NEOMYCIN SULFATE
Also listed as
NEOMYCIN, SULFATE (SALT) ; BIOSOL VETERINARY; BYKOMYCIN; FRADIOMYCIN SULFATE; LIDAMYCIN CREME; MYCAIFRADIN SULFATE; MYCIFRADIN-N; MYCIGIENT; NEO-MANTLE CREME; NEOBIOTIC; NEOFRACIN
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Other moderate concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive) |
 | Lesser or emerging concerns for this ingredient: Endocrine disruption, Irritation (skin, eyes, or lungs), Data gaps, Biochemical or cellular level changes |
|
See products containing NEOMYCIN SULFATE | |
NEOMYCIN SULFATE has reported used in the following product types: wound treatment (9); pain relief (5); scar treatment (2)
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Known human immune system toxicant | National Library of Medicine HazMap |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| Possible human developmental toxicant | California EPA Proposition 65 |
Cancer
| type of concern | product conditions | reference |
| One or more animal studies show tumor formation at very low doses | RTECS®- European Journal of Pharmacology 2004 |
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at very low doses | RTECS®- Brazilian Journal of Medical and Biological Research 2002 | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at very low doses | RTECS®- Archivum Immunologiae et Therapiae Experimentalis 1962 | |
| One or more animal studies show blood effects at very low doses | RTECS®- European Journal of Pharmacology 2004 | |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- Toxicology and Applied Pharmacology 1975 |
Biochemical or cellular level changes
| type of concern | product conditions | reference |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1994 |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| One or more animal studies show skin irritation at moderate doses | RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 |
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 1,896 studies on toxicity in PubMed see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Environmental Canada Domestic Substance List | NEOMYCIN, SULFATE (SALT) | •This chemical was NOT flagged by CEPA for further attention. |
| National Library of Medicine HazMap | NEOMYCIN | •Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes; |
| California EPA Proposition 65 | NEOMYCIN SULFATE (INTERNAL USE) | •Developmental toxin: California Proposition 65 |
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 | NEOMYCIN SULFATE | • skin - Primary skin irritant ( human ) |
| RTECS®- Annals of Otology, Rhinology, & Laryngology 1969 | NEOMYCIN SULFATE | • sense organ - Change in acuity (monkey TDLo) • sense organ - Changes in cochlear structure or function (monkey TDLo) • kidney or renal system - Other changes in urine composition (monkey TDLo) |
| RTECS®- Antibiotics and Chemotherapy (Washington, DC) 1958 | NEOMYCIN SULFATE | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Antibiotiki 1973 | NEOMYCIN SULFATE | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Archives of Internal Medicine 1967 | NEOMYCIN SULFATE | • brain and nervous system - Convulsions or effect on seizure threshold (mouse LD50) |
| RTECS®- Archives of Surgery (Chicago) 1976 | NEOMYCIN SULFATE | • brain and nervous system - Anorexia (human) (woman TDLo) • brain and nervous system - Hallucinations, distorted perceptions (woman TDLo) • brain and nervous system - Somnolence (general depressed activity) (woman TDLo) |
| RTECS®- Archivum Immunologiae et Therapiae Experimentalis 1962 | NEOMYCIN SULFATE | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Arzneimittel-Forschung 1962 | NEOMYCIN SULFATE | • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- Brazilian Journal of Medical and Biological Research 2002 | NEOMYCIN SULFATE | • brain and nervous system - Analgesia (rat TDLo) |
| RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1994 | NEOMYCIN SULFATE | • kidney or renal system - Changes in bladder weight (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) • gastrointestinal - Other changes (mouse TDLo) • kidney or renal system - Other changes in urine composition (mouse TDLo) • biochemical - Other enzymes (mouse TDLo) • biochemical - Phosphatases (rat TDLo) |
| RTECS®- European Journal of Pharmacology 2004 | NEOMYCIN SULFATE | • cancer - biochemical (rat TDLo) • blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo) |
| RTECS®- Toxicology and Applied Pharmacology 1975 | NEOMYCIN SULFATE | • sense organ - Change in acuity (guinea pig TDLo) • endocrine system - Death in the "U" data type field (guinea pig TDLo) • sense organ - Changes in cochlear structure or function (guinea pig TDLo) |
| RTECS®- Toxicology and Applied Pharmacology 1965 | NEOMYCIN SULFATE | • broad systemic - Broad systemic toxicity (mouse LD50) |
references
| government/industry list/academic study | reference |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| California EPA Proposition 65 | California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. |
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 | RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 -,127,1977 |
| RTECS®- Annals of Otology, Rhinology, & Laryngology 1969 | RTECS®- Annals of Otology, Rhinology, & Laryngology. (Annals Publishing Co., 4507 Laclede Ave., St. Louis, MO 63108) V.6- 1897- 78,1007,1969 |
| RTECS®- Antibiotics and Chemotherapy (Washington, DC) 1958 | RTECS®- Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. 8,198,1958 |
| RTECS®- Antibiotiki 1973 | RTECS®- Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. 18,444,1973 |
| RTECS®- Archives of Internal Medicine 1967 | RTECS®- Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- 119,493,1967 |
| RTECS®- Archives of Surgery (Chicago) 1976 | RTECS®- Archives of Surgery (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-61, 1920-50; V.81- 1960- 111,822,1976 |
| RTECS®- Archivum Immunologiae et Therapiae Experimentalis 1962 | RTECS®- Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- 10,947,1962 |
| RTECS®- Arzneimittel-Forschung 1962 | RTECS®- Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- 12,597,1962 |
| RTECS®- Brazilian Journal of Medical and Biological Research 2002 | RTECS®- Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- 35,395,2002 |
| RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1994 | RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.74- 1983- 109,77,1994 |
| RTECS®- European Journal of Pharmacology 2004 | RTECS®- European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- 499,99,2004 |
| RTECS®- Toxicology and Applied Pharmacology 1975 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 33,320,1975 |
| RTECS®- Toxicology and Applied Pharmacology 1965 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 7,361,1965 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
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