METHOXYISOPROPANOL || Skin Deep: Cosmetic Safety Reviews

METHOXYISOPROPANOL

Fragrance Ingredient; Solvent; Viscosity Decreasing Agent; PERFUMING

SCORE

	3	moderate hazard to moderate hazard depending on product usage
	4
	66%	data gap
(why scores have changed)

Also listed as

1-METHOXY-2-HYDROXYPROPANE; 1-METHOXYPROPAN-2-OL; 1-METHOXY-2-PROPANOL; 2-PROPANOL, 1-METHOXY-; PROPYLENE GLYCOL MONOMETHYL ETHER; 1-METHOXY- 2-PROPANOL; 2PROPANOL, 1METHOXY; PROPYLENE GLYCOL 1-METHYL ETHER; 1-METHOXY-2-PROPANOL; ALPHA-PROPYLENE GLYCOL MONOMETHYL ETHER; DOWANOL 33B

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
	Lesser or emerging concerns for this ingredient: Data gaps
	See products containing METHOXYISOPROPANOL

About METHOXYISOPROPANOL: Methoxyisopropanol is the aliphatic ether alcohol.

METHOXYISOPROPANOL has reported used in the following product types: nail polish (11); nail treatment (1); styling gel/lotion (1)

Violations, restrictions & warnings

type of concern	product conditions	reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		Cosmetic Ingredient Review Assessments

Developmental/reproductive toxicity

type of concern	product conditions	reference
Limited evidence of reproductive toxicity		National Library of Medicine HazMap

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Limited evidence of kidney toxicity

National Library of Medicine HazMap

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

Human irritant - strong evidence

products for use around the eyes, on the skin, or may be aerosolized (airborne)

Cosmetic Ingredient Review Assessments

Occupational hazards

type of concern

product conditions

reference

Allowed workplace exposures restricted to high doses

RTECS^®- TLV/BEI,2006

Data gaps

type of concern	product conditions	reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		Cosmetic Ingredient Review Assessments
Considered safe based on assumption of low absorption		Cosmetic Ingredient Review Assessments
Safety unknown for products that may be inhaled	products that may be aerosolized (airborne)	Cosmetic Ingredient Review Assessments
55 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Neurotoxicity

type of concern	product conditions	reference
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		National Library of Medicine HazMap

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
European Union - Classification & Labelling	1-METHOXY-2-PROPANOL; MONOPROPYLENE GLYCOL METHYL ETHER	R10 R67
Cosmetic Ingredient Review Assessments	METHOXYISOPROPANOL	•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Insufficient data to determine safety of products where ingredients are likely to be inhaled •Product type restrictions or differences noted in safety assessment by industry panel • • • •Determined safe for use in cosmetics based on assumption of low absorption through skin •Irritation (eyes, skin, or lungs)
National Library of Medicine HazMap	PROPYLENE GLYCOL MONOMETHYL ETHER	•Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male and female reproductive function: Yes; •Nephrotoxin: Yes; •Neurotoxin: CNS Solvent Syndrome; •STEL (ACGIH) - Short-term exposure limits (ACGIH): 150 ppm; •TLV (ACGIH) - Threshold limit value (ACGIH): 100 ppm; •Flammability (NFPA) - NFPA flammability code: 0 = will not burn; 1 = must be preheated; 2 = high ambient temp required; 3 = may ignite at ambient temp; 4 = burn readily: 3: may ignite at ambient temperature; •Odor Threshold Low - The lowest concentration at which a substance can be detected or recognized using the sense of smell: 10 ppm; •MAK - Maximum Allowable Concentration (Federal Republic of Germany): 100 ppm;
EPA Categorized List of Inert Pesticide Ingredients	2- METHOXY-1-METHYLETHANOL	•Pesticide inerts: potentially toxic, testing priority, according to EPA (Environmental Protection Agency)
California EPA, Office of Environmental Health Hazard Assessment, 2003	PROPYLENE GLYCOL MONOMETHYL ETHER	•Gastrointestinal or liver toxicity hazards: suspected
Environmental Canada Domestic Substance List	2-PROPANOL, 1-METHOXY-	•This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for as a low human health priority.
IFRA Fragrance Ingredient List	1-METHOXYPROPAN-2-OL	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
RTECS^®- TLV/BEI,2006	METHOXYISOPROPANOL	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- TLV/BEI,2007	METHOXYISOPROPANOL	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	METHOXYISOPROPANOL	• sense organ - Primary eye irritant (rabbit )
RTECS^®- MSHA STANDARD-air: 3,27,1973	METHOXYISOPROPANOL	• occupationally related - MSHA STANDARD-air (human TWA)
RTECS^®- Union Carbide Data Sheet 1971	METHOXYISOPROPANOL	• skin - Primary skin irritant (rabbit )

references

government/industry list/academic study	reference
European Union - Classification & Labelling	CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
EPA Categorized List of Inert Pesticide Ingredients	EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
Scorecard.org Toxicity Information	California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document 'Determination of Noncancer Chronic Reference Exposure Levels'. Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (http://www.oehha.ca.gov/air/chronic_rels/AllChrels.html, plus draft CRELS proposed through March 2004 (http://www.oehha.ca.gov/air/chronic_rels/index.html., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS^®- TLV/BEI,2006	RTECS^®- TLV/BEI,2006
RTECS^®- TLV/BEI,2007	RTECS^®- TLV/BEI,2007
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,625,1986
RTECS^®- MSHA STANDARD-air: 3,27,1973	RTECS^®- MSHA STANDARD-air: 3,27,1973
RTECS^®- Union Carbide Data Sheet 1971	RTECS^®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 11/15/1971

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