata JR. "Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone." Ann Endocrinol (Paris). 1998;59(6):433-42. |
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 | RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 -,127,1977 |
| RTECS®- "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J 1970 | RTECS®- "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70 6,245,1968/1970 |
| RTECS®- Eisei Shikenjo Hokoku 1987 | RTECS®- Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- (105),28,1987 |
| RTECS®- Industrial Medicine and Surgery 1969 | RTECS®- Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. 38,64,1969 |
| RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981 | RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan). (Nippon Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104, Japan) V.10- 15,243,1981 |
| RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981 | RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan). (Nippon Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104, Japan) V.10- 1976- 15,243,1981 |
| RTECS®- Yakkyoku 1977 | RTECS®- Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- 28,985,1977 |
| RTECS®- Yakkyoku 1977 | RTECS®- Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 28,985,1977 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
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