BUTYL BENZYL PHTHALATE

Plasticizer  

Also listed as

1,2-BENZENEDICARBOXYLIC ACID, BUTYL PHENYLMETHYL ESTER; PHTHALIC ACID, BENZYL BUTYL ESTER; BUTYL PHENYLMETHYL ESTER 1,2-BENZENEDICARBOXYLIC ACID; BENZYL BUTYL ESTER PHTHALIC ACID; BBP; BENZYL BUTYL PHTHALATE; BUTYL BENZYLPHTHALATE; BZBP; 1,2-BENZENEDICARBOXYLIC ACID, BUTYL PHENYLMETHYL ESTER; AI3-14777; BBP


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
yes, moderateCancer
yes, moderateDevelopmental/reproductive toxicity
noViolations, restrictions & warnings
noAllergies/immunotoxicity
noContamination concerns
noOther moderate concerns for this ingredient:
Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
noLesser or emerging concerns for this ingredient:
Neurotoxicity, Ecotoxicology, Data gaps
 

About BUTYL BENZYL PHTHALATE: Butyl Benzyl Phthalate is the aromatic ester.


Developmental/reproductive toxicity

type of concern product conditions reference
Possible human developmental toxicant    California EPA Proposition 65
Limited evidence of developmental toxicity    European Union - Classification & Labelling
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Endocrine disruption

type of concern product conditions reference
Human disruptor - strong evidence    European Commission on Endocrine Disruption
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Cancer

type of concern product conditions reference
Limited evidence of carcinogenicity    EPA Integrated Risk Information System (IRIS)
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Persistence and bioaccumulation

type of concern product conditions reference
Persistent or bioaccumulative and moderate to high toxicity concern in humans    Environmental Canada Domestic Substance List
Persistent, bioaccumulative in wildlife    OSPAR PBTs - Substances of Possible Concern
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Organ system toxicity (non-reproductive)

type of concern product conditions reference
One or more animal studies show broad systemic effects at very low doses    RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1988
Classified as expected to be toxic or harmful    Environmental Canada Domestic Substance List
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Neurotoxicity

type of concern product conditions reference
One or more animal studies show brain and nervous system effects at high doses    RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1980
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Ecotoxicology

