HUMAN PLACENTAL PROTEIN || Skin Deep: Cosmetic Safety Reviews

HUMAN PLACENTAL PROTEIN

Hair Conditioning Agent; Skin-Conditioning Agent - Miscellaneous

SCORE

	5	moderate hazard
	75%	data gap
(why scores have changed)

Also listed as

PLACENTA EXTRACT, HUMAN; PLACENTAL PROTEINS, HUMAN; PROTEINS, PLACENTAL, HUMAN; HUMAN PLACENTAL PROTEINS; HUMAN PROTEINS, PLACENTAL; PLACENTAL HUMAN PROTEINS

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns - PROGESTERONE, ESTROGEN, ESTRONE
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Endocrine disruption, Data gaps

About HUMAN PLACENTAL PROTEIN: Human Placental Protein is the protein derived from human placenta obtained from normalafterbirth.

Violations, restrictions & warnings

type of concern	product conditions	reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		Canada - Prohibited and Restricted Cosmetics Ingredients

Organ system toxicity (non-reproductive)

type of concern	product conditions	reference
Potential risk of infectious disease - Must be free of detectable pathogenic viruses or infectious agents		Cosmetic Ingredient Review Assessments

Endocrine disruption

type of concern

product conditions

reference

One or more studies show weak endocrine disruption

Tiwary, C, 1998

Data gaps

type of concern	product conditions	reference
Insufficient data to determine safety		Cosmetic Ingredient Review Assessments
8 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Canada - Prohibited and Restricted Cosmetics Ingredients	HUMAN PLACENTAL PROTEIN	•Use is restricted in Canadian cosmetics
Cosmetic Ingredient Review Assessments	HUMAN PLACENTAL PROTEIN	•Insufficient data to support safe use in cosmetics •Should not deliver any metabolic or endocrine activity •Must be free of detectable pathogenic viruses or infectious agents: warning from industry safety panel (Cosmetic Ingredient Review, CIR) •May contain harmful impurities
FDA, 2006	ESTROGEN, ESTRONE, ESTRADIOL, PROGESTERONE, PLACENTAL EXTRACT OR VITAMINS	FDA may consider this a misbranded cosmetic if the extract has been prepared from placentas from which the hormones and other biologically active substances have not been removed and the extracted substance consists principally of protein.
FDA, 2006	PLACENTAL EXTRACT	Impurity: estradiol, estrone, progesterone
Tiwary, C, 1998	PLACENTA-CONTAINING HAIR PRODUCTS	Girls developed breasts or pubic hair 2 to 24 months after starting the use of estrogen or placenta-containing hair products

references

government/industry list/academic study	reference
Canada - Prohibited and Restricted Cosmetics Ingredients	Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Open scientific literature	FDA, 2006. "GUIDE TO INSPECTIONS OF COSMETIC PRODUCT MANUFACTURERS," U.S. Food and Drug Administration, Accessed on May 14th, 2007 at: http://www.fda.gov/ora/inspect_ref/igs/cosmet.html.
Open scientific literature	FDA, 2006. "GUIDE TO INSPECTIONS OF COSMETIC PRODUCT MANUFACTURERS," U.S. Food and Drug Administration, Accessed on May 14th, 2007 at: http://www.fda.gov/ora/inspect_ref/igs/cosmet.html.
Open scientific literature	Tiwary, C. M. (1998). "Premature sexual development in children following the use of estrogen- or placenta-containing hair products." Clin Pediatr (Phila) 37(12): 733-9.

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