DIETHYLHEXYL PHTHALATE || Skin Deep: Cosmetic Safety Reviews

DIETHYLHEXYL PHTHALATE

Fragrance Ingredient; Plasticizer; Solvent

SCORE

	10	high hazard
	53%	data gap
(why scores have changed)

Also listed as

1,2-BENZENEDICARBOXYLIC ACID, BIS (2-ETHYLHEXYL) ESTER; DI (2-ETHYLHEXYL) PHTHALATE; DI (2-ETHYLHEXYL) PHTHALATE; DIOCTYL PHTHALATE; BIS (2-ETHYLHEXYL) ESTER 1,2-BENZENEDICARBOXYLIC ACID; BIS (2-ETHYLHEXYL) PHTHALATE; DEHP; 1,2-BENZENEDICARBOXYLIC ACID, BIS (2-ETHYLHEXYL) ESTER; 2-ETHYLHEXYL PHTHALATE; BIS (2-ETHYLHEXYL) -1,2-BENZENEDICARBOXYLATE; BIS (2-ETHYLHEXYL) PHTHALATE

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other strong concerns for this ingredient: Organ system toxicity (non-reproductive)
	Other moderate concerns for this ingredient: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Occupational hazards
	Lesser or emerging concerns for this ingredient: Ecotoxicology, Irritation (skin, eyes, or lungs), Data gaps, Biochemical or cellular level changes
	See products containing DIETHYLHEXYL PHTHALATE

About DIETHYLHEXYL PHTHALATE: Diethylhexyl Phthalate is the diester of a 2-ethylhexyl alcohol and phthalic acid. It conformsgenerally to the formula:

DIETHYLHEXYL PHTHALATE has reported used in the following product types: eyelash glue (1)

Violations, restrictions & warnings

type of concern	product conditions	reference
Violation of government restrictions - Banned or found unsafe for use in cosmetics		European Union - Banned or Restricted in Cosmetics

Developmental/reproductive toxicity

type of concern

product conditions

reference

Possible human developmental toxicant

California EPA Proposition 65

Limited evidence of reproductive toxicity

European Union - Classification & Labelling

Limited evidence of reproductive toxicity

National Library of Medicine HazMap

Cancer

type of concern

product conditions

reference

Possible human carcinogen

EPA Integrated Risk Information System (IRIS)

Possible human carcinogen

NTP Report on Carcinogens, 11th Edition

Limited evidence of carcinogenicity

Amer Conf of Gov't Industrial Hygienists - Carcinogens

One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Journal of Pharmaceutical Sciences 1976
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Mutation Research 1989
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Progress in Mutation Research 1985
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Proceedings of the American Association for Cancer Research 1986
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- EHP, Environmental Health Perspectives 1986
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Toxicology and Applied Pharmacology 1988
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Mutation Research 1995
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Toxicology and Applied Pharmacology 1974
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Journal of Toxicology and Environmental Health 1985
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- EHP, Environmental Health Perspectives 1982
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Science 1987
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Environmental and Molecular Mutagenesis 2000
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Food and Chemical Toxicology 2004
Cancer - not classifiable/not likely to be human carcinogen		Int'l Agency for Research on Cancer (IARC) - Carcinogens
One or more in vitro tests non-mammalian cells show positive mutation results		RTECS^®- EHP, Environmental Health Perspectives 1982
One or more in vitro tests non-mammalian cells show positive mutation results		RTECS^®- Mutation Research 1991
One or more in vitro tests non-mammalian cells show positive mutation results		RTECS^®- Mutation Research 1989
One or more in vitro tests non-mammalian cells show positive mutation results		RTECS^®- Progress in Mutation Research 1985
One or more in vitro tests non-mammalian cells show positive mutation results		RTECS^®- Mutagenesis 2004
One or more animal studies show tumor formation at high doses		RTECS^®- National Toxicology Program Technical Report Series 1982
One or more animal studies show tumor formation at high doses		RTECS^®- Carcinogenesis (London) 1983
One or more animal studies show tumor formation at high doses		RTECS^®- EHP, Environmental Health Perspectives 1986
One or more animal studies show tumor formation at high doses		RTECS^®- Cancer Letters (Shannon, Ireland) 1987
One or more animal studies show tumor formation at high doses		RTECS^®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 1999
One or more animal studies show tumor formation at high doses		RTECS^®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 2000
One or more animal studies show tumor formation at high doses		RTECS^®- National Technical Information Service 4011
One or more animal studies show tumor formation at high doses		RTECS^®- Journal of Toxicologic Pathology 2001

