HYDROXYPROPYL METHACRYLATE || Skin Deep: Cosmetic Safety Reviews

HYDROXYPROPYL METHACRYLATE

Artificial Nail Builder; FILM FORMING

SCORE

	4	moderate hazard
	71%	data gap
(why scores have changed)

Also listed as

2-PROPENOIC ACID, 2-METHYL-, MONOESTER WITH 1,2-PROPANEDIOL; PROPYLENE GLYCOL MONOMETHACRYLATE; MONOESTER WITH 1,2-PROPANEDIOL 2-PROPENOIC ACID, 2-METHYL-; 2-METHYL- MONOESTER WITH 1,2-PROPANEDIOL 2-PROPENOIC ACID; 2PROPENOIC ACID, 2METHYL, MONOESTER WITH 1,2PROPANEDIOL; METHACRYLIC ACID, MONOESTER WITH PROPANE-1,2-DIOL; 1,2-PROPANEDIOL, MONOMETHACRYLATE (8CI) ; METHACRYLIC ACID, ESTER WITH 1,2-PROPANEDIOL (7CI) ; METHACRYLIC ACID, MONOESTER WITH 1,2-PROPANEDIOL (8CI) ; PROPYLENE GLYCOL MONOMETHACRYLATE; ROCRYL 410

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Data gaps

About HYDROXYPROPYL METHACRYLATE: Hydroxypropyl Methacrylate is the organic compound.

Allergies/immunotoxicity

type of concern	product conditions	reference
Known human immune system toxicant		National Library of Medicine HazMap
Human skin toxicant - strong evidence		Cosmetic Ingredient Review Assessments
Human skin toxicant - strong evidence

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Potential risk of infectious disease - Must be free of detectable pathogenic viruses or infectious agents

Cosmetic Ingredient Review Assessments

Data gaps

type of concern	product conditions	reference
Insufficient data to determine safety		Cosmetic Ingredient Review Assessments
68 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Endocrine disruption

type of concern	product conditions	reference
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		Cosmetic Ingredient Review Assessments

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	HYDROXYPROPYL METHACRYLATE	•Insufficient data to support safe use in cosmetics •Should not deliver any metabolic or endocrine activity •Must be free of detectable pathogenic viruses or infectious agents: warning from industry safety panel (Cosmetic Ingredient Review, CIR) •Sensitizer - can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin • •
Environmental Canada Domestic Substance List	2-PROPENOIC ACID, 2-METHYL-, MONOESTER WITH 1,2-PROPANEDIOL	•This chemical was NOT flagged by CEPA for further attention.
National Library of Medicine HazMap	2-HYDROXYPROPYL METHACRYLATE	•Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes;
RTECS^®- National Technical Information Service 4834	HYDROXYPROPYL METHACRYLATE	• respiratory - Acute pulmonary edema (rat LD50) • respiratory - Dyspnea (rat LD50) • gastrointestinal - Other changes (rat LD50)

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
RTECS^®- National Technical Information Service 4834	RTECS^®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0544834

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.