UBIQUINONE
Antioxidant; Skin-Conditioning Agent - Miscellaneous; SKIN CONDITIONING
Also listed as
COENZYME Q10; TETRACONTADECAENYL) -5,6-DIMETHOXY-3-METHYL-,; UBIQUINONE 10; UBIQUINONE 50; UBIQUINONE Q10; COENZYME Q (SUB 10) ; COQ (SUB 10) ; NEUQUINON; NEUQUINONE; UBIDECARENONE; UBIQUINONE 10
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
| Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Data gaps, Biochemical or cellular level changes |
|
See products containing UBIQUINONE | |
About UBIQUINONE: Ubiquinone is the organic compound.
UBIQUINONE has reported used in the following product types: facial moisturizer/treatment (160); anti-aging (143); around-eye cream (32); sunscreen: moisturizer (25); sunscreen: SPF 15-30 (25); moisturizer (24); facial cleanser (18); sunscreen: makeup (17); body firming lotion (9); foundation (9)
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at moderate doses | RTECS®- Iyakuhin Kenkyu 1972 | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show blood effects at moderate doses (low dose studies may be unavailable for this ingredient) | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999 | |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- Oyo Yakuri 1972 |
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at high doses | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1993 |
Biochemical or cellular level changes
| type of concern | product conditions | reference |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999 | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 1,494 studies on toxicity in PubMed see search results -> | PubMed |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1993 | UBIQUINONE | • metabolic - Weight loss or decreased weight gain (rat TDLo) • brain and nervous system - Alteration of classical conditioning (rat TDLo) • brain and nervous system - Changes in motor activity (specific assay) (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999 | UBIQUINONE | • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • biochemical - Other enzymes (rat TDLo) |
| RTECS®- Iyakuhin Kenkyu 1972 | UBIQUINONE | • reproductive - Fetotoxicity (rat TDLo) • reproductive - Musculoskeletal system (mouse TDLo) • developmental - Other developmental abnormalities (rat TDLo) • developmental - Physical (rat TDLo) • reproductive - Post-implantation mortality (rat TDLo) |
| RTECS®- Oyo Yakuri 1972 | UBIQUINONE | • endocrine system - Death in the "U" data type field (rat TDLo) • gastrointestinal - Hypermotility, diarrhea (rat TDLo) • respiratory - Other changes (rat TDLo) |
| RTECS®- Toxicologist 2001 | UBIQUINONE | • biochemical - Effect on mitochondrial function (rat TDLo) • sense organ - Other (rat TDLo) |
| RTECS®- Toxicology 2003 | UBIQUINONE | • blood - Changes in spleen (mouse TDLo) • biochemical - Effect on cyclic nucleotides (mouse TDLo) |
references
| government/industry list/academic study | reference |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1993 | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 56,55,1993 |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1999 | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 62,56,1999 |
| RTECS®- Iyakuhin Kenkyu 1972 | RTECS®- Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- 3,306,1972 |
| RTECS®- Oyo Yakuri 1972 | RTECS®- Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- -1967 6,769,1972 |
| RTECS®- Toxicologist 2001 | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 1,98,2001 |
| RTECS®- Toxicology 2003 | RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 187,171,2003 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
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