Endocrine disruption

type of concern

product conditions

reference

Human disruptor - strong evidence

European Commission on Endocrine Disruption

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Known human respiratory toxicant

EPA Hazardous Air Pollutants

One or more animal studies show classified as toxic effects at low doses		EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show respiratory effects at low doses	products that may be aerosolized (airborne)	RTECS^®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1961
One or more animal studies show blood effects at low doses		RTECS^®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1961
Limited evidence of gastrointestinal or liver toxicity		US EPA, Air Risk Information Support Center, 2003
Limited evidence of respiratory toxicity		California EPA, Office of Environmental Health Hazard Assessment, 2003
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient)		EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		EPA Toxic Release Inventory PBTs
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- Toxicology and Applied Pharmacology 1978
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1961
One or more animal studies show gastrointestinal effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1961
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- National Technical Information Service
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	RTECS^®- American Journal of Ophthalmology 1946
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Raw Material Data Handbook, Vol 1975
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Journal of Industrial Hygiene and Toxicology 1945
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Gigiena Truda i Professional'nye Zabolevaniya 1988
One or more animal studies show cardiovascular effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Journal of Pharmaceutical Sciences 1966
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- EHP, Environmental Health Perspectives 1973
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 1982
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology Letters 1979
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology Letters 1979
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Veterinary and Human Toxicology 1995
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1953
One or more animal studies show kidney or renal system effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1953
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1953
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology and Applied Pharmacology 1981
One or more animal studies show kidney or renal system effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Cosmetics Toxicology 1977
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Cosmetics Toxicology 1977
One or more animal studies show blood effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Cosmetics Toxicology 1977
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Food and Cosmetics Toxicology 1977
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology and Applied Pharmacology 1985
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Toxicology Letters 1993
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		National Library of Medicine HazMap
Classified as not expected to be potentially toxic or harmful		Environmental Canada Domestic Substance List
Classified as a low human health priority		Environmental Canada Domestic Substance List

Neurotoxicity

type of concern

product conditions

reference

One or more animal studies show brain and nervous system effects at low doses

RTECS^®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1961

Persistence and bioaccumulation

type of concern

product conditions

reference

Persistent, bioaccumulative in wildlife

Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Persistent, bioaccumulative in wildlife

OSPAR PBTs - Substances of Possible Concern

Persistent, bioaccumulative in wildlife

Emerging PBTs from peer-reviewed literature

Occupational hazards

type of concern	product conditions	reference
Allowed workplace exposures restricted to moderate doses		RTECS^®- TLV/BEI,2005
Allowed workplace exposures restricted to moderate doses		RTECS^®- TLV/BEI,2006
Allowed workplace exposures restricted to moderate doses		RTECS^®- TLV/BEI,2007

