AMYLCINNAMALDEHYDE || Skin Deep: Cosmetic Safety Reviews

AMYLCINNAMALDEHYDE

Fragrance Ingredient; MASKING

SCORE

	6	moderate hazard
	61%	data gap
(why scores have changed)

Also listed as

AMYL CINNAMAL, ALPHA-AMYLCINNAMALDEHYDE; A-AMYL CINNAMIC ALDEHYDE; A-AMYLCINNMAMALDEHYDE; HEPTANAL, 2- (PHENYLMETHYLENE) ; 2- (PHENYLMETHYLENE) HEPTANAL; 2- (PHENYLMETHYLENE) HEPTANAL; 2-BENZYLIDENEHEPTANAL; HEPTANAL, 2 (PHENYLMETHYLENE) ; 2-BENZYLIDENEHEPTANAL; ALPHA-AMYL CINNAMALDEHYDE; ALPHA-AMYL CINNAMIC ALDEHYDE

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Irritation (skin, eyes, or lungs)
	Lesser or emerging concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive), Data gaps
	See products containing AMYLCINNAMALDEHYDE

About AMYLCINNAMALDEHYDE: Amyl Cinnamal is the organic compound.

AMYLCINNAMALDEHYDE has reported used in the following product types: hair color and bleaching (124); styling gel/lotion (33); fragrance for women (24); conditioner (21); sunless tanning (13); shampoo (12); moisturizer (12); hair spray (11); facial moisturizer/treatment (9); body spray (8)

Allergies/immunotoxicity

type of concern	product conditions	reference
Known human immune system toxicant		EU Banned and Restricted Fragrances

Violations, restrictions & warnings

type of concern	product conditions	reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		International Fragrance Association Codes & Standards

Neurotoxicity

type of concern	product conditions	reference
One or more animal studies show brain and nervous system effects at high doses		RTECS^®- Food and Cosmetics Toxicology 1964

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

One or more animal studies show skin irritation at very low doses

RTECS^®- Cosmetics and Toiletries 1979

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show sense organ effects at high doses (low dose studies may be unavailable for this ingredient)

products for use around the eyes, mouth, or lips

RTECS^®- Food and Cosmetics Toxicology 1964

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
14 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
FDA Everything Added to Food	ALPHA-AMYLCINNAMALDEHYDE	• Fully up-to-date toxicology information has been sought.
Environmental Canada Domestic Substance List	HEPTANAL, 2-(PHENYLMETHYLENE)-	•This chemical was NOT flagged by CEPA for further attention.
EU Banned and Restricted Fragrances	AMYLCINNAMALDEHYDE	Fragrance chemical, which, according to existing knowledge, is frequently reported as a well-recognised consumer allergen
IFRA Fragrance Ingredient List	ALPHA-AMYLCINNAMALDEHYDE	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
International Fragrance Association Codes & Standards	ALPHA-AMYL CINNAMIC ALDEHYDE	•Fragrance subject to restrictions: safe only within recommended use or concentration limits
RTECS^®- Acta Dermato-Venereologica 1978	AMYLCINNAMALDEHYDE	• skin - Primary skin irritant (guinea pig )
RTECS^®- Acta Dermato-Venereologica 1978	AMYLCINNAMALDEHYDE	• skin - Primary skin irritant (guinea pig )
RTECS^®- Cosmetics and Toiletries 1979	AMYLCINNAMALDEHYDE	• skin - Primary skin irritant (rabbit )
RTECS^®- Cosmetics and Toiletries 1979	AMYLCINNAMALDEHYDE	• skin - Primary skin irritant (rabbit )
RTECS^®- Food and Cosmetics Toxicology 1964	AMYLCINNAMALDEHYDE	• sense organ - Other (rat LD50) • sense organ - Other changes (rat LD50) • brain and nervous system - Somnolence (general depressed activity) (rat LD50)

references

government/industry list/academic study	reference
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU Banned and Restricted Fragrances	SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
International Fragrance Association Codes & Standards	IFRA (International Fragrance Association). 2006. Codes and Standards.
RTECS^®- Acta Dermato-Venereologica 1978	RTECS^®- Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1920- 58,121,1978
RTECS^®- Acta Dermato-Venereologica 1978	RTECS^®- Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- -1920 58,121,1978
RTECS^®- Cosmetics and Toiletries 1979	RTECS^®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- 94(8),41,1979
RTECS^®- Cosmetics and Toiletries 1979	RTECS^®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 94(8),41,1979
RTECS^®- Food and Cosmetics Toxicology 1964	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 2,327,1964

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