ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT || Skin Deep: Cosmetic Safety Reviews

ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT

Fragrance Ingredient; Skin-Conditioning Agent - Miscellaneous; MASKING; SKIN CONDITIONING

SCORE

	1	low hazard
	80%	data gap
(why scores have changed)

Also listed as

ANTHEMIS NOBILIS FLOWER EXTRACT, CHAMOMILE (ANTHEMIS NOBILIS) EXTRACT; CHAMOMILE EXTRACT; CHAMOMILE EXTRACT, ENGLISH; CHAMOMILE EXTRACT, ROMAN; CHAMOMILE FLOWER, ROMAN, EXTRACT (ANTHEMIS NOBILIS L.) ; ENGLISH CHAMOMILE EXTRACT; EXTRACT OF ANTHEMIS NOBILIS; EXTRACT OF CHAMOMILE, ENGLISH; EXTRACT OF CHAMOMILE FLOWERS; EXTRACT OF CHAMOMILE, ROMAN; EXTRACT OF ENGLISH CHAMOMILE

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other strong concerns for this ingredient: Enhanced skin absorption
	Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Data gaps
	See products containing ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT

About ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT: Anthemis Nobilis Flower Extract is an extract of the flowers of the chamomile, Anthemisnobilis. See "Regulatory and Ingredient Use Information," regarding the labeling names for botanicalingredients in Volume 1, Introduction, Part A.

ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT has reported used in the following product types: facial moisturizer/treatment (87); moisturizer (72); anti-aging (57); body wash/cleanser (53); hair color and bleaching (53); facial cleanser (50); shampoo (48); conditioner (31); toners/astringents (31); liquid hand soap (30)

Neurotoxicity

type of concern	product conditions	reference
One or more animal studies show brain and nervous system effects at moderate doses		RTECS^®- International Journal of Toxicology

Endocrine disruption

type of concern	product conditions	reference
One or more animal studies show endocrine system disruption at high doses		RTECS^®- International Journal of Toxicology

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)

products that may be aerosolized (airborne)

RTECS^®- International Journal of Toxicology

Irritation (skin, eyes, or lungs)

type of concern	product conditions	reference
One or more animal studies show skin irritation at moderate doses		RTECS^®- International Journal of Toxicology

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		Cosmetic Ingredient Review Assessments
4 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Enhanced skin absorption

type of concern	product conditions	reference
Penetration enhancer		Cosmetic Ingredient Review Assessments

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food

Persistence and bioaccumulation

type of concern	product conditions	reference
Not suspected to be persistent		Environmental Canada Domestic Substance List

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
FDA Everything Added to Food	CHAMOMILE FLOWER, ROMAN, EXTRACT (ANTHEMIS NOBILIS L.)	• Fully up-to-date toxicology information has been sought.
IFRA Fragrance Ingredient List	CHAMOMILE FLOWER, ROMAN, EXTRACT (ANTHEMIS NOBILIS L.)	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
Cosmetic Ingredient Review Assessments	BISABOLOL	•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Penetration enhancer - alters skin structure, allows other chemicals to penetrate deeper into the skin
Environmental Canada Domestic Substance List	3-CYCLOHEXENE-1-METHANOL, _,4-DIMETHYL-_-(4-METHYL-3-PENTENYL)-, (R,R)-	•This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected bioaccumulation.
RTECS^®- International Journal of Toxicology	ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT	• metabolic - Weight loss or decreased weight gain (rat TDLo) • liver - Changes in liver weight (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) • respiratory - Dyspnea (mouse LD50) • skin - Hair (mouse LD50) • brain and nervous system - Tremor (mouse LD50)

references

government/industry list/academic study	reference
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS^®- International Journal of Toxicology	RTECS^®- International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997- 18(Suppl

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