Biochemical or cellular level changes

type of concern

product conditions

reference

One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood

RTECS^®- Veterinary and Human Toxicology 1995

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

One or more animal studies show skin irritation at moderate doses

RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986

Ecotoxicology

type of concern

product conditions

reference

Wildlife and environmental toxicity

EPA Clean Water Act - Priority Pollutants

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
1,178 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
European Union - Classification & Labelling	BIS(2-ETHYLHEXYL) PHTHALATE	•May be toxic to the reproductive system •May impair fertility
Amer Conf of Gov't Industrial Hygienists - Carcinogens	DI(2-ETHYLHEXYL)PHTHALATE (DEHP)	•Confirmed animal carcinogen with unknown relevance to humans (ACGIH classification A3)
EPA Clean Water Act - Priority Pollutants	BIS(2-ETHYLHEXYL)PHTHALATE	•Priority water pollutant under the Clean Water Act
Illinois EPA Chemicals Associated with Endocrine System	DI(2-ETHYLHEXYL)PHTHALATE	•EPA: probable endocrine disruptor
EPA Integrated Risk Information System (IRIS)	DI (2-ETHYLHEXYL)PHTHALATE (DEHP)	•Group B2: Probable human carcinogen - sufficient data in animals (EPA classification)
European Union - Banned or Restricted in Cosmetics	BIS(2-ETHYLHEXYL) PHTHALATE	•Prohibited in EU cosmetics: must not form part of the composition of cosmetic products
European Union - Water Framework Directive	DI(2-ETHYLHEXYL)PHTHALATE (DEHP)	•Priority substance in EU water policy
EPA Hazardous Air Pollutants	BIS(2-ETHYLHEXYL)PHTHALATE (DEHP)	•Hazardous air pollutant under Clean Air Act
National Library of Medicine HazMap	DI-SEC-OCTYL PHTHALATE	•Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male and female reproductive function: Yes; •PEL (OSHA) - Permissible exposure limit (OSHA): 5 mg/m3; •TLV (ACGIH) - Threshold limit value (ACGIH): 5 mg/m3; •Flammability (NFPA) - NFPA flammability code: 0 = will not burn; 1 = must be preheated; 2 = high ambient temp required; 3 = may ignite at ambient temp; 4 = burn readily: 1: must be preheated; •IDLH (NIOSH) - Immediately Dangerous to Life or Health: 5000 mg/m3; •MAK - Maximum Allowable Concentration (Federal Republic of Germany): 10 mg/m3;
Int'l Agency for Research on Cancer (IARC) - Carcinogens	DI(2-ETHYLHEXYL) PHTHALATE	•IARC Group 3 (no cancer link)
EPA Categorized List of Inert Pesticide Ingredients	DIOCTYL PHTHALATE	•Pesticide inerts: potentially toxic, testing priority, according to EPA (Environmental Protection Agency)
EPA Categorized List of Inert Pesticide Ingredients	PHTHALIC ACID, BIS(2-ETHYLHEXYL) ESTER C1980	•Pesticide inerts of toxicological concern according to EPA (Environmental Protection Agency)
NTP Report on Carcinogens, 11th Edition	DI(2-ETHYLHEXYL) PHTHALATE	•Reasonably anticipated to be a human carcinogen (National Toxicology Program classification)
NTP - Risks to Human Reproduction	DI(2-ETHYLHEXYL) PHTHALATE	<>
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)	BIS(2-ETHYLHEXYL) ESTER1,2-BENZENEDICARBOXYLIC ACID	•Bioaccumulative toxicant under Canada's Accelerated Reduction/Elimination of Toxics program - targeted for elimination or reduction
OSPAR PBTs - Substances of Possible Concern	BIS(2-ETHYLHEXYL) ESTER1,2-BENZENEDICARBOXYLIC ACID	•Persistent, bioaccumulative toxicant - Oslo-Paris (OSPAR) Convention for the Protection of the Marine Environment of the North-East Atlantic, chemical of concern
Emerging PBTs from peer-reviewed literature	1,2-BENZENEDICARBOXYLIC ACID, BIS(2-ETHYLHEXYL) ESTER	•Persistent, bioaccumulative toxicant - Limited or emerging evidence in open scientific literature
EPA Toxic Release Inventory PBTs	BIS(2-ETHYLHEXYL) ESTER1,2-BENZENEDICARBOXYLIC ACID	•Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs
California EPA Proposition 65	DI(2-ETHYLHEXYL)PHTHALATE	•Developmental toxin: California Proposition 65 •Reproductive toxin, male: California Proposition 65