type of concern product conditions reference
Wildlife and environmental toxicity    European Union - Classification & Labelling
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Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
167 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
European Union - Classification & LabellingBBP•May cause harm to the unborn child
•Possible risk of impaired fertility
•Dangerous for the environment
•Very toxic to aquatic organisms
Cosmetic Ingredient Review AssessmentsBUTYL BENZYL PHTHALATE•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR)
•Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product
EPA Clean Water Act - Priority PollutantsBENZYL BUTYL PHTHALATE•Priority water pollutant under the Clean Water Act
Environmental Canada Domestic Substance List1,2-BENZENEDICARBOXYLIC ACID, BUTYL PHENYLMETHYL ESTER•This chemical was flagged for further attention by CEPA due to suspected bioaccumulation and aquatic toxicity. The chemical was also flagged as a low human health priority.
Illinois EPA Chemicals Associated with Endocrine SystemBUTYL BENZYL PHTHALATE•EPA: suspected endocrine disruptor
EPA Integrated Risk Information System (IRIS)BUTYL BENZYL PHTHALATE•Group C: Possible human carcinogen (EPA classification)
European Commission on Endocrine DisruptionBUTYLBENZYLPHTHALATE (BBP)•Evidence of endocrine disrupting activity in at least one species using intact animals, high human health concern.
•No evidence of endocrine disrupting activity or no data available.
Int'l Agency for Research on Cancer (IARC) - CarcinogensBUTYL BENZYL PHTHALATE•IARC Group 3 (no cancer link)
EPA Categorized List of Inert Pesticide IngredientsBUTYL BENZYL PHTHALATE•Pesticide inerts: potentially toxic, testing priority, according to EPA (Environmental Protection Agency)
NTP - Risks to Human ReproductionBUTYL BENZYL PHTHALATEREPRO: Men: negligle concern; Women: data are insufficient to reach conclusions. || DEVELOPMENT: Fetuses and children: minimal concern
Our Stolen Future Endocrine DisruptorsBUTYL BENZYL PHTHALATE (BBP)
OSPAR PBTs - Substances of Possible ConcernBUTYL PHENYLMETHYL ESTER1,2-BENZENEDICARBOXYLIC ACID•Persistent, bioaccumulative toxicant - Oslo-Paris (OSPAR) Convention for the Protection of the Marine Environment of the North-East Atlantic, chemical of concern
EPA Toxic Release Inventory PBTsBUTYL PHENYLMETHYL ESTER1,2-BENZENEDICARBOXYLIC ACID•Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs
California EPA Proposition 65BUTYL BENZYL PHTHALATE (BBP)•Developmental toxin: California Proposition 65
BKH/European Commission, 2000BENZYL BUTYL PHTHALATE•Endocrine toxicity hazards: suspected
National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, 2002BENZYL BUTYL PHTHALATE•Reproductive toxicity hazards: suspected
National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, 2002BENZYL BUTYL PHTHALATE•Developmental toxicity hazards: suspected
RTECS®- EHP, Environmental Health Perspectives 1995BUTYL BENZYL PHTHALATE• developmental - Delayed effects (rat TDLo)
• reproductive - Urogenital system (rat TDLo)
RTECS®- EHP, Environmental Health Perspectives 1973BUTYL BENZYL PHTHALATE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- EHP, Environmental Health Perspectives 1986BUTYL BENZYL PHTHALATE• cancer - blood tumors (rat TD)
RTECS®- Environmental and Molecular Mutagenesis 2004BUTYL BENZYL PHTHALATE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Environmental and Molecular Mutagenesis 2004BUTYL BENZYL PHTHALATE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Gigiena i Sanitariya 1974BUTYL BENZYL PHTHALATE• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1980BUTYL BENZYL PHTHALATE• metabolic - Weight loss or decreased weight gain (guinea pig LD50)
• brain and nervous system - Somnolence (general depressed activity) (guinea pig LD50)
• brain and nervous system - Withdrawal (guinea pig LD50)
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1988BUTYL BENZYL PHTHALATE• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 1982BUTYL BENZYL PHTHALATE• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- JAT, Journal of Applied Toxicology 1992BUTYL BENZYL PHTHALATE• developmental - Musculoskeletal system (rat TDLo)
• reproductive - Post-implantation mortality (rat TDLo)
RTECS®- JAT, Journal of Applied Toxicology 1999BUTYL BENZYL PHTHALATE• reproductive - Post-implantation mortality (rat TDLo)
RTECS®- Journal of the American College of Toxicology 1992BUTYL BENZYL PHTHALATE• liver - Changes in liver weight (rat TDLo)
RTECS®- Mutation Research 1996BUTYL BENZYL PHTHALATE• mutagenic - Positive mutation assay: Morphological Transform (hamster emb)
