SODIUM MONOFLUOROPHOSPHATE
Anticaries Agent; Oral Care Agent; ANTIPLAQUE
Also listed as
MFP; PHOSPHOROFLUORIDIC ACID, SODIUM SALT; SODIUM PHOSPHOROFLUORIDATE; SODIUM SALT PHOSPHOROFLUORIDIC ACID; DISODIUM FLUOROPHOSPHATE; DISODIUM MONOFLUOROPHOSPHATE; DISODIUM PHOSPHOROFLUORIDATE; SODIUM FLUOROPHOSPHATE (NA2PO3F) ; SODIUM PHOSPHOROFLUORIDATE; SODIUM PHOSPHOROFLURIDATE
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
 | Other strong concerns for this ingredient: Occupational hazards |
| Other moderate concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive) |
| Lesser or emerging concerns for this ingredient: Data gaps |
|
See products containing SODIUM MONOFLUOROPHOSPHATE | |
About SODIUM MONOFLUOROPHOSPHATE: See "Regulatory and Ingredient Use Information," regard ing the labeling names for U.S. OTC Drug Ingredients in Volume 1, Introduction, Part A.
SODIUM MONOFLUOROPHOSPHATE has reported used in the following product types: toothpaste (51); tooth whitening (18); mouthwash (1)
Neurotoxicity
| type of concern | product conditions | reference |
| Strong evidence of human neurotoxicity | Chemicals known to be neurotoxic to humans | |
| show more | ||
Violations, restrictions & warnings
| type of concern | product conditions | reference |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| Human nervous system toxicant - moderate evidence | Chemicals known to be neurotoxic to humans | |
| show more | ||
Occupational hazards
| type of concern | product conditions | reference |
| Allowed workplace exposures restricted to low doses | RTECS®- TLV/BEI,2006 |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at very low doses | RTECS®- Microvascular Research 1974 | |
| show more | ||
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- Acta Pharmacologica et Toxicologica 1979 | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 176 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be bioaccumulative | Environmental Canada Domestic Substance List |
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Canada - Prohibited and Restricted Cosmetics Ingredients | SODIUM MONOFLUOROPHOSPHATE | •Use is restricted in Canadian cosmetics |
| Environmental Canada Domestic Substance List | PHOSPHOROFLUORIDIC ACID, SODIUM SALT | •This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected persistence. |
| Chemicals known to be neurotoxic to humans | FLUORIDE COMPOUNDS | •Known to be neurotoxic to humans, suspected developmental neurotoxin |
| California EPA, Office of Environmental Health Hazard Assessment | FLUORIDE | •Musculoskeletal toxicity hazards: suspected |
| California EPA, Office of Environmental Health Hazard Assessment | FLUORIDE | •Respiratory toxicity hazards: suspected |
| RTECS®- TLV/BEI,2006 | SODIUM MONOFLUOROPHOSPHATE | • occupationally related - ACGIH TLV (human TWA) |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | SODIUM MONOFLUOROPHOSPHATE | • mutagenic - Positive mutation assay: DNA Inhibition (mouse fbr) |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | SODIUM MONOFLUOROPHOSPHATE | • mutagenic - Positive mutation assay: DNA Inhibition (mouse fbr) |
| RTECS®- Bromatologia i Chemia Toksykologiczna 1989 | SODIUM MONOFLUOROPHOSPHATE | • reproductive - Behavioral (rat TDLo) |
| RTECS®- Bulletin of Environmental Contamination and Toxicology 1981 | SODIUM MONOFLUOROPHOSPHATE | • kidney or renal system - Other changes (rat TDLo) • metabolic - Other metals (rat TDLo) |
| RTECS®- Food and Chemical Toxicology 2001 | SODIUM MONOFLUOROPHOSPHATE | • musculoskeletal - Changes in teeth and supporting structures (rat TDLo) • metabolic - Weight loss or decreased weight gain (rat TDLo) • kidney or renal system - Proteinuria (rat TDLo) |
| RTECS®- Genetics 1977 | SODIUM MONOFLUOROPHOSPHATE | • mutagenic - Positive mutation assay: Dominant Lethal Strain (Drosophila melanogaster orl) |
| RTECS®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 1982 | SODIUM MONOFLUOROPHOSPHATE | • brain and nervous system - Convulsions or effect on seizure threshold ( human TDLo) • liver - Other changes ( human TDLo) |
| RTECS®- Microvascular Research 1974 | SODIUM MONOFLUOROPHOSPHATE | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Neurotoxicology and Teratology 2002 | SODIUM MONOFLUOROPHOSPHATE | • musculoskeletal - Changes in teeth and supporting structures (rat TDLo) • metabolic - Weight loss or decreased weight gain (rat TDLo) • brain and nervous system - Other degenerative changes (rat TDLo) |
| RTECS®- Toxicologist 2004 | SODIUM MONOFLUOROPHOSPHATE | • musculoskeletal - Osteoporosis ( human TDLo) |
references
| government/industry list/academic study | reference |
| Canada - Prohibited and Restricted Cosmetics Ingredients | Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| Chemicals known to be neurotoxic to humans | Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. |
| Scorecard.org Toxicity Information | California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document |
| Scorecard.org Toxicity Information | California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document |
| RTECS®- TLV/BEI,2006 | RTECS®- TLV/BEI,2006 |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | RTECS®- Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH 45,96,1979 |
| RTECS®- Acta Pharmacologica et Toxicologica 1979 | RTECS®- Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH 45,96,1979 |
| RTECS®- Bromatologia i Chemia Toksykologiczna 1989 | RTECS®- Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- -1971 22,158,1989 |
| RTECS®- Bulletin of Environmental Contamination and Toxicology 1981 | RTECS®- Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- 26,428,1981 |
| RTECS®- Food and Chemical Toxicology 2001 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 39,615,2001 |
| RTECS®- Genetics 1977 | RTECS®- Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 87,67,1977 |
| RTECS®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 1982 | RTECS®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- 27,237,1982 |
| RTECS®- Microvascular Research 1974 | RTECS®- Microvascular Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- -1968 8,320,1974 |
| RTECS®- Neurotoxicology and Teratology 2002 | RTECS®- Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- 24,751,2002 |
| RTECS®- Toxicologist 2004 | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 78,366,2004 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
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