HYDROXYCITRONELLAL || Skin Deep: Cosmetic Safety Reviews

HYDROXYCITRONELLAL

Fragrance Ingredient; MASKING

SCORE

	5	moderate hazard to moderate hazard depending on product usage
	6
	62%	data gap
(why scores have changed)

Also listed as

7-HYDROXY-3,7-DIMETHYLOCTANOL; OCTANOL, 7-HYDROXY-3,7-DIMETHYL-; 7-HYDROXY-3,7-DIMETHYL- OCTANOL; 7-HYDROXYCITRONELLAL; OCTANAL, 7HYDROXY3,7DIMETHYL; 3,7-DIMETHYL-7-HYDROXYOCTANAL; 7-HYDROXY-3,7-DIMETHYLOCTAN-1-AL; 7-HYDROXYCITRONELLAL; CITRONELLAL HYDRATE; CITRONELLAL, HYDROXY-; CYCLALIA

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
	Lesser or emerging concerns for this ingredient: Data gaps
	See products containing HYDROXYCITRONELLAL

About HYDROXYCITRONELLAL: Hydroxycitronellal is the aldehyde.

HYDROXYCITRONELLAL has reported used in the following product types: fragrance for women (55); hair color and bleaching (38); lipstick (32); moisturizer (23); body spray (22); conditioner (22); styling gel/lotion (20); facial moisturizer/treatment (15); fragrance for men (14); shampoo (13)

Allergies/immunotoxicity

type of concern	product conditions	reference
Known human immune system toxicant		EU Banned and Restricted Fragrances

Violations, restrictions & warnings

type of concern	product conditions	reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		International Fragrance Association Codes & Standards

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show sense organ effects at very low doses

products for use around the eyes, mouth, or lips

RTECS^®- National Technical Information Service 5057

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

One or more animal studies show skin irritation at low doses

RTECS^®- Cosmetics and Toiletries 1979

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
43 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
FDA Everything Added to Food	HYDROXYCITRONELLAL	• Fully up-to-date toxicology information has been sought.
EU Banned and Restricted Fragrances	HYDROXYCITRONELLAL	Fragrance chemical, which, according to existing knowledge, is frequently reported as a well-recognised consumer allergen
International Fragrance Association Codes & Standards	HYDROXYCITRONELLAL	•Fragrance subject to restrictions: safe only within recommended use or concentration limits
Environmental Canada Domestic Substance List	OCTANAL, 7-HYDROXY-3,7-DIMETHYL-	•This chemical was NOT flagged by CEPA for further attention.
IFRA Fragrance Ingredient List	HYDROXYCITRONELLAL	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
International Fragrance Association Codes & Standards	HYDROXYCITRONELLAL	•Fragrance subject to restrictions: safe only within recommended use or concentration limits
International Fragrance Association Codes & Standards	HYDROXYCITRONELLAL	•Fragrance subject to restrictions: safe only within recommended use or concentration limits
International Fragrance Association Codes & Standards	#22 43A HYDROXYCITRONELLAL	•Fragrance subject to restrictions: safe only within recommended use or concentration limits
RTECS^®- Contact Dermatitis 2001	HYDROXYCITRONELLAL	• skin - Cutaneous sensitization (experimental) (mouse TDLo)
RTECS^®- Cosmetics and Toiletries 1979	HYDROXYCITRONELLAL	• skin - Primary skin irritant (rabbit )
RTECS^®- Cosmetics and Toiletries 1979	HYDROXYCITRONELLAL	• skin - Primary skin irritant (rabbit )
RTECS^®- Food and Cosmetics Toxicology 1974	HYDROXYCITRONELLAL	• skin - Primary skin irritant (rabbit )
RTECS^®- National Technical Information Service 5057	HYDROXYCITRONELLAL	• sense organ - Primary eye irritant (rabbit )
RTECS^®- National Technical Information Service 5057	HYDROXYCITRONELLAL	• sense organ - Primary eye irritant (rabbit )

references

government/industry list/academic study	reference
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
EU Banned and Restricted Fragrances	SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000.
International Fragrance Association Codes & Standards	IFRA (International Fragrance Association). 2006. Codes and Standards.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS^®- Contact Dermatitis 2001	RTECS^®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- 45,89,2001
RTECS^®- Cosmetics and Toiletries 1979	RTECS^®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- 94(8),41,1979
RTECS^®- Cosmetics and Toiletries 1979	RTECS^®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 94(8),41,1979
RTECS^®- Food and Cosmetics Toxicology 1974	RTECS^®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 12,921,1974
RTECS^®- National Technical Information Service 5057	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0535057
RTECS^®- National Technical Information Service 5057	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0535057

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