ALUMINUM DICHLOROHYDREX PEG || Skin Deep: Cosmetic Safety Reviews

ALUMINUM DICHLOROHYDREX PEG

Antiperspirant Agent; Cosmetic Astringent; Deodorant Agent

SCORE

	7	high hazard to high hazard depending on product usage
	9	high hazard to high hazard depending on product usage
	74%	data gap
(why scores have changed)

Also listed as

ALUMINUM DICHLOROHYDREX POLYETHYLENE GLYCOL COMPLEX

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns - ETHYLENE OXIDE, 1,4-DIOXANE
	Other moderate concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Data gaps

About ALUMINUM DICHLOROHYDREX PEG: Aluminum Dichlorohydrex PEG is a coordination complex of Aluminum Dichlorohydrate (q.v.)and polyethylene glycol in which some of the water molecules normally coordinated to the metal havebeen displaced by the polyethylene glycol. In the Unite d States, Aluminum Dichlorohydrex PEG may beused as an active ingredient OTC drug products. When used as an active drug ingredient, the establishedname for Aluminum Dichlorohydrex PEG is Aluminum Dichlorohydrex Polyethylene Glycol. See"Regulatory and In gredient Use Information," regarding the labeling names for U.S. OTC Drug Ingredientsin Volume 1, Introduction, Part A.

Violations, restrictions & warnings

type of concern	product conditions	reference
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	Cosmetic Ingredient Review Assessments
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Neurotoxicity

type of concern	product conditions	reference
Strong evidence of human neurotoxicity		Chemicals known to be neurotoxic to humans

Developmental/reproductive toxicity

type of concern	product conditions	reference
Human nervous system toxicant - moderate evidence		Chemicals known to be neurotoxic to humans

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Limited evidence of toxicity

products that may be aerosolized (airborne)

Klaassen, C

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Food Additive Status

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Chemicals known to be neurotoxic to humans	ALUMINUM COMPOUNDS	•Known to be neurotoxic to humans, suspected developmental neurotoxin
Klaassen, C	ALUMINUM COMPOUNDS	•Respiratory toxicity hazards: suspected
FDA Food Additive Status	POLYETHYLENE GLYCOL	• Food additive: boiler compound • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • In boiler water -173.310 • Food additive: antifoaming (or defoaming) agent • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Comp of defoaming agent -173.340 • CTG • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Ctg on fresh citrus fruits -172.210
FDA Food Additive Status	POLYETHYLENE GLYCOL	• miscellaneous • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Ctg • binder • plasticizing agent • and/or lubricant in tablets used for food • Adjuvant in nonnutritive sweeteners • vitamin and mineral preparations • Ctg for sodium nitrite to inhibit hygroscopic properties - CFR172.820 • ZERO - In milk - CFR172.820; 526.820
Cosmetic Ingredient Review Assessments	PEG-6	•Safe for use in cosmetics with some qualifications •Not safe for use on injured or damaged skin •May contain harmful impurities
CIR	PEG-6	•Ethylene oxide
Harvell, J, 1994	POLYETHYLENE GLYCOL	•Skin or sense organ toxicity hazards: suspected

references

government/industry list/academic study	reference
Chemicals known to be neurotoxic to humans	Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78.
Scorecard.org Toxicity Information	Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull
FDA Food Additive Status	FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Impurities - Open Scientific Literature	CIR
Scorecard.org Toxicity Information	Harvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).

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