GOSSYPOL
GOSSYPOL may be an impurity the following product types:
mascara (198)
moisturizer (108)
facial moisturizer/treatment (85)
anti-aging (66)
lip gloss (66)
foundation (56)
lip liner (53)
shampoo (53)
eye liner (44)
facial powder (36)
eye shadow (34)
body wash/cleanser (33)
exfoliant/scrub (33)
facial cleanser (32)
conditioner (31)
brow liner (29)
lipstick (28)
hair color and bleaching (28)
around-eye cream (27)
sunscreen: makeup (22)
body oil (20)
Also listed as
(+) -GOSSYPOL; (+-) -GOSSYPOL; (-) -GOSSYPOL; RACEMIC-GOSSYPOL; TASH 1
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| Human reproductive toxicant - moderate evidence | CHE Toxicant and Disease Database | |
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Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- Cancer Research 1984 | |
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Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at moderate doses | RTECS®- Journal of the American Oil Chemists' Society 1963 | |
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Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show gastrointestinal effects at moderate doses (low dose studies may be unavailable for this ingredient) | RTECS®- Journal of the American Oil Chemists' Society 1963 | |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- American Journal of Pathology 1957 | |
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Biochemical or cellular level changes
| type of concern | product conditions | reference |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | RTECS®- Journal of Animal Science 1993 |
Data gaps
| type of concern | product conditions | reference |
| 482 studies on toxicity in PubMed see search results -> | PubMed |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| CHE Toxicant and Disease Database | GOSSYPOL | •Moderate evidence in humans: reproductive system toxicity; Condition: abnormal sperm (morphology, motility, and sperm count); Organs/tissues affected: testes |
| Jankovic, J, 1996 | GOSSYPOL | •Reproductive toxicity hazards: suspected |
| RTECS®- American Journal of Pathology 1957 | GOSSYPOL | • endocrine system - Death in the "U" data type field (pig TDLo) • respiratory - Chronic pulmonary edema (pig TDLo) • brain and nervous system - Muscle weakness (pig TDLo) |
| RTECS®- Archives of Andrology 1984 | GOSSYPOL | • reproductive - Spermatogenesis (monkey TDLo) |
| RTECS®- Cancer Research 1984 | GOSSYPOL | • mutagenic - Positive mutation assay: DNA Inhibition ( human hla) |
| RTECS®- Cancer Research 1984 | GOSSYPOL | • mutagenic - Positive mutation assay: DNA Inhibition ( human hla) |
| RTECS®- Contraceptive Delivery Systems 1982 | GOSSYPOL | • reproductive - Spermatogenesis (rat TDLo) |
| RTECS®- Fertility and Sterility 1982 | GOSSYPOL | • reproductive - Male fertility index (hamster TDLo) • reproductive - Spermatogenesis (hamster TDLo) |
| RTECS®- In Vitro 1983 | GOSSYPOL | • mutagenic - Positive mutation assay: DNA Inhibition (hamster ovr) • mutagenic - Positive mutation assay: other mutation test systems (hamster ovr) |
| RTECS®- Journal of Animal Science 1993 | GOSSYPOL | • reproductive - Ovaries, fallopian tubes (cattle TDLo) • endocrine system - Changes in LH (cattle TDLo) • biochemical - Other (cattle TDLo) • blood - Other hemolysis with or without anemia (cattle TDLo) |
| RTECS®- Journal of the American Oil Chemists' Society 1963 | GOSSYPOL | • metabolic - Weight loss or decreased weight gain (pig LD50) • gastrointestinal - Hypermotility, diarrhea (pig LD50) • brain and nervous system - Muscle weakness (pig LD50) |
| RTECS®- Nippon Funin Gakkai Zasshi 1981 | GOSSYPOL | • reproductive - Spermatogenesis (rat TDLo) |
references
| government/industry list/academic study | reference |
| CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. |
| Scorecard.org Toxicity Information | Jankovic, J. A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996. |
| RTECS®- American Journal of Pathology 1957 | RTECS®- American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- 33,353,1957 |
| RTECS®- Archives of Andrology 1984 | RTECS®- Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- 13,199,1984 |
| RTECS®- Cancer Research 1984 | RTECS®- Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- 44,35,1984 |
| RTECS®- Cancer Research 1984 | RTECS®- Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 44,35,1984 |
| RTECS®- Contraceptive Delivery Systems 1982 | RTECS®- Contraceptive Delivery Systems. (Kluwer Academic Pub. Group, Distribution Centre, POB 322, 3300 AH Dordrecht, Netherlands) V.1- 1980- 3,#278,1982 |
| RTECS®- Fertility and Sterility 1982 | RTECS®- Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- 37,311,1982 |
| RTECS®- In Vitro 1983 | RTECS®- In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher information, see ICDBEO. 19,53,1983 |
| RTECS®- Journal of Animal Science 1993 | RTECS®- Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- 71,3052,1993 |
| RTECS®- Journal of the American Oil Chemists' Society 1963 | RTECS®- Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. 40,571,1963 |
| RTECS®- Nippon Funin Gakkai Zasshi 1981 | RTECS®- Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- 26,393,1981 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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