RTECS®- Mutation Research 1996BUTYL BENZYL PHTHALATE• mutagenic - Positive mutation assay: Morphological Transform (hamster emb)
RTECS®- National Technical Information Service BUTYL BENZYL PHTHALATE• reproductive - Fetotoxicity (rat TDLo)
• reproductive - Other developmental abnormalities (rat TDLo)
RTECS®- National Technical Information Service 9999BUTYL BENZYL PHTHALATE• reproductive - Fetal death (mouse TDLo)
• reproductive - Fetotoxicity (mouse TDLo)
RTECS®- National Technical Information Service 8398BUTYL BENZYL PHTHALATE• cancer - blood tumors (rat TDLo)
RTECS®- National Technical Information Service 5346BUTYL BENZYL PHTHALATE• reproductive - Fetal death (rat TDLo)
• reproductive - Other effects (rat TDLo)
• reproductive - Other effects on embryo (rat TDLo)
• reproductive - Uterus, cervix, vagina (rat TDLo)
RTECS®- National Technical Information Service 9999BUTYL BENZYL PHTHALATE• reproductive - Litter size (mouse TDLo)
• reproductive - Other effects (mouse TDLo)
• reproductive - Other effects on embryo (mouse TDLo)
• reproductive - Post-implantation mortality (mouse TDLo)
RTECS®- National Technical Information Service 1014BUTYL BENZYL PHTHALATE• cancer - gastrointestinal neoplasms (rat TDLo)
RTECS®- National Technical Information Service 1089BUTYL BENZYL PHTHALATE• cancer - gastrointestinal tumor formations - equivocal (rat TDLo)
• cancer - kidney or renal system tumor formations - equivocal (rat TDLo)
RTECS®- National Toxicology Program Technical Report Series 1982BUTYL BENZYL PHTHALATE• cancer - blood tumors (rat TDLo)
RTECS®- National Toxicology Program Technical Report Series 1997BUTYL BENZYL PHTHALATE• reproductive - Male fertility index (rat TDLo)
• reproductive - Spermatogenesis (rat TDLo)
• reproductive - Testes, epididymis, sperm duct (rat TDLo)
• cancer - gastrointestinal tumors (rat TDLo)
RTECS®- Regulatory Toxicology and Pharmacology 1997BUTYL BENZYL PHTHALATE• reproductive - Urogenital system (rat TDLo)
RTECS®- Reproductive Toxicology 1998BUTYL BENZYL PHTHALATE• reproductive - Other effects (rat TDLo)
RTECS®- Reproductive Toxicology 2000BUTYL BENZYL PHTHALATE• reproductive - Central nervous system (rat TDLo)
• reproductive - Eye, ear (rat TDLo)
• reproductive - Fetotoxicity (rat TDLo)
• reproductive - Post-implantation mortality (rat TDLo)
• developmental - Urogenital system (rat TDLo)
RTECS®- Reproductive Toxicology 2000BUTYL BENZYL PHTHALATE• reproductive - Cardiovascular (rat TDLo)
• developmental - Delayed effects (rat TDLo)
• reproductive - Endocrine system (rat TDLo)
• reproductive - Physical (rat TDLo)
• reproductive - Respiratory system (rat TDLo)
• developmental - Viability index (rat TDLo)
RTECS®- Reproductive Toxicology 2002BUTYL BENZYL PHTHALATE• reproductive - Fetal death (rat TDLo)
• reproductive - Urogenital system (rat TDLo)
RTECS®- Reproductive Toxicology 2003BUTYL BENZYL PHTHALATE• reproductive - Fetal death (mouse TDLo)
• reproductive - Fetotoxicity (mouse TDLo)
• reproductive - Post-implantation mortality (mouse TDLo)
• metabolic - Weight loss or decreased weight gain (mouse TDLo)
• broad systemic - Broad systemic toxicity (mouse LD)
RTECS®- Reproductive Toxicology 2004BUTYL BENZYL PHTHALATE• reproductive - Blood and lymphatic system (rat TDLo)
• reproductive - Central nervous system (rat TDLo)
• developmental - Growth statistics (rat TDLo)
• reproductive - Hepatobiliary system (rat TDLo)
• developmental - Other developmental abnormalities (rat TDLo)
• reproductive - Urogenital system (rat TDLo)
RTECS®- Reproductive Toxicology 1994BUTYL BENZYL PHTHALATE• reproductive - Post-implantation mortality (rat TDLo)
RTECS®- Toxicologist 1984BUTYL BENZYL PHTHALATE• reproductive - Prostate, seminal vesicle, Cowper's gland, accessory glands (rat TDLo)
• reproductive - Testes, epididymis, sperm duct (rat TDLo)
RTECS®- Toxicologist 2005BUTYL BENZYL PHTHALATE• reproductive - Biochemical and metabolic (rat TDLo)
• developmental - Delayed effects (rat TDLo)
RTECS®- Toxicologist 2001BUTYL BENZYL PHTHALATE• reproductive - Fetotoxicity (rat TDLo)
• reproductive - Urogenital system (rat TDLo)
RTECS®- Toxicologist 2003BUTYL BENZYL PHTHALATE• reproductive - Fetotoxicity (rat TDLo)
RTECS®- Toxicologist 2004BUTYL BENZYL PHTHALATE• reproductive - Endocrine system (rat TDLo)
RTECS®- Toxicology and Industrial Health 1987BUTYL BENZYL PHTHALATE• blood - Hemorrhage (rat TDLo)
• kidney or renal system - Changes in bladder weight (rat TDLo)
• liver - Changes in liver weight (rat TDLo)
• brain and nervous system - Food intake (animal) (rat TDLo)
RTECS®- Toxicology 1995BUTYL BENZYL PHTHALATE• reproductive - Fetotoxicity (rat TDLo)
• reproductive - Growth statistics (rat TDLo)
• reproductive - Post-implantation mortality (rat TDLo)

