ISOPROPYLPARABEN || Skin Deep: Cosmetic Safety Reviews

ISOPROPYLPARABEN

Preservative

SCORE

	3	moderate hazard
	84%	data gap
(why scores have changed)

Also listed as

BENZOIC ACID, 4-HYDROXY-, 1-METHYLETHYL ESTER; P-HYDROXYBENZOIC ACID ISOPROPYL ESTER; 4-HYDROXYBENZOIC ACID, 1-METHYLETHYL ESTER; ISOPROPYL P-HYDROXYBENZOATE; 1-METHYLETHYL-4-HYDROXYBENZOATE; PARAHYDROXYBENZOATE, ISOPROPYL ESTER; 1-METHYLETHYL ESTER BENZOIC ACID, 4-HYDROXY-; 1-METHYLETHYL ESTER 4-HYDROXYBENZOIC ACID; ISOPROPYL ESTER PARAHYDROXYBENZOATE; 4-HYDROXY- 1-METHYLETHYL ESTER BENZOIC ACID; BENZOIC ACID, 4HYDROXY, 1METHYLETHYL ESTER

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Endocrine disruption, Data gaps
	See products containing ISOPROPYLPARABEN

About ISOPROPYLPARABEN: Isopropylparaben is the ester of isopropyl alcohol and p-hydroxybenzoic acid. It conforms tothe formula:

ISOPROPYLPARABEN has reported used in the following product types: lipstick (92); lip gloss (49); eye shadow (34); mascara (33); lip plumper (30); facial moisturizer/treatment (28); sunscreen: makeup (23); eye liner (21); blush (17); foundation (17)

Allergies/immunotoxicity

type of concern	product conditions	reference
Human skin toxicant - strong evidence		Cosmetic Ingredient Review Assessments
Human skin toxicant - strong evidence

Endocrine disruption

type of concern	product conditions	reference
One or more studies show weak endocrine disruption		Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD, 2002

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Limited evidence of sense organ toxicity

Harvell, J, 1994

Data gaps

type of concern	product conditions	reference
Safety assessment was based on related chemical		Cosmetic Ingredient Review Assessments
6 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	ISOPROPYLPARABEN	•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Determined safe for use in cosmetics based on concentrations of surrogate, related chemical in cosmetics, by industry safety panel (Cosmetic Ingredient Review, CIR) • •Safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) is based on safety or product use data for a different, related ingredient •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin
Environmental Canada Domestic Substance List	BENZOIC ACID, 4-HYDROXY-, 1-METHYLETHYL ESTER	•This chemical was NOT flagged by CEPA for further attention.
Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD, 2002	PARABENS	•Hormonally active (parabens)
Harvell, J, 1994	PARABENS	•Skin or sense organ toxicity hazards: suspected
RTECS^®- Archives Internationales de Pharmacodynamie et de Therapie 1960	ISOPROPYLPARABEN	• broad systemic - Broad systemic toxicity (mouse LD50)

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EWG Assessment of Open Scientific Literature	Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD. Oestrogenic activity of parabens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol. 2002 Jan;80(1):49-60.
Scorecard.org Toxicity Information	Harvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
RTECS^®- Archives Internationales de Pharmacodynamie et de Therapie 1960	RTECS^®- Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- 128,135,1960

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