CITRAL
Flavoring Agent; Fragrance Ingredient; MASKING
Also listed as
3,7-DIMETHYL-2,6-OCTADIENAL; 2,6-OCTADIENAL, 3,7-DIMETHYL-; 3,7-DIMETHYL- 2,6-OCTADIENAL; 2,6OCTADIENAL, 3,7DIMETHYL; 3,7-DIMETHYL-2,6-OCTADIENAL; LEMSYN GB; NCI-C56348
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
 | Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
 | Contamination concerns |
| Other strong concerns for this ingredient: Irritation (skin, eyes, or lungs) |
| Lesser or emerging concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive), Data gaps, Biochemical or cellular level changes |
|
See products containing CITRAL | |
About CITRAL: Citral is the aldehyde.
CITRAL has reported used in the following product types: fragrance for women (98); moisturizer (79); lip gloss (62); facial moisturizer/treatment (58); body spray (49); fragrance for men (45); body wash/cleanser (35); anti-aging (33); exfoliant/scrub (26); styling gel/lotion (23)
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Known human immune system toxicant | EU Banned and Restricted Fragrances | |
| Limited evidence of immune system toxicity | products for use on skin | European Union - Classification & Labelling |
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn) | International Fragrance Association Codes & Standards |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| Classified as irritant | European Union - Classification & Labelling | |
| One or more animal studies show skin irritation at very low doses | RTECS®- Cosmetics and Toiletries 1979 | |
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Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | RTECS®- Journal of Reproduction and Fertility 1979 | |
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Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at high doses | RTECS®- Food and Cosmetics Toxicology 1964 |
Cancer
| type of concern | product conditions | reference |
| One or more animal studies show tumor formation at high doses | RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1996 |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at high doses | RTECS®- "Vrednie chemichescie veshestva 1998 | |
| show more | ||
Biochemical or cellular level changes
| type of concern | product conditions | reference |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | RTECS®- Food and Chemical Toxicology 1987 |
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 178 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Multiple, additive exposure sources
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| European Union - Classification & Labelling | CITRAL | •Irritant (eyes, skin, or lungs) •Irritating to skin •May cause sensitization by skin contact |
| FDA Everything Added to Food | CITRAL | • Fully up-to-date toxicology information has been sought. |
| Environmental Canada Domestic Substance List | 2,6-OCTADIENAL, 3,7-DIMETHYL- | •This chemical was NOT flagged by CEPA for further attention. |
| EU Banned and Restricted Fragrances | CITRAL | Fragrance chemical, which, according to existing knowledge, is frequently reported as a well-recognised consumer allergen |
| IFRA Fragrance Ingredient List | CITRAL | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| International Fragrance Association Codes & Standards | CITRAL | •Fragrance subject to restrictions: safe only within recommended use or concentration limits |
| International Fragrance Association Codes & Standards | CITRAL | •Fragrance subject to restrictions: safe only within recommended use or concentration limits |
| International Fragrance Association Codes & Standards | CITRAL | •Fragrance subject to restrictions: safe only within recommended use or concentration limits |
| RTECS®- "Vrednie chemichescie veshestva 1998 | CITRAL | • reproductive - Post-implantation mortality (rat TDLo) |
| RTECS®- "Vrednie chemichescie veshestva 1998 | CITRAL | • reproductive - Ovaries, fallopian tubes (rat TDLo) • broad systemic - Broad systemic toxicity (mouse LD50) • kidney or renal system - Changes in kidney weight (rat LD50) • liver - Changes in liver weight (rat LD50) |
| RTECS®- Biochemical Journal 1940 | CITRAL | |
| RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1996 | CITRAL | • tumore formation - Other changes (rat TDLo) |
| RTECS®- Cosmetics and Toiletries 1979 | CITRAL | • skin - Primary skin irritant (rabbit ) |
| RTECS®- Cosmetics and Toiletries 1979 | CITRAL | • skin - Primary skin irritant (guinea pig ) |
| RTECS®- FAO Nutrition Meetings Report Series 1967 | CITRAL | • kidney or renal system - Interstitial nephritis (rabbit TDLo) • blood - Other changes (rabbit TDLo) • kidney or renal system - Proteinuria (rabbit TDLo) |
