LINALOOL

Fragrance Ingredient; DEODORANT; MASKING  

Also listed as

2,6-DIMETHYL-2,7-OCTADIEN-6-OL; 3,7-DIMETHYL-1,6-OCTADIEN-3-OL; LINALYL ALCOHOL; 1,6-OCTADIEN-3-OL, 3,7-DIMETHYL-; 2,7-OCTADIEN-6-OL, 2,6-DIMETHYL-; 3,7-DIMETHYL- 1,6-OCTADIEN-3-OL; 2,6-DIMETHYL- 2,7-OCTADIEN-6-OL; LINALOOL ESSENTIAL OIL; 1,6OCTADIEN3OL, 3,7DIMETHYL; 3,7-DIMETHYL-1,6-OCTADIENE-3-OL ; 2,6-DIMETHYLOCTA-2,7-DIEN-6-OL


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
yes, weakCancer
noDevelopmental/reproductive toxicity
yes, moderateViolations, restrictions & warnings
yes, moderateAllergies/immunotoxicity
noContamination concerns
noOther moderate concerns for this ingredient:
Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
noLesser or emerging concerns for this ingredient:
Neurotoxicity, Data gaps
 
See products containing LINALOOL

About LINALOOL: Linalool is the terpene.

LINALOOL has reported used in the following product types: hair color and bleaching (226); facial moisturizer/treatment (202); moisturizer (153); fragrance for women (116); conditioner (112); styling gel/lotion (101); anti-aging (89); body wash/cleanser (79); shampoo (75); lip gloss (67)


Allergies/immunotoxicity

type of concern product conditions reference
Possible human immune system toxicant    EU Banned and Restricted Fragrances

Violations, restrictions & warnings

type of concern product conditions reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limits, according to industry safety panel (International Fragrance Association)   International Fragrance Association Codes & Standards

Neurotoxicity

type of concern product conditions reference
One or more animal studies show brain and nervous system effects at moderate doses    RTECS®- Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite 1973
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Organ system toxicity (non-reproductive)

type of concern product conditions reference
One or more animal studies show sense organ effects at low doses products for use around the eyes, mouth, or lips  RTECS®- National Technical Information Service 3729
show more

Cancer

type of concern product conditions reference
One or more in vitro tests non-mammalian cells show positive mutation results    RTECS®- Osaka-shi Igakkai Zasshi 1985

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
One or more animal studies show skin irritation at very low doses    RTECS®- Cosmetics and Toiletries 1979
show more

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
207 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be persistent     Environmental Canada Domestic Substance List
show more

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin     Environmental Canada Domestic Substance List



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
FDA Everything Added to FoodLINALOOL• Fully up-to-date toxicology information has been sought.
Environmental Canada Domestic Substance List1,6-OCTADIEN-3-OL, 3,7-DIMETHYL-•This chemical was NOT flagged by CEPA for further attention.
EU Banned and Restricted FragrancesLINALOOLFragrance chemical, which is less frequently reported and thus less documented as a consumer allergen.
IFRA Fragrance Ingredient ListLINALOOL•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
International Fragrance Association Codes & StandardsLINALOOL•Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limitation
International Fragrance Association Codes & StandardsLINALOOL•Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limitation
International Fragrance Association Codes & StandardsLINALOOL•Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limitation
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986LINALOOL• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Cosmetics and Toiletries 1979LINALOOL• skin - Primary skin irritant (rabbit )
RTECS®- Cosmetics and Toiletries 1979LINALOOL• skin - Primary skin irritant (rabbit )
RTECS®- Food and Cosmetics Toxicology 1975LINALOOL• broad systemic - Broad systemic toxicity (rabbit LD50)
RTECS®- Food and Cosmetics Toxicology 1976LINALOOL• skin - Primary skin irritant (rabbit )
RTECS®- Food and Cosmetics Toxicology 1964LINALOOL• brain and nervous system - Ataxia (rat LD50)
RTECS®- Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite 1973LINALOOL• brain and nervous system - Ataxia (rat LD50)
• brain and nervous system - Changes in motor activity (specific assay) (rat LD50)
• brain and nervous system - Somnolence (general depressed activity) (rat LD50)
RTECS®- Journal of Scientific and Industrial Research, Section C: Biological Sciences 1962LINALOOL• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- National Technical Information Service 3729LINALOOL• sense organ - Primary eye irritant (rabbit )
RTECS®- National Technical Information Service 3729LINALOOL• brain and nervous system - Ataxia (mouse LD50)
• respiratory - Dyspnea (mouse LD50)
• sense organ - Primary eye irritant (rabbit )
• brain and nervous system - Somnolence (general depressed activity) (mouse LD50)
RTECS®- Osaka-shi Igakkai Zasshi 1985LINALOOL• mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis )
RTECS®- Osaka-shi Igakkai Zasshi 1985LINALOOL• mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis )
RTECS®- Sapporo Igaku Zasshi 1952LINALOOL• brain and nervous system - Spastic paralysis with or without sensory change (mouse LD50)

references

government/industry list/academic study reference
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environmental Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU Banned and Restricted FragrancesSCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 1999. Opinion Concerning Fragrance Allergy In Consumers. . SCCNFP/0017/98 Final, December 1999; and SCCPNFP (Scientific Committee On Cosmetic Products And Non-Food Products). 2000. An Initial List Of Perfumery Materials Which Must Not Form Part Of Fragrances Compounds Used In Cosmetic Products. SCCNFP/0320/00, final May 2000.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
International Fragrance Association Codes & StandardsIFRA (International Fragrance Association). 2006. Codes and Standards.
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,202,1986
RTECS®- Cosmetics and Toiletries 1979RTECS®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- 94(8),41,1979
RTECS®- Cosmetics and Toiletries 1979RTECS®- Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 94(8),41,1979
RTECS®- Food and Cosmetics Toxicology 1975RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 13,827,1975
RTECS®- Food and Cosmetics Toxicology 1976RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 14,673,1976
RTECS®- Food and Cosmetics Toxicology 1964RTECS®- Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. 2,327,1964
RTECS®- Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite 1973RTECS®- Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite. (Sofia, Bulgaria) V.4-16, 1960-74. For publisher information, see APPBDI. 15,149,1973
RTECS®- Journal of Scientific and Industrial Research, Section C: Biological Sciences 1962RTECS®- Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. 21,342,1962
RTECS®- National Technical Information Service 3729RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0543729
RTECS®- National Technical Information Service 3729RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0543729
RTECS®- Osaka-shi Igakkai Zasshi 1985RTECS®- Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- 34,267,1985
RTECS®- Osaka-shi Igakkai Zasshi 1985RTECS®- Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 34,267,1985
RTECS®- Sapporo Igaku Zasshi 1952RTECS®- Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952- 3,73,1952

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.

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