CYCLOPENTASILOXANE || Skin Deep: Cosmetic Safety Reviews

CYCLOPENTASILOXANE

Hair Conditioning Agent; Skin-Conditioning Agent - Emollient; Solvent; SKIN CONDITIONING

SCORE

	2	low hazard to moderate hazard depending on product usage
	3	low hazard to moderate hazard depending on product usage
	79%	data gap
(why scores have changed)

Also listed as

CYCLOPENTASILOXANE, DECAMETHYL-; DECAMETHYLCYCLOPENTASILOXANE; DECAMETHYL- CYCLOPENTASILOXANE

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Ecotoxicology, Irritation (skin, eyes, or lungs), Data gaps, Biochemical or cellular level changes
	See products containing CYCLOPENTASILOXANE

About CYCLOPENTASILOXANE: Cyclopentasiloxane is the cyclic dimethyl polysiloxane. where n equals 5, and the other components of cyclomethicone (where n equals 3, 4, 6, or 7) are present at levels of less than 1%.

CYCLOPENTASILOXANE has reported used in the following product types: foundation (442); facial moisturizer/treatment (304); conditioner (214); anti-aging (213); sunscreen: makeup (206); antiperspirant/deodorant (179); hair color and bleaching (170); mascara (132); moisturizer (111); sunscreen: moisturizer (110)

Persistence and bioaccumulation

type of concern	product conditions	reference
Persistent, bioaccumulative in wildlife		Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Classified as expected to be toxic or harmful

Environmental Canada Domestic Substance List

Endocrine disruption

type of concern

product conditions

reference

One or more animal studies show endocrine disruption at moderate doses

Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG, 2007

Cancer

type of concern	product conditions	reference
One or more animal studies show tumor formation at moderate doses		Dow Corning Corporation, 2005

Neurotoxicity

type of concern	product conditions	reference
One or more animal studies show effects at moderate doses		Jean PA, McCracken KA, Arthurton JA, Plotzke KP, 2005

Biochemical or cellular level changes

type of concern	product conditions	reference
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		RTECS^®- National Technical Information Service 0101

Ecotoxicology

type of concern

product conditions

reference

Suspected to be an environmental toxin and be persistent or bioaccumulative

Environmental Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

type of concern	product conditions	reference
One or more animal studies show skin irritation at moderate doses		RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
16 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Environmental Canada Domestic Substance List	CYCLOPENTASILOXANE, DECAMETHYL-	•This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulation.
IFRA Fragrance Ingredient List	DECAMETHYLCYCLOPENTASILOXANE	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)	CYCLOPENTASILOXANE, DECAMETHYL	•Suspected persistent, bioaccumulative toxicant - Environment Canada, July 2006 chemical inventory review
Dow Corning Corporation, 2005	DECAMETHYLCYCLOPENTASILOXANE	Uterine tumors in female rats
Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG, 2007	DECAMETHYLCYCLOPENTASILOXANE	Increased anogenital distance observed in rats at a moderate dose.
McKim JM Jr, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A, Meeks RG, 1999	DECAMETHYLCYCLOPENTASILOXANE	Alters activity of liver enzyemes that metabolize chemicals with hormone activity.
Jean PA, McCracken KA, Arthurton JA, Plotzke KP, 2005	DECAMETHYLCYCLOPENTASILOXANE	Moderate dose in rate suggested dopamine D2-receptor behavior on pituitary cells.
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	CYCLOPENTASILOXANE	• sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit )
RTECS^®- National Technical Information Service 0101	CYCLOPENTASILOXANE	• liver - Changes in liver weight (rat TDLo) • biochemical - Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) (rat TDLo) • liver - Other changes (rat TDLo)

references

government/industry list/academic study	reference
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)	EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
Open scientific literature	Dow Corning Corporation. 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.
Open scientific literature	Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG. 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.
Open scientific literature	McKim JM Jr, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A, Meeks RG. 1999. Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopenta- siloxane. Toxicol Sci. 50(1):10-19.
Open scientific literature	Jean PA, McCracken KA, Arthurton JA, Plotzke KP. 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,1234,1986
RTECS^®- National Technical Information Service 0101	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0590101

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