SODIUM LAURETH SULFATE || Skin Deep: Cosmetic Safety Reviews

SODIUM LAURETH SULFATE

Surfactant - Cleansing Agent; Surfactant - Emulsifying Agent

SCORE

	4	moderate hazard
	88%	data gap
(why scores have changed)

Also listed as

DODECYL SODIUM SULFATE; PEG- (1-4) LAURYL ETHER SULFATE, SODIUM SALT; POLYETHYLENE GLYCOL (1-4) LAURYL ETHER SULFATE, SODIUM SALT; POLY (OXY-1,2-ETHANEDIYL) ,A -SULFO-W (DODECYLOXY) -, SODIUM SALT; POLYOXYETHYLENE (1-4) LAURYL ETHER SULFATE , SODIUM SALT; SODIUM PEG LAURYL ETHER SULFATE; SODIUM POLYOXYETHYLENE LAURYL ETHER SULFATE; SODIUM POLYOXYETHYLENE LAURYL SULFATE; SODIUM SALT PEG- (1-4) LAURYL ETHER SULFATE; SODIUM SALT POLYETHYLENE GLYCOL (1-4) LAURYL ETHER SULFATE; SODIUM SALT POLY (OXY-1,2-ETHANEDIYL) ,A -SULFO-W (DODECYLOXY) -

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns - ETHYLENE OXIDE, 1,4-DIOXANE
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
	Lesser or emerging concerns for this ingredient: Data gaps
	See products containing SODIUM LAURETH SULFATE

About SODIUM LAURETH SULFATE: Sodium Laureth Sulfate is the sodium salt of sulfated ethoxylated lauryl alcohol that conformsgenerally to the formula: where n averages between 1 and 4.

SODIUM LAURETH SULFATE has reported used in the following product types: shampoo (506); body wash/cleanser (395); facial cleanser (189); liquid hand soap (98); exfoliant/scrub (95); mascara (93); hair color and bleaching (82); bubble bath (68); dandruff/scalp treatment (54); conditioner (54)

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show sense organ effects at very low doses

products for use around the eyes, mouth, or lips

RTECS^®- National Technical Information Service 9868

Classified as expected to be toxic or harmful

Environment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

Human irritant - strong evidence

products for use around the eyes, on the skin, or may be aerosolized (airborne)

Cosmetic Ingredient Review Assessments

One or more animal studies show skin irritation at very low doses

RTECS^®- "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J 1972

Data gaps

type of concern	product conditions	reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		Cosmetic Ingredient Review Assessments
15 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	SODIUM LAURETH SULFATE	•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Irritation (eyes, skin, or lungs) •
RODERICK E, 2020	SODIUM LAURETH SULFATE	Impurity: 1,4-Dioxane
Environment Canada Domestic Substance List	POLY(OXY-1,2-ETHANEDIYL), _-SULFO-_-(DODECYLOXY)-, SODIUM SALT	•This chemical was deemed a moderate human health priority and was flagged by CEPA for further attention.
IFRA Fragrance Ingredient List	POLY(OXY-1,2-ETHANEDIYL), A-SULFO-W-(DODECYLOXY)-, SODIUM SALT	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
ATSDR, 2007	PEGS, -ETHS, -OXYNOLS
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	SODIUM LAURETH SULFATE	• skin - Primary skin irritant (rabbit )
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	SODIUM LAURETH SULFATE	• skin - Primary skin irritant (guinea pig )
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	SODIUM LAURETH SULFATE	• skin - Primary skin irritant (rabbit )
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	SODIUM LAURETH SULFATE	• skin - Primary skin irritant (guinea pig )
RTECS^®- "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J 1972	SODIUM LAURETH SULFATE	• sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit )
RTECS^®- Journal of the American College of Toxicology 1983	SODIUM LAURETH SULFATE	• broad systemic - Broad systemic toxicity (rat LD50)
RTECS^®- National Technical Information Service 9868	SODIUM LAURETH SULFATE	• sense organ - Primary eye irritant (rabbit )
RTECS^®- National Technical Information Service 9868	SODIUM LAURETH SULFATE	• sense organ - Primary eye irritant (rabbit )

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Open scientific literature	RODERICK E. BLACK, FRED J. HURLEY, and DONALD C. HAVERY. "Occurrence of 1,4-Dioxane in Cosmetic Raw Materials and Finished Cosmetic Products." U.S. Food and Drug Administration, 200 C St, SW, Washington, DC 20204. 666 BLACK ET AL.: JOURNAL OF AOAC INTERNATIONAL VOL. 84, NO. 3, 2001
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Open scientific literature	ATSDR. 2007. Agency for Toxic Substances and Disease Registry: Public Health Statement for 1,4 Dioxane Available: http://www.atsdr.cdc.gov/toxprofiles/phs187.html [accessed April 16 2008].
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H., ed., New York, Churchill Livingston, 1975 -,12,1975
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H., ed., New York, Churchill Livingston, 1975 -.12,1975
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H., ed., New York, Churchill Livingston, 1975 -,12,1975
RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H 1975	RTECS^®- "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H., ed., New York, Churchill Livingston, 1975 -.12,1975
RTECS^®- "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J 1972	RTECS^®- "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 -,275,1972
RTECS^®- Journal of the American College of Toxicology 1983	RTECS^®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 2(5),1,1983
RTECS^®- National Technical Information Service 9868	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0539868
RTECS^®- National Technical Information Service 9868	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0539868

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