ALPHA-ISOMETHYL IONONE || Skin Deep: Cosmetic Safety Reviews

ALPHA-ISOMETHYL IONONE

Fragrance Ingredient; MASKING

SCORE

	4	moderate hazard
	68%	data gap
(why scores have changed)

Also listed as

3-BUTEN-2-ONE, 3-METHYL-4- (2,6,6-TRIMETHYL-2-CYCLOHEXEN-1-YL) -; CETONE; ISOMETHYL-A -IONONE; ALPHA-ISO-METHYLIONONE; 3-METHYL-4- (2,6,6-TRIMETHYL-2-CYCLOHEXEN-1-YL) - 3-BUTEN-2-ONE; ALPHA-METHYL IONONE; 3BUTEN2ONE, 3METHYL4 (2,6,6TRIMETHYL2CYCLOHEXEN1YL) ; 3-METHYL-4- (2,6,6-TRIMETHYL-2-CYCLOHEXEN-1-YL) -3-BUTEN-2-ONE; 4- (2,6,6-TRIMETHYL-2-CYCLOHEXEN-1-YL) -3-METHYL-3-BUTEN-2-ONE; 1- (2,6,6-TRIMETHYL-2-CYCLOHEXEN-1-YL) PENT-1-EN-3-ONE; 1PENTEN3ONE, 1 (2,6,6TRIMETHYL2CYCLOHEXEN1YL)

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Lesser or emerging concerns for this ingredient: Ecotoxicology, Data gaps
	See products containing ALPHA-ISOMETHYL IONONE

About ALPHA-ISOMETHYL IONONE: Alpha-Isomethyl Ionone is the organic compound.

ALPHA-ISOMETHYL IONONE has reported used in the following product types: hair color and bleaching (177); fragrance for women (64); moisturizer (47); facial moisturizer/treatment (43); anti-aging (36); styling gel/lotion (35); body spray (34); fragrance for men (24); foundation (22); lip gloss (21)

Allergies/immunotoxicity

type of concern	product conditions	reference
Possible human immune system toxicant		EU Banned and Restricted Fragrances

Violations, restrictions & warnings

type of concern	product conditions	reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		International Fragrance Association Codes & Standards

Ecotoxicology

type of concern	product conditions	reference
Suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
6 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Organ system toxicity (non-reproductive)

type of concern	product conditions	reference
Classified as not expected to be potentially toxic or harmful		Environmental Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
FDA Everything Added to Food	ALPHA-ISOMETHYLIONONE	• Fully up-to-date toxicology information has been sought.
Environmental Canada Domestic Substance List	3-BUTEN-2-ONE, 3-METHYL-4-(2,6,6-TRIMETHYL-2-CYCLOHEXEN-1-YL)-	•This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected aquatic toxicity.
EU Banned and Restricted Fragrances	ALPHA-ISOMETHYL IONONE	Fragrance chemical, which is less frequently reported and thus less documented as a consumer allergen.
IFRA Fragrance Ingredient List	ALPHA-ISO-METHYLIONONE	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
International Fragrance Association Codes & Standards	#24 43A METHYL IONONE, MIXED ISOMERS	•Fragrance subject to restrictions: safe only within recommended use or concentration limits
International Fragrance Association Codes & Standards	METHYL IONONE, MIXED ISOMERS	•Fragrance subject to restrictions: safe only within recommended use or concentration limits
International Fragrance Association Codes & Standards	METHYL IONONE, MIXED ISOMERS	•Fragrance subject to restrictions: safe only within recommended use or concentration limits

references

government/industry list/academic study	reference
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU Banned and Restricted Fragrances	SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
International Fragrance Association Codes & Standards	IFRA (International Fragrance Association). 2006. Codes and Standards.

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