BKH/European Commission, 2000	BIS(2-ETHYLHEXYL)PHTHALATE	•Endocrine toxicity hazards: suspected
US EPA, Air Risk Information Support Center, 2003	BIS(2-ETHYLHEXYL)PHTHALATE	•Gastrointestinal or liver toxicity hazards: suspected
California EPA, Office of Environmental Health Hazard Assessment, 2003	BIS(2-ETHYLHEXYL)PHTHALATE	•Respiratory toxicity hazards: suspected
Our Stolen Future Endocrine Disruptors	DI-ETHYLHEXYL PHTHALATE (DEHP)	•
European Commission on Endocrine Disruption	DI-(2-ETHYLHEXYL)PHTHALATE (DEHP)	•Evidence of endocrine disrupting activity in at least one species using intact animals, high human health concern. •No evidence of endocrine disrupting activity or no data available.
Environmental Canada Domestic Substance List	1,2-BENZENEDICARBOXYLIC ACID, BIS(2-ETHYLHEXYL) ESTER	•This chemical was NOT flagged by CEPA for further attention. The chemical was flagged as a low human health priority and for suspected aquatic toxicity.
Association of Occupational and Environmental Clinics	DIOCTYLPHTHALATE	• o
IFRA Fragrance Ingredient List	DI(2-ETHYLHEXYL) PHTHALATE	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
RTECS^®- TLV/BEI,2005	DIETHYLHEXYL PHTHALATE	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- TLV/BEI,2006	DIETHYLHEXYL PHTHALATE	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- TLV/BEI,2007	DIETHYLHEXYL PHTHALATE	• occupationally related - ACGIH TLV (human TWA)
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	DIETHYLHEXYL PHTHALATE	• sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit )
RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1953	DIETHYLHEXYL PHTHALATE	• metabolic - Weight loss or decreased weight gain (rat TDLo) • kidney or renal system - Changes in bladder weight (rat TDLo) • liver - Changes in liver weight (rat TDLo)
RTECS^®- American Journal of Ophthalmology 1946	DIETHYLHEXYL PHTHALATE	• sense organ - Primary eye irritant (rabbit )
RTECS^®- American Journal of Ophthalmology 1946	DIETHYLHEXYL PHTHALATE	• sense organ - Primary eye irritant (rabbit )
RTECS^®- Archives of Toxicology 1986	DIETHYLHEXYL PHTHALATE	• reproductive - Prostate, seminal vesicle, Cowper's gland, accessory glands (rat TDLo) • reproductive - Testes, epididymis, sperm duct (rat TDLo)
RTECS^®- Cancer Letters (Shannon, Ireland) 1987	DIETHYLHEXYL PHTHALATE	• cancer - liver tumors (rat TD)
RTECS^®- Carcinogenesis (London) 1983	DIETHYLHEXYL PHTHALATE	• cancer - liver tumor formations - equivocal (mouse TD)
RTECS^®- EHP, Environmental Health Perspectives 1982	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster orl) • mutagenic - Positive mutation assay: Morphological Transform (hamster orl)
RTECS^®- EHP, Environmental Health Perspectives 1986	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: sperm (rat orl)
RTECS^®- EHP, Environmental Health Perspectives 1973	DIETHYLHEXYL PHTHALATE	• broad systemic - Broad systemic toxicity (guinea pig LD50)
RTECS^®- EHP, Environmental Health Perspectives 1982	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium ) • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster orl) • mutagenic - Positive mutation assay: Morphological Transform (hamster orl)
RTECS^®- EHP, Environmental Health Perspectives 1986	DIETHYLHEXYL PHTHALATE	• cancer - liver tumors (mouse TD)
RTECS^®- EHP, Environmental Health Perspectives 1986	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: sperm (rat orl)
RTECS^®- Environmental and Molecular Mutagenesis 2000	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Morphological Transform (mouse fbr)
RTECS^®- Environmental and Molecular Mutagenesis 2000	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Morphological Transform (mouse fbr)
RTECS^®- Food and Chemical Toxicology 2004	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: DNA Damage (rat orl)
RTECS^®- Food and Chemical Toxicology 2004	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: DNA Damage (rat orl)
