DIAZOLIDINYL UREA || Skin Deep: Cosmetic Safety Reviews

DIAZOLIDINYL UREA

Preservative

SCORE

	6	moderate hazard
	59%	data gap
(why scores have changed)

Also listed as

N- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL] -N,N'-BIS (HYDROXYMETHYL) UREA; UREA, N- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL-N,N'-BIS (HYDROXYMETHYL) -; N- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL-N,N'-BIS (HYDROXYMETHYL) - UREA; DIAZOLIDYNL UREA; 1- [1,3-BIS (HYDROXYMETHYL) -2,5-DIOXOIMIDAZOLIDIN-4-YL] -1,3-BIS (HYDROXYMETHYL) UREA; UREA, N [1,3BIS (HYDROXYMETHYL) 2,5DIOXO4IMIDAZOLIDINYL] N,N BIS (HYDROXYMETHYL) ; GERMALL 11; IMIDAZOLIDINYL UREA 11; N- (1,3-BIS (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL) -N,N'-BIS (HYDROXYMETHYL) UREA

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns - FORMALDEHYDE
	Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive)
	See products containing DIAZOLIDINYL UREA

About DIAZOLIDINYL UREA: Diazolidinyl Urea is the heterocyclic substituted urea.

This ingredient may be derived from animals. From PETA's Caring Consumer: Excreted from urine and other bodily fluids. In deodorants, ammoniated dentifrices, mouthwashes, hair colorings, hand creams, lotions, shampoos, etc. Used to "brown" baked goods, such as pretzels. Derivatives: Imidazolidinyl Urea, Uric Acid. Alternatives: synthetics.

DIAZOLIDINYL UREA has reported used in the following product types: facial moisturizer/treatment (215); anti-aging (167); foundation (142); moisturizer (142); styling gel/lotion (111); facial cleanser (110); sunscreen: makeup (95); conditioner (65); shampoo (52); around-eye cream (47)

Allergies/immunotoxicity

type of concern	product conditions	reference
Known human immune system toxicant		National Library of Medicine HazMap
Human skin toxicant - strong evidence		Cosmetic Ingredient Review Assessments
Human skin toxicant - strong evidence

Cancer

type of concern

product conditions

reference

One or more in vitro tests on mammalian cells show positive mutation results

RTECS^®- Mutation Research 2002

Violations, restrictions & warnings

type of concern	product conditions	reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Neurotoxicity

type of concern

product conditions

reference

One or more animal studies show brain and nervous system effects at high doses

RTECS^®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1995

Endocrine disruption

type of concern	product conditions	reference
One or more animal studies show endocrine system disruption at high doses		RTECS^®- Journal of the American College of Toxicology 1990

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)

RTECS^®- Journal of the American College of Toxicology 1990

Data gaps

type of concern	product conditions	reference
33 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	DIAZOLIDINYL UREA	•Safe for use in cosmetics with some qualifications •Determined safe for use in cosmetics up to a specified concentration limit •May contain harmful impurities •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin
Environmental Canada Domestic Substance List	UREA, N-[1,3-BIS(HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL]-N,N'-BIS(HYDROXYMETHYL )-	•This chemical was NOT flagged by CEPA for further attention.
National Library of Medicine HazMap	DIAZOLIDINYL UREA	•Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes;
RTECS^®- Journal of the American College of Toxicology 1990	DIAZOLIDINYL UREA	• metabolic - Weight loss or decreased weight gain (rat TDLo) • broad systemic - Broad systemic toxicity (rat LD50) • endocrine system - Changes in adrenal weight (rat TDLo) • brain and nervous system - Food intake (animal) (rat TDLo) • gastrointestinal - Gastritis (rat TDLo)
RTECS^®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1995	DIAZOLIDINYL UREA	• gastrointestinal - Changes in structure or function of salivary glands (mouse LD50) • brain and nervous system - Altered sleep time (including change in righting reflex) (mouse LD50) • brain and nervous system - Ataxia (mouse LD50)
RTECS^®- Mutation Research 2002	DIAZOLIDINYL UREA	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) • mutagenic - Positive mutation assay: Micronucleus test (hamster fbr)
RTECS^®- Mutation Research 2002	DIAZOLIDINYL UREA	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) • mutagenic - Positive mutation assay: Micronucleus test (hamster fbr)

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
RTECS^®- Journal of the American College of Toxicology 1990	RTECS^®- Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. 9(2),229,1990
RTECS^®- Journal of Toxicology, Cutaneous and Ocular Toxicology 1995	RTECS^®- Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- 14,3,1995
RTECS^®- Mutation Research 2002	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 514,133,2002
RTECS^®- Mutation Research 2002	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 514,133,2002

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