ALOE BARBADENSIS (ALOE VERA) GEL || Skin Deep: Cosmetic Safety Reviews

ALOE BARBADENSIS (ALOE VERA) GEL

Skin-Conditioning Agent - Miscellaneous; SKIN CONDITIONING

SCORE

	1	low hazard
	72%	data gap
(why scores have changed)

Also listed as

ALOE BARBADENSIS LEAF JUICE, ALOE BARBADENSIS GEL; ALOE GEL; ALOE JUICE; ALOE VERA GEL; CHIRUKATTALI EXTRACT

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Lesser or emerging concerns for this ingredient: Organ system toxicity (non-reproductive), Data gaps
	See products containing ALOE BARBADENSIS (ALOE VERA) GEL

About ALOE BARBADENSIS (ALOE VERA) GEL: Aloe Barbadensis Leaf Juice is the juice expressed from the leaves of the aloe, Aloebarbadensis. See "Regulatory and Ingredient Use Information," regarding the labeling names for botanicalingredients in Volume 1, Introduction, Part A.

ALOE BARBADENSIS (ALOE VERA) GEL has reported used in the following product types: facial moisturizer/treatment (298); moisturizer (283); facial cleanser (168); anti-aging (158); body wash/cleanser (145); foundation (118); sunscreen: SPF 15-30 (96); shampoo (95); sunscreen: makeup (94); conditioner (85)

Developmental/reproductive toxicity

type of concern	product conditions	reference
One or more animal studies show effects at moderate doses		CIR (2006)

Violations, restrictions & warnings

type of concern	product conditions	reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

type of concern	product conditions	reference
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Indian Journal of Experimental Biology 1968

Data gaps

type of concern	product conditions	reference
Missing safety data noted by cosmetic industry review		Cosmetic Ingredient Review Assessments
74 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Food Additive Status

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
FDA Food Additive Status	ALOE	• Food additive: used in conjunction with flavors • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Used only in conjunction w/flavors - CFR172.510
Cosmetic Ingredient Review Assessments	ALOE BARBADENSIS LEAF JUICE	•Safe for use in cosmetics with some qualifications •Industry safety panel (Cosmetic Ingredient Review, CIR) notes missing safety data in its review of this ingredient •Restrictions on impurities recommended by industry safety panel •Determined safe for use in cosmetics up to a specified concentration limit • •May contain harmful impurities
CIR (2006)	ALOE VERA	3 month rat study produced significant sperm damage
RTECS^®- Indian Journal of Experimental Biology 1968	ALOE BARBADENSIS (ALOE VERA) GEL	• broad systemic - Broad systemic toxicity (mouse LD50)

references

government/industry list/academic study	reference
FDA Food Additive Status	FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Open scientific literature	CIR (2006). 2006 CIR Compendium. Washington, Cosmetic Ingredient Review.
RTECS^®- Indian Journal of Experimental Biology 1968	RTECS^®- Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 6,232,1968

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.