| RTECS®- Food and Chemical Toxicology 1987 | CITRAL | • broad systemic - Broad systemic toxicity (rabbit LD50) • liver - Changes in liver weight (rat TDLo) • biochemical - CoA (rat TDLo) • biochemical - Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) (rat TDLo) |
| RTECS®- Food and Chemical Toxicology 1993 | CITRAL | • liver - Changes in liver weight (mouse TDLo) • liver - Other changes (mouse TDLo) |
| RTECS®- Food and Cosmetics Toxicology 1979 | CITRAL | • skin - Primary skin irritant (rabbit ) |
| RTECS®- Food and Cosmetics Toxicology 1980 | CITRAL | • reproductive - Oogenesis (rat TDLo) • reproductive - Post-implantation mortality (rat TDLo) • reproductive - Pre-implantation mortality (rat TDLo) • reproductive - Viability index (rat TDLo) |
| RTECS®- Food and Cosmetics Toxicology 1964 | CITRAL | • brain and nervous system - Somnolence (general depressed activity) (rat LD50) |
| RTECS®- Journal of Reproduction and Fertility 1979 | CITRAL | • reproductive - Live birth index (rat TDLo) • reproductive - Other measures of fertility (rat TDLo) • reproductive - Ovaries, fallopian tubes (rat TDLo) • reproductive - Viability index (rat TDLo) • broad systemic - Broad systemic toxicity (rat LD50) |
| RTECS®- Journal of the Society of Cosmetic Chemists 1977 | CITRAL | • skin - Primary skin irritant (guinea pig ) |
| RTECS®- Journal of the Society of Cosmetic Chemists 1977 | CITRAL | • skin - Primary skin irritant (guinea pig ) |
| RTECS®- Toxicology 2005 | CITRAL | • immune system - Increase in cellular immune response (mouse TDLo) • immune system - Increase in humoral immune response (mouse TDLo) |
| RTECS®- Toxicology 1995 | CITRAL | • reproductive - Female fertility index (rat TDLo) • reproductive - Fetal death (rat TDLo) • reproductive - Fetotoxicity (rat TDLo) • reproductive - Musculoskeletal system (rat TDLo) • reproductive - Other effects (rat TDLo) • reproductive - Pre-implantation mortality (rat TDLo) |
| RTECS®- Urological Research 1992 | CITRAL | • reproductive - Prostate, seminal vesicle, Cowper's gland, accessory glands (rat TDLo) • skin - Dermatitis, other (rat TDLo) • skin - Hair (rat TDLo) |
references
| government/industry list/academic study | reference |
| European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| EU Banned and Restricted Fragrances | SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| International Fragrance Association Codes & Standards | IFRA (International Fragrance Association). 2006. Codes and Standards. |
| RTECS®- "Vrednie chemichescie veshestva 1998 | RTECS®- "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998. -,286,1998 |
| RTECS®- "Vrednie chemichescie veshestva 1998 | RTECS®- "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998. -,291,1998 |
| RTECS®- Biochemical Journal 1940 | RTECS®- Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- 34,1196,1940 |
| RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology 1996 | RTECS®- Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.74- 1983- 115,169,1996 |
| RTECS®- Cosmetics and Toiletries 1979 | RTECS®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- 94(8),41,1979 |
| RTECS®- Cosmetics and Toiletries 1979 | RTECS®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 94(8),41,1979 |
| RTECS®- FAO Nutrition Meetings Report Series 1967 | RTECS®- FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. 44A,1,1967 |
| RTECS®- Food and Chemical Toxicology 1987 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 25,505,1987 |
| RTECS®- Food and Chemical Toxicology 1993 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 31,463,1993 |
| RTECS®- Food and Cosmetics Toxicology 1979 | RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 17,259,1979 |
| RTECS®- Food and Cosmetics Toxicology 1980 | RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 18,547,1980 |
| RTECS®- Food and Cosmetics Toxicology 1964 | RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 2,327,1964 |
| RTECS®- Journal of Reproduction and Fertility 1979 | RTECS®- Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- 55,347,1979 |
| RTECS®- Journal of the Society of Cosmetic Chemists 1977 | RTECS®- Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- 28,357,1977 |
| RTECS®- Journal of the Society of Cosmetic Chemists 1977 | RTECS®- Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 28,357,1977 |
| RTECS®- Toxicology 2005 | RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 206,285,2005 |
| RTECS®- Toxicology 1995 | RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 96,105,1995 |
| RTECS®- Urological Research 1992 | RTECS®- Urological Research. (Springer Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973- 20,139,1992 |
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