FLUORIDE ION
Also listed as
FLUORIDE; FLUORIDE ION (1-) ; FLUORIDE ION (F-) ; FLUORIDE (1-) ; FLUORINE ION (1-) ; HYDROFLUORIC ACID, ION (1-) ; PERFLUORIDE
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
 | Other strong concerns for this ingredient: Occupational hazards |
| Other moderate concerns for this ingredient: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive) |
 | Lesser or emerging concerns for this ingredient: Data gaps |
|
See products containing FLUORIDE ION | |
FLUORIDE ION has reported used in the following product types: toothpaste (1); tooth whitening (1)
Neurotoxicity
| type of concern | product conditions | reference |
| Strong evidence of human neurotoxicity | Chemicals known to be neurotoxic to humans | |
| show more | ||
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| Human nervous system toxicant - moderate evidence | Chemicals known to be neurotoxic to humans | |
| show more | ||
Occupational hazards
| type of concern | product conditions | reference |
| Allowed workplace exposures restricted to low doses | RTECS®- TLV/BEI,2006 |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Possible human renal toxicant | CHE Toxicant and Disease Database | |
| Possible human musculoskeletal toxicant | CHE Toxicant and Disease Database | |
| One or more animal studies show broad systemic effects at very low doses | RTECS®- Microvascular Research 1974 | |
| show more | ||
Endocrine disruption
| type of concern | product conditions | reference |
| Limited evidence of endocrine disruption | CHE Toxicant and Disease Database |
Cancer
| type of concern | product conditions | reference |
| Cancer - limited evidence | CHE Toxicant and Disease Database | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 5,893 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Canada - Prohibited and Restricted Cosmetics Ingredients | FLUORIDE | •Use is restricted in Canadian cosmetics |
| CHE Toxicant and Disease Database | FLUORIDE | •Limited evidence in humans: musculoskeletal system toxicity; Condition: bone cancer/Ewings sarcoma; Organs/tissues affected: bone |
| CHE Toxicant and Disease Database | FLUORIDE | •Limited evidence in humans: nervous system toxicity, developmental toxicity; Condition: cognitive impairment (includes impaired learning, impaired memory, and decreased attention span)/mental retardation/developmental delay; Organs/tissues affected: brain |
| CHE Toxicant and Disease Database | FLUORIDE | •Moderate evidence in humans: renal system toxicity; Condition: glomerulonephritis; Organs/tissues affected: kidney |
| CHE Toxicant and Disease Database | FLUORIDE | •Moderate evidence in humans: musculoskeletal system toxicity; Condition: osteoporosis; Organs/tissues affected: bone |
| CHE Toxicant and Disease Database | FLUORIDE | •Moderate evidence in humans: musculoskeletal system toxicity; Condition: osteosclerosis; Organs/tissues affected: bone |
| CHE Toxicant and Disease Database | FLUORIDE | •Limited evidence in humans: endocrine system toxicity; Condition: thyroid disorders - hypothyroidism; Organs/tissues affected: thyroid gland |
| Chemicals known to be neurotoxic to humans | FLUORIDE COMPOUNDS | •Known to be neurotoxic to humans, suspected developmental neurotoxin |
| California EPA, Office of Environmental Health Hazard Assessment | FLUORIDE | •Musculoskeletal toxicity hazards: suspected |
| California EPA, Office of Environmental Health Hazard Assessment | FLUORIDE | •Respiratory toxicity hazards: suspected |
| RTECS®- TLV/BEI,2006 | FLUORIDE ION | • occupationally related - ACGIH TLV (human TWA) |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | FLUORIDE ION | • mutagenic - Positive mutation assay: DNA Inhibition (mouse fbr) |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | FLUORIDE ION | • mutagenic - Positive mutation assay: DNA Inhibition (mouse fbr) |
| RTECS®- Bromatologia i Chemia Toksykologiczna 1989 | FLUORIDE ION | • reproductive - Behavioral (rat TDLo) |
| RTECS®- Bulletin of Environmental Contamination and Toxicology 1981 | FLUORIDE ION | • kidney or renal system - Other changes (rat TDLo) • metabolic - Other metals (rat TDLo) |
| RTECS®- Food and Chemical Toxicology 2001 | FLUORIDE ION | • musculoskeletal - Changes in teeth and supporting structures (rat TDLo) • metabolic - Weight loss or decreased weight gain (rat TDLo) • kidney or renal system - Proteinuria (rat TDLo) |
| RTECS®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 1982 | FLUORIDE ION | • brain and nervous system - Convulsions or effect on seizure threshold ( human TDLo) • liver - Other changes ( human TDLo) |
| RTECS®- Microvascular Research 1974 | FLUORIDE ION | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Neurotoxicology and Teratology 2002 | FLUORIDE ION | • musculoskeletal - Changes in teeth and supporting structures (rat TDLo) • metabolic - Weight loss or decreased weight gain (rat TDLo) • brain and nervous system - Other degenerative changes (rat TDLo) |
| RTECS®- Toxicologist 2004 | FLUORIDE ION | • musculoskeletal - Osteoporosis ( human TDLo) |
references
| government/industry list/academic study | reference |
| Canada - Prohibited and Restricted Cosmetics Ingredients | Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. |
| Chemicals known to be neurotoxic to humans | Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. |
| Scorecard.org Toxicity Information | California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document |
| Scorecard.org Toxicity Information | California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document |
| RTECS®- TLV/BEI,2006 | RTECS®- TLV/BEI,2006 |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | RTECS®- Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH 45,96,1979 |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | RTECS®- Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH 45,96,1979 |
| RTECS®- Bromatologia i Chemia Toksykologiczna 1989 | RTECS®- Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- -1971 22,158,1989 |
| RTECS®- Bulletin of Environmental Contamination and Toxicology 1981 | RTECS®- Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- 26,428,1981 |
| RTECS®- Food and Chemical Toxicology 2001 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 39,615,2001 |
| RTECS®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 1982 | RTECS®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- 27,237,1982 |
| RTECS®- Microvascular Research 1974 | RTECS®- Microvascular Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- -1968 8,320,1974 |
| RTECS®- Neurotoxicology and Teratology 2002 | RTECS®- Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- 24,751,2002 |
| RTECS®- Toxicologist 2004 | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 78,366,2004 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
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