IMIDAZOLIDINYL UREA || Skin Deep: Cosmetic Safety Reviews

IMIDAZOLIDINYL UREA

Preservative

SCORE

	5	moderate hazard
	70%	data gap
(why scores have changed)

Also listed as

N,N"-METHYLENEBIS [N'- [1- (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL] UREA] ; UREA, N,N"-METHYLENEBIS [N'- [1- (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL] -; N,N''-METHYLENEBIS [N'- [3- (HYDROXYMETHYL) -2,5-DIOXOIMIDAZOLIDIN-4-YL] UREA] ; UREA, N,N METHYLENEBIS [N [3 (HYDROXYMETHYL) 2,5DIOXO4IMIDAZOLIDINYL] ; GERMALL 115; METHANEBIS (N,N'- (5-UREIDO-2,4-DIKETOTETRAHYDROIMIDAZOLE) -N,N-DIMETHYLOL) ; N,N''-METHYLENEBIS (N'- (1- (HYDROXYMETHYL) -2,5-DIOXO-4-IMIDAZOLIDINYL) UREA)

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns - FORMALDEHYDE
	Lesser or emerging concerns for this ingredient: Organ system toxicity (non-reproductive), Data gaps
	See products containing IMIDAZOLIDINYL UREA

About IMIDAZOLIDINYL UREA: Imidazolidinyl Urea is the heterocyclic substituted urea.

This ingredient may be derived from animals. From PETA's Caring Consumer: Excreted from urine and other bodily fluids. In deodorants, ammoniated dentifrices, mouthwashes, hair colorings, hand creams, lotions, shampoos, etc. Used to "brown" baked goods, such as pretzels. Derivatives: Imidazolidinyl Urea, Uric Acid. Alternatives: synthetics.

IMIDAZOLIDINYL UREA has reported used in the following product types: facial moisturizer/treatment (101); eye shadow (85); mascara (74); anti-aging (57); foundation (50); facial cleanser (41); moisturizer (39); facial powder (34); body wash/cleanser (27); sunscreen: makeup (24)

Allergies/immunotoxicity

type of concern	product conditions	reference
Known human immune system toxicant		National Library of Medicine HazMap
Human skin toxicant - strong evidence		Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)

RTECS^®- Journal of Environmental Pathology and Toxicology 1980

Data gaps

type of concern	product conditions	reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		Cosmetic Ingredient Review Assessments
60 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	IMIDAZOLIDINYL UREA	•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin
Environmental Canada Domestic Substance List	UREA, N,N''-METHYLENEBIS[N'-[3- (HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]-	•This chemical was NOT flagged by CEPA for further attention.
IFRA Fragrance Ingredient List	UREA, N,N'-METHYLENEBIS[N'-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]-	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
National Library of Medicine HazMap	IMIDAZOLIDINYL UREA	•Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes;
RTECS^®- Journal of Environmental Pathology and Toxicology 1980	IMIDAZOLIDINYL UREA	• gastrointestinal - Hypermotility, diarrhea (rat LDLo) • gastrointestinal - Ulceration or bleeding from duodenum (rat LDLo) • gastrointestinal - Ulceration or bleeding from stomach (rat LDLo)

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
RTECS^®- Journal of Environmental Pathology and Toxicology 1980	RTECS^®- Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. 4(4),133,1980

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