RTECS^®- Food and Cosmetics Toxicology 1977	DIETHYLHEXYL PHTHALATE	• reproductive - Ovaries, fallopian tubes (rat TDLo) • metabolic - Weight loss or decreased weight gain (rat TDLo) • kidney or renal system - Changes in bladder weight (rat TDLo) • liver - Changes in liver weight (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) • skin - Hair (rat TDLo) • blood - Other changes (rat TDLo)
RTECS^®- Gigiena i Sanitariya 1980	DIETHYLHEXYL PHTHALATE	• skin - Other glands (rat LDLo)
RTECS^®- Gigiena Truda i Professional'nye Zabolevaniya 1988	DIETHYLHEXYL PHTHALATE	• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS^®- IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 1982	DIETHYLHEXYL PHTHALATE	• broad systemic - Broad systemic toxicity (guinea pig LD50)
RTECS^®- Indian Journal of Experimental Biology 1989	DIETHYLHEXYL PHTHALATE	• reproductive - Fetotoxicity (rat TDLo) • developmental - Hepatobiliary system (rat TDLo)
RTECS^®- Journal of Industrial Hygiene and Toxicology 1945	DIETHYLHEXYL PHTHALATE	• broad systemic - Broad systemic toxicity (rabbit LD50)
RTECS^®- Journal of Pharmaceutical Sciences 1976	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Cytogenetic Analysis ( human leu)
RTECS^®- Journal of Pharmaceutical Sciences 1966	DIETHYLHEXYL PHTHALATE	• cardiovascular - BP lowering not characterized in autonomic section (mouse LD50) • brain and nervous system - Excitement (mouse LD50)
RTECS^®- Journal of Pharmaceutical Sciences 1976	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Cytogenetic Analysis ( human leu)
RTECS^®- Journal of Toxicologic Pathology 2001	DIETHYLHEXYL PHTHALATE	• cancer - liver neoplasms (mouse TDLo)
RTECS^®- Journal of Toxicology and Environmental Health 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse scu)
RTECS^®- Journal of Toxicology and Environmental Health 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse scu)
RTECS^®- Mutagenesis 2004	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Saccharomyces cerevisiae )
RTECS^®- Mutation Research 1989	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human lym)
RTECS^®- Mutation Research 1989	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: (Drosophila melanogaster orl)
RTECS^®- Mutation Research 1991	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Phage Inhibition Capacity (Escherichia coli )
RTECS^®- Mutation Research 1995	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: other mutation test systems (mouse orl)
RTECS^®- Mutation Research 1989	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human lym)
RTECS^®- Mutation Research 1989	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: (Drosophila melanogaster orl)
RTECS^®- Mutation Research 1991	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Phage Inhibition Capacity (Escherichia coli )
RTECS^®- Mutation Research 1995	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: other mutation test systems (mouse orl)
RTECS^®- National Technical Information Service	DIETHYLHEXYL PHTHALATE	• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS^®- National Technical Information Service 4011	DIETHYLHEXYL PHTHALATE	• cancer - liver tumors (mouse TDLo)
RTECS^®- National Toxicology Program Technical Report Series 1982	DIETHYLHEXYL PHTHALATE	• mutagenic - endocrine system tumors (rat TDLo) • cancer - liver tumors (rat TDLo) • mutagenic - reproductive tumors (rat TD)
RTECS^®- Nippon Eiseigaku Zasshi 1976	DIETHYLHEXYL PHTHALATE	• reproductive - Post-implantation mortality (rat TDLo)
RTECS^®- Proceedings of the American Association for Cancer Research 1986	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat orl)
RTECS^®- Proceedings of the American Association for Cancer Research 1986	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat orl)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Gene Conversion and Mitotic Recombination (Saccharomyces cerevisiae )
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Saccharomyces cerevisiae )