references

government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
EPA Clean Water Act - Priority Pollutants
Environmental Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Illinois EPA Chemicals Associated with Endocrine SystemIllinois EPA (Illinois Environmental Protection Agency). 2000. Preliminary list of chemicals associated with endocrine system effects in animals and humans (*) or in vitro (+). In EPA (U.S. Environmental Protection Agency) 2000. Handbook for Non-Cancer Health Effects Valuation, Appendix C.
EPA Integrated Risk Information System (IRIS)EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
European Commission on Endocrine DisruptionEU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
Int'l Agency for Research on Cancer (IARC) - CarcinogensIARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
EPA Categorized List of Inert Pesticide IngredientsEPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
NTP - Risks to Human ReproductionNTP (National Toxicology Program). 2006. NTP Center for the Evaluation fo Risks to Human Reproduction (CERHR). NTP-CERHR Reports and Monographs.
Our Stolen Future Endocrine DisruptorsColborn T, D Dumanoski, JP Myers. 2006. Widespread Pollutants with Endocrine-disrupting Effects. Updated from original listing in "Our Stolen Future" (1996).
OSPAR PBTs - Substances of Possible ConcernOSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
EPA Toxic Release Inventory PBTsEPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
California EPA Proposition 65California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
Scorecard.org Toxicity InformationBKH/European Commission. Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption: - preparation of a candidate list of substances as a basis for priority setting. Final report-November 2000. http://europa.eu.int/comm/environment/docum/01262_en.htm#bkh. Category 1 chemicals from Annex 1: Candidate list of 553 substances. http://europa.eu.int/comm/environment/docum/bkh_annex_01.pdf, Japanese National Institute of Health Sciences. Lists of Paradigmatic Chemicals. http://www.nihs.go.jp/hse/endocrine-e/paradigm/paradigm.html, Keith, L.H. (ed.). Environmental Endocrine Disruptors. John Wiley & Sons, NY. 1997. http://www.wileyeurope.com/cda/product/0,,0471191450%7Cdesc%7C3037,00.html, World Wildlife Fund. Our Stolen Future. Widespread Pollutants with Endocrine-disrupting Effects. http://www.ourstolenfuture.org/Basics/chemlist.htm. The WWF list is derived from references detailed at http://www.ourstolenfuture.org/Sources/chemsources.htm and was originally published in: Colborn, T., F.S. vom Saal, and A.M. Soto. Developmental Effects of Endocrine-Disrupting Chemicals In Wildlife and Humans. Environmental Health Perspectives 101(5): 378-384. 1993.
Scorecard.org Toxicity InformationNational Toxicology Program Center for the Evaluation of Risks to Human Reproduction. National Toxicology Program. 10th Report on Carcinogens (2002). http://ehis.niehs.nih.gov/roc/toc10.htmlERHR Briefs and Expert Panel Reports. http://cerhr.niehs.nih.gov/
Scorecard.org Toxicity InformationNational Toxicology Program Center for the Evaluation of Risks to Human Reproduction. National Toxicology Program. 10th Report on Carcinogens (2002). http://ehis.niehs.nih.gov/roc/toc10.htmlERHR Briefs and Expert Panel Reports. http://cerhr.niehs.nih.gov/, Proposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.-CAND
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RTECS®- Environmental and Molecular Mutagenesis 2004RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 44,329,2004
RTECS®- Environmental and Molecular Mutagenesis 2004RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 44,329,2004
RTECS®- Gigiena i Sanitariya 1974RTECS®- Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- 39(6),25,1974
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1980RTECS®- Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI 24(3),25,1980
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1988RTECS®- Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI 32(7),52,1988
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"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.

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