AMMONIUM THIOGLYCOLATE
Hair-Waving/Straightening Agent; Reducing Agent; DEPILATORY; HAIR WAVING OR STRAIGHTENING
Also listed as
ACETIC ACID, MERCAPTO-, MONOAMMONIUM SALT; AMMONIUM MERCAPTOACETATE; AMMONIUM THIOGLYCOLLATE; MERCAPTOACETIC ACID, MONOAMMONIUM SALT; THIOGLYCOLIC ACID AMMONIUM SALT; MONOAMMONIUM SALT ACETIC ACID, MERCAPTO-; MONOAMMONIUM SALT MERCAPTOACETIC ACID; MERCAPTO- MONOAMMONIUM SALT ACETIC ACID; ACETIC ACID, MERCAPTO, MONOAMMONIUM SALT; AMMONIUM MERCAPTOACETATE; AMMONIUM MERCAPTOACETATE; AMMONIUM MERCAPTOACETATE
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Other moderate concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive) |
 | Lesser or emerging concerns for this ingredient: Irritation (skin, eyes, or lungs) |
|
See products containing AMMONIUM THIOGLYCOLATE | |
About AMMONIUM THIOGLYCOLATE: Ammonium Thioglycolate is the ammonium salt of thioglycolic acid that conforms to theformula:
AMMONIUM THIOGLYCOLATE has reported used in the following product types: hair perm (14); hair relaxer (2); styling gel/lotion (1)
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Known human immune system toxicant | National Library of Medicine HazMap | |
| Human skin toxicant - strong evidence | ||
| Human skin toxicant - strong evidence | Cosmetic Ingredient Review Assessments |
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at low doses | RTECS®- Journal of Pharmacology and Experimental Therapeutics 1949 |
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Recommendation to minimize use in cosmetics - Hairdressers should avoid or minimize consumer skin exposure | Cosmetic Ingredient Review Assessments | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at low doses | RTECS®- National Technical Information Service | |
| show more | ||
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| One or more animal studies show skin irritation at high doses | RTECS®- Journal of the American College of Toxicology 1991 |
Data gaps
| type of concern | product conditions | reference |
| 66 studies on toxicity in PubMed see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Cosmetic Ingredient Review Assessments | AMMONIUM THIOGLYCOLATE | •Safe for use in cosmetics with some qualifications •Determined safe for use in cosmetics up to a specified concentration limit •Hairdressers should avoid or minimize consumer skin exposure •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin |
| Environmental Canada Domestic Substance List | ACETIC ACID, MERCAPTO-, MONOAMMONIUM SALT | •This chemical was NOT flagged by CEPA for further attention. |
| National Library of Medicine HazMap | AMMONIUM THIOGLYCOLATE | •Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes; |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1949 | AMMONIUM THIOGLYCOLATE | • brain and nervous system - Somnolence (general depressed activity) (rabbit LD50) |
| RTECS®- Journal of the American College of Toxicology 1991 | AMMONIUM THIOGLYCOLATE | • sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit ) |
| RTECS®- Journal of the American College of Toxicology 1991 | AMMONIUM THIOGLYCOLATE | • broad systemic - Broad systemic toxicity (rat LD50) • sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit ) |
| RTECS®- National Technical Information Service | AMMONIUM THIOGLYCOLATE | • broad systemic - Broad systemic toxicity (mouse LD50) |
references
| government/industry list/academic study | reference |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1949 | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 97,349,1949 |
| RTECS®- Journal of the American College of Toxicology 1991 | RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 10,135,1991 |
| RTECS®- Journal of the American College of Toxicology 1991 | RTECS®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 10,135,1991 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD277-689 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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