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat lvr)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (hamster lvr)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Mutation in Micro-organism (mouse lym)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Morphological Transform (hamster emb)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Gene Conversion and Mitotic Recombination (Saccharomyces cerevisiae )
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Saccharomyces cerevisiae )
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat lvr)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (hamster lvr)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Mutation in Micro-organism (mouse lym)
RTECS^®- Progress in Mutation Research 1985	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Morphological Transform (hamster emb)
RTECS^®- Raw Material Data Handbook, Vol 1975	DIETHYLHEXYL PHTHALATE	• broad systemic - Broad systemic toxicity (rat LD50)
RTECS^®- Science 1987	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr)
RTECS^®- Science 1987	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Sister Chromatid Exchange (hamster ovr)
RTECS^®- Teratology, The International Journal of Abnormal Development 1987	DIETHYLHEXYL PHTHALATE	• reproductive - Musculoskeletal system (rat TDLo) • developmental - Urogenital system (rat TDLo)
RTECS^®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1961	DIETHYLHEXYL PHTHALATE	• blood - Hemorrhage (rat LDLo) • gastrointestinal - Necrotic changes (mouse LD50) • brain and nervous system - Somnolence (general depressed activity) (rat LDLo) • respiratory - Structural or functional change in trachea or bronchi (rat LDLo)
RTECS^®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 1999	DIETHYLHEXYL PHTHALATE	• cancer - liver tumors (rat TD)
RTECS^®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 2000	DIETHYLHEXYL PHTHALATE	• cancer - gastrointestinal neoplasms (rat TDLo)
RTECS^®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 2000	DIETHYLHEXYL PHTHALATE
RTECS^®- Toxicology and Applied Pharmacology 1973	DIETHYLHEXYL PHTHALATE	• reproductive - Fetotoxicity (rat TDLo)
RTECS^®- Toxicology and Applied Pharmacology 1974	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse ipr)
RTECS^®- Toxicology and Applied Pharmacology 1978	DIETHYLHEXYL PHTHALATE	• respiratory - Other changes (rat LD50)
RTECS^®- Toxicology and Applied Pharmacology 1981	DIETHYLHEXYL PHTHALATE	• liver - Changes in liver weight (rat TDLo) • endocrine system - Changes in testicular weight (rat TDLo) • biochemical - Dehydrogenases (rat TDLo)
RTECS^®- Toxicology and Applied Pharmacology 1985	DIETHYLHEXYL PHTHALATE	• biochemical - Catalases (rat TDLo) • liver - Changes in liver weight (rat TDLo) • biochemical - Phosphatases (rat TDLo)
RTECS^®- Toxicology and Applied Pharmacology 1988	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (mouse orl)
RTECS^®- Toxicology and Applied Pharmacology 1974	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse ipr)
RTECS^®- Toxicology and Applied Pharmacology 1988	DIETHYLHEXYL PHTHALATE	• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (mouse orl)
RTECS^®- Toxicology Letters 1979	DIETHYLHEXYL PHTHALATE	• metabolic - Weight loss or decreased weight gain (mouse TDLo) • broad systemic - Broad systemic toxicity (mouse LD50)
RTECS^®- Toxicology Letters 1993	DIETHYLHEXYL PHTHALATE	• liver - Changes in liver weight (rat TDLo) • liver - Other changes (rat TDLo)
RTECS^®- Veterinary and Human Toxicology 1995	DIETHYLHEXYL PHTHALATE	• endocrine system - Changes in testicular weight (rat TDLo) • biochemical - Dehydrogenases (rat TDLo) • liver - Other changes (rat TDLo)

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RTECS^®- TLV/BEI,2005	RTECS^®- TLV/BEI,2005
RTECS^®- TLV/BEI,2006	RTECS^®- TLV/BEI,2006
RTECS^®- TLV/BEI,2007	RTECS^®- TLV/BEI,2007
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RTECS^®- National Technical Information Service	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB250-102
RTECS^®- National Technical Information Service 4011	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB82-184011
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